The information presented in GeneCards is extracted from or linked to the following databases:
Abcam maintains a
catalog of antibodies, some are made internally, while others are sourced from institutes,
academic laboratories and primary manufacturers.
AceView offers an integrated view of the human and nematode genes as
reconstructed by mRNA and EST alignments.
AKS extracts knowledge
from biological databases and text repositories, enabling users to uncover the knowledge
hidden within these data sources.
The Alternative Splicing
Database (ASD) maintains a database of alternative splice events and the resultant
isoform splice patterns of genes from human, and other model species.
Applied Biosystems
is a supplier of life science tools world-wide, including gene expression and genotyping
assays and resequencing sets.
ATLAS of Genetics and Cytogenetics in Oncology and Haematology.
BLOCKS is a database of
Blocks multiply aligned ungapped segments corresponding to the most highly conserved regions
of proteins.
BIOMOL is a supplier of
specialty biochemicals, with applications in signal transduction, lipid research, apoptosis,
neuroscience and drug discovery.
CGAP (The Cancer Genome
Anatomy Project) determines the gene expression profiles of normal, precancer, and cancer cells, leading eventually to improved detection, diagnosis, and treatment for the patient.
CroW21 is
the Human Chromosome 21 Database at the Weizmann Institute of Science.
CST (Cell Signaling
Technology) provides discovery tools for cell signaling research, including information
about pathways and phosphorylation sites.
DiscoveRx provides
a family of assay solutions for GPCRs, Kinases, Protein Expression and Translocation, using
its proprietary EFC chemiluminescent detection technology.
Doctor's Guide to the
Internet: a Web service presenting news about biomedical research and its applications.
GeneCards presents links and titles of interesting articles stored there.
ECgene: a new EST
clustering method that produces gene models based on genomic alignment of mRNA and ESTs.
Ensembl: a software system
producing and maintaining automatic annotation on eukaryotic genomes, which provides
identification of known human genes in the genome sequence and prediction of additional genes
with supporting evidence.
EntrezGene at NCBI provides a single query interface to curated sequence and descriptive
information about genetic loci.
euGenes: Genomic
Information for Eukaryotic Organisms Database for more details on similar genes in other
organisms.
EXPOLDB: a database of
expression variation in blood leukocytes in monozygotic twins and unrelated individuals.
GDB (Genome Database)
stores information about genes and other genomic features. GeneCards
presents extracts taken from gene entries, namely the synonyms for the
gene symbol, and links to the GDB entries for the genes.
Genatlas: a
catalog of genes, markers and phenotypes with many links to major data sources. GeneCards
offers the short description of the gene that often contains interesting, concise information
about its cellular functions and/or role in diseases.
GenBank: the NIH genetic sequence database, an annotated collection of all
publicly available DNA sequences.
GeneAnnot:
Annotation of high-density oligunocleotide arrays at the Weizmann Institute of Science, with
links to Affymetrix probe-sets.
GeneLoc
(formerly The Unified DataBase (UDB)) integrates information on the human genome, with
emphasis on mapping information. Mapped DNA segments, classified by categories (such as genes,
EST clusters and STSs mapped by various methods) are presented on a Megabase-scale integrated
map, with further links to relevant databases.
GeneLynx: a portal to a
collection of hyperlinks for each human gene.
GeneNote:
the Gene Normal Tissue Expression database at the Weizmann Institute of Science
GeneTests (formerly
GeneClinics): a clinical information resource relating genetic testing to the diagnosis,
management, and genetic counseling of individuals and families with specific inherited
disorders.
GeneTex
provides research tools including immunological reagents (antibodies, etc) used to study specific proteins
and events involved in the regulation of the cell cycle and DNA repair and replication.
GeneTide,
the Gene Terra Incognita Discovery Endeavor, is an automated system for human transcript
(mRNAs & ESTs) annotation and elucidation of de-novo genes.
GO, the Gene Ontology, is a dynamic controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing.
The International HapMap Project
aims to develop a public resource that will help researchers find genes associated with human disease and response to pharmaceuticals.
HGMD
(Human Gene Mutation Database): information about disease-causing mutations
in genes. GeneCards presents a link to specific entries in this database
whenever they can be found.
HInv-DB: H-Invitational Database (H-InvDB) is an integrated database of curated annotations of human genes and transcripts.
HomoloGene: a resource of curated and calculated orthologs for genes as represented by UniGene or by annotation of genomic sequences.
HORDE is the Human Olfactory Receptor Data Exploratorium at the Weizmann Institute of Science.
HUGE: the Database of Human Unidentified Gene-Encoded Large Proteins.
The
Human Genome Epidemiology Navigator (HuGE Navigator) provides access to a continuously updated
knowledge base in human genome epidemiology, including information on population prevalence of genetic
variants, gene-disease associations, gene-gene and gene-environment interactions, and evaluation
of genetic tests.
IMGT: a high-quality
integrated information system specialising in Immunoglobulins (IG), T cell receptors (TR) and
Major Histocompatibility Complex (MHC) molecules of all vertebrate species.
IntAct: IntAct provides a
freely available, open source database system and analysis tools for protein interaction data.
All interactions are derived from literature curation or direct user submissions and are freely
available.
InterPro: a database
of protein families, domains and functional sites in which identifiable features found in
known proteins can be applied to unknown protein sequences.
Invitrogen is a
supplier of life science tools world-wide, including RNAi, pathways, antibodies, and
recombinant proteins.
IUBMB: The International Union of Biochemistry and Molecular Biology - the Nomenclature Committee
The Mammary Transgene Database summarizes the results of experiments in which transgenes are expressed in the mammary gland of experimental and agricultural animals.
MGI (Mouse Genome Informatics, formerly MGD) provides a comprehensive source of information on the experimental genetics of the laboratory mouse; it includes information on mouse markers, mammalian homologies, probes and clones. GeneCards presents links to mammalian homology pages, the name of the mouse gene, its location (in centiMorgan), phenotypic alleles, and links to the entries for the mouse gene.
MINT (Molecular Interactions Database) focuses on experimentally verified protein interactions with special emphasis on proteomes from mammalian organisms, consists of entries mined in the scientific literature by curators.
miRBase is the new home for microRNA data, incorporating the database and gene naming roles previously provided by the miRNA Registry, and including the new miRBase Target database.
Nature 405, 311-319: is the chromosome 21 mapping and sequencing
consortium paper entitled "The DNA sequence of human chromosome 21".
OMIM (Online Mendelian Inheritance in Man): a catalog of human genes and
genetic disorders
with a lot of information about many different aspects
(medical and genetic).
GeneCards presents a
list of diseases listed
as allelic variants in the respective entry for the gene, synonyms for
the gene, and a
link to the OMIM database entry.
OriGene is a world-wide supplier
of authentic full-length CDNA clones in a standard expression vector.
The PharmGKB is an integrated resource about how variation in human genes leads to variation in our response to drugs.
PhosphoSite from CST is a
curated, sequence-oriented protein database dedicated to in vivo phosphorylation sites.
ProtoNet at the Hebrew University of Jerusalem provides global classification of the proteins into hierarchical clusters.
pseudogene.org, a project of the Gerstein Lab at Yale University, provides information on pseudogenes and intergenic analyses.
PubMed: NLM's search service to access the 9 million citations in MEDLINE and Pre-MEDLINE (with links to participating on-line journals), and other related databases.
PupaSUITE/PupaSNP is an interactive web-based SNP analysis tool.
R&D Systems:a specialty manufacturer of biological products with two operating divisions: Biotechnology and Hematology.
RZPD German Resource Center for Genome Research offers direct access to a multitude of validated clone material.
SALK Institute: Dr. Jonas Salk, developer of the polio vaccine, established the Salk Institute for Biological Studies, to pursue questions about the basic principles of life.Today, the Salk Institute conducts its biological research under the guidance of 59 faculty investigators. It employs a scientific staff of more than 850, including visiting scientists, postdoctoral fellows, and graduate students.
SGD™ is a scientific database of the molecular
biology and genetics of the yeast Saccharomyces cerevisiae, which is commonly
known as baker's or budding yeast.
Sigma-Aldrich: Sigma-Aldrich Corporation is a leading Life Science and High Technology company, providing biochemical and organic chemical products and kits.
SNP Database at NCBI provides information on Single Nucleotide Polymorphisms.
Swiss-Prot stores information about proteins (the sequence, some notes about cellular functions, and many other useful data, as well as links to related sites on the web). GeneCards extracts from Swiss-Prot the name of the product(s) of the gene and data about the cellular functions, similarities, involvement in diseases, and links to other databases related to the gene product(s).
TrEMBL: a computer-annotated supplement of Swiss-Prot that contains all the translations of EMBL nucleotide sequence entries not yet integrated in Swiss-Prot. GeneCards extracts from TrEMBL the name of the product(s) of the gene and data about the cellular functions, similarities, involvement in diseases, and links to other databases related to the gene product(s).
The Tumor Gene Database contains information about genes that are targets for cancer-causing mutations.
UCSC Golden Path: the University of California at Santa Cruz Human Draft Genomic Assembly.
UniGene: an experimental system for automatically partitioning GenBank sequences into a non-redundant set of gene-oriented clusters. GeneCards extracts from UniGene the cluster (Hs.) number, gene symbol or title, GenBank accession, EST's clone identifier and library ID.
Yeda: Yeda Research and Development Company Ltd. is responsible for technology transfer from the Weizmann Institute of Science, Israel's leading center of research and graduate education.
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