ZNF277 Gene
protein-coding GIFtS: 49
GCID: GC07P111846
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zinc finger protein 277(Previous names: zinc finger protein (C2H2 type) 277, zinc finger protein...)
(Previous symbol: ZNF277P)
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Aliases
for ZNF277 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 2771 2 | | NRIF41 2 3 | | ZNF277P1 2 3 | | Zinc Finger Protein (C2H2 Type) 2771 2 | | Zinc Finger Protein 277 Pseudogene1 2 | | Nuclear Receptor-Interacting Factor 42 3 |
Export aliases for ZNF277 gene to outside databasesPrevious GC identifers: GC07P110330 GC07P111393 GC07P111407 GC07P111440 GC07P111633 GC07P106214 |
Summaries
for ZNF277 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF277 (ZNF277P)
|
Genomic Views
for ZNF277 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF277 gene promoter:
STAT5B Olf-1 IRF-1 Evi-1 Egr-4 CREB AREB6 Chx10 TGIF Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF277
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF277 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.1 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31.1ZNF277 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P111846: view genomic region
(about GC identifiers)
Start:
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111,846,643 bp from pter |
End:
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111,983,989 bp from pter |
Size:
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137,347 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 111,215,182-111,352,524 |
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Proteins
for ZNF277 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2 (See
protein sequence)Recommended Name: Zinc finger protein 277 Size: 450 amino acids; 52788 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAF85941.1; Type=Erroneous initiation; Sequence=AAS07413.1; Type=Erroneous initiation;
Secondary accessions: Q75MZ2 Q75MZ3 Q8WY14Explore the universe of human proteins at neXtProt for ZNF277: NX_Q9NRM2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRM2
ZNF277 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068834.2
ENSEMBL proteins: ENSP00000354501 ENSP00000355043 ENSP00000410538 ENSP00000402846 ENSP00000390359 ENSP00000402292 ENSP00000415735
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF277 for ontologies About GeneDecksing
ZNF277 Antibody Products:
Assay Products for ZNF277: |
Protein
Domains /
Families
for ZNF277 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF277 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRM2ProtoNet protein and cluster: Q9NRM2 UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2Similarity: Belongs to the ZNF277 familySimilarity: Contains 2 C2H2-type zinc fingers |
Function
for ZNF277 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN277_HUMAN, Q9NRM2Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF277 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF277 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF277 (NM_021994) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF277 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF277 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF277 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF277 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF277 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF277
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/14 Interacting proteins for ZNF277 (Q9NRM23 ENSP000003545014) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- |
ZNF277 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF277 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF277
Search CenterWatch for drugs/clinical trials and news about ZNF277 / ZN277
|
Transcripts
for ZNF277 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF277 gene: NM_021994.2 Unigene Cluster for ZNF277: Zinc finger protein 277 Hs.655904 [show with all ESTs]Unigene Representative Sequence: NM_0219947 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361822(uc003vge.2 uc003vgf.2) ENST00000361946 ENST00000421043(uc003vgc.3)
ENST00000457808 ENST00000425229 ENST00000450657(uc003vgd.3) ENST00000421864
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF277 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF277 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF277 (NM_021994) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF277 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF277 |
Additional cDNA sequence: AF209198.1 AF308819.1 AK027128.1 AK314630.1 AL713791.1 BC020626.1 8 DOTS entries: DT.100776590 DT.112863 DT.91677011 DT.95269735 DT.87011048 DT.121115903 DT.99992738 DT.121115930 24/142 AceView cDNA sequences (see all 142): AL522105 CA449429 BF939578 CD244265 CA309216 AI927421 BM455964 BX423817 NM_021994 CR600080 AI635559 BC020626 CR605159 BM546821 BE645373 AW028141 BF727443 AI077944 BX091635 BM822099 AF209198 CR604080 AA486202 AI638572
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF277 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF277
|
Expression
for ZNF277 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF277 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCAGTCTG
About this image
See ZNF277 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF277
SOURCE GeneReport for Unigene cluster: Hs.655904
SABiosciences Custom PCR Arrays for ZNF277
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF277
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF277 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF277 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF277 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF277 |
Orthologs
for ZNF277 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF277 gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for ZNF277 (if available)
TreeFam Gene Tree for ZNF277 (if available) |
Paralogs
for ZNF277 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF277 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF277 (111846643 - 111983989 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF277
1 CNV: 5246 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF277 |
|
Disorders
/ Diseases
for ZNF277 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF277 for disorders About GeneDecksing
OMIM gene information: 605465
OMIM disorders: --
1  disease for ZNF277: About MalaCardsataxia
Export disorders for ZNF277 gene to outside databases
|
Publications
for ZNF277 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF277 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZNF277) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. (PubMed id 10860669)1, 2, 3 Liang H.... Nagarajan L. (2000)
- Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (2006)
- Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. (PubMed id 16213364)1, 3 Liang H....Nagarajan L. (2005)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for ZNF277 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF277 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF277 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF277 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF277 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF277 gene:
Search GeneIP for patents involving ZNF277
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF277 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ZNF277 | | OriGene shRNA RFP for ZNF277 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF277 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF277 | | | OriGene Protein Over-expression Lysate for ZNF277 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF277 | | OriGene 3'-UTR Clone for ZNF277 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF277 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF277 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF277 | | OriGene Custom Protein Services for ZNF277 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF277 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF277 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF277 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF277 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF277 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF277 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF277 |
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 | | | ZNF277 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF277 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF277 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF277 |
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