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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WWP2 Gene

protein-coding   GIFtS: 62
GCID: GC16P069796

WW domain containing E3 ubiquitin protein ligase 2
 Explore 7 diseases affiliated with
WWP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WWP2    

Aliases
for WWP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WW Domain Containing E3 Ubiquitin Protein Ligase 21 2     EC 6.3.2.-3
AIP21 2 3     Atrophin-1-Interacting Protein 23
WWp2-Like1     WW Domain-Containing Protein 23
Atrophin-1 Interacting Protein 22     EC 6.3.28
NEDD4-Like E3 Ubiquitin-Protein Ligase WWP22     

External Ids:    HGNC: 168041   Entrez Gene: 110602   Ensembl: ENSG000001983737   OMIM: 6023085   UniProtKB: O003083   

Export aliases for WWP2 gene to outside databases

Previous GC identifers: GC16P060490 GC16P070230 GC16P069545 GC16P069586 GC16P069572 GC16P068353 GC16P055674


Summaries
for WWP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WWP2:
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination.
The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and
the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a
pseudogene of this gene is located on the long arm of chromosome 10. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by
'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the
ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal
degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the
ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal
degradation

Gene Wiki entry for WWP2


Genomic Views
for WWP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WWP2 gene promoter:
         AP-1   ATF-2   c-Jun   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WWP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

WWP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P069796:  view genomic region     (about GC identifiers)

Start:
 69,796,209 bp from pter      End:
 69,975,644 bp from pter
Size:
 179,436 bases      Orientation:
 plus strand

Proteins
for WWP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308 (See protein sequence)
Recommended Name: NEDD4-like E3 ubiquitin-protein ligase WWP2  
Size: 870 amino acids; 98912 Da
Subunit: Interacts with POU5F1, RBP1, EGR2 and SLC11A2 (By similarity). Interacts with SCNN1A, SCNN1B, SCNN1G, WBP1,
WBP2, ATN1 and adenovirus type 2 PIII. Interacts with ERBB4, NDFIP1 AND NDFIP2
Subcellular location: Nucleus
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression is reduced after embryoid
body (EB) formation. Not detectable at day 13 of EB formation; low levels are again detected at day 18 of EB formation
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Secondary accessions: A6NEP1 B2R706 B4DTL5 F5H213 I3RSG8 Q96CZ2 Q9BWN6
Alternative splicing: 2 isoforms:  O00308-1   O00308-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WWP2: NX_O00308

Post-translational modifications:

  • Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00308

    • 4/15 DME Specific Peptides for WWP2 (O00308) (see all 15)
     LQINPAS  PLPPGWE  TQWEDPR  RLLQFVTG 

    WWP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257382.1  NP_001257383.1  NP_001257384.1  NP_008945.2  NP_955456.1  

    ENSEMBL proteins: 
     ENSP00000352069   ENSP00000456451   ENSP00000456582   ENSP00000455347   ENSP00000455311  
     ENSP00000456216   ENSP00000396871   ENSP00000348283   ENSP00000445616  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): WWP2
    OriGene Protein Over-expression Lysate (see all 2): WWP2
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    Novus Biologicals WWP2 Proteins
    Novus Biologicals WWP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WWP2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS9647693
    GO:0005622intracellular ----
    GO:0005634nucleus IDA19274063
    GO:0005737cytoplasm ISS15047715


    WWP2 for ontologies           About GeneDecksing



    WWP2 Antibody Products: 
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    Uscn Antibodies for WWP2
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    Assay Products for WWP2: 
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    Uscn ELISAs and CLIAs for WWP2

    Protein Domains /
    Families
    for WWP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WWP2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR024928 E3_ub_ligase_SMURF1
     IPR001202 WW_Rsp5_WWP
     IPR000569 HECT
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry O00308

    ProtoNet protein and cluster: O00308

    3 Blocks protein families:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)
    IPB002349 WW domain signature


    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Domain: The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain (By
    similarity)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    Function
    for WWP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
    thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by
    'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the
    ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal
    degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the
    ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal
    degradation
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): WWP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WWP2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate WWP2 (see all 34):
    hsa-miR-3678-3p hsa-miR-25 hsa-miR-219-5p hsa-miR-508-3p hsa-miR-4267 hsa-miR-9 hsa-miR-637 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: WWP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WWP2 (see all 7)
    OriGene shRNA RFP: WWP2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WWP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for WWP2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWP2 (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for WWP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding ISS15047715
    GO:0004842ubiquitin-protein ligase activity IMP18776082
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IPI19651900
    GO:0016881acid-amino acid ligase activity ----


    WWP2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for WWP2:
     Decreased viability  Elongated cells  G0/1 arrest  Increased G1 DNA content 


    Pathways & Interactions
    for WWP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    		CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)1.00
    2Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    3SMAD Signaling Network
    		SMAD Signaling Network1.00
    4Antigen processing: Ubiquitination & Proteasome degradation
    		Ubiquitin mediated proteolysis0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WWP2
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis

    1 GeneGo (Thomson Reuters) Pathway for WWP2
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)


    1         Kegg Pathway  (Kegg details for WWP2):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Pathway: Protein modification; protein ubiquitination


    WWP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WWP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for WWP2 (O003081, 2, 3 ENSP000003482834) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF6Q166302, 3, ENSP000003917744MINT-67985 I2D: score=5 STRING: ENSP00000391774
    SMAD2Q157961, 3, ENSP000002621604EBI-743923,EBI-1040141 I2D: score=5 STRING: ENSP00000262160
    SMAD3P840221, 3, ENSP000003329734EBI-743923,EBI-1965323 I2D: score=4 STRING: ENSP00000332973
    SMAD7O151051, 3, ENSP000002621584EBI-743923,EBI-3861591 I2D: score=2 STRING: ENSP00000262158
    RNF11Q9Y3C52, 3MINT-60864 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS15047715
    GO:0006464cellular protein modification process TAS9169421
    GO:0010629negative regulation of gene expression IMP18776082
    GO:0016567protein ubiquitination IDA18776082
    GO:0032410negative regulation of transporter activity IDA18776082


    WWP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WWP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WWP2

    4 HMDB Compounds for WWP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about WWP2 

    Transcripts
    for WWP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WWP2 gene (5 alternative transcripts): 
    NM_001270453.1  NM_001270454.1  NM_001270455.1  NM_007014.4  NM_199424.2  

    Unigene Cluster for WWP2:

    WW domain containing E3 ubiquitin protein ligase 2
    Hs.408458  [show with all ESTs]
    Unigene Representative Sequence: NM_007014
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000359154(uc002exv.1) ENST00000561780 ENST00000569620 ENST00000568845
    ENST00000563659 ENST00000569658 ENST00000569174(uc002ext.3) ENST00000544162
    ENST00000567986 ENST00000563618 ENST00000570104 ENST00000569297 ENST00000567579
    ENST00000566463 ENST00000568684(uc002exw.1) ENST00000568185 ENST00000568818
    ENST00000567161

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WWP2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate WWP2 (see all 34):
    hsa-miR-3678-3p hsa-miR-25 hsa-miR-219-5p hsa-miR-508-3p hsa-miR-4267 hsa-miR-9 hsa-miR-637 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: WWP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WWP2 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ001982.1 AK126332.1 AK295070.1 AK295701.1 AK300266.1 AK312792.1 AK316097.1 BC000108.2 
    BC013645.1 BC064531.1 U96114.1 

    14 DOTS entries:

    DT.99940438  DT.410681  DT.101954997  DT.102845576  DT.100795826  DT.100795824  DT.420430  DT.91707635 
    DT.91752262  DT.91884610  DT.100742767  DT.100795828  DT.100795829  DT.75137354 

    24/209 AceView cDNA sequences (see all 209):

    CD623555 BE314296 CR599492 BI769584 BM818120 BI195805 AL583086 AK126332 
    CB054385 CD106378 NM_007014 BQ063835 BQ919036 AJ705788 NM_199424 AI635734 
    BM700600 BU737819 BX471495 BU188599 BQ215659 BU737757 AA719649 BM800835 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WWP2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
    SP1:              -           -                 -                 -                       -     -           -           -                                   -   
    SP2:                          -                 -                 -                       -     -           -           -                                   -   
    SP3:                          -                 -                 -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
    SP1:                                      -     -                                             
    SP2:                                      -     -                                             
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for WWP2

    Expression
    for WWP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WWP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTGGTCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WWP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungTracheal CartilageChondrocytesLung
    BoneAutopod Long BoneBone
    BoneCaudal Endochondral BonesBone
    BoneEndochondral Facial BonesBone
    BoneMandibular CondyleBone
    BoneMandibular FossaBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Long BoneBone
    CartilageMeckel's CartilageCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite

    See WWP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WWP2

    SOURCE GeneReport for Unigene cluster: Hs.408458

    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Tissue specificity: Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also
    detected in spleen and peripheral blood leukocytes

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    Orthologs
    for WWP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WWP2 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WWP21 WW domain containing E3 ubiquitin protein ligase 2 78.52(n)
    84.81(a)    		   415868  NM_001039260.1  NP_001034349.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WWP26
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343643.1(177570-212326)
    zebrafish
    (Danio rerio)    		 Actinopterygii idibd11212 idibd1121 78.63(n)   58020  57049991 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Su(dx)3 N receptor signaling pathway
    ubiquitin-protein more    		 67(a)   2 22C1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y65B4BR.4a3   -- 64(a)
    (best of 2)    		   I(537141-541634)   --


    ENSEMBL Gene Tree for WWP2 (if available)
    TreeFam Gene Tree for WWP2 (if available) 

    Paralogs
    for WWP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WWP2 gene
    HACE12  NEDD4L2  HECW22  KIAA03172  SMURF12  HECW12  SMURF22  WWP12  
    NEDD42  ITCH2  
    18/21 SIMAP similar genes for WWP2 using alignment to 5 protein entries:     WWP2_HUMAN (see all proteins) (see all similar genes):
    WWP1    ITCH    DKFZp564H223    NEDD4    HUWE1    UBE3A
    SMURF2    NEDD4L    SMURF1    HECW1    HECW2    NEDL1
    HACE1    HECTD2    UBE3C    HERC3    HERC4    KIAA0317

    WWP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WWP2
    PGOHUM00000238507


    Genomic Variants
    for WWP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3334 NCBI SNPs in WWP2 are shown (see all 3334)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1390579901,2
    		--69794318(+) CCTCCA/GCCTCC 3 -- us2k10--------
    rs1498989271,2
    		--69794435(+) GAGATA/GGGGTT 3 -- us2k10--------
    rs1925357771,2
    		--69794457(+) GCCAAA/GTGGGT 3 -- us2k10--------
    rs1439632591,2
    		--69794605(+) ATAACA/GGATTA 3 -- us2k10--------
    rs1849596901,2
    		--69794737(+) AGGCCA/GGGCGC 3 -- us2k10--------
    rs1890271071,2
    		--69794937(+) TTGAAC/TCTGGG 3 -- us2k10--------
    rs1398996991,2
    		--69794938(+) TGAACC/TTGGGA 3 -- us2k10--------
    rs1807978681,2
    		--69794992(+) CCTGGA/GCTACA 3 -- us2k10--------
    rs1431856671,2
    		--69795024(+) CAAGC-/AAAT  
                AAATA     		3 -- us2k10--------
    rs1433837011,2
    		--69795038(+) AATAAA/GTAAAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for WWP2 (69796209 - 69975644 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for WWP2
         3 CNVs: 72603 7124 4009

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    Disorders / Diseases
    for WWP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WWP2 for disorders           About GeneDecksing

    OMIM gene information: 602308    OMIM disorders: --

    7 diseases for WWP2:    About MalaCards
    campomelic dysplasia    pick's disease    gout    pharyngitis
    ataxia    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for WWP2:
    Campomelic dysplasia
    Human Genome Epidemiology (HuGE) Navigator: WWP2 (1 document)

    Export disorders for WWP2 gene to outside databases

    Publications
    for WWP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WWP2 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with WWP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. (PubMed id 12167593)1, 2, 3, 9 McDonald F.J....Snyder P.M. (2002)
    2. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2, 3 Pirozzi G.... Fowlkes D.M. (1997)
    3. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PubMed id 12450395)1, 2, 9 Galinier R.... Chroboczek J. (2002)
    4. WWP2 promotes degradation of transcription factor OCT 4 in human embryonic stem cells. (PubMed id 19274063)1, 2 Xu H....Jin Y. (2009)
    5. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2 Mund T. and Pelham H.R. (2009)
    6. The HECT-type E3 ubiquitin ligase AIP2 inhibits activ ation-induced T-cell death by catalyzing EGR2 ubiquitination. (PubMed id 19651900)1, 2 Chen A....Fang D. (2009)
    7. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. (PubMed id 17719543)1, 2 Wiesner S.... Forman-Kay J.D. (2007)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. (PubMed id 11748237)1, 2 Harvey K.F.... Kumar S. (2002)

    External Searches for WWP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WWP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11060 HGNC: 16804 AceView: WWP2 Ensembl:ENSG00000198373 euGenes: HUgn11060
    ECgene: WWP2 Kegg: 11060 H-InvDB: WWP2

    Other Databases showing WWP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WWP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WWP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WWP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WWP2 gene:
    Search GeneIP for patents involving WWP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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