Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPREB1 Gene

protein-coding   GIFtS: 57
GCID: GC22P022600

pre-B lymphocyte 1

 Explore 12 diseases affiliated with
VPREB1 via our new
 Human Malady Compendium 
Biological research products
for VPREB1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Pre-B Lymphocyte 11 2     CD179a2
VPREB2 3 5     IGVPB2
V(Pre)B Protein2 3     Immunoglobulin Iota Chain2
CD179 Antigen-Like Family Member A2 3     CD179a Antigen3
IGI2 5     Protein VPreB13
CD179A1     VpreB Protein3
VpreB1     

External Ids:    HGNC: 127091   Entrez Gene: 74412   Ensembl: ENSG000001695757   OMIM: 6051415   UniProtKB: P120183   

Export aliases for VPREB1 gene to outside databases

Previous GC identifers: GC22P019297 GC22P020923 GC22P005557


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPREB1:
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early
stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that
is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The
complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. (provided by
RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
Function: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation

Gene Wiki entry for VPREB1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPREB1 gene promoter:
         HOXA9   HOXA9B   STAT1   MIF-1   Meis-1b   RORalpha1   HEN1   FAC1   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPREB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPREB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

VPREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPREB1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022600:  view genomic region     (about GC identifiers)

Start:
22,599,087 bp from pter      End:
22,599,927 bp from pter
Size:
841 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018 (See protein sequence)
Recommended Name: Immunoglobulin iota chain precursor  
Size: 145 amino acids; 16605 Da
Subunit: Associates non-covalently with IGLL1
3 PDB 3D structures from and Proteopedia for VPREB1:
2H32 (3D)        2H3N (3D)        3BJ9 (3D)    
Secondary accessions: B5MCG2

Explore the universe of human proteins at neXtProt for VPREB1: NX_P12018

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12018

  • VPREB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009059.1  
    ENSEMBL proteins: 
     ENSP00000385361   ENSP00000304590  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for VPREB1 
    GenScript Custom Purified and Recombinant Proteins Services for VPREB1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VPREB1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--


    VPREB1 for ontologies           About GeneDecksing



    VPREB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VPREB1 
    GenScript Custom Superior Antibodies Services for VPREB1
    Novus Biologicals VPREB1 Antibodies
    Search for Antibodies for VPREB1 at Abcam  
    Uscn Antibodies for VPREB1
    ThermoFisher Antibodies for VPREB1

    Assay Products for VPREB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VPREB1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for VPREB1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VPREB1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry P12018

    ProtoNet protein and cluster: P12018

    2 Blocks protein families:
    IPB003596 Immunoglobulin V-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
    Function: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.
    This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation

         Genatlas biochemistry entry for VPREB1:
    immunoglobulin-like V gene,expressed in pre-B cells

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPREB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VPREB1
    SwitchGear 3'UTR luciferase reporter plasmidVPREB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPREB1 (see all 4)
    OriGene shRNA RFP: VPREB1
    OriGene siRNA: VPREB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPREB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VPREB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPREB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPREB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: VPREB1 (NM_007128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPREB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPREB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VPREB1
    Search LifeMap BioReagents cell lines for VPREB1

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for VPREB1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS--


    VPREB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for VPREB1:
     Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-outs for VPREB1: Vpreb1tm1Shim Vpreb1tm1Ilm
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vpreb1):
     cellular  hematopoietic system  immune system 

    VPREB1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for VPREB1 (P120182, 3 ENSP000003853614) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110863 I2D: score=3 STRING: ENSP00000361423
    LGALS1P093823, ENSP000002159094I2D: score=1 STRING: ENSP00000215909
    VPREB3Q9UKI33, ENSP000002489484I2D: score=1 STRING: ENSP00000248948
    IGHMP018713I2D: score=1 
    IGLL1ENSP000003293124STRING: ENSP00000329312
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS--


    VPREB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VPREB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPREB1
    1 Novoseek chemical compound relationship for VPREB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    probenecid 69.1 3 8833898 (1), 11187899 (1), 9232432 (1)

    Search CenterWatch for drugs/clinical trials and news about VPREB1 / VPREB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPREB1 gene: 
    NM_007128.2  

    Unigene Cluster for VPREB1:

    Pre-B lymphocyte 1
    Hs.247979  [show with all ESTs]
    Unigene Representative Sequence: BU180896
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403807(uc002zvx.1) ENST00000302273

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPREB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VPREB1
    SwitchGear 3'UTR luciferase reporter plasmidVPREB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPREB1 (see all 4)
    OriGene shRNA RFP: VPREB1
    OriGene siRNA: VPREB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPREB1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPREB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPREB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: VPREB1 (NM_007128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPREB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPREB1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPREB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPREB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPREB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPREB1

    Additional cDNA sequence: 

    BC017922.1 CR456609.1 

    3 DOTS entries:

    DT.91716305  DT.120678050  DT.91716303 

    3 AceView cDNA sequences:

    NM_007128 CR456609 BC017922 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VPREB1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:              -         
    SP2:                        


    ECgene alternative splicing isoforms for VPREB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPREB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGAGGGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    VPREB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VPREB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPREB1

    SOURCE GeneReport for Unigene cluster: Hs.247979

    UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
    Tissue specificity: Only expressed by pre-B-cells

        SABiosciences Custom PCR Arrays for VPREB1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPREB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPREB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPREB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPREB1
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for VPREB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VPREB1 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    55(a)
    54(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343282.1(578996-579274)
    GL343282.1(587154-587477)


    ENSEMBL Gene Tree for VPREB1 (if available)
    TreeFam Gene Tree for VPREB1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPREB1 gene
    IGLV3-122  IGLV2-182  IGLV3-192  IGLV1-512  IGLV9-492  IGLV3-222  IGLV2-232  IGLV8-612  
    IGLV4-602  IGLV1-472  IGLV2-142  IGLV2-332  IGLV3-322  IGLV5-522  IGLV1-442  IGLV3-212  
    IGLV2-112  IGLV3-102  IGLV3-92  IGLV5-372  IGLV1-502  VPREB32  IGLV3-252  IGLV2-82  
    IGLV10-542  IGLV7-432  IGLV5-452  IGLV3-272  IGLV7-462  IGLV1-402  IGLV11-552  IGLV5-482  
    IGLV3-12  IGLV4-32  IGLV6-572  IGLV3-162  IGLV4-692  IGLV1-362  
    18/78 SIMAP similar genes for VPREB1 using alignment to 2 protein entries:     VPREB_HUMAN (see all proteins) (see all similar genes):
    IGLV4-3    IGLV5-37    IGLV5-45    IGLV11-55    V4-4    IGLV4-60
    V4-3    BV05S1J2.2    IGLV4-69    VLC8    BV05S1J2.1    IGLV1-40
    V5-2    V1-18    VKA17    V1    VL3L    IGKV1-5

    VPREB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/29 NCBI SNPs in VPREB1 are shown (see all 29    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460198431,2
    C,F--22599238(+) GGGCTC/GCTGTC 2 P A mis11Minor allele frequency- G:0.00NA 4548
    rs2017223571,2
    --22599378(+) CGGTGC/GTGCAT 2 L V mis10--------
    rs96198521,2
    C,F,H,--22599380(+) GTGCTG/ACATCA 2 /L syn1 ese318Minor allele frequency- A:0.07NA NS EA EU 7899
    rs2012070081,2
    --22599404(+) TCCTCA/GGCCCT 2 S syn10--------
    rs1399511331,2
    C,F,--22599424(+) AATCCG/ACCTCA 2 /H /R mis11Minor allele frequency- A:0.01NA 4550
    rs13201,2
    C,F,H,--22599537(+) AATCAG/AACAAG 2 /N /D mis1 ese323Minor allele frequency- A:0.04NA MN NS EA EU 7855
    rs626408701,2
    C,F,--22599549(+) GCCAGG/AGCCCC 2 /S /G mis13Minor allele frequency- A:0.00NS CSA NA 4626
    rs1454232921,2
    F--22599560(+) CAGGTC/GCCCCC 2 V syn11Minor allele frequency- G:0.00NA 4534
    rs1492181371,2
    C,F--22599568(+) CCCTCG/ACTTCT 2 /H /R mis11Minor allele frequency- A:0.00NA 4506
    rs1889174011,2
    C,--22599602(+) AACAGC/GGGGTA 2 S R mis10--------

    HapMap Linkage Disequilibrium report for VPREB1 (22599087 - 22599927 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for VPREB1
         15/16 CNVs (see all 16): 103136 35986 2265 34540 53883 10613 5356 59057 5451 67845 53738 10609 67849 35987 10615
    Human Gene Mutation Database (HGMD): VPREB1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPREB1
    DNA2.0 Custom Variant and Variant Library Synthesis for VPREB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VPREB1 for disorders           About GeneDecksing

    OMIM gene information: 605141    OMIM disorders: --

    12 diseases for VPREB1:    About MalaCards
    common variable immunodeficiency    conidiobolomycosis    crouzon syndrome    lymphoblastic leukemia
    acute lymphoblastic leukemia    agammaglobulinemia    rheumatoid arthritis    hepatitis b
    leukemia    immunodeficiency    arthritis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for VPREB1:
    Conidiobolomycosis

    3 Novoseek disease relationships for VPREB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    common variable immunodeficiency 57.2 3 8031574 (2), 7710759 (1)
    lymphoblastic leukemia acute 27 1 1884024 (1)
    leukemia 24.3 2 1884024 (2)

    Human Genome Epidemiology (HuGE) Navigator: VPREB1 (2 documents)

    Export disorders for VPREB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPREB1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with VPREB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. (PubMed id 7935499)1, 2, 9 Guelpa-Fonlupt V....Schiff C. (1994)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2 Kawasaki K....Shimizu N. (1997)
    4. The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments. (PubMed id 3139558)1, 3 Bauer S.R....Melchers F. (1988)
    5. Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species. (PubMed id 3258819)1, 2 Bauer S.R.... Melchers F. (1988)
    6. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. (PubMed id 2117639)1, 9 Tsubata T. and Reth M. (1990)
    7. Engineering and characterization of a single chain surrogate light chain variable domain. (PubMed id 18287279)2, 9 Morstadt L....Baleja J.D. (2008)
    8. Secretion of soluble pre-B cell receptors by pre-B cells. (PubMed id 9058786)1, 9 Bornemann K.D....Corley R.B. (1997)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. The potential role of VPREB1 gene copy number variati on in susceptibility to rheumatoid arthritis. (PubMed id 21144590)1 Yim S.H....Chung H.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7441 HGNC: 12709 AceView: VPREB1 Ensembl:ENSG00000169575 euGenes: HUgn7441
    ECgene: VPREB1 H-InvDB: VPREB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPREB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPREB1 Genetics and Cytogenetics in Oncology and Haematology
    IMGT entry for VPREB The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    Wikipedia http://en.wikipedia.org/wiki/VPREB1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPREB1 gene:
    Search GeneIP for patents involving VPREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for VPREB1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPREB1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPREB1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for VPREB1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPREB1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPREB1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VPREB1   OriGene Custom Protein Services for VPREB1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPREB1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPREB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPREB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPREB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPREB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPREB1
     GenScript Custom Purified and Recombinant Proteins Services for VPREB1 GenScript cDNA clones with any tag delivered in your preferred vector for VPREB1
     GenScript Custom Assay Services for VPREB1 GenScript Custom Superior Antibodies Services for VPREB1
     GenScript Custom overexpressing Cell Line Services for VPREB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VPREB1 promoter
     Search Chromatin IP Primers for VPREB1
     RT2 qPCR Primer Assay in human, mouse, rat VPREB1
     GNC Network for VPREB1
     SABiosciences Custom PCR Arrays for VPREB1
     Search Tocris compounds for VPREB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VPREB1 antibodies
     Search for Antibodies for VPREB1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for VPREB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     VPREB1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for VPREB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for VPREB1
     SwitchGear 3'UTR luciferase reporter plasmids for VPREB1
     SwitchGear Promoter luciferase reporter plasmids for VPREB1
     ThermoFisher Antibodies for VPREB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPREB1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VPREB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4