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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VEGFC Gene

protein-coding   GIFtS: 67
GCID: GC04M177604

vascular endothelial growth factor C
 Explore 121 diseases affiliated with
VEGFC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VEGFC    

Aliases
for VEGFC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vascular Endothelial Growth Factor C1 2     VEGF-C2 3
VRP1 2 3     FLT4 Ligand DHM2
Vascular Endothelial Growth Factor-Related Protein2 3     Flt4 Ligand3
Flt4-L2 3     

External Ids:    HGNC: 126821   Entrez Gene: 74242   Ensembl: ENSG000001506307   OMIM: 6015285   UniProtKB: P497673   

Export aliases for VEGFC gene to outside databases

Previous GC identifers: GC04M178492 GC04M178154 GC04M178300 GC04M177979 GC04M177841 GC04M173355


Summaries
for VEGFC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VEGFC:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor
(PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of
blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms
which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This
protein is structurally and functionally similar to vascular endothelial growth factor D. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and
migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and
lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium
in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

Gene Wiki entry for VEGFC (Vascular endothelial growth factor C)


Genomic Views
for VEGFC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VEGFC gene promoter:
         NF-1   NF-1/L   HOXA3   p53   Nkx2-5   Tal-1beta   Cdc5   GATA-1   Evi-1   GATA-6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VEGFC promoter sequence
   Search SABiosciences Chromatin IP Primers for VEGFC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEGFC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.3   Ensembl cytogenetic band:  4q34.3   HGNC cytogenetic band: 4q34.3

VEGFC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEGFC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M177604:  view genomic region     (about GC identifiers)

Start:
 177,604,689 bp from pter      End:
 177,713,895 bp from pter
Size:
 109,207 bases      Orientation:
 minus strand

Proteins
for VEGFC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767 (See protein sequence)
Recommended Name: Vascular endothelial growth factor C precursor  
Size: 419 amino acids; 46883 Da
Subunit: Homodimer; non-covalent and antiparallel
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for VEGFC:
2X1W (3D)        2X1X (3D)    
Secondary accessions: B2R9Q8

Explore the universe of human proteins at neXtProt for VEGFC: NX_P49767

Post-translational modifications:

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased
    • activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel
    homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a
    heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature
    VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49767

    • VEGFC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005420.1  
    ENSEMBL proteins: 
     ENSP00000280193  
    Reactome Protein details: P49767
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for VEGFC (VEGF-C)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate: VEGFC
    OriGene Custom Protein Services for VEGFC 
    GenScript Custom Purified and Recombinant Proteins Services for VEGFC
    Novus Biologicals VEGFC Proteins
    Novus Biologicals VEGFC Lysate
    Sino Biological Recombinant Protein for VEGFC
    ProSpec Recombinant Protein for VEGFC
    Uscn Proteins for VEGFC

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--
    GO:0031093platelet alpha granule lumen TAS--


    VEGFC for ontologies           About GeneDecksing



    VEGFC Antibody Products: 
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    Abcam antibodies for VEGFC 
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    ThermoFisher Antibodies for VEGFC

    Assay Products for VEGFC: 
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    R&D Systems ELISAs for VEGFC (VEGF-C)         (see all)
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    Enzo Life Sciences assays for VEGFC
    Uscn ELISAs and CLIAs for VEGFC

    Protein Domains /
    Families
    for VEGFC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VEGFC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000072 PD_growth_factor
     IPR023581 PD_growth_factor_CS
     IPR004153 CXCXC_repeat

    Graphical View of Domain Structure for InterPro Entry P49767

    ProtoNet protein and cluster: P49767

    3 Blocks protein families:
    IPB000072 Platelet-derived growth factor (PDGF)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB004153 CXCXC repeat


    UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
    Similarity: Belongs to the PDGF/VEGF growth factor family


    Function
    for VEGFC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
    Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and
    migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and
    lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium
    in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors

         Genatlas biochemistry entry for VEGFC:
    vascular endothelial growth factor C,expressed in heart,placenta,ovary,small intestine,with two alternatively spliced
    forms,PDGF family,hypoxia-inducible,involved in vasculogenesis,downregulated by VHL

         Summary:  
    During embryonic development, VEGFC as signaling molecule is secreted from the following cells: Venous Endothelial Cells in Veins It affects the following cells: Lymphatic Endothelial Cells in Lymphatic Vessels

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEGFC
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate VEGFC (see all 13):
    hsa-miR-3163 hsa-miR-16-2* hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-374c hsa-miR-338-5p hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmid: VEGFC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEGFC (see all 7)
    OriGene shRNA RFP: VEGFC
    OriGene siRNA: VEGFC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEGFC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for VEGFC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEGFC (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEGFC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: VEGFC (NM_005429)
    Sino Biological Human cDNA Clone for VEGFC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEGFC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFC 

    Cell Line
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    Search LifeMap BioReagents cell lines for VEGFC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFC

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008083growth factor activity IEA--
    GO:0042056chemoattractant activity IDA19275959
    GO:0043185vascular endothelial growth factor receptor 3 binding IEA--


    VEGFC for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for VEGFC:
     Decreased focal adhesion (FA)   Stronger migration 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vegfc):
     cardiovascular system  homeostasis/metabolism  immune system  mortality/aging 

    VEGFC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VEGFC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    3TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    5VEGF Family Ligands and Receptor Interactions
    		VEGF Family Ligands and Receptor Interactions1.00
    		Development_VEGF-family signaling0.36
    		VEGF Pathway0.66
    		Development VEGF-family signaling0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for VEGFC
        Selected targets of Oct-3/4
    Development VEGF-family signaling

    5/62 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VEGFC (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for VEGFC
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for VEGFC
        Development VEGF-family signaling

    4 BioSystems Pathways for VEGFC 
        Focal Adhesion
    Heart Development
    VEGFR3 signaling in lymphatic endothelium
    Signaling events mediated by VEGFR1 and VEGFR2

    5/8        Reactome Pathways for VEGFC (see all 8)
        VEGF ligand-receptor interactions
    Signaling by VEGF
    Hemostasis
    VEGF binds to VEGFR leading to receptor dimerization
    Platelet degranulation

    1 PharmGKB Pathway for VEGFC
        VEGF Signaling Pathway

    5/7         Kegg Pathways  (Kegg details for VEGFC) (see all 7):
        Cytokine-cytokine receptor interaction
    mTOR signaling pathway
    Focal adhesion
    Pathways in cancer
    Renal cell carcinoma


    VEGFC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VEGFC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for VEGFC (P497671, 3 ENSP000002801934) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT4P359161, 3, ENSP000002619374EBI-3405539,EBI-1005467 I2D: score=3 STRING: ENSP00000261937
    KDRP359683, ENSP000002639234I2D: score=2 STRING: ENSP00000263923
    ALBENSP000002958974STRING: ENSP00000295897
    APPENSP000002849814STRING: ENSP00000284981
    CRKENSP000003005744STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002052positive regulation of neuroblast proliferation IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006929substrate-dependent cell migration TAS8617204
    GO:0007165signal transduction TAS8617204


    VEGFC for ontologies           About GeneDecksing



    Drugs & Compounds
    for VEGFC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VEGFC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VEGFC
    10/27 Novoseek chemical compound relationships for VEGFC gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 89.2 484 15637689 (10), 11579392 (9), 17536453 (9), 16961284 (8) (see all 99)
    tyrosine 50.2 45 8700872 (2), 8617204 (2), 8612600 (1), 11106244 (1) (see all 40)
    matrigel 46.4 3 19825968 (1), 16687456 (1), 20080299 (1)
    paraffin 24.2 6 16299237 (1), 17970053 (1), 19280060 (1), 15816493 (1) (see all 5)
    trastuzumab 12.3 5 17425844 (2), 18509974 (2), 12471041 (1)
    estrogen 9.18 10 11948478 (4), 11106244 (1), 16080559 (1), 16418144 (1) (see all 5)
    oligonucleotide 8.35 11 12594815 (1), 17393109 (1), 12479067 (1), 20137690 (1)
    dexamethasone 5.28 6 17062674 (5), 9525952 (1)
    testosterone 4.89 16 16964283 (4), 15897888 (3)
    glyceraldehyde 3-phosphate 3.08 2 18945297 (1)

    Search CenterWatch for drugs/clinical trials and news about VEGFC 

    Transcripts
    for VEGFC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VEGFC gene: 
    NM_005429.2  

    Unigene Cluster for VEGFC:

    Vascular endothelial growth factor C
    Hs.435215  [show with all ESTs]
    Unigene Representative Sequence: NM_005429
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280193(uc003ius.1) ENST00000507638

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEGFC
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate VEGFC (see all 13):
    hsa-miR-3163 hsa-miR-16-2* hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-374c hsa-miR-338-5p hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmid: VEGFC 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEGFC (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEGFC
    Clone
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    GenScript: all cDNA clones in your preferred vector: VEGFC (NM_005429)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEGFC 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VEGFC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEGFC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEGFC

    Additional cDNA sequence: 

    AK313879.1 BC035212.1 BC063685.1 CR541897.1 U43142.1 U58111.1 X94216.1 

    2 DOTS entries:

    DT.444976  DT.92421196 

    24/82 AceView cDNA sequences (see all 82):

    Z40230 BE041634 CK904861 NM_005429 AA479987 CA488579 BC063685 AA425303 
    BM055226 AI168770 Z44272 AI753125 U43142 CR541897 N42368 AA478766 
    BC035212 AW294939 BU619991 BM127468 AA406492 BF528469 BG680919 AW137803 

    GeneLoc Exon Structure


    Expression
    for VEGFC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VEGFC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAAATATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VEGFC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LymphLymphatic VesselsLymphatic Endothelial CellsEndothelium
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    BoneZeugopod PeriosteumBone
    BrainThalamusBrain
    KidneyRenal VesicleKidney
    KidneyS-shaped BodyKidney
    Neural TubeDiencephalic Roof PlateNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Primitive gut tube-like cells (A scalable, suspensi...)

    See VEGFC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VEGFC

    SOURCE GeneReport for Unigene cluster: Hs.435215

    UniProtKB/Swiss-Prot: VEGFC_HUMAN, P49767
    Tissue specificity: Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle,
    prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte

        SABiosciences Expression via Pathway-Focused PCR Arrays including VEGFC (see all 6): 
              mTOR Signaling in human mouse rat
              Growth Factors in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEGFC
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEGFC

    Orthologs
    for VEGFC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for VEGFC gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Vegfc1 , 5 vascular endothelial growth factor C1, 5 87.71(n)1
    86.27(a)1    		   8 (29.20 cM)5
    223411  NM_009506.21  NP_033532.11 
     540775325 
    chicken
    (Gallus gallus)    		 Aves VEGFC1 vascular endothelial growth factor C 79.78(n)
    76.02(a)    		   422573  XM_420532.3  XP_420532.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VEGFC6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 5(117275960-117296116)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.264502 Danio rerio vascular endothelial growth factor C mRNA, more 76.09(n)    AF466147.1 


    ENSEMBL Gene Tree for VEGFC (if available)
    TreeFam Gene Tree for VEGFC (if available) 

    Paralogs
    for VEGFC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VEGFC gene
    PGF2  FIGF2  VEGFA2  VEGFB2  
    1 SIMAP similar gene for VEGFC using alignment to 2 protein entries:     VEGFC_HUMAN (see all proteins):
    FIGF

    VEGFC for paralogs           About GeneDecksing



    Genomic Variants
    for VEGFC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VEGFC
    DNA2.0 Custom Variant and Variant Library Synthesis for VEGFC

    Disorders / Diseases
    for VEGFC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VEGFC for disorders           About GeneDecksing

    OMIM gene information: 601528    OMIM disorders: --

    20/121 diseases for VEGFC (see all 121):    About MalaCards
    diffuse large b-cell lymphoma    cervical intraepithelial neoplasia    age related macular degeneration    squamous cell carcinoma
    non-small cell lung carcinoma    lymphedema    b-cell lymphomas    laryngeal squamous cell carcinoma
    carcinoma    clear cell renal cell carcinoma    renal cell carcinoma    bile duct carcinoma
    non-hodgkin lymphoma    soft tissue sarcoma    macular degeneration    lymphangioma
    angiosarcoma    hereditary lymphedema    papillary renal cell carcinoma    kaposi's sarcoma

    4 diseases from the University of Copenhagen DISEASES database for VEGFC:
    Lymphedema     Carcinoma     Lung cancer     Breast cancer

    10/95 Novoseek disease relationships for VEGFC gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphatic metastasis 92.8 130 15025957 (5), 14724935 (4), 20137690 (4), 18353210 (3) (see all 69)
    metastasis 82.2 811 19080076 (7), 15040017 (7), 18295452 (7), 15302715 (7) (see all 99)
    congenital lymphedema 72.8 5 19002718 (2), 19093784 (1), 12162200 (1), 11175851 (1)
    lymphedema 72.7 29 19302023 (4), 18269031 (3), 17176124 (2), 12235206 (2) (see all 12)
    lymphatic vessel tumors 70.6 4 16562672 (2), 16540684 (1)
    tumors 70.2 641 19608016 (6), 9665470 (5), 12566318 (5), 11477575 (5) (see all 99)
    carcinoma squamous cell 61.7 102 14613645 (5), 15272284 (4), 15656516 (4), 17354029 (3) (see all 48)
    cancer 60.3 157 16482630 (5), 11291931 (4), 16755294 (3), 10430087 (3) (see all 94)
    nsclc 59.1 155 16755294 (7), 12875690 (7), 16159440 (5), 15173661 (5) (see all 31)
    primary tumor 58.1 59 20137690 (6), 16474989 (3), 16843872 (3), 12660643 (2) (see all 31)

    Human Genome Epidemiology (HuGE) Navigator: VEGFC (17 documents)

    Export disorders for VEGFC gene to outside databases

    Publications
    for VEGFC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VEGFC gene, integrated from 9 sources (see all 815):
    (articles sorted by number of sources associating them with VEGFC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PubMed id 8617204)1, 2, 3, 9 Joukov V.... Alitalo K. (1996)
    2. Characterization of murine Flt4 ligand/VEGF-C. (PubMed id 9247316)1, 2, 9 Fitz L.J.... Wood C.R. (1997)
    3. Structural determinants of growth factor binding and specificity by VEGF receptor 2. (PubMed id 20145116)1, 2, 9 LeppAonen V.M....Alitalo K. (2010)
    4. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. (PubMed id 8700872)1, 2, 9 Lee J.... Wood W.I. (1996)
    5. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (PubMed id 8612600)1, 2, 9 Joukov V....Alitalo K. (1996)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Proteolytic processing regulates receptor specificity and activity of VEGF-C. (PubMed id 9233800)1, 2 Joukov V.... Alitalo K. (1997)
    9. [Clinical significance of HIF-lalpha,VEGF and VEGF-C expression in papillary thyroid carcinoma] (PubMed id 17536453)1, 9 Wang Y. and Hua Q. (2007)
    10. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. (PubMed id 15240540)1, 9 Lopez de Cicco R....Klein-Szanto A.J. (2004)

    External Searches for VEGFC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VEGFC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7424 HGNC: 12682 AceView: VEGFC Ensembl:ENSG00000150630 euGenes: HUgn7424
    ECgene: VEGFC Kegg: 7424 H-InvDB: VEGFC

    Other Databases showing VEGFC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VEGFC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VEGFC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VEGFC Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for VEGFC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VEGFC gene:
    Search GeneIP for patents involving VEGFC

    Licensable Technologies for VEGFC gene:
    Weizmann Institute:A Novel target for regulating lymphangiogenesis and lymph-node metastasis    (see all 2)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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