USP5 Gene
protein-coding GIFtS: 62
GCID: GC12P007047
|
|
ubiquitin specific peptidase 5 (isopeptidase T)(Previous name: ubiquitin specific protease 5 (isopeptidase T) )
| |
Aliases
for USP5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 5 (Isopeptidase T)1 2 | | IsoT1 | | ISOT2 3 5 | | Ubiquitin Carboxyl-Terminal Hydrolase 52 | | Ubiquitin Specific Protease 5 (Isopeptidase T)1 2 | | Ubiquitin Isopeptidase T2 | | Deubiquitinating Enzyme 52 3 | | Ubiquitin Thiolesterase 52 | | Isopeptidase T2 3 | | Ubiquitin-Specific Protease-5 (Ubiquitin Isopeptidase T)2 | | Ubiquitin Thioesterase 52 3 | | EC 3.4.19.123 | | Ubiquitin-Specific-Processing Protease 52 3 | | EC 3.1.2.158 |
Export aliases for USP5 gene to outside databasesPrevious GC identifers: GC12M006999 GC12M007084 GC12P006840 GC12P006831 GC12P006815 GC12P006978 GC12P006985 GC12P006991 GC12P006998 GC12P007006 GC12P007024 |
Summaries
for USP5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP5:
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diversecellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. Alate step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitinmonomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal endof the chain (Wilkinson et al., 1995 (PubMed 7578059)).(supplied by OMIM, Mar 2010)
UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involvedin unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a loweraffinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activitybecause the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2for proteasomal recognition
Gene Wiki entry for USP5
|
Genomic Views
for USP5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP5 gene promoter:
c-Fos PPAR-gamma1 AP-1 ATF-2 PPAR-gamma2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13USP5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P007047: view genomic region
(about GC identifiers)
Start:
|
6,961,285 bp from pter |
End:
|
6,975,796 bp from pter |
Size:
|
14,512 bases |
Orientation:
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plus strand |
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Proteins
for USP5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 5 Size: 858 amino acids; 95786 Da
Cofactor: Binds 1 zinc ion
Subunit: Interacts with TRIML1 (By similarity)
Miscellaneous: The UBP-type zinc finger domain crystallizes as a dimer linked by a disulfide bond between the Cys-195residues of both molecules, but there is no evidence that the full-length USP5 exists as a dimer
5 PDB 3D structures from  and Proteopedia  for USP5:2DAG (3D)
2DAK (3D)
2G43 (3D)
2G45 (3D)
3IHP (3D)
Secondary accessions: D3DUS7 D3DUS8 Q96J22Alternative splicing: 2 isoforms: P45974-1 P45974-2 Explore the universe of human proteins at neXtProt for USP5: NX_P45974
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P45974
4/15 DME Specific Peptides for USP5 (P45974) (see all 15)
USP5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092006.1 NP_003472.2
ENSEMBL proteins: ENSP00000229268 ENSP00000373883 ENSP00000444668
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
USP5 for ontologies About GeneDecksing
USP5 Antibody Products:
Assay Products for USP5: |
Protein
Domains /
Families
for USP5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP5 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P45974ProtoNet protein and cluster: P45974 3 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB001394 Ubiquitin thiolesterase IPB001607 Zn-finger in ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974Domain: The UBP-type zinc finger domain interacts selectively with an unmodified C-terminus of the proximal ubiquitin.Both UBA domains are involved in polyubiquitin recognitionSimilarity: Belongs to the peptidase C19 familySimilarity: Contains 2 UBA domainsSimilarity: Contains 1 UBP-type zinc finger |
Function
for USP5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involvedin unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a loweraffinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activitybecause the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2for proteasomal recognitionCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Genatlas biochemistry entry for USP5:ubiquitin specific protease 5,100kDa,expressed in brain,deubiquitin enzyme family
Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP5 (NM_004419) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP5 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
USP5 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Usp5 (no phenotypes)
USP5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP5
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/90 Interacting proteins for USP5 (P459741, 2, 3 ENSP000002292684) via UniProtKB, MINT, STRING, and/or I2D (see all 90)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
IMP | 19098288 | | GO:0071108 | protein K48-linked deubiquitination |
IMP | 19098288 |
USP5 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
USP5 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for USP5 |
 Browse Tocris compounds for USP5
1 HMDB Compound for USP5 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
2 Novoseek chemical compound relationships for USP5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cysteine |
25.4 |
1 |
17449248 (1) |
| zinc |
24.5 |
8 |
17512543 (2), 12435595 (2) |
Search CenterWatch for drugs/clinical trials and news about USP5 / UBP5
|
Transcripts
for USP5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP5 gene (2 alternative transcripts): NM_001098536.1 NM_003481.2 Unigene Cluster for USP5: Ubiquitin specific peptidase 5 (isopeptidase T) Hs.631661 [show with all ESTs]Unigene Representative Sequence: NM_0010985367 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229268(uc001qrh.4 uc001qri.4) ENST00000389231 ENST00000542087
ENST00000535080 ENST00000537267 ENST00000541969 ENST00000542371
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP5 (NM_004419) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP5 |
Additional cDNA sequence: AK308021.1 BC004889.2 BC005139.2 U35116.1 U47927.1 X91349.1 17 DOTS entries: DT.100822891 DT.97855337 DT.92449342 DT.86855142 DT.100038284 DT.92449347 DT.101986303 DT.97762970 DT.100760153 DT.121170406 DT.100658021 DT.100822894 DT.100822898 DT.100822903 DT.102841601 DT.102841609 DT.95313280 9 AceView cDNA sequences: CR621700 BC005139 U47927 CR598459 BC004889 CR620906 NM_003481 U35116 X91349
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for USP5 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP5
|
Expression
for USP5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGAGAGGG
About this image
See USP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP5
SOURCE GeneReport for Unigene cluster: Hs.631661
SABiosciences Expression via Pathway-Focused PCR Array including USP5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP5 |
Orthologs
for USP5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP5 gene from 10/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Usp51 , 5 |
ubiquitin specific peptidase 5 (isopeptidase T)1, 5 |
91.96(n)1
98.37(a)1 |
|
6 (59.17 cM)5
222251 NM_013700.11 NP_038728.11
1248150195 |
chicken
(Gallus gallus) |
Aves |
USP51 |
ubiquitin specific peptidase 5 (isopeptidase T) |
81.33(n)
91.35(a) |
|
418290 XM_003640442.1 XP_003640490.1 |
lizard
(Anolis carolinensis) |
Reptilia |
USP56 |
-- |
85(a) |
1 ↔ 1 |
GL343453.1(422406-448825) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC056002.12 |
-- |
78.34(n) |
|
BC056002.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
usp51 |
ubiquitin specific protease 5 |
66.83(n)
70.22(a) |
|
406618 NM_214755.2 NP_999920.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG120821 , 3 |
protein deubiquitination ubiquitin
isopeptidase more3
CG120821 |
50(a)3
58.58(n)1
53.61(a)1 |
|
63B63
383751 NM_139516.11 NP_647773.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
T27A3.23 |
ubiquitin carboxyl-terminal hydrolase |
35(a) |
|
I(6118275-6122458) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBP14(YBR058C)4
UBP141 |
Ubiquitin-specific protease that specifically disassembles more4
Ubp14p1 |
43.84(n)1
33.97(a)1 |
|
2(356017-353672)4
8523491, 4 NP_009614.21, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBP141 |
ubiquitin carboxyl-terminal hydrolase 14 |
56.02(n)
52.16(a) |
|
821610 NM_112954.3 NP_566666.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.71732 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
76.59(n) |
|
AK103230.1 |
ENSEMBL Gene Tree for USP5 (if available)
TreeFam Gene Tree for USP5 (if available) |
Paralogs
for USP5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP5 gene
- USP132
1 SIMAP similar gene for USP5 using alignment to 2 protein entries: UBP5_HUMAN (see all proteins):USP13
USP5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for USP5
PGOHUM00000248261
|
Genomic Variants
for USP5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP5 (6961285 - 6975796 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP5 |
|
Disorders
/ Diseases
for USP5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP5 for disorders About GeneDecksing
OMIM gene information: 601447
OMIM disorders: --
3  diseases for USP5: About MalaCardsdown syndrome prostatitis malaria
Export disorders for USP5 gene to outside databases
|
Publications
for USP5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP5 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with USP5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PubMed id 8723724)1, 2, 3, 9 Ansari-Lari M.A....Gibbs R.A. (1996)
- The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. (PubMed id 16564012)1, 2, 9 Reyes-Turcu F.E....Wilkinson K.D. (2006)
- Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. (PubMed id 18482987)1, 2, 9 Reyes-Turcu F.E....Wilkinson K.D. (2008)
- Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. (PubMed id 19098288)1, 2, 9 Dayal S....Saville M.K. (2009)
- Domain analysis reveals that a deubiquitinating enzym e USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. (PubMed id 22216260)1, 2 Zhang Y.H....Hu H.Y. (2011)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)1, 2 Ansari-Lari M.A....Gibbs R.A. (1997)
- cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2). (PubMed id 7498549)1, 2 Falquet L....Jaton J.-C. (1995)
|
External Searches for USP5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for USP5 gene:
Search GeneIP for patents involving USP5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for USP5 | | OriGene shRNA RFP for USP5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP5 | | | OriGene Protein Over-expression Lysate for USP5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP5 | | OriGene 3'-UTR Clone for USP5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP5 | | OriGene Custom Protein Services for USP5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP5 |
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| | | | Search Tocris compounds for USP5 |
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 | | | USP5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP5 |
|  |  |  | | | | ThermoFisher Antibodies for USP5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP5 |
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