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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBTD1 Gene

protein-coding GIFtS: 45
GCID: GC10P099248

ubiquitin domain containing 1

Search for UBTD1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Domain Containing 1¹ ²
FLJ11807¹
Ubiquitin Domain-Containing Protein 1²

External Ids:	HGNC: 25683¹	Entrez Gene: 80019²	Ensembl: ENSG00000165886⁷	UniProtKB: Q9HAC8³

Export aliases for UBTD1 gene to outside databases

Previous GC identifers: GC10P098924 GC10P092884

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBTD1 gene promoter:
p53 Pax-6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBTD1 promoter sequence

Search SABiosciences Chromatin IP Primers for UBTD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBTD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q24.2

UBTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBTD1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P099248: view genomic region (about GC identifiers)

Start:	99,258,625 bp from pter	End:	99,330,966 bp from pter
Size:	72,342 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBTD1_HUMAN, Q9HAC8 (See protein sequence)

Recommended Name: Ubiquitin domain-containing protein 1

Size: 227 amino acids; 25938 Da

Secondary accessions: D3DR57 Q53HI3

Explore the universe of human proteins at neXtProt for UBTD1: NX_Q9HAC8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HAC8

UBTD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079230.1

ENSEMBL proteins:

ENSP00000359698

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBTD1 for domains About GeneDecksing

3 InterPro domains/families:

IPR019956 Ubiquitin_subgr

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry Q9HAC8

ProtoNet protein and cluster: Q9HAC8

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: UBTD1_HUMAN, Q9HAC8

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UBTD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/8 Interacting proteins for UBTD1 (Q9HAC8^{2, 3} ENSP00000359698⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIM39	Q9HCM9²^,³	MINT-66738 I2D: score=4
UBE2D4	Q9Y2X8³, ENSP00000222402⁴	I2D: score=1 STRING: ENSP00000222402
WIPF1	O43516³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
CD1A	ENSP00000289429⁴	STRING: ENSP00000289429

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBTD1
Search CenterWatch for drugs/clinical trials and news about UBTD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for UBTD1 gene:

NM_024954.3

Unigene Cluster for UBTD1:

Ubiquitin domain containing 1

Hs.500724 [show with all ESTs]

Unigene Representative Sequence: BM906603

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000370664(uc001knv.1)

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		hsa-miR-644 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-218 hsa-miR-3161 hsa-miR-125b hsa-miR-1914 hsa-miR-1827

		SwitchGear 3'UTR luciferase reporter plasmid: UBTD1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBTD1

Additional cDNA sequence:

AK021869.1 AK222597.1 BC007331.2

3 DOTS entries:

DT.313017 DT.91910353 DT.100785995

24/118 AceView cDNA sequences (see all 118):

BF035667 BQ934823 BM919838 BM782106 BM725240 BI823467 BM695060 BE276842

BI825413 BI830834 CB216539 BM695795 BE893355 BI825936 CB243503 BI085100

BG338821 BI907707 BC007331 BQ949749 AI090530 BM922594 BG250626 BG760806

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCCACAG

About this image

UBTD1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UBTD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBTD1

SOURCE GeneReport for Unigene cluster: Hs.500724

SABiosciences Custom PCR Arrays for UBTD1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD1 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	UBTD1¹	ubiquitin domain containing 1	81.26(n) 82.49(a)		431558 XM_429110.3 XP_429110.3
lizard (Anolis carolinensis)	Reptilia	UBTD1⁶	--	78(a)	1 ↔ 1	3(39259818-39263829)
tropical clawed frog (Xenopus tropicalis)	Amphibia	141999747²	--	77.72(n)		141999747
zebrafish (Danio rerio)	Actinopterygii	ubtd1b¹	ubiquitin domain containing 1b	69.79(n) 74.55(a)		571832 NM_001030265.1 NP_001025436.1
fruit fly (Drosophila melanogaster)	Insecta	CG1172⁶	--	44(a)	1 → many	3R(1219628-1225235)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G45740¹	Ubiquitin domain-containing protein	47.49(n) 45.13(a)		834613 NM_123941.2 NP_199386.2
rice (Oryza sativa)	Liliopsida	Os05g0529400¹	hypothetical protein	50.84(n) 49.49(a)		4339404 NM_001062657.1 NP_001056122.1

ENSEMBL Gene Tree for UBTD1 (if available)
TreeFam Gene Tree for UBTD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UBTD1 gene

UBTD2²

2 SIMAP similar genes for UBTD1 using alignment to 1 protein entry: UBTD1_HUMAN:

DC-UbP UBTD2

UBTD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35441025^1,2	C	--	99264080(+)	`AGCCTT/-CCTGT`	1	--	int¹		1		NA	2
rs63554364^1,2	C,	--	99284043(+)	`GGATGC/GGGGGG`	1	--	int¹		0	--	--	--	--
rs147732362^1,2	C,	--	99284043(+)	`GGATG-/CGGGGG`	1	--	int¹		0	--	--	--	--
rs4595477^1,2	C,H	--	99289074(+)	`CCAGAC/TGATGG`	1	--	int¹		2		NA	4
rs11362598^1,2	C	--	99289357(+)	`CCACC-/AAAAAA`	1	--	int¹ trp³		1		NA	2
rs71824395^1,2	C,	--	99289477(+)	`GGCAT-/GAGAGGGAGAC CGTGGAAAGAGAGGGAGAG`	1	--	int¹		0	--	--	--	--
rs113236509^1,2	C,	--	99289957(+)	`TTTCTTGAA/- TTGAA`	1	--	int¹		1		CSA	2
rs138300991^1,2	C	--	99290973(+)	`CCATC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs56227762^1,2	C,	--	99292939(+)	`ATGCC-/TTTT CCACCAGCTGGG`	1	--	int¹		2		NA CSA	4
rs201996409^1,2		--	99295732(+)	`TATTA-/TTATTA TTATTATTGTTATT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBTD1 (99258625 - 99330966 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBTD1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBTD1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UBTD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBTD1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80019	HGNC: 25683	AceView: UBTD1	Ensembl:ENSG00000165886	euGenes: HUgn80019
ECgene: UBTD1	H-InvDB: UBTD1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UBTD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBTD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for UBTD1 gene:
Search GeneIP for patents involving UBTD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	GenScript Custom Purified and Recombinant Proteins Services for UBTD1		GenScript cDNA clones with any tag delivered in your preferred vector for UBTD1
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTD1

	SwitchGear 3'UTR luciferase reporter plasmids for UBTD1
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ThermoFisher Antibody for UBTD1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBTD1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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UBTD1 Gene

ubiquitin domain containing 1

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UBTD1 Gene

ubiquitin domain containing 1

Aliasesfor UBTD1 gene

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Genomic Viewsfor UBTD1 gene

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Protein Domains /Familiesfor UBTD1 gene

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Specialized Databases showing UBTD1 gene

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for UBTD1 gene

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for UBTD1 gene

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for UBTD1 gene

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for UBTD1 gene

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for UBTD1 gene

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