UBA2 Gene
protein-coding GIFtS: 64
GCID: GC19P034919
|
|
ubiquitin-like modifier activating enzyme 2(Previous name: SUMO1 activating enzyme subunit 2 )
(Previous symbol: SAE2)
| |
Aliases
for UBA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like Modifier Activating Enzyme 21 2 | | HRIHFB21151 | | SAE21 2 3 5 | | SUMO-1 Activating Enzyme Subunit 22 | | ARX1 2 | | SUMO-Activating Enzyme Subunit 22 | | SUMO1 Activating Enzyme Subunit 21 2 | | UBA2, Ubiquitin-Activating Enzyme E1 Homolog2 | | Anthracycline-Associated Resistance ARX2 3 | | EC 6.3.2.-3 | | Ubiquitin-Like 1-Activating Enzyme E1B2 3 | | UBLE1B3 | | FLJ130581 | | EC 6.3.28 |
Export aliases for UBA2 gene to outside databasesPrevious GC identifers: GC19P035536 GC19P035368 GC19P039595 GC19P039611 GC19P031425 |
Summaries
for UBA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBA2:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), orsumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimerthat functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 (PubMed9920803)).(supplied by OMIM, Mar 2010)
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Function: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependentactivation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved activesite cysteine residue on UBA2/SAE2
Gene Wiki entry for UBA2
|
Genomic Views
for UBA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBA2 gene promoter:
XBP-1 CUTL1 C/EBPalpha PPAR-alpha POU2F1 HFH-1 HOXA5 POU2F1a NF-kappaB1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q12 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11UBA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P034919: view genomic region
(about GC identifiers)
Start:
|
34,919,264 bp from pter |
End:
|
34,960,853 bp from pter |
Size:
|
41,590 bases |
Orientation:
|
plus strand |
|
Proteins
for UBA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2 (See
protein sequence)Recommended Name: SUMO-activating enzyme subunit 2 Size: 640 amino acids; 71224 Da
Subunit: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a singlepolypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I
Subcellular location: Nucleus
5 PDB 3D structures from  and Proteopedia  for UBA2:1Y8Q (3D)
1Y8R (3D)
2PX9 (3D)
3KYC (3D)
3KYD (3D)
Secondary accessions: O95605 Q59H87 Q6IBP6 Q9NTJ1 Q9UED2Explore the universe of human proteins at neXtProt for UBA2: NX_Q9UBT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBT2
4/13 DME Specific Peptides for UBA2 (Q9UBT2) (see all 13)
UBA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005490.1
ENSEMBL proteins: ENSP00000468538 ENSP00000246548 ENSP00000467433 ENSP00000437484 ENSP00000468756
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
UBA2 for ontologies About GeneDecksing
UBA2 Antibody Products:
Assay Products for UBA2: |
Protein
Domains /
Families
for UBA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBA2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9UBT2ProtoNet protein and cluster: Q9UBT2 1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Similarity: Belongs to the ubiquitin-activating E1 family |
Function
for UBA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Function: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependentactivation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved activesite cysteine residue on UBA2/SAE2 Genatlas biochemistry entry for UBA2:sentrin (UBL1) avtivating protein component with AOS1(SAE1) and UBL1 required for activation of UBL1
Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBA2 (NM_005499) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA2 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
UBA2 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for UBA2:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Uba2):
UBA2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Proteolysis Putative SUMO-1 pathway | | | 2 | DNA damage Role of SUMO in p53 regulation | | | 3 | Protein Stability | | | 4 | Antigen processing: Ubiquitination & Proteasome degradation | | | 5 | 4-1BB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for UBA2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for UBA2
1 
Cell Signaling Technology (CST) Pathway for UBA2
2  GeneGo (Thomson Reuters) Pathways for UBA2
1 
Kegg Pathway (Kegg details for UBA2):
UniProtKB/Swiss-Prot: SAE2_HUMAN, Q9UBT2Pathway: Protein modification; protein sumoylation
UBA2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/84 Interacting proteins for UBA2 (Q9UBT21, 2, 3 ENSP000002465484) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SAE1 | Q9UBE01, 2, 3, ENSP000002702254 | EBI-718569,EBI-743154 MINT-66320 I2D:
score=16 STRING: ENSP00000270225 | | SUMO1 | P631652, 3, ENSP000003760764 | MINT-8173832 I2D:
score=3 STRING: ENSP00000376076 | | BRIX1 | Q8TDN62, 3, ENSP000003388624 | MINT-65042 I2D:
score=4 STRING: ENSP00000338862 | | UBE2I | P632793, ENSP000003248974 | I2D:
score=5 STRING: ENSP00000324897 | | UFD1L | Q928903, ENSP000002632024 | I2D:
score=3 STRING: ENSP00000263202 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | cellular protein modification process |
-- | -- | | GO:0016925 | protein sumoylation |
IEA | -- | | GO:0043085 | positive regulation of catalytic activity |
TAS | 10187858 |
UBA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBA2
4 HMDB Compounds for UBA2 About this table
Search CenterWatch for drugs/clinical trials and news about UBA2 / SAE2
|
Transcripts
for UBA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBA2 gene: NM_005499.2 Unigene Cluster for UBA2: Ubiquitin-like modifier activating enzyme 2 Hs.631580 [show with all ESTs]Unigene Representative Sequence: AK1247309 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586313 ENST00000246548(uc010xrx.1 uc002nvk.3) ENST00000590048
ENST00000592841 ENST00000439527(uc002nvl.3) ENST00000592672 ENST00000591016
ENST00000592791 ENST00000588585
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBA2 (NM_005499) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBA2 |
Additional cDNA sequence: AB015337.1 AB208872.1 AF079566.1 AF090384.1 AF110957.1 AK023120.1 AK024114.1 AK124730.1 AK299514.1 AK315521.1 AL136905.1 BC003153.1 BT009781.1 CR456756.1 U35832.1 24/30 DOTS entries (see all 30): DT.417687 DT.91769032 DT.95371608 DT.100827743 DT.100647308 DT.95371580 DT.101984590 DT.100827746 DT.121476967 DT.100838603 DT.100827747 DT.121476497 DT.40225546 DT.91769042 DT.100827744 DT.91877659 DT.95184015 DT.100827735 DT.100838962 DT.121398493 DT.121476622 DT.121476680 DT.121476978 DT.86855221 24/478 AceView cDNA sequences (see all 478): BQ889284 AA865810 BM830585 AA553714 BM845318 BE349506 BQ889474 BM750823 BG166807 AU119912 AA693705 BM710638 BC003153 AU139782 AW449744 CB150349 CD171589 BF436280 CD557600 AL039462 BQ898253 BI838445 BU173065 AI193292
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UBA2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBA2
|
Expression
for UBA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCTTTTT
About this image
See UBA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBA2
SOURCE GeneReport for Unigene cluster: Hs.631580
SABiosciences Expression via Pathway-Focused PCR Array including UBA2: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA2 |
Orthologs
for UBA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBA2 gene from 10/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Uba21 , 5 |
ubiquitin-like modifier activating enzyme 21, 5 |
87.72(n)1
94.36(a)1 |
|
7 (19.41 cM)5
509951 NM_016682.21 NP_057891.11
341406895 |
chicken
(Gallus gallus) |
Aves |
UBA21 |
ubiquitin-like modifier activating enzyme 2 |
83.37(n)
89.88(a) |
|
415784 NM_001030571.1 NP_001025742.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBA26 |
-- |
80(a) |
1 ↔ 1 |
GL344074.1(8149-22569) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.151512 |
Xenopus laevis, Similar to SUMO-1 activating enzyme more |
79.33(n) |
|
BC043962.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi17g062 |
Danio rerio cDNA clone MGC66354 IMAGE5604607, complete more |
78.8(n) |
|
BC055614.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Uba21 , 3 |
SMT3-dependent protein catabolism
ubiquitin-like more3
Smt3 activating enzyme 21 |
49(a)3
55.91(n)1
53.14(a)1 |
|
66B73
444961 NM_080017.21 NP_524756.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
uba-21 , 3 |
ThiF family3
UBA (human ubiquitin) related1 |
47(a)3
52.24(n)1
46.95(a)1 |
|
I(12749657-12753353)3
1731451 NM_001026477.21 NP_001021648.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBA2(YDR390C)4
UBA21 |
Subunit of a heterodimeric nuclear SUMO activating more4
Uba2p1 |
47.28(n)1
36.81(a)1 |
|
4(1256847-1254937)4
8519981, 4 NP_010678.31 NP_010678.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SAE21 |
SUMO-activating enzyme subunit 2 |
53.08(n)
44.04(a) |
|
816686 NM_001202641.1 NP_001189570.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.180652 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
75.22(n) |
|
AK120683.1 |
ENSEMBL Gene Tree for UBA2 (if available)
TreeFam Gene Tree for UBA2 (if available) |
Paralogs
for UBA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBA2 gene
1 SIMAP similar gene for UBA2 using alignment to 5 protein entries: SAE2_HUMAN (see all proteins):UBA6
UBA2 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for UBA2
PGOHUM00000244088 PGOHUM00000244782 PGOHUM00000243796
|
Genomic Variants
for UBA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBA2 (34919264 - 34960853 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBA2 |
|
Disorders
/ Diseases
for UBA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBA2 for disorders About GeneDecksing
OMIM gene information: 613295
OMIM disorders: --
1  disease for UBA2: About MalaCardsmalaria
1 disease from the University of Copenhagen DISEASES database for UBA2:Adult dermatomyositis Export disorders for UBA2 gene to outside databases
|
Publications
for UBA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBA2 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with UBA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. (PubMed id 10187858)1, 2, 3, 9 Desterro J.M.P.... Hay R.T. (1999)
- In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. (PubMed id 9920803)1, 2, 3 Okuma T.... Yasuda H. (1999)
- Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. (PubMed id 10217437)1, 2, 9 Gong L.... Yeh E.T.H. (1999)
- A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. (PubMed id 16620772)1, 2 Li T....Chock P.B. (2006)
- Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. (PubMed id 15660128)1, 2 Lois L.M. and Lima C.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Expression and regulation of the mammalian SUMO-1 E1 enzyme. (PubMed id 11481243)1, 2 Azuma Y....Dasso M. (2001)
- Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. (PubMed id 11451954)1, 2 Tatham M.H.... Hay R.T. (2001)
- Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (1998)
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External Searches for UBA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing UBA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing UBA2 gene
(According to HUGE)
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Specialized Databases showing UBA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for UBA2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for UBA2 gene:
Search GeneIP for patents involving UBA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for UBA2 | | OriGene shRNA RFP for UBA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBA2 | | | OriGene Protein Over-expression Lysate for UBA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBA2 | | OriGene 3'-UTR Clone for UBA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBA2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBA2 | | OriGene Custom Protein Services for UBA2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBA2 |
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| | Antibodies & Assays for UBA2 (SAE2) |
| | | | Search Tocris compounds for UBA2 |
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 | | | UBA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBA2 |
|  |  |  | | | | ThermoFisher Antibody for UBA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBA2 |
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