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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TXNDC11 Gene

protein-coding   GIFtS: 45
GCID: GC16M011772

thioredoxin domain containing 11

 Explore 4 diseases affiliated with
TXNDC11 via our new
 Human Malady Compendium 
Biological research products
for TXNDC11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thioredoxin Domain Containing 111 2
EFP11 2 3
EF-Hand-Binding Protein 12 3
EF-Hand Binding Protein 12
Thioredoxin Domain-Containing Protein 112

External Ids:    HGNC: 280301   Entrez Gene: 510612   Ensembl: ENSG000001530667   UniProtKB: Q6PKC33   

Export aliases for TXNDC11 gene to outside databases

Previous GC identifer: GC16M011681


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
Function: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest
that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not
sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXNDC11 gene promoter:
         Nkx3-1   p53   RREB-1   ATF-2   Nkx3-1 v1   E47   Nkx3-1 v2   HEN1   Nkx3-1 v3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXNDC11 promoter sequence
   Search SABiosciences Chromatin IP Primers for TXNDC11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXNDC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

TXNDC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXNDC11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M011772:  view genomic region     (about GC identifiers)

Start:
11,772,936 bp from pter      End:
11,836,734 bp from pter
Size:
63,799 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3 (See protein sequence)
Recommended Name: Thioredoxin domain-containing protein 11  
Size: 985 amino acids; 110529 Da
Subunit: Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAD20043.1; Type=Frameshift; Positions=618; Sequence=AAH13727.1; Type=Erroneous initiation;
Sequence=BAB55129.1; Type=Erroneous initiation; Sequence=BAC11044.1; Type=Miscellaneous discrepancy; Note=Intron
retention;
Secondary accessions: O95887 Q6PJA6 Q8N2Q4 Q96K45 Q96K53
Alternative splicing: 3 isoforms:  Q6PKC3-1   Q6PKC3-2   Q6PKC3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TXNDC11: NX_Q6PKC3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6PKC3

  • TXNDC11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056998.4  
    ENSEMBL proteins: 
     ENSP00000283033   ENSP00000349439   ENSP00000458263   ENSP00000458687   ENSP00000460058  

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    Uscn Proteins for TXNDC11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    TXNDC11 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TXNDC11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6PKC3

    ProtoNet protein and cluster: Q6PKC3

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
    Similarity: Belongs to the protein disulfide isomerase family
    Similarity: Contains 2 thioredoxin domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
    Function: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest
    that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not
    sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation

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    Animal Models:
         1 MGI phenotypic allele for Txndc11 (no phenotypes)

    TXNDC11 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXNDC11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/22 Interacting proteins for TXNDC11 (Q6PKC32, 3 ENSP000002830334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2872920 I2D: score=3 STRING: ENSP00000344782
    KRT15P190123, ENSP000002540434I2D: score=4 STRING: ENSP00000254043
    DUOX1Q9NRD93, ENSP000003179974I2D: score=1 STRING: ENSP00000317997
    TPOP072023, ENSP000003298694I2D: score=1 STRING: ENSP00000329869
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--


    TXNDC11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXNDC11
    Search CenterWatch for drugs/clinical trials and news about TXNDC11 / TXD11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TXNDC11 gene: 
    NM_015914.5  

    Unigene Cluster for TXNDC11:

    Thioredoxin domain containing 11
    Hs.313847  [show with all ESTs]
    Unigene Representative Sequence: BC002856
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283033(uc002dbg.1) ENST00000570917 ENST00000356957(uc010buu.1)
    ENST00000575349 ENST00000572732 ENST00000575591 ENST00000576969 ENST00000571882
    ENST00000573174

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    hsa-miR-3163 hsa-miR-29a* hsa-miR-4282
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    Additional cDNA sequence: 

    AF131780.1 AK027464.1 AK027646.1 AK074534.1 AK297094.1 BC002856.1 BC013727.1 BC018635.2 
    BX648407.1 CR457152.1 

    16 DOTS entries:

    DT.40126694  DT.447430  DT.101980962  DT.92440994  DT.101980963  DT.120656182  DT.100776378  DT.120656177 
    DT.97846332  DT.40191440  DT.91906292  DT.95374641  DT.97771102  DT.120656220  DT.40246110  DT.91675198 

    24/178 AceView cDNA sequences (see all 178):

    AW589294 BQ227252 BU618920 AI923678 BM985045 BM793792 AI590859 BM670578 
    CA309280 BQ709056 BU501810 AI033959 AI422429 CB243295 BU538371 M79219 
    AA359283 AA296427 BG060051 BM700464 BM974993 BC013727 AI813964 BM743119 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC11 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -           -                                                                           
    SP2:                                            -                                                                           
    SP3:                                                                                                                        
    SP4:                                            -                                                                           
    SP5:                                -           -     -     -                                                               


    ECgene alternative splicing isoforms for TXNDC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TXNDC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGGAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TXNDC11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TXNDC11

    SOURCE GeneReport for Unigene cluster: Hs.313847

    UniProtKB/Swiss-Prot: TXD11_HUMAN, Q6PKC3
    Tissue specificity: Widely expressed at low level. Expressed at higher level in thyroid and prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TXNDC11 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txndc111 , 5 thioredoxin domain containing 111, 5 83.65(n)1
    83.19(a)1
      16 (6.33 cM)5
    1062001  NM_029582.21  NP_083858.11 
     110749115 
    chicken
    (Gallus gallus)
    Aves TXNDC111 thioredoxin domain containing 11 69.19(n)
    67.21(a)
      416428  XM_414741.3  XP_414741.3 
    lizard
    (Anolis carolinensis)
    Reptilia TXNDC116
    --
    65(a)
    1 ↔ 1
    GL343691.1(250369-282035)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003304331 thioredoxin domain-containing protein 11-like 56.06(n)
    49.45(a)
      100330433  XM_002660673.1  XP_002660719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136716
    --
    17(a)
    1 ↔ 1
    3L(8293164-8295441)


    ENSEMBL Gene Tree for TXNDC11 (if available)
    TreeFam Gene Tree for TXNDC11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TXNDC11 gene

    TXNDC11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TXNDC11
    PGOHUM00000243958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1212 NCBI SNPs in TXNDC11 are shown (see all 1212    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415917471,2
    C,F--11773535(+) TGTGCC/GCCCGC 2 A G mis11Minor allele frequency- G:0.00NA 4552
    rs1463654811,2
    C,--11773598(+) TCTGGG/AGGCTG 2 /P /L mis11Minor allele frequency- A:0.00NA 4552
    rs31903211,2
    C,F,A,H,--11773662(-) AAGACG/CTCCCC 2 /L /V mis1 ese326Minor allele frequency- C:0.49NS MN EA NA WA CSA EU 7688
    rs81913521,2
    C,F,H,--11773733(+) TCACAC/GCAACA 1 -- int17Minor allele frequency- G:0.09NS EA NA 776
    rs71885111,2
    C,F,A,H,--11773743(+) ACAATG/TAGTCC 1 -- int132Minor allele frequency- T:0.46NS NA EA WA CSA 3093
    rs771316201,2
    --11773800(+) AAAGAC/TGTTCC 1 -- int10--------
    rs794902301,2
    F,--11773801(+) AAGACG/ATTCCG 1 -- int11Minor allele frequency- A:0.03EA 120
    rs81913531,2
    C,F,H,--11773806(+) GTTCCG/ATGGAT 1 -- int18Minor allele frequency- A:0.10NS EA WA CSA 712
    rs81913541,2
    C,F,H,--11773885(+) TATGCT/ACGTTC 1 -- int117Minor allele frequency- A:0.02NS EA NA WA 2046
    rs37849201,2
    C,F,--11773981(+) GGCCTA/GAAGCC 1 -- int15Minor allele frequency- G:0.07EA NS NA 1886

    HapMap Linkage Disequilibrium report for TXNDC11 (11772936 - 11836734 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TXNDC11: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TXNDC11 for disorders           About GeneDecksing

    4 diseases for TXNDC11:    About MalaCards
    macular degeneration    ataxia    thyroiditis    prostatitis


    Export disorders for TXNDC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TXNDC11 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TXNDC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel partner of duox: EFP1, a thioredoxin- related protein. (PubMed id 15561711)1, 2, 9 Wang D....Miot F. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
    8. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    9. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)
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    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51061 HGNC: 28030 AceView: LOC51061 Ensembl:ENSG00000153066 euGenes: HUgn51061
    ECgene: TXNDC11 H-InvDB: TXNDC11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TXNDC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TXNDC11 gene:
    Search GeneIP for patents involving TXNDC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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