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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIAP1 Gene

protein-coding   GIFtS: 48
GCID: GC12M120881

TP53 regulated inhibitor of apoptosis 1

 Explore 7 diseases affiliated with
TRIAP1 via our new
 Human Malady Compendium 
Biological research products
for TRIAP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TP53 Regulated Inhibitor Of Apoptosis 11 2     P53-Inducible Cell-Survival Factor2 3
WF-11 2 3     HSPC1321
MDM351 2     Mitochondrial Distribution And Morphology 35 Homolog2
P53CSV1 2     TP53-Regulated Inhibitor Of Apoptosis 12
P53CSV1 2     15E1.13
Protein 15E1.12 3     

External Ids:    HGNC: 269371   Entrez Gene: 514992   Ensembl: ENSG000001708557   OMIM: 6149435   UniProtKB: O437153   

Export aliases for TRIAP1 gene to outside databases

Previous GC identifers: GC12M119366 GC12M117891


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TRIA1_HUMAN, O43715
Function: Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIAP1 gene promoter:
         GR   RFX1   GR-beta   MyoD   Olf-1   MIF-1   C/EBPalpha   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

TRIAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIAP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120881:  view genomic region     (about GC identifiers)

Start:
120,881,764 bp from pter      End:
120,884,215 bp from pter
Size:
2,452 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRIA1_HUMAN, O43715 (See protein sequence)
Recommended Name: TP53-regulated inhibitor of apoptosis 1  
Size: 76 amino acids; 8786 Da
Subunit: Interacts with APAF1 and HSP70
Subcellular location: Cytoplasm, perinuclear region
Sequence caution: Sequence=AAR00584.1; Type=Erroneous initiation;
Secondary accessions: B2R4Z7 Q5RKS5 Q6LCA7

Explore the universe of human proteins at neXtProt for TRIAP1: NX_O43715

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43715

  • TRIAP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057483.1  
    ENSEMBL proteins: 
     ENSP00000449795  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIAP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA15735003
    GO:0048471perinuclear region of cytoplasm IEA--


    TRIAP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRIAP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRIAP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007918 MDM35_apoptosis

    Graphical View of Domain Structure for InterPro Entry O43715

    ProtoNet protein and cluster: O43715

    1 Blocks protein family: IPB007918 Protein of unknown function UPF0203

    UniProtKB/Swiss-Prot: TRIA1_HUMAN, O43715
    Similarity: Belongs to the TRIAP1/MDM35 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TRIA1_HUMAN, O43715
    Function: Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis
    Induction: In p53/TP53-dependent manner in response to low levels of DNA damage. Not induced when DNA damage is severe

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    hsa-miR-4324 hsa-miR-320a hsa-miR-125a-5p hsa-miR-320d hsa-miR-103a hsa-miR-320b hsa-miR-125b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidTRIAP1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIAP1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15735003
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA15735003


    TRIAP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TRIAP1:
     Actin fiber cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Direct p53 effectors
    Direct p53 effectors1.00


    1 BioSystems Pathway for TRIAP1 
        Direct p53 effectors


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIAP1

    4 Interacting proteins for TRIAP1 (O437153) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073I2D: score=1 
    HSPA1BP081073I2D: score=1 
    APAF1O147273I2D: score=1 
    TP53P046373I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS15735003
    GO:0030330DNA damage response, signal transduction by p53 class mediator IEP15735003
    GO:0043066negative regulation of apoptotic process IMP15735003
    GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA15735003


    TRIAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIAP1
    Search CenterWatch for drugs/clinical trials and news about TRIAP1 / TRIA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIAP1 gene: 
    NM_016399.2  

    Unigene Cluster for TRIAP1:

    TP53 regulated inhibitor of apoptosis 1
    Hs.69499  [show with all ESTs]
    Unigene Representative Sequence: BQ953918
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546954(uc001tyg.3) ENST00000302432

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIAP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIAP1 (see all 10):
    hsa-miR-4324 hsa-miR-320a hsa-miR-125a-5p hsa-miR-320d hsa-miR-103a hsa-miR-320b hsa-miR-125b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidTRIAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIAP1 (see all 7)
    OriGene shRNA RFP: TRIAP1
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIAP1
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    Additional cDNA sequence: 

    AF161481.1 AK312006.1 BC002638.2 BC055313.1 U75688.1 

    6 DOTS entries:

    DT.412908  DT.95275447  DT.100863697  DT.92438289  DT.97843950  DT.92438291 

    24/229 AceView cDNA sequences (see all 229):

    BF683935 BU848872 U75688 BE394127 AW327600 BQ071011 BG743205 CB141335 
    CR598391 BU845708 BQ775340 BG678393 AI284246 BE858411 BQ962184 BQ070872 
    BU191667 AI458093 BM850790 BC002638 BU553342 BE747267 BU175259 BQ021182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAAAGAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TRIAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIAP1

    SOURCE GeneReport for Unigene cluster: Hs.69499
        SABiosciences Expression via Pathway-Focused PCR Array including TRIAP1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRIAP1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Triap11 , 5 TP53 regulated inhibitor of apoptosis 11, 5 92.11(n)1
    98.68(a)1
      5 (56.06 cM)5
    690761  NM_026933.21  NP_081209.11 
     1153412255 
    chicken
    (Gallus gallus)
    Aves TRIAP11 TP53 regulated inhibitor of apoptosis 1 83.33(n)
    82.89(a)
      416977  XM_429464.3  XP_429464.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRIAP16
    --
    81(a)
    1 ↔ 1
    GL343338.1(71804-72517)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.202012 Xenopus laevis transcribed sequence with moderate similarity more 77.38(n)    BG552101.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.178762 Transcribed sequence with moderate similarity to protein more 79.9(n)    57061833 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301086
    CG301096
    --
    40(a)
    34(a)
    many → 1
    many → 1
    2R(13556905-13557505)
    2R(13556910-13558253)


    ENSEMBL Gene Tree for TRIAP1 (if available)
    TreeFam Gene Tree for TRIAP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIAP1 gene

    TRIAP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TRIAP1
    PGOHUM00000238381 PGOHUM00000260622


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 NCBI SNPs in TRIAP1 are shown (see all 88    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11518451,2
    C,F,O,A,H,--120881288(+) GTACCA/GTAGTG 1 -- int129Minor allele frequency- G:0.23NS EA NA WA CSA 2656
    rs1857434191,2
    --120881329(+) AAATCA/TGTGAG 1 -- int10--------
    rs1161226321,2
    C,F,--120881348(+) TGGGTG/TCGGTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1132789021,2
    C--120881591(+) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1468321631,2
    --120881621(+) ATTGCC/TATACT 1 -- int10--------
    rs1392192131,2
    --120881764(+) GCAAAC/TAATGA 1 -- ut310--------
    rs38093091,2
    C,H,--120881917(-) TGCATA/TTCCTA 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 416
    rs1175196881,2
    F,--120881931(+) TGACAA/GTTCAC 1 -- ut311Minor allele frequency- G:0.02NA 120
    rs1900645041,2
    --120882122(+) TAAAAA/GCTGTC 1 -- ut310--------
    rs10488301,2
    C,F,A,H,--120882217(-) CACAAC/AAGTTT 1 -- ut3115Minor allele frequency- A:0.35MN NA WA CSA EA 702

    HapMap Linkage Disequilibrium report for TRIAP1 (120881764 - 120884215 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRIAP1
         1 CNV: 58553

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRIAP1 for disorders           About GeneDecksing

    OMIM gene information: 614943    OMIM disorders: --

    7 diseases for TRIAP1:    About MalaCards
    connective tissue disease    intrahepatic cholangiocarcinoma    lupus erythematosus    multiple myeloma
    cholangiocarcinoma    myeloma    twinning

    4 diseases from the University of Copenhagen DISEASES database for TRIAP1:
    Lupus erythematosus     Nephritis     Connective tissue disease     Proteinuria
    Human Genome Epidemiology (HuGE) Navigator: TRIAP1 (1 document)

    Export disorders for TRIAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIAP1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TRIAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. (PubMed id 15735003)1, 2, 3, 9 Park W.-R. and Nakamura Y. (2005)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Genome-wide detection of allele specific copy number v ariation associated with insulin resistance in African Americans from the HyperG EN study. (PubMed id 21901158)1 Irvin M.R....Arnett D.K. (2011)
    8. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    9. SAGE analysis highlights the importance of p53csv, ddx5, mapkapk2 and ranbp2 to multiple myeloma tumorigenesis. (PubMed id 19171422)1 Felix R.S....Vettore A.L. (2009)
    10. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51499 HGNC: 26937 AceView: HSPC132 Ensembl:ENSG00000170855 euGenes: HUgn51499
    ECgene: TRIAP1 H-InvDB: TRIAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIAP1 gene:
    Search GeneIP for patents involving TRIAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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