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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNS1 Gene

protein-coding GIFtS: 57
GCID: GC02M218664

tensin 1

(Previous names: tensin, matrix-remodelling associated 6 )
(Previous symbols: TNS, MXRA6)

Explore 7 diseases affiliated with
TNS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tensin 1¹ ²		MST122²
TNS¹ ² ³ ⁵		MST127²
MXRA6¹ ²		MSTP122²
Matrix-Remodelling Associated 6¹ ²		MSTP127²
DKFZp586K0617¹		Matrix-Remodelling-Associated Protein 6²
Tensin¹		Tensin-1¹
MST091²

External Ids:	HGNC: 11973¹	Entrez Gene: 7145²	Ensembl: ENSG00000079308⁷	OMIM: 600076⁵	UniProtKB: Q9HBL0³

Export aliases for TNS1 gene to outside databases

Previous GC identifers: GC02M218492 GC02M218375 GC02M210519

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNS1:

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches

to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which

is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second

transcript from this gene has been described, but its full length nature has not been determined. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0

Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the

cytoskeleton

Gene Wiki entry for TNS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNS1 gene promoter:
c-Fos AP-1 ATF-2 LUN-1 c-Jun Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNS1 promoter sequence

Search SABiosciences Chromatin IP Primers for TNS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35-q36 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35-q36

TNS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNS1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M218664: view genomic region (about GC identifiers)

Start:	218,664,512 bp from pter	End:	218,867,718 bp from pter
Size:	203,207 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0 (See protein sequence)

Recommended Name: Tensin-1

Size: 1735 amino acids; 185701 Da

Subunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8

Subcellular location: Cell junction, focal adhesion. Cytoplasm, cytoskeleton

Secondary accessions: Q4ZG71

Explore the universe of human proteins at neXtProt for TNS1: NX_Q9HBL0

Post-translational modifications:

Rapidly cleaved by calpain II¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBL0

TNS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_072174.3

ENSEMBL proteins:

ENSP00000171887 ENSP00000394171 ENSP00000408724 ENSP00000406016 ENSP00000405460

ENSP00000400383 ENSP00000308321 ENSP00000414704 ENSP00000395615 ENSP00000404477

ENSP00000411349 ENSP00000393925

Human Recombinant Protein Products:

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	Novus Biologicals TNS1 Protein Novus Biologicals TNS1 Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TNS1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005925	focal adhesion	IDA	--
GO:0030055	cell-substrate junction	--	--

TNS1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TNS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNS1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR014019 Phosphatase_tensin-typ

IPR013625 PTB

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR006020 PTyr_interaction_dom

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q9HBL0

ProtoNet protein and cluster: Q9HBL0

3 Blocks protein families:

IPB000209 Subtilisin serine protease family (S8) signature

IPB000980 SH2 domain signature

IPB013625 Tensin phosphotyrosine-binding domain

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0

Similarity: Contains 1 C2 tensin-type domain

Similarity: Contains 1 phosphatase tensin-type domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0

Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the

cytoskeleton

miRNA Products:		OriGene 3'-UTR Clone: TNS1 Browse MicroRNA Expression Plasmids
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		8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate TNS1 (see all 101):
		hsa-miR-548j hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-1321 hsa-miR-642a hsa-miR-4272 hsa-miR-106a

		SwitchGear 3'UTR luciferase reporter plasmid: TNS1 3' UTR sequence

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TNS1

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		Search LifeMap BioReagents cell lines for TNS1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	17190795
GO:0046872	metal ion binding	--	--

TNS1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TNS1:

Decreased Wnt reporter activit

Increased mitotic index

Animal Models:
Mouse knock-out Tns1^tm1Efu for TNS1
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tns1):

behavior/neurological	cardiovascular system	cellular	immune system	renal/urinary system
reproductive system

TNS1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Focal Adhesion

Integrin-mediated cell adhesion

0.38

1 BioSystems Pathway for TNS1

Integrin-mediated cell adhesion

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TNS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/15 Interacting proteins for TNS1 (Q9HBL0^{2, 3} ENSP00000171887⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KLF10	Q13118²^,³, ENSP00000285407⁴	MINT-8259241 I2D: score=2 STRING: ENSP00000285407
OSGEP	Q9NPF4²^,³, ENSP00000206542⁴	MINT-8265301 I2D: score=2 STRING: ENSP00000206542
CAPN2	P17655²^,³, ENSP00000295006⁴	MINT-8216416 I2D: score=2 STRING: ENSP00000295006
NPHP1	O15259³, ENSP00000313169⁴	I2D: score=1 STRING: ENSP00000313169
BCAR1	P56945³, ENSP00000162330⁴	I2D: score=1 STRING: ENSP00000162330

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007044	cell-substrate junction assembly	IEA	--
GO:0010761	fibroblast migration	IEA	--
GO:0035556	intracellular signal transduction	--	--

TNS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNS1
Search CenterWatch for drugs/clinical trials and news about TNS1 / TENS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNS1 gene:

NM_022648.4

Unigene Cluster for TNS1:

Tensin 1

Hs.471381 [show with all ESTs]

Unigene Representative Sequence: NM_022648

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000171887(uc002vgq.2 uc002vgr.2 uc002vgs.2 uc002vgt.2 uc010zjv.1 uc010fvk.1)

ENST00000446688 ENST00000490566 ENST00000419504 ENST00000430930(uc010fvj.1)

ENST00000480416 ENST00000495556 ENST00000446903 ENST00000479185(uc010fvi.1)

ENST00000480665 ENST00000413554 ENST00000310858(uc002vgu.3) ENST00000453356

ENST00000492338 ENST00000413280(uc002vgv.1) ENST00000439083 ENST00000423413

ENST00000449814

miRNA Products:		OriGene 3'-UTR Clone: TNS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNS1
		8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate TNS1 (see all 101):
		hsa-miR-548j hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-1321 hsa-miR-642a hsa-miR-4272 hsa-miR-106a

		SwitchGear 3'UTR luciferase reporter plasmid: TNS1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: TNS1 (NM_022648)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS1

Additional cDNA sequence:

AB209238.1 AF116610.1 AF172820.1 AF173897.1 AF176917.1 AK001785.2 AK057328.1 AK300345.1

AK309785.1 AK310169.1 AL117537.1 BC014042.2 BC033065.1 BC051304.1 BC063142.1 BC071905.1

BC107758.1 BC116187.1 BC116188.1 BC126910.1 BC140942.1 BC141869.1

22 DOTS entries:

DT.65288302 DT.95254148 DT.409061 DT.91638643 DT.102842684 DT.120930058 DT.102842683 DT.95081881

DT.100722094 DT.91762106 DT.100010105 DT.40284680 DT.97855834 DT.100000225 DT.100787292 DT.120930045

DT.91762101 DT.92007742 DT.40312695 DT.424486 DT.448615 DT.91762112

24/115 AceView cDNA sequences (see all 115):

AI034472 AI696766 BG818827 BF913272 BU734360 AW848727 AW272238 BM701389

BM704950 BF222588 BP363359 BP372749 AA777636 BM976854 AL117537 AL708889

AI609948 BQ949180 AW578368 BU838467 BC033065 BC071905 AI065093 BG328062

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TNS1 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^
SP1:													-		-		-		-								-												-
SP2:																	-		-																				-
SP3:
SP4:					-								-		-		-		-
SP5:

ExUns:	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33	^	34	^	35	^	36	^	37
SP1:	-
SP2:
SP3:																							-
SP4:
SP5:

ECgene alternative splicing isoforms for TNS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTATTGT

About this image

TNS1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Kidney

Afferent Arteriole

Juxtaglomerular Cells

Kidney, Smooth Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNS1

SOURCE GeneReport for Unigene cluster: Hs.471381

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Array including TNS1:

Focal Adhesions in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNS1 gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNS1¹	tensin 1	71.74(n) 73.69(a)		396439 NM_205455.1 NP_990786.1
lizard (Anolis carolinensis)	Reptilia	TNS1⁶	--	65(a)	1 ↔ 1	1(89361222-89472941)
African clawed frog (Xenopus laevis)	Amphibia	CB559530.1²	--	75.28(n)		CB559530.1
zebrafish (Danio rerio)	Actinopterygii	57043942²	--	77.78(n)		57043942
honey bee (Apis mellifera)	Insecta	--	--	31(a)	1 → many	Group13.7(501651-513471)
worm (Caenorhabditis elegans)	Secernentea	tag-83⁶	Putative protein phosphatase tag-83	31(a)	1 → many	I(5600672-5603484)
thale cress (Arabidopsis thaliana)	eudicotyledons	PEN2⁶ PEN3⁶	phosphatidylinositol-3,4,5-trisphosphate 3-phospha... phosphatidylinositol-3,4,5-trisphosphate 3-phospha...	15(a) 14(a)	possible ortholog possible ortholog	3(6731376-6735623) 3(18580609-18584535)
rice (Oryza sativa)	Liliopsida	--	PTEN, putative, expressed	12(a)	possible ortholog	12(12318999-12327551)

ENSEMBL Gene Tree for TNS1 (if available)
TreeFam Gene Tree for TNS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNS1 gene

DNAJC6² PTEN² TPTE² TNS4² TNS3² TENC1² GAK² TPTE2²

8 SIMAP similar genes for TNS1 using alignment to 18 protein entries: TENS1_HUMAN (see all proteins):

DKFZp434G162 TNS3 GAK TNS4 PTEN PTEN2

TENC1 DKFZp434I2435

TNS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183401572^1,2		--	218664072(+)	`GAACAC/TTGGGA`	1	--	ds500¹		0	--	--	--	--
rs141366741^1,2		--	218664151(+)	`CCGCCA/GCTCAG`	1	--	ds500¹		0	--	--	--	--
rs78900453^1,2	F,	--	218664268(+)	`CACTCG/TGGCCA`	1	--	ds500¹		1		EA	120
rs62183751^1,2		--	218664368(+)	`ACCACG/ACAGAT`	1	--	ds500¹		1		NA	2
rs139039958^1,2		--	218664429(+)	`AAGCCA/CACCTG`	1	--	ds500¹		0	--	--	--	--
rs142246801^1,2		--	218664488(+)	`TGTCCA/GAACAA`	1	--	ds500¹		0	--	--	--	--
rs188847783^1,2		--	218664507(+)	`GATAAC/TGGCAC`	1	--	ds500¹		0	--	--	--	--
rs150814497^1,2		--	218664525(+)	`TCTTTA/GACTTT`	1	--	ut3¹		0	--	--	--	--
rs192537803^1,2		--	218664552(+)	`TACAAC/TGCATT`	1	--	ut3¹		0	--	--	--	--
rs138158878^1,2		--	218664592(+)	`GGGGAC/TGCGTC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNS1 (218664512 - 218867718 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TNS1
2 Indels: 45946 98135

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNS1 for disorders           About GeneDecksing

OMIM gene information: 600076    OMIM disorders: --

7 diseases for TNS1:    About MalaCards

bannayan-riley-ruvalcaba syndrome peanut allergic reaction ruvalcaba syndrome cowden disease

obstructive lung disease kidney cancer liver cancer

3 diseases from the University of Copenhagen DISEASES database for TNS1:

Cowden disease Cancer Bannayan-Riley-Ruvalcaba syndrome

Human Genome Epidemiology (HuGE) Navigator: TNS1 (3 documents)

Export disorders for TNS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNS1 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with TNS1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of human tensin. (PubMed id 11023826)^{1, 2} Chen H.... Lo S.H. (2000)
Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PubMed id 16953426)^{1, 9} Beaty T.H....Scott A.F. (2006)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effec ts on lung function. (PubMed id 21965014)¹ Soler Artigas M....Tobin M.D. (2011)
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)¹ N'Diaye A....Haiman C.A. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Genome-wide association study identifies five loci as sociated with lung function. (PubMed id 20010834)¹ Repapi E....Rudnicka A.R. (2010)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7145	HGNC: 11973	AceView: TNS	Ensembl:ENSG00000079308	euGenes: HUgn7145
ECgene: TNS1	H-InvDB: TNS1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TNS1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TNS1 gene:
Search GeneIP for patents involving TNS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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