TIGIT Gene
protein-coding GIFtS: 43
GCID: GC03P113995
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T cell immunoreceptor with Ig and ITIM domains(Previous names: V-set and immunoglobulin domain containing 9, V-set and...)
(Previous symbols: VSIG9, VSTM3)
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Aliases
for TIGIT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| T Cell Immunoreceptor With Ig And ITIM Domains1 2 | | V-Set And Transmembrane Domain-Containing Protein 32 3 | | VSIG91 2 3 | | DKFZp667A2051 | | VSTM31 2 3 | | FLJ398731 | | V-Set And Immunoglobulin Domain Containing 91 2 | | WUCAM2 | | V-Set And Transmembrane Domain Containing 31 2 | | T-Cell Immunoreceptor With Ig And ITIM Domains2 | | V-Set And Immunoglobulin Domain-Containing Protein 92 3 | | Washington University Cell Adhesion Molecule2 |
Export aliases for TIGIT gene to outside databasesPrevious GC identifers: GC03P115496 GC03P111385 |
Summaries
for TIGIT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TIGIT:
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this geneis expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown tobind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells toregulate T cell dependent B cell responses.(provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: TIGIT_HUMAN, Q495A1Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 anddecreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatorydendritic cells
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Genomic Views
for TIGIT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TIGIT gene promoter:
AML1a HNF-4alpha2 GATA-1 HNF-4alpha1 PPAR-gamma1 FOXJ2 (long isoform) Chx10 PPAR-gamma2 FOXJ2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TIGIT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGIT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.31 Ensembl cytogenetic band: 3q13.31 HGNC cytogenetic band: 3q13.31TIGIT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P113995: view genomic region
(about GC identifiers)
Start:
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113,995,760 bp from pter |
End:
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114,029,135 bp from pter |
Size:
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33,376 bases |
Orientation:
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plus strand |
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Proteins
for TIGIT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIGIT_HUMAN, Q495A1 (See
protein sequence)Recommended Name: T-cell immunoreceptor with Ig and ITIM domains precursor Size: 244 amino acids; 26319 Da
Subunit: Binds with high affinity to PVR and with lower affinity to PVRL2 and PVRL3
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAI46183.1; Type=Erroneous initiation;
4 PDB 3D structures from  and Proteopedia  for TIGIT:3Q0H (3D)
3RQ3 (3D)
3UCR (3D)
3UDW (3D)
Secondary accessions: Q495A3 Q5JPD8 Q6MZS2 Q8N877Alternative splicing: 2 isoforms: Q495A1-1 Q495A1-2 Explore the universe of human proteins at neXtProt for TIGIT: NX_Q495A1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q495A1
TIGIT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776160.2
ENSEMBL proteins: ENSP00000418917 ENSP00000420552 ENSP00000419085 ENSP00000419706 ENSP00000373167
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TIGIT for ontologies About GeneDecksing
TIGIT Antibody Products:
Assay Products for TIGIT: |
Protein
Domains /
Families
for TIGIT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TIGIT for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q495A1ProtoNet protein and cluster: Q495A1 UniProtKB/Swiss-Prot: TIGIT_HUMAN, Q495A1Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif(ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2domain of several SH2-containing phosphatasesSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for TIGIT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TIGIT_HUMAN, Q495A1Function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 anddecreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatorydendritic cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIGIT (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIGIT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TIGIT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGIT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGIT |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TIGIT for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tigittm1Sdl for TIGIT
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tigit):
TIGIT for phenotypes About GeneDecksing
|
Pathways & Interactions
for TIGIT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TIGIT
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for TIGIT (Q495A11 ENSP000003731674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TIGIT for ontologies About GeneDecksing
|
Drugs & Compounds
for TIGIT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TIGIT
Search CenterWatch for drugs/clinical trials and news about TIGIT
|
Transcripts
for TIGIT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TIGIT gene: NM_173799.3 Unigene Cluster for TIGIT: T cell immunoreceptor with Ig and ITIM domains Hs.421750 [show with all ESTs]Unigene Representative Sequence: NM_1737997 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461158 ENST00000481065 ENST00000486257 ENST00000485814 ENST00000484319
ENST00000496848 ENST00000383671(uc003ebg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIGIT (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIGIT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TIGIT (NM_173799) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TIGIT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGIT |
Additional cDNA sequence: AK097192.1 BC101288.1 BC101289.1 BC101290.1 BC101291.1 BX640915.1 EU675310.1 4 DOTS entries: DT.100017515 DT.120919727 DT.120919733 DT.99939627 18 AceView cDNA sequences: AW768244 AW594641 AI365257 BX089912 BX640915 BX089103 CA449645 AA527065 NM_173799 AK097192 AL833175 AI769887 AA353061 AW512550 AA505489 BQ377877 BG211784 AA527161
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TIGIT About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
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| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TIGIT
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Expression
for TIGIT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TIGIT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TIGIT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIGIT
SOURCE GeneReport for Unigene cluster: Hs.421750
UniProtKB/Swiss-Prot: TIGIT_HUMAN, Q495A1Tissue specificity: Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and isup-regulated following activation of these cells (at protein level)
SABiosciences Custom PCR Arrays for TIGIT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIGIT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TIGIT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIGIT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGIT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGIT |
Orthologs
for TIGIT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for TIGIT gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for TIGIT (if available)
TreeFam Gene Tree for TIGIT (if available) |
Paralogs
for TIGIT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TIGIT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TIGIT (113995760 - 114029135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TIGIT
1 CNV: 38465
1 Indel: 46274 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIGIT |
|
Disorders
/ Diseases
for TIGIT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TIGIT for disorders About MalaCards
TIGIT for disorders About GeneDecksing
OMIM gene information: 612859
OMIM disorders: --
Export disorders for TIGIT gene to outside databases
|
Publications
for TIGIT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TIGIT gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TIGIT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PubMed id 19011627)1, 2, 3 Yu X.... Grogan J.L. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The TIGIT/CD226 axis regulates human T cell function. (PubMed id 22427644)1 Lozano E....Hafler D.A. (2012)
- Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection. (PubMed id 22706088)1 Moorman J.P....Yao Z.Q. (2012)
- Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis- trans receptor clustering. (PubMed id 22421438)1 Stengel K.F....Grogan J.L. (2012)
- Vstm3 is a member of the CD28 family and an important modulator of T-cell function. (PubMed id 21416464)1 Levin S.D....Lewis K.E. (2011)
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. (PubMed id 19815499)1 Stanietsky N....Mandelboim O. (2009)
- A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. (PubMed id 19197944)1 Boles K.S....Colonna M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for TIGIT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TIGIT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TIGIT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TIGIT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TIGIT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TIGIT gene:
Search GeneIP for patents involving TIGIT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TIGIT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for TIGIT | | OriGene Custom Protein Services for TIGIT | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TIGIT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TIGIT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIGIT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIGIT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIGIT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIGIT |
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 |  |  |  | |
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 | | | TIGIT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIGIT |
|  |  |  | | | | ThermoFisher Antibody for TIGIT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIGIT |
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