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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SUCLG2 Gene

protein-coding   GIFtS: 59
GCID: GC03M067507

succinate-CoA ligase, GDP-forming, beta subunit

 Explore 8 diseases affiliated with
SUCLG2 via our new
 Human Malady Compendium 
Biological research products
for SUCLG2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Succinate-CoA Ligase, GDP-Forming, Beta Subunit1 2     GTP-Specific Succinyl-CoA Synthetase Beta Subunit2
Succinyl-CoA Synthetase Beta-G Chain2 3     Succinyl-CoA Ligase [GDP-Forming] Subunit Beta, Mitochondrial2
SCS-BetaG1     Succinyl-CoA Ligase, GDP-Forming, Beta Chain, Mitochondrial2
GTP-Specific Succinyl-CoA Synthetase Subunit Beta2 3     Succinyl-CoA Synthetase, Beta-G Chain2
EC 6.2.1.43 8     EC 6.2.18
GBETA2     

External Ids:    HGNC: 114501   Entrez Gene: 88012   Ensembl: ENSG000001723407   OMIM: 6039225   UniProtKB: Q96I993   

Export aliases for SUCLG2 gene to outside databases

Previous GC identifers: GC03M066056 GC03M066888 GC03M067249 GC03M067358


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SUCLG2:
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the
reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple
transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
Function: Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022459.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SUCLG2 gene promoter:
         ISGF-3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   CREB   IRF-2   Nkx6-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSUCLG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SUCLG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SUCLG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.3

SUCLG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SUCLG2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M067507:  view genomic region     (about GC identifiers)

Start:
67,410,884 bp from pter      End:
67,705,038 bp from pter
Size:
294,155 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99 (See protein sequence)
Recommended Name: Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial precursor  
Size: 432 amino acids; 46511 Da
Subunit: Heterodimer of an alpha and a beta subunit
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH07716.3; Type=Erroneous initiation; Sequence=AAH47024.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31;
Note=Translated as Gln;
Secondary accessions: C9JVT2 O95195 Q6NUH7 Q86VX8 Q8WUQ1
Alternative splicing: 2 isoforms:  Q96I99-1   Q96I99-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SUCLG2: NX_Q96I99

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96I99

  • 4/13 DME Specific Peptides for SUCLG2 (Q96I99) (see all 13)
     DAKINFD  VNIFGGI  VPLVVRL  SGLKGGV 

    SUCLG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171070.1  NP_003839.2  

    ENSEMBL proteins: 
     ENSP00000419325   ENSP00000307432   ENSP00000417260   ENSP00000417589  
    Reactome Protein details: Q96I99
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    Uscn Proteins for SUCLG2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--


    SUCLG2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SUCLG2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR005809 Succ_CoA_synthase_bsu
     IPR017866 Succ-CoA_synthase_bsu_CS
     IPR013650 ATP-grasp_succ-CoA_synth-type
     IPR013815 ATP_grasp_subdomain_1
     IPR005811 CoA_ligase

    Graphical View of Domain Structure for InterPro Entry Q96I99

    ProtoNet protein and cluster: Q96I99

    2 Blocks protein families:
    IPB005809 Succinyl-CoA synthetase
    IPB013650 ATP-grasp fold


    UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Similarity: Belongs to the succinate/malate CoA ligase beta subunit family
    Similarity: Contains 1 ATP-grasp domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Function: Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity)
    Catalytic activity: GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

    Enzyme Numbers (IUBMB): EC 6.2.1.41 2 EC 6.2.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SUCLG2
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SUCLG2 (see all 24):
    hsa-miR-30c hsa-miR-3910 hsa-miR-16-2* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSUCLG2 3' UTR sequence
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004776succinate-CoA ligase (GDP-forming) activity NAS9765291
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--


    SUCLG2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SUCLG2:
     Decreased Wnt reporter activit 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TCA Cycle
    TCA Cycle1.00
    Pyruvate metabolism and Citric Acid (TCA) cycle0.64
    Citrate cycle (TCA cycle)0.65
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3Valproic Acid Pathway, Pharmacodynamics
    Valproic Acid Pathway, Pharmacodynamics1.00
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    5TCA cycle II (eukaryotic)
    Citric acid cycle (TCA cycle)0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SUCLG2 
        TCA Cycle

    4        Reactome Pathways for SUCLG2
        Pyruvate metabolism and Citric Acid (TCA) cycle
    Metabolism
    Citric acid cycle (TCA cycle)
    The citric acid (TCA) cycle and respiratory electron transport

    1 PharmGKB Pathway for SUCLG2
        Valproic Acid Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for SUCLG2):
        Citrate cycle (TCA cycle)
    Propanoate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Pathway: Carbohydrate metabolism; tricarboxylic acid cycle


    SUCLG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SUCLG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for SUCLG2 (Q96I993 ENSP000003074324) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    SUCLG1P535973, ENSP000003774464I2D: score=1 STRING: ENSP00000377446
    DMWDQ090193, ENSP000002702234I2D: score=2 STRING: ENSP00000270223
    GPR143P518103, ENSP000003703164I2D: score=1 STRING: ENSP00000370316
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006099tricarboxylic acid cycle TAS--
    GO:0006104succinyl-CoA metabolic process NAS9765291
    GO:0044281small molecule metabolic process TAS--


    SUCLG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SUCLG2

    10 HMDB Compounds for SUCLG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Itaconic acid2-Hydroxy-3-Naphthoyl-2-Naphthylamine (see all 12)97-65-4--
    Itaconyl-CoAS-(1-hydrogen methylenesuccinate) Coenzyme A (see all 8)6008-93-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Succinic acid1,2-Ethanedicarboxylate (see all 11)110-15-6--
    Succinyl-CoACoenzyme A S-(hydrogen succinate) (see all 24)604-98-8--

    1 DrugBank Compound for SUCLG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Succinic acid1,2-Ethanedicarboxylic acid (see all 8)110-15-6target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about SUCLG2 / SUCB2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SUCLG2 gene (2 alternative transcripts): 
    NM_001177599.1  NM_003848.3  

    Unigene Cluster for SUCLG2:

    Succinate-CoA ligase, GDP-forming, beta subunit
    Hs.644919  [show with all ESTs]
    Unigene Representative Sequence: BC068602
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493112(uc021xae.1) ENST00000307227(uc003dna.4) ENST00000460567(uc010hob.3)
    ENST00000492795

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    hsa-miR-30c hsa-miR-3910 hsa-miR-16-2* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSUCLG2 3' UTR sequence
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    Additional cDNA sequence: 

    AF058954.1 AF131748.1 AK294598.1 AK310527.1 AL050226.1 BC007716.2 BC019868.1 BC035149.1 
    BC047024.1 BC068602.1 

    5 DOTS entries:

    DT.97773778  DT.216109  DT.97796010  DT.95292139  DT.100788201 

    24/219 AceView cDNA sequences (see all 219):

    BU681960 BF594275 AV660709 AA346109 BX461233 AW152457 AI474658 AV650276 
    BQ440436 BQ949231 AI913750 AI133377 T31340 AI572877 CK724886 CR592655 
    BE673177 T32341 AA687678 BX282340 BU626715 BC019868 AA305543 BI089794 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SUCLG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTCCAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SUCLG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SUCLG2

    SOURCE GeneReport for Unigene cluster: Hs.644919

    UniProtKB/Swiss-Prot: SUCB2_HUMAN, Q96I99
    Tissue specificity: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and
    colon, and in low amounts in lung, brain, prostate, testis and ovary

        SABiosciences Expression via Pathway-Focused PCR Arrays including SUCLG2: 
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SUCLG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SUCLG2 gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Suclg21 , 5 succinate-Coenzyme A ligase, GDP-forming, beta subunit1, 5 88.32(n)1
    93.27(a)1
      6 (44.63 cM)5
    209171  NM_011507.21  NP_035637.21 
     954741345 
    chicken
    (Gallus gallus)
    Aves SUCLG21 succinate-CoA ligase, GDP-forming, beta subunit 79.55(n)
    87.04(a)
      416087  NM_001006141.1  NP_001006141.1 
    lizard
    (Anolis carolinensis)
    Reptilia SUCLG26
    --
    84(a)
    1 ↔ 1
    2(183710297-183906301)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.54422 Xenopus laevis transcribed sequence with weak similarity more 78.1(n)    BQ731661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64e032 Danio rerio cDNA clone IMAGE6794135, partial cds 78.06(n)    BC056551.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sucb1 CG10622-PA 60.07(n)
    59.39(a)
      44001  NM_143706.3  NP_651963.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sucg-11 Protein SUCG-1 59.97(n)
    55.15(a)
      177555  NM_068865.3  NP_501266.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G204206
    Succinyl-CoA ligase [GDP-forming] subunit beta
    46(a)
    1 ↔ 1
    2(8805453-8808120)
    rice
    (Oryza sativa)
    Liliopsida --
    succinyl-CoA ligase beta-chain, mitochondrial prec...
    45(a)
    1 ↔ 1
    2(24735880-24742096)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria sucC6
    succinyl-CoA synthetase, beta subunit
    41(a)
    1 → many
    Chromosome(762237-763403)


    ENSEMBL Gene Tree for SUCLG2 (if available)
    TreeFam Gene Tree for SUCLG2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SUCLG2 gene
    SUCLA22  
    4 SIMAP similar genes for SUCLG2 using alignment to 4 protein entries:     SUCB2_HUMAN (see all proteins):
    DKFZp564P2062    SUCLA2    DKFZp686D0880    DKFZp586M2023

    SUCLG2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SUCLG2
    PGOHUM00000242466 PGOHUM00000239896 PGOHUM00000237799 PGOHUM00000235537


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5768 NCBI SNPs in SUCLG2 are shown (see all 5768    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915247481,2
    --67410387(+) AACCAA/GCCCTA 1 -- ds50010--------
    rs1829450151,2
    --67410398(+) GAACCA/GCCCTA 1 -- ds50010--------
    rs1853665621,2
    --67410455(+) TAGCTC/TTTATA 1 -- ds50010--------
    rs1901195781,2
    --67410498(+) CTAACA/GGATAT 1 -- ds50010--------
    rs799623131,2
    C,--67410541(+) TATAAA/GCAGAT 1 -- ds50014Minor allele frequency- G:0.18CSA WA NA EA 360
    rs1456466841,2
    --67410579(+) ACTGGA/CGTGGA 1 -- ds50010--------
    rs1381859241,2
    --67410588(+) GAATAA/CTCTGA 1 -- ds50010--------
    rs1426152811,2
    --67410650(+) AGGCT-/GGGTTAT 1 -- ds50010--------
    rs1820744681,2
    --67410654(+) CTGTTA/TTATAG 1 -- ds50010--------
    rs763644671,2
    F,--67410700(+) AGGAGG/AATTAA 1 -- ds50011Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for SUCLG2 (67410884 - 67660884 bp, first 250kb of SUCLG2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for SUCLG2
         6 CNVs: 98337 63487 23017 62062 23690 44114
         4 Indels: 60422 79785 91339 91338

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SUCLG2 for disorders           About GeneDecksing

    OMIM gene information: 603922    OMIM disorders: --

    8 diseases for SUCLG2:    About MalaCards
    ocular albinism    albinism    cholera    pertussis
    tuberculosis    malaria    prostatitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for SUCLG2:
    Cholera     Pharyngitis
    Human Genome Epidemiology (HuGE) Navigator: SUCLG2 (5 documents)

    Export disorders for SUCLG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SUCLG2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with SUCLG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. (PubMed id 9765291)1, 2, 3 Johnson J.D.... Lambeth D.O. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. The interplay between SUCLA2, SUCLG2, and mitochondri al DNA depletion. (PubMed id 21295139)1 Miller C....Saada A. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Genome-wide meta-analysis of five Asian cohorts identi fies PDGFRA as a susceptibility locus for corneal astigmatism. (PubMed id 22144915)1 Fan Q....Saw S.M. (2011)
    10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8801 HGNC: 11450 AceView: SUCLG2 Ensembl:ENSG00000172340 euGenes: HUgn8801
    ECgene: SUCLG2 Kegg: 8801 H-InvDB: SUCLG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SUCLG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SUCLG2 gene:
    Search GeneIP for patents involving SUCLG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in SUCLG2 promoter
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