Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSTR3 Gene

protein-coding   GIFtS: 68
GCID: GC22M037600

somatostatin receptor 3
 Explore 37 diseases affiliated with
SSTR3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SSTR3    

Aliases
for SSTR3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Somatostatin Receptor 31 2
SS-3-R2 3
SS3-R2 3
SS3R2 3
SSR-282 3
Somatostatin Receptor Type 32

External Ids:    HGNC: 113321   Entrez Gene: 67532   Ensembl: ENSG000001834737   OMIM: 1824535   UniProtKB: P327453   
ORGUL members:         
NONCODE:n338063    

Export aliases for SSTR3 gene to outside databases

Previous GC identifers: GC22M034217 GC22M035845 GC22M035926 GC22M020567


Summaries
for SSTR3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SSTR3:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological
effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a
tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is
expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to
inhibition of adenylyl cyclase

summary for SSTR3:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR3 (Somatostatin receptor 3)


Genomic Views
for SSTR3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSTR3 gene promoter:
         AhR   NF-1   NF-1/L   Tal-1   p53   E47   GATA-2   HEN1   AREB6   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSTR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSTR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSTR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

SSTR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037600:  view genomic region     (about GC identifiers)

Start:
 37,600,278 bp from pter      End:
 37,608,362 bp from pter
Size:
 8,085 bases      Orientation:
 minus strand

Proteins
for SSTR3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745 (See protein sequence)
Recommended Name: Somatostatin receptor type 3  
Size: 418 amino acids; 45847 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Note=Internalized into endoplasmic
vesicles upon somatostatin-stimulation (By similarity)
Secondary accessions: A8K550 Q53ZR7

Explore the universe of human proteins at neXtProt for SSTR3: NX_P32745

Post-translational modifications:

  • Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32745

    • SSTR3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001042.1  
    ENSEMBL proteins: 
     ENSP00000330138   ENSP00000384904  
    Reactome Protein details: P32745
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SSTR3
    OriGene Custom Protein Services for SSTR3 
    GenScript Custom Purified and Recombinant Proteins Services for SSTR3
    Novus Biologicals SSTR3 Protein
    Novus Biologicals SSTR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SSTR3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1337145
    GO:0031513nonmotile primary cilium ISS--


    SSTR3 for ontologies           About GeneDecksing



    SSTR3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SSTR3
    R&D Systems Antibodies for SSTR3 (Somatostatin R3/SSTR3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SSTR3 
    GenScript Custom Superior Antibodies Services for SSTR3
    Novus Biologicals SSTR3 Antibodies
    Abcam antibodies for SSTR3 
    Uscn Antibodies for SSTR3
    ThermoFisher Antibody for SSTR3

    Assay Products for SSTR3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript SSTR3-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SSTR3

    Protein Domains /
    Families
    for SSTR3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SSTR3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000586 Somatstn_rcpt
     IPR001856 Somatstn_rcpt_3
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32745

    ProtoNet protein and cluster: P32745

    2 Blocks protein families:
    IPB000586 Somatostatin receptor signature
    IPB001856 Somatostatin receptor type 3 signature


    UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for SSTR3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
    Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to
    inhibition of adenylyl cyclase

         Genatlas biochemistry entry for SSTR3:
    somatostatin receptor gene 3,G protein coupled receptor superfamily

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSTR3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SSTR3:
    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-377 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: SSTR3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR3 (see all 7)
    OriGene shRNA RFP: SSTR3
    OriGene siRNA: SSTR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSTR3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SSTR3

    Clone
    Products:             		EMD Millipore Clones for the Expression of SSTR3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SSTR3 (NM_001051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSTR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR3 

    Cell Line
    Products:             		GenScript SSTR3-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for SSTR3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004994somatostatin receptor activity IEA--
    GO:0005515protein binding IPI--


    SSTR3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SSTR3:
     Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Sstr3tm1Ute for SSTR3
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sstr3):
     no phenotypic analysis 

    SSTR3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SSTR3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SSTR3
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for SSTR3 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for SSTR3 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for SSTR3):
        Neuroactive ligand-receptor interaction


    SSTR3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSTR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for SSTR3 (P327451, 2, 3 ENSP000003301384) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-6800756 MINT-6800770 MINT-6800562 MINT-6800607 MINT-6801122 I2D: score=1 STRING: ENSP00000370410
    SSTP612783, ENSP000002876414I2D: score=2 STRING: ENSP00000287641
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8405411
    GO:0007267cell-cell signaling TAS1337145
    GO:0007283spermatogenesis IEA--
    GO:0008285negative regulation of cell proliferation TAS8961277
    GO:0008628hormone-mediated apoptotic signaling pathway TAS8961277


    SSTR3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SSTR3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSTR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SSTR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    RC 160Somatostatin analog[103222-11-3]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    1 Novoseek chemical compound relationship for SSTR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 82.9 7 15197339 (2), 15326367 (1), 16625842 (1), 9744346 (1)

    Search CenterWatch for drugs/clinical trials and news about SSTR3 / SSR3 

    Transcripts
    for SSTR3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SSTR3 gene: 
    NM_001051.2  

    Unigene Cluster for SSTR3:

    Somatostatin receptor 3
    Hs.225995  [show with all ESTs]
    Unigene Representative Sequence: AK291165
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328544(uc003ara.3 uc003arb.3) ENST00000402501

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSTR3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SSTR3:
    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-377 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: SSTR3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR3 (see all 7)
    OriGene shRNA RFP: SSTR3
    OriGene siRNA: SSTR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSTR3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SSTR3 (NM_001051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSTR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSTR3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSTR3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSTR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSTR3

    Additional cDNA sequence: 

    AK291165.1 BC042068.1 BC096829.1 CR456585.1 

    1 DOTS entry:

    DT.65284413 

    19 AceView cDNA sequences:

    AW453011 CR456585 NM_001051 BX281894 BU584980 BF434297 AW028270 BF515539 
    BC042068 BV198331 AI475600 CA772710 CF147825 BV196234 BI828469 BF513812 
    BU584704 BM805640 CA771848 

    GeneLoc Exon Structure


    Expression
    for SSTR3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSTR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGGATGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SSTR3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SSTR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSTR3

    SOURCE GeneReport for Unigene cluster: Hs.225995

    UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
    Tissue specificity: Brain, pituitary and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including SSTR3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSTR3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSTR3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSTR3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSTR3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR3

    Orthologs
    for SSTR3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SSTR3 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SSTR31 somatostatin receptor 3 72.58(n)
    74.04(a)    		   427907  NM_001024583.1  NP_001019754.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SSTR36
    		 --
    		 67(a)
    		 1 ↔ 1
    		 5(22844936-22846144)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003345181 somatostatin receptor type 5-like 61.08(n)
    64.05(a)    		   100334518  XM_003201636.1  XP_003201684.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Drostar13 G-protein coupled receptor protein signaling
    pathway more    		 40(a)
    (best of 2)    		   75D2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea npr-161 Protein NPR-16 40.33(n)
    30.07(a)    		   180643  NM_001047793.1  NP_001041258.1 


    ENSEMBL Gene Tree for SSTR3 (if available)
    TreeFam Gene Tree for SSTR3 (if available) 

    Paralogs
    for SSTR3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSTR3 gene
    OPRD12  SSTR42  GALR22  MCHR22  SSTR12  GALR32  OPRL12  NPBWR12  
    OPRK12  KISS1R2  GALR12  SSTR52  SSTR22  MCHR12  NPBWR22  OPRM12  
    18/30 SIMAP similar genes for SSTR3 using alignment to 1 protein entry:     SSR3_HUMAN(see all similar genes):
    SSTR2    SSTR5    SSTR1    SSTR4    NPBWR1    OPRM1
    OPRK1    OPRD1    GALR1    NPBWR2    BLR1    CXCR5
    OPRL1    APLNR    CXCR6    GALR2    AGTR1    GPR24

    SSTR3 for paralogs           About GeneDecksing



    Genomic Variants
    for SSTR3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/222 NCBI SNPs in SSTR3 are shown (see all 222)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2013843871,2
    		C,other37603112(+) GGCACA/GAGGGT 2 S L mis10--------
    rs358095251,2
    		C,F,--37601957(-) CTCCTG/CGACGG 1 -- ds50015Minor allele frequency- C:0.03NA EU CSAM EA 380
    rs2295661,2
    		C,F,A,H,--37602131(-) TAACCC/TGGTGG 1 -- ds500126Minor allele frequency- T:0.37MN NS EA NA EU CSAM WA 2900
    rs81422551,2
    		C,F,H,--37602248(+) TCTAGT/CTGATG 1 -- ut3110Minor allele frequency- C:0.04NS EA NA WA 1372
    rs81413121,2
    		C,F,--37602304(+) TTTTGC/TCTGCT 1 -- ut316Minor allele frequency- T:0.02NA EU CSAM EA WA 498
    rs1920180541,2
    		--37602396(+) GTCACA/CGAGGA 1 -- ut310--------
    rs2295671,2
    		C,F,A,H,--37602446(-) TTGCTG/ATGTGA 1 -- ut31 ese321Minor allele frequency- A:0.29NS EA NA EU CSAM WA 1898
    rs2015912831,2
    		--37602543(+) CCCACA/GGCTTC 1 -- ut310--------
    rs114319491,2
    		C,--37602583(+) CCAGG-/CCCCTA 1 -- ut310--------
    rs114067611,2
    		C--37602584(+) GGCCCC/-TACAG 1 -- ut312Minor allele frequency- -:0.00NA CSA 6

    HapMap Linkage Disequilibrium report for SSTR3 (37600278 - 37608362 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SSTR3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSTR3
    DNA2.0 Custom Variant and Variant Library Synthesis for SSTR3

    Disorders / Diseases
    for SSTR3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SSTR3 for disorders           About GeneDecksing

    OMIM gene information: 182453    OMIM disorders: --

    20/37 diseases for SSTR3 (see all 37):    About MalaCards
    bardet-biedl syndrome    oncogenic osteomalacia    pancreatitis    functioning pituitary adenoma
    pituitary adenoma    osteomalacia    prolactinoma    vipoma
    pancreatic endocrine tumors    pituitary tumor    insulinoma    diabetic retinopathy
    adenoma    dyspepsia    neuroendocrine tumor    graves' disease
    acromegaly    gastric cancer    lung cancer    hepatitis b

    1 disease from the University of Copenhagen DISEASES database for SSTR3:
    Adenoma

    10/12 Novoseek disease relationships for SSTR3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 69.1 3 12721506 (1), 7521350 (1)
    prolactinoma 62.9 1 7521350 (1)
    pituitary tumors 56.2 1 7521350 (1)
    adenoma 42.4 6 8866248 (1), 7714115 (1), 11415850 (1), 17420609 (1)
    insulinoma 41.5 4 8132773 (1), 7714115 (1)
    adenocarcinoma gastric 41.1 2 15197339 (1), 15326367 (1)
    tumors 34.3 22 8012966 (3), 19330452 (2), 8515684 (2), 10768564 (1) (see all 13)
    carcinoid 31.1 1 16508627 (1)
    gastric cancer 11 18 15197339 (6), 17683502 (5), 17679363 (1)
    primary tumor 0 1 8012966 (1)

    Genetic Association Database (GAD): SSTR3
    Human Genome Epidemiology (HuGE) Navigator: SSTR3 (13 documents)

    Export disorders for SSTR3 gene to outside databases

    Publications
    for SSTR3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSTR3 gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with SSTR3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. (PubMed id 1337145)1, 2, 9 Yamada Y.... Seino S. (1992)
    2. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. (PubMed id 8097479)1, 2, 9 Corness J.D.... Niznik H.B. (1993)
    3. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PubMed id 8449518)1, 3, 9 Yamada Y....Bell G.I. (1993)
    4. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4 Canzian F....Kaaks R. (2005)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. The effect of somatostatin and SSTR3 on proliferation and apoptosis of gastric cancer cells. (PubMed id 15197339)1, 9 Hu C....Fan D. (2004)
    9. Expression of somatostatin receptor subtype 3 in the gastric mucosa of dyspeptic patients in relation to Helicobacter pylori infection and a family history of gastric cancer. (PubMed id 17683502)1, 9 Stec-Michalska K....Nawrot B. (2008)
    10. [Somatostatin receptor subtype 3 (SSTR3) mRNA level in gastric mucosa of patients with dyspepsia] (PubMed id 17679363)1, 9 Stec-Michalska K....Nawrot B. (2007)

    External Searches for SSTR3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SSTR3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6753 HGNC: 11332 AceView: SSTR3 Ensembl:ENSG00000183473 euGenes: HUgn6753
    ECgene: SSTR3 Kegg: 6753 H-InvDB: SSTR3

    Other Databases showing SSTR3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SSTR3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSTR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SSTR3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SSTR3 gene:
    Search GeneIP for patents involving SSTR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SSTR3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SSTR3
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Clones for the Expression of SSTR3
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SSTR3 (Somatostatin R3/SSTR3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SSTR3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSTR3  
     OriGene Protein Over-expression Lysate for SSTR3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SSTR3   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SSTR3   OriGene Custom Protein Services for SSTR3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSTR3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSTR3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSTR3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSTR3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSTR3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSTR3
     GenScript Custom Purified and Recombinant Proteins Services for SSTR3 GenScript cDNA clones with any tag delivered in your preferred vector for SSTR3
     GenScript SSTR3-overexpressing Cell Line for Assay GenScript Custom Superior Antibodies Services for SSTR3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SSTR3 promoter
     Search Chromatin IP Primers for SSTR3
     RT2 qPCR Primer Assay in human, mouse, rat SSTR3
     GNC Network for SSTR3
     SABiosciences PCR Arrays including human, mouse, rat SSTR3
     Tocris compounds for SSTR3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SSTR3 antibodies
     SSTR3 proteins
     SSTR3 lysates
     Antibodies for SSTR3
     See all of Abcam's Antibodies, Kits and Proteins for SSTR3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SSTR3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SSTR3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR3
     SwitchGear 3'UTR luciferase reporter plasmids for SSTR3
     SwitchGear Promoter luciferase reporter plasmids for SSTR3
     ThermoFisher Antibody for SSTR3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SSTR3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4