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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SSTR2 Gene

protein-coding GIFtS: 72
GCID: GC17P071161

somatostatin receptor 2

Explore 74 diseases affiliated with
SSTR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Somatostatin Receptor 2¹ ²
SRIF-1² ³
SS2R² ³
Somatostatin Receptor Type 2²
SS-2-R³
SS2-R³

External Ids:	HGNC: 11331¹	Entrez Gene: 6752²	Ensembl: ENSG00000180616⁷	OMIM: 182452⁵	UniProtKB: P30874³

Export aliases for SSTR2 gene to outside databases

Previous GC identifers: GC17P071046 GC17P074201 GC17P071625 GC17P071758 GC17P068672 GC17P066570

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSTR2:

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic

effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a

tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is

expressed in highest levels in cerebrum and kidney. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to

inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin

insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing

voltage dependent calcium-channels

summary for SSTR2:

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in

excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low

levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are

composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.

alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.

The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane

potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR2 (Somatostatin receptor 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SSTR2 gene promoter:
ER-alpha AML1a AP-1 Pbx1a MyoD NF-kappaB GATA-2 ZIC2/Zic2 NF-kappaB1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSTR2 promoter sequence

Search SABiosciences Chromatin IP Primers for SSTR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSTR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q24

SSTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P071161: view genomic region (about GC identifiers)

Start:	71,161,151 bp from pter	End:	71,168,094 bp from pter
Size:	6,944 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874 (See protein sequence)

Recommended Name: Somatostatin receptor type 2

Size: 369 amino acids; 41333 Da

Subunit: The C-terminus interacts with SHANK1 PDZ domain

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A8K3Y0 Q4VBP0 Q96GE0 Q96TF2 Q9BWH1

Alternative splicing: 2 isoforms: P30874-1 P30874-2

Explore the universe of human proteins at neXtProt for SSTR2: NX_P30874

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30874

SSTR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001041.1

ENSEMBL proteins:

ENSP00000350198 ENSP00000326616

Reactome Protein details: P30874
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SSTR2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	7914078

SSTR2 for ontologies About GeneDecksing

SSTR2 Antibody Products:

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Assay Products for SSTR2:

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	GenScript SSTR2-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SSTR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SSTR2 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000586 Somatstn_rcpt

IPR002074 Somatstn_rcpt_2

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P30874

ProtoNet protein and cluster: P30874

2 Blocks protein families:

IPB000586 Somatostatin receptor signature

IPB002074 Somatostatin receptor type 2 signature

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to

inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin

insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing

voltage dependent calcium-channels

Genatlas biochemistry entry for SSTR2:

somatostatin receptor gene 2,G protein coupled receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone: SSTR2 Browse MicroRNA Expression Plasmids
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		hsa-miR-3679-3p hsa-miR-3200-5p hsa-miR-1324 hsa-miR-146a* hsa-miR-4316 hsa-miR-3658 hsa-miR-129-5p hsa-miR-15b*

		SwitchGear 3'UTR luciferase reporter plasmid: SSTR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR2 (see all 7) OriGene shRNA RFP: SSTR2 OriGene siRNA: SSTR2
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for SSTR2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004994	somatostatin receptor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0030165	PDZ domain binding	IPI	10551867

SSTR2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SSTR2:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Sstr2^tm1Rgs for SSTR2
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sstr2):

behavior/neurological	cardiovascular system	digestive/alimentary	homeostasis/metabolism	nervous system
vision/eye

SSTR2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Proton Pump Inhibitor Pathway, Pharmacodynamics

Proton Pump Inhibitor Pathway, Pharmacodynamics

1.00

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SSTR2

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

4 BioSystems Pathways for SSTR2

	SIDS Susceptibility Pathways
	GPCRs, Class A Rhodopsin-like
	GPCRs, Other
	Peptide GPCRs

5/7 Reactome Pathways for SSTR2 (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

1 PharmGKB Pathway for SSTR2

Proton Pump Inhibitor Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for SSTR2):

	Neuroactive ligand-receptor interaction
	Gastric acid secretion

SSTR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SSTR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/153 Interacting proteins for SSTR2 (P30874^{1, 2, 3} ENSP00000350198⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 153)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-2982013 MINT-2982090 MINT-2982067 MINT-2981982 MINT-2982036 I2D: score=3 STRING: ENSP00000274335
CORT	O00230³, ENSP00000366248⁴	I2D: score=1 STRING: ENSP00000366248
GNA14	O95837³, ENSP00000365807⁴	I2D: score=1 STRING: ENSP00000365807
SST	P61278³, ENSP00000287641⁴	I2D: score=1 STRING: ENSP00000287641
PTPN6	P29350³, ENSP00000391592⁴	I2D: score=3 STRING: ENSP00000391592

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006937	regulation of muscle contraction	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7914078
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA	--
GO:0007218	neuropeptide signaling pathway	--	--

SSTR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SSTR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SSTR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Octreotide	sst2, sst3 and sst5 agonist	[79517-01-4]
Somatostatin	Influences growth hormone release	[51110-01-1]
RC 160	Somatostatin analog	[103222-11-3]
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264	Potent and selective sst2 agonist	[208706-12-1]

1 HMDB Compound for SSTR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 DrugBank Compounds for SSTR2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Octreotide	Octreotida [Spanish] (see all 3)	83150-76-9	target	binder	19537708 11752352
Vapreotide	BMY 41606 (see all 6)	103222-11-3	target	inducer	19708854

10/28 Novoseek chemical compound relationships for SSTR2 gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
octreotide	91.3	104	19590186 (6), 10443675 (4), 11231991 (4), 8866248 (3) (see all 56)
lanreotide	88.7	17	11399907 (1), 7628822 (1), 12472080 (1), 9410919 (1) (see all 14)
111in-pentetreotide	80.7	16	16470879 (4), 16625862 (1), 19245777 (1), 19068462 (1) (see all 7)
tyr-3-octreotide	75.7	2	11585290 (1), 11965608 (1)
vapreotide	67.9	1	7628822 (1)
ribonucleic acid	42.3	7	7775631 (1), 10487698 (1), 10486467 (1), 10902809 (1) (see all 5)
thymidine	39.9	8	16954557 (1), 12011224 (1), 12353250 (1), 18509006 (1) (see all 8)
adenylate	34	7	7910018 (2), 7907795 (1), 18653781 (1), 7781707 (1)
sodium iodide	27.6	1	12353250 (1)
forskolin	25.1	2	8386508 (1), 7914078 (1)

Search CenterWatch for drugs/clinical trials and news about SSTR2 / SSR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SSTR2 gene:

NM_001050.2

Unigene Cluster for SSTR2:

Somatostatin receptor 2

Hs.514451 [show with all ESTs]

Unigene Representative Sequence: NM_001050

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000579323 ENST00000357585(uc002jje.3) ENST00000315332

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		hsa-miR-3679-3p hsa-miR-3200-5p hsa-miR-1324 hsa-miR-146a* hsa-miR-4316 hsa-miR-3658 hsa-miR-129-5p hsa-miR-15b*

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSTR2

Additional cDNA sequence:

AK290745.1 AK313866.1 BC000256.1 BC009522.1 BC019610.1 BC095495.1 BT019926.1

2 DOTS entries:

DT.70101256 DT.120979121

24/66 AceView cDNA sequences (see all 66):

BQ416716 CF147826 CB177996 BE326815 BC000256 AI582640 AW772094 BC019610

BE252309 CR593522 AW405802 AA599080 NM_001050 BX090595 BE782762 BG396654

BX419487 BU178559 AL708103 AA364002 AK091326 AW263315 AI522307 BG329444

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SSTR2 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:					-

ECgene alternative splicing isoforms for SSTR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SSTR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGGCGTG

About this image

SSTR2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Intrahepatic Biliary Tree

Biliary Epithelial Cells

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SSTR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSTR2

SOURCE GeneReport for Unigene cluster: Hs.514451

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Tissue specificity: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver

SABiosciences Expression via Pathway-Focused PCR Arrays including SSTR2:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Obesity in human mouse rat

Tumor Metastasis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SSTR2 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SSTR2¹	somatostatin receptor 2	81.07(n) 88.32(a)		395305 NM_001030345.2 NP_001025516.1
lizard (Anolis carolinensis)	Reptilia	SSTR2⁶	--	85(a)	1 ↔ 1	2(96749989-96751107)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19621²	Xenopus laevis transcribed sequence with moderate similarity more	78.66(n)		BQ388082.1
zebrafish (Danio rerio)	Actinopterygii	LOC100333578¹	somatostatin receptor type 2-like	66.67(n) 68.64(a)		100333578 XM_002665602.1 XP_002665648.1
fruit fly (Drosophila melanogaster)	Insecta	AlCR2^{1 , 3}	G-protein coupled receptor protein signaling pathway more³ allatostatin C receptor 2¹	41(a) (best of 2)³ 53.15(n)¹ 44.76(a)¹		75D1³ 40019¹ NM_140782.4¹ NP_649039.4¹
worm (Caenorhabditis elegans)	Secernentea	npr-24¹	Protein NPR-24	45.41(n) 35.6(a)		187897 NM_078432.3 NP_510833.3

ENSEMBL Gene Tree for SSTR2 (if available)
TreeFam Gene Tree for SSTR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SSTR2 gene

SSTR3² OPRD1² SSTR4² GALR2² MCHR2² SSTR1² GALR3² OPRL1²

NPBWR1² OPRK1² KISS1R² GALR1² SSTR5² MCHR1² NPBWR2² OPRM1²

18/51 SIMAP similar genes for SSTR2 using alignment to 1 protein entry: SSR2_HUMAN(see all similar genes):

SSTR4 SSTR1 SSTR5 SSTR3 OPRM1 NPBWR2

OPRD1 OPRK1 CCR8 NPBWR1 GPR24 OPRL1

GALR1 GALR2 AGTR1 CCR9 MCHR2 NPFFR2

SSTR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34739008^1,2	C,F,	--	66568317(+)	`GTCTTC/TGGCTC`	1	--	us2k¹		5	NA EU CSAM EA	380
rs35790859^1,2	F	--	66568503(+)	`AGGCAC/TGTGTT`	1	--	us2k¹		5	NA EU CSAM EA	380
rs11077670^1,2	C,F,A,H,	--	66568875(+)	`CTGACG/AGTGAG`	1	--	us2k¹		28	NS EA NA EU CSAM WA	2952
rs35890524^1,2	C,	--	66569040(+)	`TAAGCC/ACTATC`	1	--	us2k¹		5	NA EU CSAM EA	380
rs35884359^1,2	C,	--	66569055(+)	`CCAACG/ATCTCA`	1	--	us2k¹		5	NA EU CSAM EA	380
rs35130440^1,2	C,F,	--	66569086(+)	`ATCCCC/TATCTC`	1	--	us2k¹		6	NA EU CSAM EA WA	498
rs57328164^1,2	C,	--	66569392(+)	`TGTGTA/GTACCT`	1	--	us2k¹		3	WA NA	240
rs78480992^1,2	F,	--	66569512(+)	`CCATGC/TGACTC`	1	--	us2k¹		1	EA	120
rs34862776^1,2	C,F,	--	66569666(+)	`ACAGCT/CGGGAC`	1	--	us2k¹		10	NA EU CSAM EA WA	506
rs74504639^1,2	F,	--	66569852(+)	`AAACAC/TAGCTT`	1	--	us2k¹		2	NA EA	240

HapMap Linkage Disequilibrium report for SSTR2 (71161151 - 71168094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SSTR2: --
Human Gene Mutation Database (HGMD): SSTR2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSTR2

DNA2.0 Custom Variant and Variant Library Synthesis for SSTR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SSTR2 for disorders           About GeneDecksing

OMIM gene information: 182452    OMIM disorders: --

20/74 diseases for SSTR2 (see all 74):    About MalaCards

supratentorial primitive neuroectodermal tumor growth hormone secreting pituitary adenoma supratentorial primitive neuroectodermal tumors, childhood primitive neuroectodermal tumor

oncogenic osteomalacia pituitary adenoma non-small cell lung carcinoma neuroectodermal tumors

functioning pituitary adenoma somatostatinoma type c thymoma glucagonoma

herpes simplex idiopathic pulmonary fibrosis gastrinoma osteomalacia

esthesioneuroblastoma neuroendocrine tumor prolactinoma fetal adenoma

6 diseases from the University of Copenhagen DISEASES database for SSTR2:

Adenoma Acromegaly Neuroendocrine tumor Pancreatic cancer

Thyroid medullary carcinoma Pituitary adenoma

10/49 Novoseek disease relationships for SSTR2 gene (see all 49) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroendocrine tumors	73.5	13	20228164 (2), 10718213 (2), 16135387 (1), 19245777 (1) (see all 9)
pituitary adenoma	69.9	12	8866248 (4), 11264647 (1), 11399907 (1), 15472224 (1) (see all 8)
acromegaly	69.6	11	15914528 (2), 10207690 (1), 19533047 (1), 15077912 (1) (see all 6)
prolactinoma	65.3	6	16595604 (1), 9410919 (1), 8106629 (1), 16625843 (1) (see all 5)
insulinoma	60.9	8	8132773 (1), 16479142 (1), 12021920 (1), 14602773 (1) (see all 6)
carcinoid	60.2	15	9622077 (2), 12734860 (2), 8653698 (2), 8132773 (1) (see all 9)
thyroid carcinoma medullary	59.9	6	12734860 (2), 15077916 (1), 8012966 (1), 11344221 (1)
tumors	59.8	195	19707908 (6), 10768564 (4), 7854974 (4), 16470879 (4) (see all 92)
adenoma	59.8	53	11399907 (5), 14661732 (4), 9059557 (3), 8866248 (3) (see all 22)
pituitary tumors	58.8	3	7530798 (1), 8106629 (1), 18653781 (1)

Genetic Association Database (GAD): SSTR2
Human Genome Epidemiology (HuGE) Navigator: SSTR2 (17 documents)

Export disorders for SSTR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SSTR2 gene, integrated from 9 sources (see all 399):
(articles sorted by number of sources associating them with SSTR2)

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Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. (PubMed id 15914528)^{1, 4, 9} Filopanti M....Spada A. (2005)
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PubMed id 1346068)^{1, 2, 9} Yamada Y.... Seino S. (1992)
Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PubMed id 8449518)^{1, 3, 9} Yamada Y....Bell G.I. (1993)
Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)^{1, 4, 9} Canzian F....Kaaks R. (2005)
Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. (PubMed id 8386508)^{1, 2, 9} Patel Y.C.... Srikant C.B. (1993)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. (PubMed id 10551867)^{1, 2} Zitzer H.... Kreienkamp H.-J. (1999)
Genomic structure and transcriptional regulation of the human somatostatin receptor type 2. (PubMed id 10619399)^{1, 2} Petersenn S.... Schulte H.M. (1999)
Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker. (PubMed id 18682975)^{1, 9} Kouch-El Filali M....Luyten G.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6752	HGNC: 11331	AceView: SSTR2	Ensembl:ENSG00000180616	euGenes: HUgn6752
ECgene: SSTR2	Kegg: 6752	H-InvDB: SSTR2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SSTR2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SSTR2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SSTR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SSTR2 gene:
Search GeneIP for patents involving SSTR2

GeneCards and IP:
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somatostatin receptor 2

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