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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPE Gene

protein-coding   GIFtS: 57
GCID: GC01P203834

small nuclear ribonucleoprotein polypeptide E
 Explore 8 diseases affiliated with
SNRPE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNRPE    

Aliases
for SNRPE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Small Nuclear Ribonucleoprotein Polypeptide E1 2     HYPT112
Sm-E1 2 3     SME2
Sm Protein E2 3     Small Nuclear Ribonucleoprotein E2
SnRNP-E1     SmE3
B-Raf1     

External Ids:    HGNC: 111611   Entrez Gene: 66352   Ensembl: ENSG000001820047   OMIM: 1282605   UniProtKB: P623043   

Export aliases for SNRPE gene to outside databases

Previous GC identifers: GC01P201548 GC01P199291 GC01P200191 GC01P201008 GC01P200563 GC01P202097 GC01P203831 GC01P174996


Summaries
for SNRPE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RUXE_HUMAN, P62304
Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with
snRNP U1, U2, U4/U6 and U5

Gene Wiki entry for SNRPE (Small nuclear ribonucleoprotein polypeptide E)


Genomic Views
for SNRPE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPE gene promoter:
         AML1a   AP-1   Brachyury   ATF-2   CUTL1   Tal-1beta   Evi-1   STAT3   c-Jun   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNRPE promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

SNRPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203834:  view genomic region     (about GC identifiers)

Start:
 203,830,731 bp from pter      End:
 203,840,280 bp from pter
Size:
 9,550 bases      Orientation:
 plus strand

Proteins
for SNRPE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RUXE_HUMAN, P62304 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein E  
Size: 92 amino acids; 10804 Da
Subunit: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10,
LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated
by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10
and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the
U12-type spliceosome
Subcellular location: Nucleus
Miscellaneous: Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins
6/7 PDB 3D structures from and Proteopedia for SNRPE (see all 7):
2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)        3CW1 (3D)        3PGW (3D)    
Secondary accessions: B2R5B9 P08578 Q15498 Q5BKT2

Explore the universe of human proteins at neXtProt for SNRPE: NX_P62304

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62304

    • SNRPE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003085.1  
    ENSEMBL proteins: 
     ENSP00000400591   ENSP00000356176  
    Reactome Protein details: P62304
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SNRPE
    OriGene Protein Over-expression Lysate: SNRPE
    OriGene Custom Protein Services for SNRPE 
    GenScript Custom Purified and Recombinant Proteins Services for SNRPE
    Novus Biologicals SNRPE Protein
    Novus Biologicals SNRPE Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SNRPE
    Uscn Proteins for SNRPE

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex NAS2974536
    GO:0005683U7 snRNP IDA11574479
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0005829cytosol TAS--


    SNRPE for ontologies           About GeneDecksing



    SNRPE Antibody Products: 
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    OriGene Custom Antibody Services for SNRPE 
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    Search for Antibodies for SNRPE at Abcam  
    Uscn Antibodies for SNRPE
    ThermoFisher Antibody for SNRPE

    Assay Products for SNRPE: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNRPE
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SNRPE

    Protein Domains /
    Families
    for SNRPE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNRPE for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001163 Ribonucl_LSM
     IPR027078 snRNP-E
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom

    Graphical View of Domain Structure for InterPro Entry P62304

    ProtoNet protein and cluster: P62304

    1 Blocks protein family: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: RUXE_HUMAN, P62304
    Similarity: Belongs to the snRNP Sm proteins family


    Function
    for SNRPE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RUXE_HUMAN, P62304
    Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with
    snRNP U1, U2, U4/U6 and U5

         Genatlas biochemistry entry for SNRPE:
    small ribonucleoprotein,E polypeptide

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SNRPE
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPE
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPE:
    hsa-miR-4264 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPE 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPE (see all 4)
    OriGene shRNA RFP: SNRPE
    OriGene siRNA: SNRPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPE

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNRPE

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPE (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPE
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SNRPE (NM_003094)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPE 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SNRPE
    Search LifeMap BioReagents cell lines for SNRPE

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPE

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI11714716


    SNRPE for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SNRPE:
     Decreased cell number, increas  Decreased viability  Increased gamma-H2AX phosphory 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Snrpe):
     endocrine/exocrine gland  reproductive system 

    SNRPE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SNRPE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA processing0.48
    		mRNA Splicing - Major Pathway1.00
    		mRNA Splicing - Minor Pathway0.40
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    		mRNA Processing0.82
    2SLBP independent Processing of Histone Pre-mRNAs
    		SLBP independent Processing of Histone Pre-mRNAs1.00
    		snRNP Assembly0.28
    		SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.91
    		Metabolism of non-coding RNA0.28
    3RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Cleavage of Growing Transcript in the Termination Region 1.00
    		Post-Elongation Processing of the Transcript1.00
    4Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    5Post-Elongation Processing of Intronless pre-mRNA
    		Processing of Capped Intronless Pre-mRNA1.00
    		Post-Elongation Processing of Intronless pre-mRNA1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SNRPE 
        mRNA processing

    5/18        Reactome Pathways for SNRPE (see all 18)
        mRNA Splicing
    RNA Polymerase II Transcription
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    Metabolism of non-coding RNA


    1         Kegg Pathway  (Kegg details for SNRPE):
        Spliceosome


    SNRPE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNRPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/596 Interacting proteins for SNRPE (P623041, 2, 3 ENSP000004005914) via UniProtKB, MINT, STRING, and/or I2D (see all 596)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM2Q9Y3332, 3, ENSP000003648134MINT-62691 MINT-62767 MINT-62593 I2D: score=5 STRING: ENSP00000364813
    SMN1Q166372, 3, ENSP000003700834MINT-7947479 I2D: score=3 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7947479 I2D: score=3 STRING: ENSP00000370119
    SF3A2Q154282, 3, ENSP000002214944MINT-5205350 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    SNRPFP623062, 3, ENSP000002667354MINT-49760 MINT-8332778 I2D: score=11 STRING: ENSP00000266735
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly NAS2974536
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--


    SNRPE for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNRPE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPE
    Search CenterWatch for drugs/clinical trials and news about SNRPE / RUXE 

    Transcripts
    for SNRPE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNRPE gene: 
    NM_003094.2  

    Unigene Clusters for SNRPE:

    Small nuclear ribonucleoprotein polypeptide E
    Hs.334612  [show with all ESTs], Hs.654418  [show with all ESTs]
    Unigene Representative Sequences: BC072433, BM547564
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483099 ENST00000475035 ENST00000470492 ENST00000414487(uc010pqn.2 uc001hai.3)
    ENST00000469451 ENST00000367208

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SNRPE
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPE
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPE:
    hsa-miR-4264 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPE 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPE (see all 4)
    OriGene shRNA RFP: SNRPE
    OriGene siRNA: SNRPE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPE
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPE (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPE
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SNRPE (NM_003094)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPE 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPE
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SNRPE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPE

    Additional cDNA sequence: M15919.1 

    11 DOTS entries:

    DT.99962552  DT.121339604  DT.100037060  DT.91735101  DT.216953  DT.121455651  DT.75133742  DT.102833912 
    DT.40106028  DT.121339673  DT.216954 

    24/215 AceView cDNA sequences (see all 215):

    BX280839 W94898 CB161103 BM804371 AI826356 CA772269 BM759054 D19829 
    BU196153 W42658 AW518265 AI076183 BM784865 AA313273 X12466 AI613313 
    BC002639 CR603313 AW005309 AA804898 W84630 CD516009 AA846523 AA384245 

    GeneLoc Exon Structure


    Expression
    for SNRPE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAAAAGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SNRPE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPE

    SOURCE GeneReport for Unigene clusters: Hs.334612 Hs.654418
        SABiosciences Custom PCR Arrays for SNRPE
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPE
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPE
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPE

    Orthologs
    for SNRPE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPE gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snrpe1 , 5 small nuclear ribonucleoprotein E1, 5 93.48(n)1
    100(a)1    		   1 (57.94 cM)5
    206431  NM_009227.31  NP_033253.11 
     1336038715 
    chicken
    (Gallus gallus)    		 Aves SNRPE1 small nuclear ribonucleoprotein polypeptide E 84.78(n)
    100(a)    		   396180  NM_205250.1  NP_990581.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNRPEL16
    		 --
    		 100(a)
    		 1 ↔ 1
    		 4(118051913-118059527)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BM261985.12   -- 84.25(n)    BM261985.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC049062.12   -- 75.53(n)   393979  BC049062.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG185913
    SmE1    		 mRNA splicing3
    Small ribonucleoprotein particle protein SmE1    		 75(a)3
    63.7(n)1
    76.67(a)1    		   28D23
    340801  NM_135318.11  NP_609162.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea snr-61 Protein SNR-6 61.79(n)
    67.07(a)    		   176668  NM_067219.1  NP_499620.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SME11 Sme1p 59.4(n)
    53.85(a)    		   854330   NP_014802.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G303301 small nuclear ribonucleoprotein E 68.31(n)
    69.14(a)    		   829156  NM_119179.2  NP_567844.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.66842 Oryza sativa (japonica cultivar-group) cDNA clone001-118-E07, full insert sequence less 72.31(n)    AK063621.1 


    ENSEMBL Gene Tree for SNRPE (if available)
    TreeFam Gene Tree for SNRPE (if available) 

    Paralogs
    for SNRPE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPE gene
    1 SIMAP similar gene for SNRPE using alignment to 2 protein entries:     RUXE_HUMAN (see all proteins):
    LSM5

    SNRPE for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for SNRPE (see all 9)
    PGOHUM00000238801 PGOHUM00000248750 PGOHUM00000244445 PGOHUM00000244648 PGOHUM00000240122


    Genomic Variants
    for SNRPE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/13 NCBI SNPs in SNRPE are shown (see all 13)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs671352171,2
    		C,--203829539(-) TACAC-/ATGTTAT 1 -- us2k11Minor allele frequency- AT:0.00NA 2
    rs105414381,2
    		C,--203836096(+) ACTTC-/TTTT  
                AAGAC     		1 -- int12Minor allele frequency- TTTT:0.25NA CSA 4
    rs578709201,2
    		C--203836408(+) AAAAAAAAAAA/-
                ACAGT     		1 -- int11Minor allele frequency- -:0.50CSA 2
    rs356818851,2
    		C,--203836939(+) TTAGG-/AAGCCC 1 -- int11Minor allele frequency- A:0.00NA 2
    rs345071921,2
    		C,--203837941(+) ACAGGT/-GCATG 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1422234381,2
    		C,--203838416(+) TGGAG-/TCTTTT
    TTTTTTTT    TTTTT     		1 -- int10--------
    rs352290021,2
    		----203829540(+) TAACA-/TGTGTA 1 -- us2k10--------
    rs341861881,2
    		----203837215(+) AGAGTCTCA/-  
                CTCTG     		1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2013467591,2
    		----203836095(+) CACTT-/CTTT  
                TAAGA     		1 -- int10--------
    rs347904501,2
    		----203829539(+) ATAAC-/ATGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNRPE (203830731 - 203840280 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNRPE: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SNRPE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNRPE for disorders           About GeneDecksing

    OMIM gene information: 128260    OMIM disorders: --

    8 diseases for SNRPE:    About MalaCards
    spinal muscular atrophy    muscular atrophy    bladder carcinoma    thyroiditis
    melanoma    carcinoma    malaria    neuronitis


    Export disorders for SNRPE gene to outside databases

    Publications
    for SNRPE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPE gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with SNRPE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. (PubMed id 2143747)1, 3, 9 Neiswanger K....Wieben E.D. (1990)
    2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (2001)
    6. Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins. (PubMed id 1835977)1, 3 Fautsch M.P. and Wieben E.D. (1991)
    7. The complete primary structure of the human snRNP E protein. (PubMed id 2974536)1, 2 Stanford D.R.... Wieben E.D. (1988)
    8. The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins. (PubMed id 2972723)1, 2 Stanford D.R.... Wieben E.D. (1988)
    9. DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene. (PubMed id 2440864)1, 2 Stanford D.R.... Wieben E.D. (1987)
    10. Branchpoint selection in the splicing of U12-dependent introns in vitro. (PubMed id 12022225)1, 9 McConnell T.S....Steitz J.A. (2002)

    External Searches for SNRPE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNRPE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6635 HGNC: 11161 AceView: SNRPE Ensembl:ENSG00000182004 euGenes: HUgn6635
    ECgene: SNRPE Kegg: 6635 H-InvDB: SNRPE

    Other Databases showing SNRPE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNRPE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPE Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNRPE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNRPE gene:
    Search GeneIP for patents involving SNRPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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