SHMT1 Gene
protein-coding GIFtS: 62
GCID: GC17M018231
|
|
serine hydroxymethyltransferase 1 (soluble)
| |
Aliases
for SHMT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine Hydroxymethyltransferase 1 (Soluble)1 2 | | MGC152291 | | SHMT1 2 3 | | MGC245561 | | CSHMT1 2 | | 14 KDa Protein2 | | Glycine Hydroxymethyltransferase2 3 | | Cytoplasmic Serine Hydroxymethyltransferase2 | | Serine Methylase2 3 | | Serine Hydroxymethyltransferase, Cytosolic2 | | EC 2.1.2.13 8 | | |
Export aliases for SHMT1 gene to outside databasesPrevious GC identifers: GC17M018476 GC17M019823 GC17M018174 GC17M018431 GC17M018171 GC17M017984 |
Summaries
for SHMT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SHMT1:
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme thatcatalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate.This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. Thisgene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene resultsin 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but theirbiological validity has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GLYC_HUMAN, P34896Function: Interconversion of serine and glycine
|
Genomic Views
for SHMT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SHMT1 gene promoter:
AhR CHOP-10 CBF-B CBF-A NF-YA c-Myb CP1A NF-Y CBF(2) C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SHMT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHMT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2SHMT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M018231: view genomic region
(about GC identifiers)
Start:
|
18,231,187 bp from pter |
End:
|
18,266,856 bp from pter |
Size:
|
35,670 bases |
Orientation:
|
minus strand |
|
Proteins
for SHMT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GLYC_HUMAN, P34896 (See
protein sequence)Recommended Name: Serine hydroxymethyltransferase, cytosolic Size: 483 amino acids; 53083 Da
Cofactor: Pyridoxal phosphate
Subunit: Homotetramer
Subcellular location: Cytoplasm
Miscellaneous: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one
1 PDB 3D structure from  and Proteopedia  for SHMT1:1BJ4 (3D)
Secondary accessions: D3DXD0 Q96HY0 Q9UMD1 Q9UMD2Alternative splicing: 3 isoforms: P34896-1 P34896-2 P34896-3 (Contains a N6-acetyllysine at position 271)Explore the universe of human proteins at neXtProt for SHMT1: NX_P34896
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P34896
4/28 DME Specific Peptides for SHMT1 (P34896) (see all 28)
SHMT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004160.3 NP_683718.1
ENSEMBL proteins: ENSP00000318868 ENSP00000462043 ENSP00000318805 ENSP00000379041 ENSP00000462227 ENSP00000462041 ENSP00000345881 ENSP00000440089 Reactome Protein details: P34896
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SHMT1 for ontologies About GeneDecksing
SHMT1 Antibody Products:
Assay Products for SHMT1: |
Protein
Domains /
Families
for SHMT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SHMT1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P34896ProtoNet protein and cluster: P34896 1 Blocks protein family: IPB001085 Glycine hydroxymethyltransferase
UniProtKB/Swiss-Prot: GLYC_HUMAN, P34896Similarity: Belongs to the SHMT family |
Function
for SHMT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GLYC_HUMAN, P34896Function: Interconversion of serine and glycineCatalytic activity: 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine Genatlas biochemistry entry for SHMT1:serine hydroxy-methyltransferase,cytosolic,with several alternatively spliced isoforms,catalyzing serinesynthesis,"one-carbone" metabolism,constantly deleted in Smith-Magenis syndrome,putative regulator of cell growth andproliferation
Enzyme Number (IUBMB): EC 2.1.2.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHMT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHMT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SHMT1 (NM_004169) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHMT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHMT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHMT1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
SHMT1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Shmt1tm1.1Stov for SHMT1
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Shmt1):
SHMT1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SHMT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | glycine biosynthesis I | | | 2 | Antimetabolite Pathway - Folate Cycle, Pharmacodynamics | | | 3 | Metabolism | | | 4 | One Carbon Metabolism | | | 5 | Vitamin B5 (pantothenate) metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8  BioSystems Pathways for SHMT1 (see all 8)
5/6 
Reactome Pathways for SHMT1 (see all 6)
3  PharmGKB Pathways for SHMT1
4 
Kegg Pathways (Kegg details for SHMT1):
UniProtKB/Swiss-Prot: GLYC_HUMAN, P34896Pathway: One-carbon metabolism; tetrahydrofolate interconversion
SHMT1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHMT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/78 Interacting proteins for SHMT1 (P348963 ENSP000003188684) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
SHMT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SHMT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SHMT1 for compounds About GeneDecksing
 Browse Tocris compounds for SHMT1
6 HMDB Compounds for SHMT1 About this table
7 DrugBank Compounds for SHMT1 About this table
10/18 Novoseek chemical compound relationships for SHMT1 gene (see all 18) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tetrahydrofolate |
87.3 |
9 |
11305908 (1), 11386852 (1), 12514178 (1), 9753690 (1) (see all 5) |
| thymidylate |
84 |
47 |
12161434 (3), 19513116 (3), 18067453 (3), 11516159 (1) (see all 18) |
| serine |
78.8 |
109 |
12161434 (4), 8527925 (3), 9675060 (3), 9753690 (3) (see all 53) |
| folate |
78.6 |
23 |
11386852 (2), 15122597 (1), 16536979 (1), 12161434 (1) (see all 16) |
| pyridoxal 5-phosphate |
75.3 |
21 |
17482557 (3), 12514178 (3), 8527925 (1), 9753690 (1) (see all 5) |
| methionine |
67.9 |
12 |
16536979 (1), 16410450 (1), 12161434 (1), 11986237 (1) (see all 8) |
| mimosine |
63.1 |
13 |
10766749 (4), 15531579 (4) |
| deoxyribonucleotide |
60.1 |
2 |
12161434 (1), 15531579 (1) |
| dihydrofolate |
55.4 |
8 |
19513116 (1), 18067453 (1), 11197757 (1), 17446168 (1) |
| homocysteine |
54.5 |
2 |
11386852 (1), 14656021 (1) |
1 PharmGKB related drug/compound annotation for SHMT1 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about SHMT1 / GLYC
|
Transcripts
for SHMT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SHMT1 gene (2 alternative transcripts): NM_004169.3 NM_148918.1 Unigene Clusters for SHMT1: Serine hydroxymethyltransferase 1 (soluble) Hs.513987 [show with all ESTs], Hs.636044 Unigene Representative Sequences: AK091498, Y1448812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395684(uc002gsz.3) ENST00000316694(uc002gta.3 uc002gtb.3 uc010vxt.2)
ENST00000580002 ENST00000354098 ENST00000395685(uc002gtd.1) ENST00000582352(uc002gtc.1)
ENST00000579558(uc010vxu.1) ENST00000582653 ENST00000395682 ENST00000583780
ENST00000352886 ENST00000539052
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHMT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHMT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SHMT1 (NM_004169) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHMT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHMT1 |
Additional cDNA sequence: Y14488.1 17 DOTS entries: DT.418980 DT.100817283 DT.100817277 DT.100697358 DT.95237322 DT.97847235 DT.99938562 DT.95333677 DT.100817274 DT.421797 DT.92065961 DT.95237302 DT.100817271 DT.100834637 DT.120915249 DT.95237308 DT.100817278 24/453 AceView cDNA sequences (see all 453): AL598794 AI031915 CD673011 AA553682 BM831124 AA380329 F34631 AA854873 H94643 AA005356 AV648239 L23928 BM455243 AI347367 AW614535 BI767430 BI757496 N63677 AA236270 BX486945 BI767164 BM976745 AU122696 BU740792
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SHMT1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SHMT1
|
Expression
for SHMT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SHMT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAAGGAGA
About this image
See SHMT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHMT1
SOURCE GeneReport for Unigene clusters: Hs.513987 Hs.636044
SABiosciences Custom PCR Arrays for SHMT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHMT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHMT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHMT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHMT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHMT1 |
Orthologs
for SHMT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SHMT1 gene from 10/45 species (see all 45) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SHMT11 |
serine hydroxymethyltransferase 1 (soluble) |
74.67(n)
81.68(a) |
|
416520 XM_414824.3 XP_414824.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SHMT16 |
-- |
83(a) |
1 ↔ 1 |
GL343618.1(206498-220998) |
African clawed frog
(Xenopus laevis) |
Amphibia |
shmt1-prov2 |
serine hydroxymethyltransferase 1 (soluble) |
81.3(n) |
|
BC042276.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc661712 |
similar to serine hydroxymethyl transferase 1 (soluble) |
75.95(n) |
|
394021 BC055527.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG30111 , 3 |
glycine hydroxymethyltransferase3
CG30111 |
60(a)3
59.93(n)1
60.43(a)1 |
|
5C73
315241 NM_132050.11 NP_572278.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
mel-321 , 3 |
Protein MEL-321 |
61(a)3
60.87(n)1
61.8(a)1 |
|
III(6512024-6514577)3
1759151 NM_171169.31 NP_741197.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SHM11 |
Shm1p |
55.39(n)
55.03(a) |
|
852565 NP_009822.4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SHM11 |
glycine hydroxymethyltransferase |
59.17(n)
60.26(a) |
|
829949 NM_119954.3 NP_195506.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g07384001 |
hypothetical protein |
61.5(n)
61.14(a) |
|
4334048 NM_001057746.1 NP_001051211.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
glyA6 |
serine hydroxymethyltransferase |
47(a) |
possible ortholog |
Chromosome(2682276-2683529) |
ENSEMBL Gene Tree for SHMT1 (if available)
TreeFam Gene Tree for SHMT1 (if available) |
Paralogs
for SHMT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SHMT1 gene
- SHMT22
3 SIMAP similar genes for SHMT1 using alignment to 6 protein entries: GLYC_HUMAN (see all proteins):SHMT SHMT2 DKFZp686P09201
SHMT1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SHMT1
PGOHUM00000243989
|
Genomic Variants
for SHMT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SHMT1 (18231187 - 18266856 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SHMT1
5 CNVs: 35439 35436 4024 35437 35438
1 Inversion: 0495
Human Gene Mutation Database (HGMD): SHMT1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHMT1 |
|
Disorders
/ Diseases
for SHMT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SHMT1 for disorders About GeneDecksing
OMIM gene information: 182144
OMIM disorders: --
20/50  diseases for SHMT1 (see all 50): About MalaCardssmith-magenis syndrome neural tube defect rift valley fever diffuse large b-cell lymphoma
adult acute lymphocytic leukemia patent ductus arteriosus dna topoisomerase i b-cell lymphomas
abdominal aortic aneurysm acute lymphocytic leukemia non-hodgkin lymphoma aortic aneurysm
autonomic dysfunction spina bifida squamous cell carcinoma lymphocytic leukemia
pediatric osteosarcoma squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma hodgkin's lymphoma
8 Novoseek disease relationships for SHMT1 gene About this table
Genetic Association Database (GAD): SHMT1
Human Genome Epidemiology (HuGE) Navigator: SHMT1 (75 documents)
Export disorders for SHMT1 gene to outside databases
|
Publications
for SHMT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SHMT1 gene, integrated from 9 sources (see all 161):
(articles sorted by number of sources associating them with SHMT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? (PubMed id 11386852)1, 4, 7, 9 Heil S.G....Blom H.J. (2001)
- Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization. (PubMed id 8505317)1, 2, 3, 9 Garrow T.A.... Shane B. (1993)
- The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy. (PubMed id 9753690)1, 2, 9 Renwick S.B.... Baumann U. (1998)
- Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men. (PubMed id 16046727)1, 4, 9 Lim U....Cassano P.A. (2005)
- Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication. (PubMed id 15531579)1, 7, 9 Perry C....Stover P.J. (2005)
- Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. (PubMed id 15122597)1, 4, 9 Chen J....Ma J. (2004)
- Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. (PubMed id 12604405)1, 4, 9 Hishida A....Tajima K. (2003)
- Isolation and characterisation of human genomic sequences encoding cytosolic serine hydroxymethyltransferase. (PubMed id 9056951)1, 2, 9 Chave K.J.... Sanders P.G. (1997)
- Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis. (PubMed id 16006999)1, 4, 9 Zhang Z....Wei Q. (2005)
- Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. (PubMed id 15797993)1, 4, 9 de Jonge R....Lindemans J. (2005)
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External Searches for SHMT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SHMT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SHMT1 gene
(According to HUGE)
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Specialized Databases showing SHMT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SHMT1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SHMT1 gene:
Search GeneIP for patents involving SHMT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SHMT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SHMT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHMT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHMT1 | | | OriGene Protein Over-expression Lysate for SHMT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SHMT1 | | OriGene 3'-UTR Clone for SHMT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHMT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHMT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SHMT1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SHMT1 | | OriGene Custom Protein Services for SHMT1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHMT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHMT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHMT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHMT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHMT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHMT1 |
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| | | | Search Tocris compounds for SHMT1 |
| |  |  |  |  | | | | | | Recombinant Protein for SHMT1 |
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 | | | SHMT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHMT1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SHMT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHMT1 |
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