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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SF3A1 Gene

protein-coding GIFtS: 59
GCID: GC22M030727

splicing factor 3a, subunit 1, 120kDa

(Previous names: splicing factor 3a, subunit 1, 120kD )

Explore 3 diseases affiliated with
SF3A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Splicing Factor 3a, Subunit 1, 120kDa¹ ²		SF3A120² ⁵
SAP114¹ ² ³ ⁵		Prp21¹
PRPF21¹ ²		Splicing Factor 3a, Subunit 1, 120kD¹
SF3a120¹ ³		Pre-MRNA Processing 21²
Spliceosome-Associated Protein 114² ³		Pre-MRNA Splicing Factor SF3a (120 KDa Subunit)²
SAP 114² ³		Splicing Factor 3 Subunit 1²
PRP21² ⁵		Splicing Factor 3A Subunit 1²

External Ids:	HGNC: 10765¹	Entrez Gene: 10291²	Ensembl: ENSG00000099995⁷	OMIM: 605595⁵	UniProtKB: Q15459³

Export aliases for SF3A1 gene to outside databases

Previous GC identifers: GC22M027424 GC22M029052 GC22M029054 GC22M013689

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SF3A1:

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes

subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that

performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or

Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP

motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like

domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for

binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.

Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: SF3A1_HUMAN, Q15459

Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2

snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the

branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'

complex

Gene Wiki entry for SF3A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SF3A1 gene promoter:
p53 Olf-1 Nkx2-5 HNF-3beta E47 POU2F1 POU2F1a AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SF3A1 promoter sequence

Search SABiosciences Chromatin IP Primers for SF3A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SF3A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

SF3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SF3A1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M030727: view genomic region (about GC identifiers)

Start:	30,727,977 bp from pter	End:	30,752,936 bp from pter
Size:	24,960 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SF3A1_HUMAN, Q15459 (See protein sequence)

Recommended Name: Splicing factor 3A subunit 1

Size: 793 amino acids; 88886 Da

Subunit: Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three

subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to

form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A3

Subcellular location: Nucleus (By similarity)

3 PDB 3D structures from and Proteopedia for SF3A1:

1ZKH (3D)

2DT6 (3D)

2DT7 (3D)

Explore the universe of human proteins at neXtProt for SF3A1: NX_Q15459

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15459

SF3A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001005409.1 NP_005868.1

ENSEMBL proteins:

ENSP00000215793 ENSP00000412715 ENSP00000400862 ENSP00000397267 ENSP00000390336

Reactome Protein details: Q15459
Human Recombinant Protein Products for SF3A1:

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	Uscn Proteins for SF3A1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	IDA	9731529
GO:0005684	U2-type spliceosomal complex	IDA	10882114
GO:0005730	NOT nucleolus	IDA	--

SF3A1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SF3A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR022030 PRP21-like

IPR000061 Surp

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry Q15459

ProtoNet protein and cluster: Q15459

2 Blocks protein families:

IPB000061 SWAP/Surp

IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: SF3A1_HUMAN, Q15459

Similarity: Contains 2 SURP motif repeats

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SF3A1_HUMAN, Q15459

Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2

snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the

branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E'

complex

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	10882114
GO:0005515	protein binding	IPI	--

SF3A1 for ontologies About GeneDecksing

Phenotypes:
13 GenomeRNAi human phenotypes for SF3A1:

Cell division defect	Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e
Decreased Salmonella enterica	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Decreased viability
Increased G2M DNA content	Increased cell death in HCC-19	Increased gamma-H2AX phosphory	Low eccentricity cells
Synthetic lethal with Ras

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sf3a1):

mortality/aging

SF3A1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SF3A1

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		hsa-miR-125a-3p hsa-miR-486-3p hsa-miR-520a-5p hsa-miR-28-5p hsa-miR-3662 hsa-miR-3155b hsa-miR-1298 hsa-miR-3155

		SwitchGear 3'UTR luciferase reporter plasmid: SF3A1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SF3A1

mRNA processing

5 Reactome Pathways for SF3A1

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

1 Kegg Pathway (Kegg details for SF3A1):

Spliceosome

SF3A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SF3A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/825 Interacting proteins for SF3A1 (Q15459^{1, 2, 3} ENSP00000215793⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 825)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205440 MINT-8332317 MINT-7947479 MINT-8333383 I2D: score=5 STRING: ENSP00000221494
NCOR1	O75376²^,³, ENSP00000268712⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000268712
PRPF40A	O75400²^,³	MINT-7945693 MINT-8333163 MINT-8331514 I2D: score=2
GAS7	O60861²^,³, ENSP00000322608⁴	MINT-72909 I2D: score=3 STRING: ENSP00000322608
SP1	P08047¹^,³, ENSP00000329357⁴	EBI-1054743,EBI-298336 I2D: score=3 STRING: ENSP00000329357

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000389	mRNA 3'-splice site recognition	TAS	15647371
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006396	RNA processing	--	--
GO:0006397	mRNA processing	IMP	15647371
GO:0008380	RNA splicing	TAS	--

SF3A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SF3A1
Search CenterWatch for drugs/clinical trials and news about SF3A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SF3A1 gene (2 alternative transcripts):

NM_001005409.1 NM_005877.4

Unigene Cluster for SF3A1:

Splicing factor 3a, subunit 1, 120kDa

Hs.406277 [show with all ESTs]

Unigene Representative Sequence: NM_005877

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000215793 ENST00000411423 ENST00000444440 ENST00000485618 ENST00000498259

ENST00000447376 ENST00000471037 ENST00000471342 ENST00000463818 ENST00000496189

ENST00000439242(uc003ahl.3 uc021wnt.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SF3A1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SF3A1 (see all 16):
		hsa-miR-125a-3p hsa-miR-486-3p hsa-miR-520a-5p hsa-miR-28-5p hsa-miR-3662 hsa-miR-3155b hsa-miR-1298 hsa-miR-3155

		SwitchGear 3'UTR luciferase reporter plasmid: SF3A1 3' UTR sequence

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Additional cDNA sequence:

AK098463.1 AK303273.1 BC001976.1 BC007684.2 CR456575.1 X85237.1

24/28 DOTS entries (see all 28):

DT.219200 DT.95070938 DT.100038324 DT.95271017 DT.100828643 DT.100828650 DT.95317027 DT.75139251

DT.120634019 DT.95271011 DT.95226342 DT.120634051 DT.100828648 DT.95271002 DT.99983800 DT.100761772

DT.120634010 DT.40109584 DT.95271003 DT.100806150 DT.100828645 DT.120633998 DT.120634082 DT.40214031

24/664 AceView cDNA sequences (see all 664):

BF222470 AI418658 BQ423401 BQ718290 AW196670 AI160209 AI423003 AW440751

AA039376 AI361679 BQ423786 BI871497 BU528838 AW474370 BP431321 BU845238

AA864443 CR612753 AI076290 AI963908 BQ424270 AW664720 AU125940 BU786932

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SF3A1 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^
SP1:																											-
SP2:																											-
SP3:																											-
SP4:							-				-		-
SP5:

ExUns:	17	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SF3A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SF3A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGTCTAA

About this image
See SF3A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SF3A1

SOURCE GeneReport for Unigene cluster: Hs.406277

UniProtKB/Swiss-Prot: SF3A1_HUMAN, Q15459

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for SF3A1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SF3A1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SF3A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SF3A1 gene from 10/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sf3a1^{1 , 5}	splicing factor 3a, subunit 1^{1, 5}	90.69(n)¹ 98.36(a)¹		11 (2.91 cM)⁵ 67465¹ NM_026175.5¹ NP_080451.4¹ 4160350⁵
chicken (Gallus gallus)	Aves	SF3A1¹	splicing factor 3a, subunit 1, 120kDa	81.33(n) 92.9(a)		427717 NM_001031472.1 NP_001026643.1
lizard (Anolis carolinensis)	Reptilia	SF3A1⁶	--	88(a)	1 ↔ 1	GL343417.1(117453-124205)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7478²	Xenopus laevis cDNA clone IMAGE5570158	79.74(n)		BC052220.1
zebrafish (Danio rerio)	Actinopterygii	sf3a1²	splicing factor 3a, subunit 1	81.03(n)		368732 BC056521.1
fruit fly (Drosophila melanogaster)	Insecta	CG16941^{1 , 3}	mRNA splicing pre-mRNA splicing factor³ CG16941¹	61(a)³ 59.33(n)¹ 57.87(a)¹		42048¹ NM_142326.2¹ NP_650583.1¹
worm (Caenorhabditis elegans)	Secernentea	prp-21^{1 , 3}	splicing factor³ Protein PRP-21¹	43(a)³ 52.62(n)¹ 46.35(a)¹		II(484868-490278)³ 173440¹ NM_061345.6¹ NP_493746.1¹
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AFR645W¹	AFR645Wp	42.22(n) 26.15(a)		4622481 NM_212329.1 NP_986193.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G14650¹	splicing factor 3A subunit 1	49.89(n) 40.54(a)		838027 NM_101332.3 NP_172917.1
rice (Oryza sativa)	Liliopsida	Os.7264²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	73.79(n)		AK119874.1

ENSEMBL Gene Tree for SF3A1 (if available)
TreeFam Gene Tree for SF3A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SF3A1 gene

SFSWAP²

SF3A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113468659^1,2	C	--	13689631(+)	`GCCTCG/AGCCTC`	2	--	int¹		1		WA	2
rs9606716^1,2	C,F,H	--	13690238(+)	`GGGATG/AAGCTG`	2	--	ut3¹		8		NS EA NA	1000
rs77926917^1,2		--	13690592(+)	`CCAACG/AGCATT`	2	--	ut3¹		1		NA	120
rs12169570^1,2	H	--	13690667(+)	`GTGCCC/ATAACA`	2	--	ut3¹		4		NS EA	420
rs59653506^1,2	C	--	13690938(+)	`AGGGAT/CGACAT`	2	--	ut3¹		2		WA	120
rs56184734^1,2		--	13691179(+)	`ACACAC/TGTGAG`	2	--	ut3¹		0	--	--	--	--
rs2839998^1,2	C,F,O,A,H	--	13691292(+)	`AGCTTG/AATTCT`	2	--	ut3¹ ese³		27		NA EA NS	2858
rs112624788^1,2	F	--	13691303(+)	`AAAGAT/AAACAG`	2	--	ut3¹		2		CSA	4
rs116412817^1,2	C,F	--	13691334(+)	`AGGACT/GGTGAC`	2	--	ut3¹		1		WA	118
rs115826798^1,2	C,F	--	13691503(+)	`TATTTA/CAACTT`	2	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for SF3A1 (30727977 - 30752936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SF3A1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SF3A1 for disorders           About GeneDecksing

OMIM gene information: 605595    OMIM disorders: --

3 diseases for SF3A1:    About MalaCards

fanconi's anemia anemia malaria

Human Genome Epidemiology (HuGE) Navigator: SF3A1 (1 document)

Export disorders for SF3A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SF3A1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with SF3A1)

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Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae. (PubMed id 7489498)^{1, 2, 3, 9} Kraemer A.... Bilbe G. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)
Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. (PubMed id 10882114)^{1, 2} Das R.... Reed R. (2000)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. (PubMed id 11533230)^{1, 9} Nesic D. and Kramer A. (2001)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10291	HGNC: 10765	AceView: SF3A1	Ensembl:ENSG00000099995	euGenes: HUgn10291
ECgene: SF3A1	Kegg: 10291	H-InvDB: SF3A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SF3A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SF3A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SF3A1 gene:
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splicing factor 3a, subunit 1, 120kDa

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SF3A1 Gene

splicing factor 3a, subunit 1, 120kDa

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