SDHB Gene
protein-coding GIFtS: 66
GCID: GC01M017345
|
|
succinate dehydrogenase complex, subunit B, iron sulfur...
(Previous symbols: SDH1, SDH)
| |
Aliases
for SDHB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip)1 2 | | SDH22 5 | | SDH1 2 3 | | SDHIP2 5 | | SDH11 2 3 | | IP2 | | Iron-Sulfur Subunit Of Complex II2 3 | | Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial2 | | EC 1.3.5.13 8 | | Ip3 | | PGL42 5 | | |
Export aliases for SDHB gene to outside databasesPrevious GC identifers: GC01M017082 GC01M016386 GC01M016726 GC01M017090 GC01M017217 GC01M015589 |
Summaries
for SDHB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SDHB:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electronsfrom FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial innermembrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise theiron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas andpheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: DHSB_HUMAN, P21912Function: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of themitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone(coenzyme Q)
Gene Wiki entry for SDHB
|
Genomic Views
for SDHB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SDHB gene promoter:
TBP Lmo2 Nkx2-5 c-Ets-1 PPAR-gamma1 TFIID PPAR-gamma2 ZID Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SDHB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDHB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.1-p35 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.1-p35SDHB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M017345: view genomic region
(about GC identifiers)
Start:
|
17,345,217 bp from pter |
End:
|
17,380,665 bp from pter |
Size:
|
35,449 bases |
Orientation:
|
minus strand |
|
Proteins
for SDHB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DHSB_HUMAN, P21912 (See
protein sequence)Recommended Name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor Size: 280 amino acids; 31630 Da
Cofactor: Binds 1 2Fe-2S cluster (By similarity)
Cofactor: Binds 1 3Fe-4S cluster (By similarity)
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB,and a cytochrome b560 composed of SDHC and SDHD
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Secondary accessions: B2R545 Q9NQ12Explore the universe of human proteins at neXtProt for SDHB: NX_P21912
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21912
4/9 DME Specific Peptides for SDHB (P21912) (see all 9)
SDHB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002991.2
ENSEMBL proteins: ENSP00000364649 Reactome Protein details: P21912
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- | | GO:0005743 | mitochondrial inner membrane |
TAS | -- | | GO:0005749 | mitochondrial respiratory chain complex II |
ISS | -- |
SDHB for ontologies About GeneDecksing
SDHB Antibody Products:
Assay Products for SDHB: |
Protein
Domains /
Families
for SDHB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SDHB for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry P21912ProtoNet protein and cluster: P21912 1 Blocks protein family: IPB001041 Ferredoxin
UniProtKB/Swiss-Prot: DHSB_HUMAN, P21912Similarity: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein familySimilarity: Contains 1 2Fe-2S ferredoxin-type domainSimilarity: Contains 1 4Fe-4S ferredoxin-type domain |
Function
for SDHB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DHSB_HUMAN, P21912Function: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of themitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone(coenzyme Q)Catalytic activity: Succinate + ubiquinone = fumarate + ubiquinol Genatlas biochemistry entry for SDHB:succinate dehydrogenase 1,iron sulfur protein,inner mitochondrial membrane, component,27.4kDa,of complex II ofmitochondrial respiratory chain,oxidative phosphorylation, (OXPHOS),also catalyzing the seventh step of the citricacid cycle
Enzyme Number (IUBMB): EC 1.3.5.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SDHB (NM_003000) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDHB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHB |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
SDHB for ontologies About GeneDecksing
|
Pathways & Interactions
for SDHB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | TCA Cycle | | | 3 | Metabolism | | | 4 | TCA cycle II (eukaryotic) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for SDHB
5/6 
Reactome Pathways for SDHB (see all 6)
5/6 
Kegg Pathways (Kegg details for SDHB) (see all 6):
UniProtKB/Swiss-Prot: DHSB_HUMAN, P21912Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1
SDHB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SDHB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/88 Interacting proteins for SDHB (P219121, 2, 3 ENSP000003646494) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SDHB for ontologies About GeneDecksing
|
Drugs & Compounds
for SDHB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SDHB for compounds About GeneDecksing
 Browse Tocris compounds for SDHB
9 HMDB Compounds for SDHB About this table
3 DrugBank Compounds for SDHB About this table
10/64 Novoseek chemical compound relationships for SDHB gene (see all 64) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| succinate |
95.9 |
336 |
16892081 (3), 7833834 (3), 7622334 (3), 8487494 (2) (see all 99) |
| fumarate |
68.1 |
16 |
16892081 (3), 19778456 (2), 7622334 (2), 17325041 (1) (see all 12) |
| iron-sulfur |
64 |
17 |
19233206 (2), 11692162 (1), 8161512 (1), 7958999 (1) (see all 13) |
| alpha-ketoglutarate |
62.2 |
9 |
19028544 (2), 15337301 (1), 17668068 (1), 16906525 (1) (see all 5) |
| 3-nitropropionic acid |
61 |
31 |
9453576 (4), 7798946 (3), 7689641 (2), 17011837 (1) (see all 6) |
| mannitol |
59.2 |
57 |
8344129 (4), 18760274 (3), 16483355 (2), 18566893 (2) (see all 27) |
| mibg |
58.8 |
2 |
17898811 (1), 19864450 (1) |
| glycerol 3-phosphate |
58.6 |
11 |
8167100 (1), 12632195 (1), 2167865 (1), 1816079 (1) (see all 10) |
| thenoyltrifluoroacetone |
55.7 |
4 |
10693744 (1), 7622334 (1) |
| methylmalonic acid |
55.3 |
7 |
12895456 (2), 8929440 (1), 16469366 (1), 19073247 (1) |
Search CenterWatch for drugs/clinical trials and news about SDHB / DHSB
|
Transcripts
for SDHB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SDHB gene: NM_003000.2 Unigene Cluster for SDHB: Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Hs.465924 [show with all ESTs]Unigene Representative Sequence: BQ0736928 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375499(uc001bae.3) ENST00000475049 ENST00000485092 ENST00000485515
ENST00000491274 ENST00000475506 ENST00000463045 ENST00000466613
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SDHB (NM_003000) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SDHB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHB |
Additional cDNA sequence: AK312056.1 BC007840.2 D10245.1 M32246.1 U17248.1 14 DOTS entries: DT.118174 DT.100883438 DT.100698505 DT.91752291 DT.101975035 DT.91732755 DT.100883432 DT.100883437 DT.121451924 DT.95322231 DT.95322232 DT.99943940 DT.121451899 DT.95322230 24/335 AceView cDNA sequences (see all 335): H92715 BE746202 BM675139 AA344868 BM989497 AA169559 BE408434 BG251366 BU789942 BM789508 CB306618 AA659082 BF796275 N34666 BI855954 AI623113 H38218 CD366559 BM988183 AA502375 F29315 BM672967 CR606201 AW627604
GeneLoc Exon Structure
|
Expression
for SDHB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SDHB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAATAAAA
About this image
See SDHB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SDHB
SOURCE GeneReport for Unigene cluster: Hs.465924
SABiosciences Expression via Pathway-Focused PCR Arrays including SDHB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDHB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SDHB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDHB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDHB |
Orthologs
for SDHB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SDHB gene from 11/42 species (see all 42) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sdhb1 , 5 |
succinate dehydrogenase complex, subunit B, iron sulfur more1, 5 |
85.85(n)1
92.45(a)1 |
|
4 (73.24 cM)5
676801 NM_023374.31 NP_075863.21
1409612035 |
chicken
(Gallus gallus) |
Aves |
SDHB1 |
succinate dehydrogenase complex, subunit B, iron sulfur more |
79.5(n)
86.69(a) |
|
770063 NM_001080875.1 NP_001074344.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SDHB6 |
-- |
73(a) |
1 ↔ 1 |
GL344735.1(1555-13234) |
African clawed frog
(Xenopus laevis) |
Amphibia |
sdhb-prov2 |
succinate dehydrogenase complex, subunit B, iron sulfur more |
80.96(n) |
|
BC043859.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
sdhb1 |
succinate dehydrogenase complex, subunit B, iron sulfur more |
76.52(n)
84.67(a) |
|
562149 NM_001098740.1 NP_001092210.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
SdhB1 , 3 |
tricarboxylic acid cycle succinate
dehydrogenase more3
Succinate dehydrogenase B1 |
75(a)
(best of 2)3
65.34(n)1
70.29(a)1 |
|
2 42D13
355901 NM_057753.41 NP_477101.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F42A8.23
sdhb-11 |
succinate dehydrogenase (ubiquinone) iron
sulphur more3
Protein SDHB-11 |
66(a)3
62.95(n)1
63.94(a)1 |
|
II(9350781-9352642)3
1744821 NM_063591.51 NP_495992.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SDH2(YLL041C)4
SDH21 |
Iron-sulfur protein subunit of succinate dehydrogenase more4
Sdh2p1 |
65.6(n)1
72.69(a)1 |
|
12(53931-53131)4
8506851, 4 NP_013059.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SDH2-31 |
succinate dehydrogenase [ubiquinone] iron-sulfur subunit more |
60.65(n)
62.11(a) |
|
836640 NM_148160.2 NP_680465.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.54992 |
Oryza sativa (japonica cultivar-group) mRNA for mitochondrial more |
75.36(n) |
|
AK099077.1 |
ENSEMBL Gene Tree for SDHB (if available)
TreeFam Gene Tree for SDHB (if available) |
Paralogs
for SDHB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SDHB gene
SDHB for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SDHB
PGOHUM00000238204
|
Genomic Variants
for SDHB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SDHB (17345217 - 17380665 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SDHB
3 CNVs: 4212 3284 4211
Human Gene Mutation Database (HGMD): SDHB
Locus Specific Mutation Databases (LSDB): SDHB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDHB |
|
Disorders
/ Diseases
for SDHB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SDHB for disorders About GeneDecksing
OMIM gene information: 185470
OMIM disorders: 115310 171300 606864 612359
UniProtKB/Swiss-Prot: DHSB_HUMAN, P21912
Defects in SDHB are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. Acatecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinalsymptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may bepersistent or intermittent Defects in SDHB are the cause of paragangliomas type 4 (PGL4) [MIM:115310]. A neural crest tumor usuallyderived from the chromoreceptor tissue of a paraganglion. Paragangliomas are most commonly located in the head andneck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]; also calledCarney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominantmanner, alone or as a component of a syndrome associated with other tumors, such as in the context ofneurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibilityto the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance Defects in SDHB are a cause of Cowden-like syndrome (CWDLS) [MIM:612359]. Cowden-like syndrome is a cancerpredisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus
20/88  diseases for SDHB (see all 88): About MalaCardsparaganglioma paraganglioma, familial chromaffin, 4 von hippel-lindau disease pheochromocytoma
multiple symmetric lipomatosis multiple symmetrical lipomatosis vhl-related pheochromocytoma carney triad
spinal cord injury seminal vesicle tumor multiple endocrine neoplasia cowden-like syndrome
hereditary paraganglioma-pheochromocytoma syndromes carotid body tumor mitochondrial complex ii deficiency neural crest tumor
lipomatosis paraganglioma and gastric stromal sarcoma glomus tumor striatal degeneration
5 diseases from the University of Copenhagen DISEASES database for SDHB:Paraganglioma Phaeochromocytoma Hemangioma Neurofibromatosis
Chondroma 10/55 Novoseek disease relationships for SDHB gene (see all 55) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| paraganglioma |
96.1 |
258 |
19576851 (7), 18551016 (6), 18362451 (6), 18382370 (6) (see all 99) |
| pheochromocytoma |
91 |
223 |
17308434 (7), 19576851 (7), 12618761 (6), 19215943 (5) (see all 99) |
| paraganglioma extra-adrenal |
83 |
3 |
18509008 (1), 20498024 (1), 18551016 (1) |
| multiple endocrine neoplasia |
82.7 |
16 |
15788647 (1), 15988378 (1), 17121518 (1), 15531530 (1) (see all 15) |
| von hippel-lindau disease |
82.2 |
13 |
16001332 (1), 15988378 (1), 17121518 (1), 12928344 (1) (see all 12) |
| neurofibromatosis type 1 |
74.5 |
21 |
15788647 (1), 16001332 (1), 15988378 (1), 17121518 (1) (see all 18) |
| carotid body tumor |
72 |
2 |
17041923 (1), 12381538 (1) |
| carney triad |
68.1 |
1 |
19522821 (1) |
| hlrcc |
67.6 |
1 |
15987702 (1) |
| germ-line mutation |
59.8 |
8 |
14500403 (2), 17159241 (1), 19223516 (1), 19763184 (1) (see all 6) |
GeneTests: SDHB
Hereditary Paraganglioma-Pheochromocytoma Syndromes
Genetic Association Database (GAD): SDHB
Human Genome Epidemiology (HuGE) Navigator: SDHB (38 documents)
Export disorders for SDHB gene to outside databases
|
Publications
for SDHB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SDHB gene, integrated from 9 sources (see all 461):
(articles sorted by number of sources associating them with SDHB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. (PubMed id 15328326)1, 2, 4, 9 Neumann H.P.H.... Eng C. (2004)
- Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. (PubMed id 11897817)1, 2, 4, 9 Baysal B.E.... Rubinstein W.S. (2002)
- Germ-line mutations in nonsyndromic pheochromocytoma. (PubMed id 12000816)1, 2, 4, 9 Neumann H.P.H.... Eng C. (2002)
- Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. (PubMed id 12213855)1, 2, 4, 9 Young A.L.... Young W.F. Jr. (2002)
- Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas. (PubMed id 12618761)1, 2, 9 Benn D.E.... Robinson B.G. (2003)
- Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. (PubMed id 14500403)2, 4, 9 Gimenez-Roqueplo A.-P....Jeunemaitre X. (2003)
- Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma. (PubMed id 16405730)1, 7, 9 Bayley J.P....Taschner P.E. (2006)
- Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. (PubMed id 18678321)1, 2, 9 Ni Y.... Eng C. (2008)
- Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. (PubMed id 11404820)1, 2, 9 Astuti D.... Maher E.R. (2001)
- No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. (PubMed id 16322339)1, 4, 9 Montani M....Perren A. (2005)
|
External Searches for SDHB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SDHB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SDHB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SDHB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SDHB | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for SDHB | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SDHB | | TCA Cycle Gene Mutation Database | http://chromium.liacs.nl/LOVD2/SDH/home.php?select_db=SDHB |
|
| | |
About This Section
| Patent Information for SDHB gene:
Search GeneIP for patents involving SDHB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SDHB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SDHB | | OriGene shRNA RFP for SDHB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SDHB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SDHB | | | OriGene Protein Over-expression Lysate for SDHB | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SDHB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SDHB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SDHB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SDHB | | OriGene Custom Protein Services for SDHB | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SDHB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SDHB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SDHB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SDHB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SDHB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SDHB |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SDHB |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SDHB Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for SDHB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SDHB |
|
|
|
|
