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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNMT Gene

protein-coding   GIFtS: 67
GCID: GC18P013716

RNA (guanine-7-) methyltransferase
 Explore 6 diseases affiliated with
RNMT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNMT    

Aliases
for RNMT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RNA (Guanine-7-) Methyltransferase1 2     EC 2.1.1.563 8
RG7MT11 2 3     MET2 5
HCMT11     HCMT1c1
HMet1     MRNA (Guanine-7-)Methyltransferase2
Hcm1p1     MRNA Cap Guanine-N7 Methyltransferase2
MRNA (Guanine-N(7)-)-Methyltransferase2 3     KIAA03983
MRNA Cap Methyltransferase2 3     

External Ids:    HGNC: 100751   Entrez Gene: 87312   Ensembl: ENSG000001016547   OMIM: 6035145   UniProtKB: O431483   

Export aliases for RNMT gene to outside databases

Previous GC identifers: GC18M013747 GC18P013812


Summaries
for RNMT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure
of mRNAs. Binds RNA containing 5'-terminal GpppC

summary for RNMT:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for RNMT (MRNA-methyltransferase)


Genomic Views
for RNMT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNMT gene promoter:
         STAT5A   Cdc5   AREB6   MEF-2A   POU2F1   POU2F1a   POU2F1b   aMEF-2   POU2F1c   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNMT promoter sequence
   Search SABiosciences Chromatin IP Primers for RNMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

RNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNMT gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P013716:  view genomic region     (about GC identifiers)

Start:
 13,726,659 bp from pter      End:
 13,764,557 bp from pter
Size:
 37,899 bases      Orientation:
 plus strand

Proteins
for RNMT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MCES_HUMAN, O43148 (See protein sequence)
Recommended Name: mRNA cap guanine-N7 methyltransferase  
Size: 476 amino acids; 54844 Da
Subunit: Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity.
Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in
response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase
II and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and cap
methyltransferase activity
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for RNMT:
3BGV (3D)        3EPP (3D)    
Secondary accessions: B0YJ90 D3DUJ5 O94996 Q9UIJ9
Alternative splicing: 2 isoforms:  O43148-1   O43148-2   

Explore the universe of human proteins at neXtProt for RNMT: NX_O43148

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43148

    • 4/6 DME Specific Peptides for RNMT (O43148) (see all 6)
     RSQSRIF  CGKGGDL  FDICSCQF  EMAKKYNM 

    RNMT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003790.1  
    ENSEMBL proteins: 
     ENSP00000446426   ENSP00000372804   ENSP00000467171   ENSP00000466111   ENSP00000467475  
     ENSP00000466252   ENSP00000468261   ENSP00000262173   ENSP00000438624  
    Reactome Protein details: O43148
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: RNMT
    OriGene Protein Over-expression Lysate: RNMT
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    Novus Biologicals RNMT Proteins
    Novus Biologicals RNMT Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RNMT
    Uscn Proteins for RNMT

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005845mRNA cap binding complex IDA--


    RNMT for ontologies           About GeneDecksing



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    Abcam antibodies for RNMT 
    Uscn Antibodies for RNMT
    ThermoFisher Antibodies for RNMT

    Assay Products for RNMT: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for RNMT
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RNMT

    Protein Domains /
    Families
    for RNMT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNMT for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004971 mRNA_G-N7_MeTrfase_dom
     IPR016899 mRNA_G-N7_MeTrfase

    Graphical View of Domain Structure for InterPro Entry O43148

    ProtoNet protein and cluster: O43148

    UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family
    Similarity: Contains 1 mRNA cap 0 methyltransferase domain


    Function
    for RNMT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
    Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure
    of mRNAs. Binds RNA containing 5'-terminal GpppC
    Catalytic activity: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA

         Genatlas biochemistry entry for RNMT:
    messenger RNA (guanine-7) cap methyltransferase

    Enzyme Number (IUBMB): EC 2.1.1.561 2

    miRNA
    Products:            		miRTarBase miRNAs that target RNMT:
    hsa-mir-34b (MIRT004825), hsa-mir-1 (MIRT001357), hsa-mir-34c-5p (MIRT000757), hsa-mir-340 (MIRT005458), hsa-mir-30a (MIRT005167), hsa-mir-34b (MIRT000758), hsa-mir-206 (MIRT000185), hsa-mir-562 (MIRT005024), hsa-mir-199b-3p (MIRT004514), hsa-mir-34a (MIRT000759), hsa-mir-23b (MIRT004292)

    OriGene 3'-UTR Clone: RNMT
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNMT
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate RNMT (see all 48):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-miR-30d hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNMT (see all 7)
    OriGene shRNA RFP: RNMT
    OriGene siRNA: RNMT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNMT

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RNMT

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for RNMT

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IMP9790902
    GO:0004482mRNA (guanine-N7-)-methyltransferase activity TAS--
    GO:0005515protein binding IPI--


    RNMT for ontologies           About GeneDecksing



    Pathways & Interactions
    for RNMT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    		Transcription of the HIV genome0.70
    		RNA Pol II CTD phosphorylation and interaction with CE0.55
    		mRNA Capping0.59
    		RNA Pol II CTD phosphorylation and interaction with CE0.55
    2Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    3Late Phase of HIV Life Cycle
    		Late Phase of HIV Life Cycle1.00
    		HIV Life Cycle0.90
    4mRNA Splicing - Major Pathway
    		mRNA Processing0.82
    		mRNA processing0.48
    5HIV Infection
    		HIV Infection1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Tocris Bioscience Pathway for RNMT
        Akt Pathway

    1 BioSystems Pathway for RNMT 
        mRNA processing

    5/12        Reactome Pathways for RNMT (see all 12)
        mRNA Capping
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    Disease


    1         Kegg Pathway  (Kegg details for RNMT):
        mRNA surveillance pathway


    RNMT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for RNMT (O431483 ENSP000002621734) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA2P522923, ENSP000003324554I2D: score=1 STRING: ENSP00000332455
    RNGTTO609423, ENSP000003584974I2D: score=3 STRING: ENSP00000358497
    POLR2AP249283, ENSP000003149494I2D: score=1 STRING: ENSP00000314949
    MAT1AQ002663, ENSP000003612874I2D: score=1 STRING: ENSP00000361287
    SEPSECSQ9HD403, ENSP000003059564I2D: score=5 STRING: ENSP00000305956
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:00063707-methylguanosine mRNA capping TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral reproduction TAS--
    GO:0036265RNA (guanine-N7)-methylation TAS--


    RNMT for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNMT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNMT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RNMT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    K 252aProtein kinase inhibitor[99533-80-9]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    2 HMDB Compounds for RNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    2 Novoseek chemical compound relationships for RNMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 68 2 17935775 (1), 9207015 (1)
    rrna 65.2 1 15136037 (1)

    Search CenterWatch for drugs/clinical trials and news about RNMT / MCES 

    Transcripts
    for RNMT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNMT gene: 
    NM_003799.1  

    Unigene Cluster for RNMT:

    RNA (guanine-7-) methyltransferase
    Hs.592347  [show with all ESTs]
    Unigene Representative Sequence: AF067791
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543302(uc002ksk.1) ENST00000383314(uc010dlk.2 uc010xae.1 uc002ksl.1 uc002ksm.1)
    ENST00000588457 ENST00000592764 ENST00000591746 ENST00000589866 ENST00000588417
    ENST00000593007 ENST00000591922 ENST00000262173 ENST00000535051

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RNMT
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNMT
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate RNMT (see all 48):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-miR-30d hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNMT (see all 7)
    OriGene shRNA RFP: RNMT
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB007858.1 AB020966.1 AB022604.1 AB022605.1 AB022606.1 AF067791.1 AK292561.1 AK296370.1 
    AK303842.1 BC005290.1 BC017816.1 BC036798.1 BX647977.1 

    11 DOTS entries:

    DT.100646527  DT.447268  DT.100027990  DT.95113493  DT.121105653  DT.91706823  DT.75106249  DT.95114408 
    DT.121105663  DT.86843028  DT.95113495 

    24/216 AceView cDNA sequences (see all 216):

    CN481684 NM_003799 CA419807 AW082788 BE221160 AW072682 BM906284 CB130278 
    AL597621 BM787856 BQ682848 CA392317 AI094548 AA722651 AA678116 BM466040 
    AW592787 Z40575 AL134828 AW083082 BE348916 AI141759 AF067791 AI677823 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNMT (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:              -                                                                                       
    SP2:                                                                                                      
    SP3:                                                                          -                           
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for RNMT

    Expression
    for RNMT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTGTATAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RNMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNMT

    SOURCE GeneReport for Unigene cluster: Hs.592347

    UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for RNMT
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT

    Orthologs
    for RNMT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNMT gene from 10/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnmt1 , 5 RNA (guanine-7-) methyltransferase1, 5 81.77(n)1
    77.34(a)1    		   18 (41.22 cM)5
    678971  NM_026440.41  NP_080716.11 
     683003555 
    chicken
    (Gallus gallus)    		 Aves RNMT1 RNA (guanine-7-) methyltransferase 73.27(n)
    72.34(a)    		   421046  XM_419132.3  XP_419132.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNMT6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 4(43352633-43359190)
    African clawed frog
    (Xenopus laevis)    		 Amphibia xCMT12 mRNA (guanine-7-)-methyltransferase 75.83(n)    AF218795.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi09c122 Transcribed sequence with weak similarity to protein more 79.23(n)    57097207 
    fruit fly
    (Drosophila melanogaster)    		 Insecta l(2)35Bd1 , 3 mRNA (guanine-N7)-methyltransferase3
    lethal (2) 35Bd1    		 43(a)3
    53.12(n)1
    45.8(a)1    		   35B83
    348771  NM_078844.31  NP_523568.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea C25A1.33
    tag-721    		 Yeast ABD1 protein like3
    Protein TAG-721    		 40(a)3
    51.51(n)1
    42.99(a)1    		   I(10167719-10169953)3
    1828751  NM_060273.51  NP_492674.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ABD1(YBR236C)4
    ABD11    		 Methyltransferase, catalyzes the transfer of a methyl more4
    Abd1p1    		 50.62(n)1
    36.95(a)1    		   2(691693-690383)4
    8525381, 4  NP_009795.31  NP_009795.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G206501 mRNA cap guanine-N7 methyltransferase 1 51.32(n)
    41.24(a)    		   821612  NM_112956.5  NP_188701.2 
    rice
    (Oryza sativa)    		 Liliopsida Os08g01800001 hypothetical protein 46.99(n)
    39.45(a)    		   4344818  NM_001067671.1  NP_001061136.1 


    ENSEMBL Gene Tree for RNMT (if available)
    TreeFam Gene Tree for RNMT (if available) 

    Paralogs
    for RNMT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RNMT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/74 NCBI SNPs in RNMT are shown (see all 74)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739580291,2
    		C,--13678916(+) GGGGTG/AATGGC 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs454427961,2
    		C,--13679132(+) AACCAT/CTCCGA 1 -- us2k14Minor allele frequency- C:0.11NS NA WA 280
    rs455673461,2
    		C,--13679182(+) AGAAGA/C/GGGGGA 1 -- us2k11NS 40
    rs1152041761,2
    		C,F,--13679592(+) CGTGGG/ATCCGC 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs456015411,2
    		C,F,--13679713(+) CTTCTG/CCATGC 1 -- us2k13Minor allele frequency- C:0.03NS WA NA 274
    rs455614411,2
    		C,F,--13679837(+) CGCGTG/CGCGCG 1 -- us2k13Minor allele frequency- C:0.10NS WA NA 278
    rs734166441,2
    		C,--13679926(+) TTGTGT/GTTGTC 1 -- int12Minor allele frequency- G:0.03WA 120
    rs110806841,2
    		C,F,A,H,--13679971(+) CCACCC/ACTGAC 1 -- int18Minor allele frequency- A:0.26NA NS EA 292
    rs1143933831,2
    		C,F,--13680058(+) GAAAAT/CGGGAA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs739580301,2
    		C,--13680310(+) CGGGCC/GCCGTG 1 -- int12Minor allele frequency- G:0.07WA 120

    HapMap Linkage Disequilibrium report for RNMT (13726659 - 13764557 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RNMT
         1 Indel: 60257

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNMT
    DNA2.0 Custom Variant and Variant Library Synthesis for RNMT

    Disorders / Diseases
    for RNMT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNMT for disorders           About GeneDecksing

    OMIM gene information: 603514    OMIM disorders: --

    6 diseases for RNMT:    About MalaCards
    bowen-conradi syndrome    spina bifida    dubowitz syndrome    newcastle disease
    vaccinia    homocysteine

    2 diseases from the University of Copenhagen DISEASES database for RNMT:
    Vaccinia     Newcastle disease
    Human Genome Epidemiology (HuGE) Navigator: RNMT (2 documents)

    Export disorders for RNMT gene to outside databases

    Publications
    for RNMT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNMT gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with RNMT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PubMed id 9705270)1, 2, 3 Pillutla R.C.... Shatkin A.J. (1998)
    2. Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. (PubMed id 15767670)1, 2 Shafer B.... Shatkin A.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. (PubMed id 11114884)1, 2 Wen Y. and Shatkin A.J. (2000)
    5. Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. (PubMed id 10347220)1, 2 Saha N.... Shuman S. (1999)
    6. The Candida albicans gene for mRNA 5'-cap methyltransferase: identification of the additional residues essential for catalysis. (PubMed id 10589710)1, 2 Yamada-Okabe T....Yamada-Okabe H. (1999)
    7. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PubMed id 9828141)1, 3 Pillutla R.C....Shatkin A.J. (1998)
    8. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)methyltransferase, an mRNA cap methylase. (PubMed id 9790902)1, 2 Tsukamoto T.... Kiyohisa M. (1998)
    9. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for RNMT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNMT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8731 HGNC: 10075 AceView: RNMT Ensembl:ENSG00000101654 euGenes: HUgn8731
    ECgene: RNMT Kegg: 8731 H-InvDB: RNMT

    Other Databases showing RNMT gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0398

    Specialized Databases showing RNMT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNMT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNMT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNMT gene:
    Search GeneIP for patents involving RNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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