QRFP Gene
protein-coding GIFtS: 43
GCID: GC09M133768
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|
pyroglutamylated RFamide peptide
| |
Aliases
for QRFP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pyroglutamylated RFamide Peptide1 2 | | P5181 2 3 | | 26RFa1 2 | | Orexigenic Neuropeptide QRFP2 | | P518 Precursor Protein2 | | RF(Arg-Phe)Amide Family 26 Amino Acid Peptide (P518)2 |
Export aliases for QRFP gene to outside databasesPrevious GC identifers: GC09M132759 GC09M103255 |
Summaries
for QRFP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for QRFP:
The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide peptidesshare a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors (Jiang et al.,2003 (PubMed 12714592)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May haveorexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)
Gene Wiki entry for QRFP
|
Genomic Views
for QRFP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the QRFP gene promoter:
POU2F1a SEF-1 (1) Olf-1 AP-2gamma MRF-2 LCR-F1 c-Ets-1 GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for QRFP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRFP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.12 Ensembl cytogenetic band: 9q34.12 HGNC cytogenetic band: 9q34.12QRFP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M133768: view genomic region
(about GC identifiers)
Start:
|
133,768,815 bp from pter |
End:
|
133,769,225 bp from pter |
Size:
|
411 bases |
Orientation:
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minus strand |
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Proteins
for QRFP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859 (See
protein sequence)Recommended Name: Orexigenic neuropeptide QRFP precursor Size: 136 amino acids; 14941 Da
Subunit: Ligand for the G-protein coupled receptor QRFPR/GPR103 (By similarity)
Subcellular location: Secreted
Secondary accessions: A3KFJ6 Q495K6Explore the universe of human proteins at neXtProt for QRFP: NX_P83859
QRFP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_937823.1
ENSEMBL proteins: ENSP00000345487 Reactome Protein details: P83859
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
TAS | -- |
QRFP for ontologies About GeneDecksing
QRFP Antibody Products:
Assay Products for QRFP: |
Protein
Domains /
Families
for QRFP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QRFP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P83859ProtoNet protein and cluster: P83859 UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Similarity: Belongs to the RFamide neuropeptide family |
Function
for QRFP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May haveorexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRFP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRFP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for QRFP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRFP |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001664 | G-protein coupled receptor binding |
-- | -- | | GO:0005184 | neuropeptide hormone activity |
IDA | 14657341 | | GO:0031854 | orexigenic neuropeptide QRFP receptor binding |
ISS | -- |
QRFP for ontologies About GeneDecksing
|
Pathways & Interactions
for QRFP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for QRFP (see all 9)
QRFP for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRFP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/123 Interacting proteins for QRFP (ENSP000003454874) via UniProtKB, MINT, STRING, and/or I2D (see all 123)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
QRFP for ontologies About GeneDecksing
|
Drugs & Compounds
for QRFP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
QRFP for compounds About GeneDecksing
 Browse Tocris compounds for QRFP
1 Novoseek chemical compound relationship for QRFP gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rfamide |
87.4 |
6 |
14657341 (2), 16500002 (2) |
Search CenterWatch for drugs/clinical trials and news about QRFP / OX26
|
Transcripts
for QRFP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for QRFP gene: NM_198180.1 Unigene Cluster for QRFP: Pyroglutamylated RFamide peptide Hs.660704 [show with all ESTs]Unigene Representative Sequence: CV5753641 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000343079(uc011mcb.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRFP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRFP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: QRFP (NM_198179) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRFP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRFP |
Additional cDNA sequence: AB109625.1 BC101127.2 BC101128.1 1 DOTS entry: DT.101977537 2 AceView cDNA sequences: AB109625 NM_198180
GeneLoc Exon Structure
|
Expression
for QRFP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| QRFP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See QRFP Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.660704
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Tissue specificity: Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary,retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroidgland, prostate, testis, and thyroid
SABiosciences Custom PCR Arrays for QRFP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRFP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QRFP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRFP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRFP |
Orthologs
for QRFP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for QRFP gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for QRFP (if available)
TreeFam Gene Tree for QRFP (if available) |
Paralogs
for QRFP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for QRFP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for QRFP (133768815 - 133769225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for QRFP
1 CNV: 3782 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRFP |
|
Disorders
/ Diseases
for QRFP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
QRFP for disorders About GeneDecksing
OMIM gene information: 609795
OMIM disorders: --
3  diseases for QRFP: About MalaCardsaldosteronism thyroiditis prostatitis
Export disorders for QRFP gene to outside databases
|
Publications
for QRFP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for QRFP gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with QRFP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PubMed id 12714592)1, 2, 3 Jiang Y.... Zhang F.L. (2003)
- Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. (PubMed id 14657341)1, 2, 9 Chartrel N.... Vaudry H. (2003)
- A new peptidic ligand and its receptor regulating adrenal function in rats. (PubMed id 12960173)1, 2, 9 Fukusumi S.... Fujino M. (2003)
- Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. (PubMed id 15808908)1, 3 Thuau R....Vaudry H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Orexigenic neuropeptide 26RFa: new evidence for an ada ptive profile of appetite regulation in anorexia nervosa. (PubMed id 22466335)1 Galusca B....Chartrel N. (2012)
- GPR103b functions in the peripheral regulation of adi pogenesis. (PubMed id 20534693)1 Mulumba M....Ong H. (2010)
- Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. (PubMed id 16899066)1 Bruzzone F....Chartrel N. (2006)
- Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (2006)
- Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals. (PubMed id 15891009)1 Chartrel N....Vaudry H. (2005)
|
External Searches for QRFP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QRFP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QRFP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QRFP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for QRFP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for QRFP gene:
Search GeneIP for patents involving QRFP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for QRFP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for QRFP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for QRFP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRFP | | | OriGene Protein Over-expression Lysate for QRFP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for QRFP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRFP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRFP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat QRFP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRFP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRFP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QRFP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRFP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRFP |
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| | | | Search Tocris compounds for QRFP |
| |  |  |  |  | | | | |
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 | | | QRFP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for QRFP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRFP |
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