PTX3 Gene

Aliases
for PTX3 gene

Previous GC identifers: GC03P154190 GC03P158101 GC03P158436 GC03P158475 GC03P158637 GC03P154550

Summaries
for PTX3 gene

Genomic Views
for PTX3 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmids (see all 3): PTX3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PTX3

PTX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P157154:  view genomic region     (about GC identifiers)

Proteins
for PTX3 gene

Explore the universe of human proteins at neXtProt for PTX3: NX_P26022

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for PTX3 (Pentraxin 3/TSG-14)
	Enzo Life Sciences proteins for PTX3
	OriGene Purified Protein: PTX3 OriGene Protein Over-expression Lysate: PTX3 OriGene Custom Protein Services for PTX3
	GenScript Custom Purified and Recombinant Proteins Services for PTX3
	Novus Biologicals PTX3 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PTX3
	Uscn Proteins for PTX3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PTX3
	R&D Systems Antibodies for PTX3 (Pentraxin 3/TSG-14)
	OriGene Antibodies: PTX3 OriGene Custom Antibody Services for PTX3
	GenScript Custom Superior Antibodies Services for PTX3
	Novus Biologicals PTX3 Antibodies
	Abcam antibodies for PTX3
	Uscn Antibodies for PTX3
	Search ThermoFisher Antibodies for PTX3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for PTX3 (Pentraxin 3/TSG-14)         (see all)
	GenScript Custom Assay Services for PTX3
	Enzo Life Sciences assays for PTX3
	Uscn ELISAs and CLIAs for PTX3

Protein Domains /
Families
for PTX3 gene

ProtoNet protein and cluster: P26022

Function
for PTX3 gene

miRNA Products:		miRTarBase miRNAs that target PTX3: hsa-mir-21 (MIRT005954)
		OriGene 3'-UTR Clone: PTX3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PTX3
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PTX3 (see all 14):
		hsa-miR-224 hsa-miR-520d-5p hsa-miR-3660 hsa-miR-29c hsa-miR-29a hsa-miR-548s hsa-miR-410 hsa-miR-374c
		SwitchGear 3'UTR luciferase reporter plasmid: PTX3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PTX3 (see all 7) OriGene shRNA RFP: PTX3 OriGene siRNA: PTX3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PTX3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PTX3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PTX3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PTX3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PTX3 (NM_002852)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PTX3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PTX3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PTX3
		Search LifeMap BioReagents cell lines for PTX3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTX3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Ptx3)

Pathways & Interactions
for PTX3 gene

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for PTX3 gene

Transcripts
for PTX3 gene

Expression
for PTX3 gene

PTX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTTTCAG

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryAntral FollicleCumulus Cells			Ovary
	HeartAtrioventricular NodeAtrioventricular Node Cells			Myocardium
	HeartMyocardiumCardiac Fibroblasts			Epicardium
	KidneyInterstitial Stroma			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 9 LifeMap Cells
	Name			Category
	Human umbilical vein endothelial cells (HUVEC) (Primary Cell)			Endothelium
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)			Lateral Plate Mesoderm, Neural Crest
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)
	Fetal cardiomyocytes (20 weeks) (Primary Cell)			Heart, Myocardium
	GABA neuron-like cells (Generation of motor ...)			Brain
	CD31, CD144 positive cells (Two-step protocol fo...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PTX3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PTX3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PTX3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PTX3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PTX3

Orthologs
for PTX3 gene

Paralogs
for PTX3 gene

Paralogs for PTX3 gene

NPTX2²  APCS²  CBX6²  CRP²  PTX4²  NPTX1²  NPTXR²  

PTX3 for paralogs           About GeneDecksing

Genomic Variants
for PTX3 gene

10/167 NCBI SNPs in PTX3 are shown (see all 167)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs76156211,2	C,F,A,H,	--	157152600(+)	CCTGCT/ACCTTC	4	--	us2k1 int1		13		NS EA NA WA CSA	787
rs1401150761,2		--	157152602(+)	TGCACC/TTTCTA	4	--	us2k1 int1		0	--	--	--	--
rs1155575451,2	F,	--	157152694(+)	TTTTCG/ATCCTC	4	--	us2k1 int1		1		WA	118
rs1919152491,2		--	157152985(+)	AGTTTC/TAAACA	4	--	int1 us2k1		0	--	--	--	--
rs778634671,2	C,F,	--	157153073(+)	TCTGCT/CGATTC	4	--	us2k1 int1		1		WA	118
rs76161771,2	C,F,A,H,	--	157153208(+)	ACTCAG/AAGGGA	4	--	int1 us2k1		10		NA WA CSA EA	371
rs1172874611,2	F,	--	157153232(+)	AAAGAG/CAGACA	4	--	int1 us2k1		1		EA	120
rs117201201,2	C,H	--	157153261(+)	ttgtgC/AtagGG	4	--	us2k1 int1		1		NA	2
rs556894331,2	F,	--	157153268(+)	AGGGCA/GGAGTG	4	--	us2k1 int1		3		WA NA EA	358
rs1852298281,2		--	157153282(+)	TTGTAC/TCTACT	4	--	int1 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PTX3 (157154578 - 157161417 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PTX3
     1 CNV: 3459

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PTX3

DNA2.0 Custom Variant and Variant Library Synthesis for PTX3

Disorders / Diseases
for PTX3 gene

20/57 diseases for PTX3

10/19 Novoseek disease relationships for PTX3 gene (see all 19)    About this table

Publications
for PTX3 gene

PubMed articles for PTX3 gene, integrated from 9 sources (see all 232): (articles sorted by number of sources associating them with PTX3)

Utopia: connect your pdf to the dynamic world of online information

1. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. (PubMed id 1429570)^{1, 2, 3, 9} Breviario F.... Introna M. (1992)
2. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. (PubMed id 7679696)^{1, 2, 9} Lee G.W.... Vilcek J. (1993)
3. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. (PubMed id 7523502)^{1, 2, 9} Lee G.W.... Vilcek J. (1994)
4. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. (PubMed id 12763682)^{1, 2, 9} Mantovani A.... Bottazzi B. (2003)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. IL-1 inducible genes in human umbilical vein endothelial cells. (PubMed id 8131794)^{1, 2} Introna M....Mantovani A. (1993)
7. Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. (PubMed id 7949102)^{1, 9} Alles V.V....Mantovani A. (1994)
8. Pentraxin 3 is elevated in haemodialysis patients and is associated with cardiovascular disease. (PubMed id 17496115)^{1, 9} Boehme M....Schindler R. (2007)
9. Increased serum pentraxin 3 in patients with systemic sclerosis. (PubMed id 19273457)^{1, 9} Iwata Y....Sato S. (2009)
10. Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells. (PubMed id 18703503)^{1, 9} Doni A....Mantovani A. (2008)

External Searches for PTX3 gene

Genome Databases showing PTX3 gene

Other Databases showing PTX3 gene

Specialized Databases showing PTX3 gene

Products
for PTX3 gene