POLB Gene
protein-coding GIFtS: 68
GCID: GC08P042213
|
|
polymerase (DNA directed), beta
| |
Aliases
for POLB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Polymerase (DNA Directed), Beta1 2 | | Mutant DNA Polymerase Beta2 | | DNA Pol Beta2 | | EC 2.7.7.73 | | DNA Polymerase Beta2 | | EC 4.2.99.-3 | | DNA Polymerase Beta Subunit2 | | |
Export aliases for POLB gene to outside databasesPrevious GC identifers: GC08M041722 GC08P042220 GC08P041936 GC08P042315 GC08P040719 |
Summaries
for POLB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for POLB:
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNAsynthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to thenucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one hasbeen described to date. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746Function: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRPlyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashionrather than in a processive fashion as for other DNA polymerases
Gene Wiki entry for POLB (DNA polymerase beta)
|
Genomic Views
for POLB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the POLB gene promoter:
USF1 USF2 USF-1:USF-2 HNF-4alpha2 HNF-4alpha1 CREB Egr-2 Nkx6-1 deltaCREB USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for POLB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p12-p11POLB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P042213: view genomic region
(about GC identifiers)
Start:
|
42,195,972 bp from pter |
End:
|
42,229,326 bp from pter |
Size:
|
33,355 bases |
Orientation:
|
plus strand |
|
Proteins
for POLB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746 (See
protein sequence)Recommended Name: DNA polymerase beta Size: 335 amino acids; 38178 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47
Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus followingDNA damage
6/145 PDB 3D structures from  and Proteopedia  for POLB (see all 145):1BPX (3D)
1BPY (3D)
1BPZ (3D)
1MQ2 (3D)
1MQ3 (3D)
1TV9 (3D)
Secondary accessions: B2RC78 Q3KP48 Q6FI34Explore the universe of human proteins at neXtProt for POLB: NX_P06746
Post-translational modifications:
Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity1
Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then thetarget of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome.USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and itssubsequent degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P06746
POLB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002681.1
ENSEMBL proteins: ENSP00000432084 ENSP00000265421 ENSP00000430610 ENSP00000430784 ENSP00000429436 ENSP00000427799 ENSP00000428578 ENSP00000429597 ENSP00000430478 ENSP00000428144 ENSP00000430831 ENSP00000440497 Reactome Protein details: P06746
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
POLB for ontologies About GeneDecksing
POLB Antibody Products:
Assay Products for POLB: |
Protein
Domains /
Families
for POLB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
POLB for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P06746ProtoNet protein and cluster: P06746 2 Blocks protein families: IPB002008 DNA-polymerase family X pol beta-like signature IPB003583 Helix-hairpin-helix DNA-binding
UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746Domain: Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity (By similarity)Similarity: Belongs to the DNA polymerase type-X family |
Function
for POLB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPOLB_HUMAN, P06746Function: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRPlyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashionrather than in a processive fashion as for other DNA polymerasesCatalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) Genatlas biochemistry entry for POLB:polymerase (DNA directed),beta,39kDa,highly expressed (rat) in testis may be involved in DNA repair and in meiosis,notinvolved in DNA replication
Enzyme Numbers (IUBMB): EC 4.2.99.-1 EC 2.7.7.71
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: POLB (NM_002690) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLB |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
POLB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for POLB:
Animal Models:
Mouse knock-outs for POLB: Polbtm1Koy Polbtm1.1Rsky
13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Polb):
POLB for phenotypes About GeneDecksing
|
Pathways & Interactions
for POLB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Resolution of Abasic Sites (AP sites) | | | 2 | Base-Excision Repair, AP Site Formation | | | 3 | Formation of RNA Pol II elongation complex | | | 4 | Cell Cycle Control of Chromosomal Replication | | | 5 | Nucleotide Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for POLB
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POLB
1  GeneGo (Thomson Reuters) Pathway for POLB
1  BioSystems Pathway for POLB
5/7 
Reactome Pathways for POLB (see all 7)
1 
Kegg Pathway (Kegg details for POLB):
POLB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POLB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for POLB (P067461, 2, 3 ENSP000002654214) via UniProtKB, MINT, STRING, and/or I2D (see all 62)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
POLB for ontologies About GeneDecksing
|
Drugs & Compounds
for POLB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
POLB for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for POLB |
 Browse Tocris compounds for POLB
7 HMDB Compounds for POLB About this table
3 DrugBank Compounds for POLB About this table
10/72 Novoseek chemical compound relationships for POLB gene (see all 72) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dideoxythymidine |
82.2 |
6 |
9057979 (2), 1905189 (1), 8376804 (1), 2117783 (1) (see all 5) |
| parathion |
79.9 |
21 |
18717589 (2), 11123928 (2), 8647805 (2), 12196536 (2) (see all 14) |
| ddttp |
76.7 |
6 |
7918688 (1), 1657184 (1), 16283517 (1), 1315927 (1) |
| dctp |
74.1 |
11 |
17293403 (2), 1384425 (1), 8702991 (1), 17321545 (1) (see all 8) |
| 2-deoxyribonolactone |
74 |
8 |
16793362 (2), 11805079 (2), 20077202 (1), 16199212 (1) |
| aphidicolin |
72.8 |
9 |
7918688 (1), 1657184 (1), 9057979 (1), 1905189 (1) (see all 8) |
| triphosphate |
72.1 |
6 |
11123928 (2), 7516580 (1), 16043633 (1), 11376566 (1) (see all 5) |
| aphidicolin glycinate |
72 |
2 |
8674158 (1) |
| deoxynucleoside triphosphate |
71.9 |
3 |
10200168 (1), 11756435 (1) |
| 8-oxoguanine |
71.5 |
7 |
12517331 (2), 16054643 (2), 16051529 (1), 17293403 (1) |
Search CenterWatch for drugs/clinical trials and news about POLB / DPOLB
|
Transcripts
for POLB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for POLB gene: NM_002690.2 Unigene Cluster for POLB: Polymerase (DNA directed), beta Hs.654484 [show with all ESTs]Unigene Representative Sequence: CR62736518/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000532157 ENST00000523032 ENST00000265421(uc003xoz.2 uc011lcs.2)
ENST00000520008 ENST00000518925 ENST00000519094 ENST00000530566 ENST00000522297
ENST00000522610 ENST00000519771 ENST00000524208 ENST00000521290 ENST00000519524
ENST00000518579 ENST00000523465 ENST00000517393 ENST00000521492 ENST00000521418
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: POLB (NM_002690) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POLB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLB |
Additional cDNA sequence: AK223537.1 AK294025.1 AK314976.1 BC100288.1 BC106909.1 CR536503.1 CR541802.1 CR627365.1 D29013.1 JQ664683.1 JQ927442.1 L11607.1 M13140.1 17 DOTS entries: DT.95091040 DT.101960721 DT.121466683 DT.100794886 DT.95091024 DT.92054355 DT.87015228 DT.121466677 DT.97800015 DT.40276214 DT.87015231 DT.100794885 DT.121466675 DT.40314170 DT.121016792 DT.85100102 DT.91975491 24/198 AceView cDNA sequences (see all 198): CD671591 BG251605 BQ053443 BP370385 NM_002690 AI652201 AI128173 BP370570 CB141008 CB144384 AA421330 BX646755 CB125716 BM790436 BU166001 BQ186692 AI670950 CB139224 CA314334 AA315716 AU121247 BM684499 CR541802 BM725613
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for POLB (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for POLB
|
Expression
for POLB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| POLB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTATTAAA
About this image
See POLB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for POLB
SOURCE GeneReport for Unigene cluster: Hs.654484
SABiosciences Expression via Pathway-Focused PCR Arrays including POLB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POLB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLB |
Orthologs
for POLB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for POLB gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
POLB1 |
polymerase (DNA directed), beta |
79.6(n)
86.57(a) |
|
426794 XM_424407.3 XP_424407.2 |
lizard
(Anolis carolinensis) |
Reptilia |
POLB6 |
-- |
88(a) |
1 ↔ 1 |
GL343608.1(213735-225685) |
African clawed frog
(Xenopus laevis) |
Amphibia |
polB2 |
DNA polymerase beta |
76.58(n) |
|
Y15732.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
polb1 |
polymerase (DNA directed), beta |
73.73(n)
80.3(a) |
|
554204 NM_001003879.1 NP_001003879.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G105206 |
DNA polymerase lambda subunit |
20(a) |
1 → many |
1(3465964-3469248) |
rice
(Oryza sativa) |
Liliopsida |
-- |
DNA polymerase lambda, putative, expressed |
19(a) |
1 → many |
6(7127120-7132516) |
ENSEMBL Gene Tree for POLB (if available)
TreeFam Gene Tree for POLB (if available) |
Paralogs
for POLB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for POLB gene
- POLM2 DNTT2 POLL2
2 SIMAP similar genes for POLB using alignment to 12 protein entries: DPOLB_HUMAN (see all proteins):DNA pol beta POLL
POLB for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for POLB
PGOHUM00000249579
|
Genomic Variants
for POLB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for POLB (42195972 - 42229326 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for POLB: --
Human Gene Mutation Database (HGMD): POLB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLB |
|
Disorders
/ Diseases
for POLB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
POLB for disorders About GeneDecksing
OMIM gene information: 174760
OMIM disorders: --
20/44  diseases for POLB (see all 44): About MalaCardsfamilial adenomatous polyposis dna topoisomerase ii graft versus host disease adenomatous polyposis coli
acoustic neuroma werner syndrome neuroma polyposis
malignant glioma renal cell carcinoma esophageal carcinoma rhabdomyosarcoma
esophagitis colon cancer multiple sclerosis gastric cancer
carcinoma breast carcinoma colorectal cancer colon adenocarcinoma
2 diseases from the University of Copenhagen DISEASES database for POLB:Cancer Werner syndrome 10/25 Novoseek disease relationships for POLB gene (see all 25) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| myeloblastosis |
58.6 |
3 |
1371865 (1), 7687565 (1), 20104909 (1) |
| werner syndrome |
52.4 |
2 |
8168825 (1), 16449207 (1) |
| immunodeficiency |
31 |
17 |
15701045 (2), 8702991 (1), 9367179 (1), 7516580 (1) (see all 16) |
| familial adenomatous polyposis |
17.2 |
2 |
17999539 (1), 17176113 (1) |
| cancer |
16.5 |
12 |
15280658 (2), 11593426 (2), 15963946 (1), 16722994 (1) (see all 10) |
| tumors |
9.67 |
27 |
15280658 (2), 11593426 (2), 9078303 (1), 10357787 (1) (see all 25) |
| aids |
2.74 |
2 |
7516580 (1), 1932601 (1) |
| leukemia |
0 |
1 |
15701045 (1) |
| microsatellite instability |
0 |
1 |
12414629 (1) |
| rhabdomyosarcoma |
0 |
2 |
8012971 (1), 8674158 (1) |
Genetic Association Database (GAD): POLB
Human Genome Epidemiology (HuGE) Navigator: POLB (35 documents)
Export disorders for POLB gene to outside databases
|
Publications
for POLB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for POLB gene, integrated from 9 sources (see all 434):
(articles sorted by number of sources associating them with POLB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. (PubMed id 11805079)1, 2, 9 DeMott M.S.... Demple B. (2002)
- Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4, 9 Zienolddiny S....Haugen A. (2006)
- Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. (PubMed id 9207062)1, 2, 9 Bennett R.A....Demple B. (1997)
- A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. (PubMed id 8841119)1, 2, 9 Pelletier H.... Kraut J. (1996)
- USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta. (PubMed id 21362556)1, 2 Parsons J.L.... Dianov G.L. (2011)
- Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. (PubMed id 19713937)1, 2 Parsons J.L....Dianov G.L. (2009)
- Arginine methylation regulates DNA polymerase beta. (PubMed id 16600869)1, 2 El-Andaloussi N....Hottiger M.O. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of DNA polymerase beta with the mutagenic DNA lesion 8- oxodeoxyguanine reveals structural insights into its coding potential. (PubMed id 12517346)1, 2 Krahn J.M.... Wilson S.H. (2003)
- Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups. (PubMed id 9572863)1, 2 Matsumoto Y.... Feng J.-A. (1998)
|
External Searches for POLB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing POLB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing POLB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing POLB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for POLB gene:
Search GeneIP for patents involving POLB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for POLB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for POLB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POLB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POLB | | | OriGene Protein Over-expression Lysate for POLB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for POLB | | OriGene 3'-UTR Clone for POLB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POLB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POLB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for POLB | | OriGene Custom Protein Services for POLB | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POLB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POLB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POLB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POLB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POLB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POLB |
| |
 |  |  |  | |
| | | | Search Tocris compounds for POLB |
| |  |  |  |  | | | | | | Recombinant Protein for POLB |
|
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLB |
|  |  |  | | | | ThermoFisher Antibodies for POLB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POLB |
|
|
|
|
