PEX6 Gene
protein-coding GIFtS: 60
GCID: GC06M042978
|
|
peroxisomal biogenesis factor 6
| |
Aliases
for PEX6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peroxisomal Biogenesis Factor 61 2 3 | | PDB4B2 | | PXAAA11 2 3 5 | | Peroxin-63 | | PAF-21 2 3 | | Peroxisomal AAA-Type ATPase 12 | | Peroxisomal-Type ATPase 12 3 | | Peroxisome Assembly Factor 22 | | PAF22 5 | | Peroxisome Biogenesis Factor 62 | | PBD4A2 | | Peroxin-63 |
Export aliases for PEX6 gene to outside databasesPrevious GC identifers: GC06M042933 GC06M043039 GC06M042648 |
Summaries
for PEX6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PEX6:
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. Thismember is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is requiredfor PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity.Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6.(provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: PEX6_HUMAN, Q13608Function: Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 toperoxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins intoperoxisomes
Gene Wiki entry for PEX6
|
Genomic Views
for PEX6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PEX6 gene promoter:
STAT1 AML1a STAT1beta YY1 Evi-1 STAT1alpha Egr-2 HOXA5 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PEX6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEX6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p22-p11PEX6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M042978: view genomic region
(about GC identifiers)
Start:
|
42,931,608 bp from pter |
End:
|
42,946,981 bp from pter |
Size:
|
15,374 bases |
Orientation:
|
minus strand |
|
Proteins
for PEX6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PEX6_HUMAN, Q13608 (See
protein sequence)Recommended Name: Peroxisome assembly factor 2 Size: 980 amino acids; 104061 Da
Subunit: Interacts directly with PEX26 and PEX1. Mediates the indirect interaction between PEX1 and PEX26. Interactswith ZFAND6
Subcellular location: Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes
Secondary accessions: Q8WYQ2 Q99476Explore the universe of human proteins at neXtProt for PEX6: NX_Q13608
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13608
PEX6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000278.3
ENSEMBL proteins: ENSP00000303511 ENSP00000244546
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PEX6 for ontologies About GeneDecksing
PEX6 Antibody Products:
Assay Products for PEX6: |
Protein
Domains /
Families
for PEX6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PEX6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13608ProtoNet protein and cluster: Q13608 1 Blocks protein family: IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: PEX6_HUMAN, Q13608Similarity: Belongs to the AAA ATPase family |
Function
for PEX6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PEX6_HUMAN, Q13608Function: Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 toperoxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins intoperoxisomes Genatlas biochemistry entry for PEX6:peroxin 6,peroxisome biogenesis factor 6
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEX6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEX6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PEX6 (NM_000287) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PEX6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEX6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEX6 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PEX6 for ontologies About GeneDecksing
|
Pathways & Interactions
for PEX6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Peroxisome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for PEX6):
PEX6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PEX6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/24 Interacting proteins for PEX6 (Q136081, 2, 3 ENSP000003035114) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
PEX6 for ontologies About GeneDecksing
|
Drugs & Compounds
for PEX6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PEX6 for compounds About GeneDecksing
 Browse Tocris compounds for PEX6
5 Novoseek chemical compound relationships for PEX6 gene About this table
Search CenterWatch for drugs/clinical trials and news about PEX6
|
Transcripts
for PEX6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PEX6 gene: NM_000287.3 Unigene Cluster for PEX6: Peroxisomal biogenesis factor 6 Hs.656425 [show with all ESTs]Unigene Representative Sequence: NM_0002872 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304611(uc003otf.3 uc010jya.3) ENST00000244546
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEX6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEX6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PEX6 (NM_000287) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PEX6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEX6 |
Additional cDNA sequence: AB051076.1 AB051077.1 AB051078.1 AK314237.1 BC033487.1 BC048331.1 D83703.1 11 DOTS entries: DT.97772771 DT.100783318 DT.91664193 DT.95280068 DT.100774435 DT.121394179 DT.40131739 DT.99980029 DT.100770460 DT.100783317 DT.99938508 24/140 AceView cDNA sequences (see all 140): CK819544 CN481379 BC048331 BQ773648 BM767959 NM_000287 AI654922 AB051077 BM128966 CN481492 AA324773 BQ053030 CB266400 AB051076 BQ065854 BX114032 BQ054426 BC033487 AI651017 AI093165 BX397653 BC026732 AI689909 BE245286
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PEX6 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PEX6
|
Expression
for PEX6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PEX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PEX6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PEX6
SOURCE GeneReport for Unigene cluster: Hs.656425
SABiosciences Custom PCR Arrays for PEX6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEX6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PEX6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEX6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEX6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEX6 |
Orthologs
for PEX6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PEX6 gene from 7/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PEX61 |
peroxisomal biogenesis factor 6 |
67.79(n)
68.31(a) |
|
416709 XM_415006.3 XP_415006.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PEX66 |
-- |
60(a) |
1 ↔ 1 |
2(144862111-144876941) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch73-197b13.21 |
si:ch73-197b13.2 |
54.79(n)
50.94(a) |
|
792998 XM_001332616.4 XP_001332652.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG119193 |
peroxisome organization and biogenesis |
38(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
prx-63 |
ATPase |
35(a) |
|
V(4715239-4719853) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PEX61 |
peroxin 6 |
47.72(n)
43.15(a) |
|
839315 NM_100181.4 NP_171799.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.250462 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
71.47(n) |
|
AK067035.1 |
ENSEMBL Gene Tree for PEX6 (if available)
TreeFam Gene Tree for PEX6 (if available) |
Paralogs
for PEX6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PEX6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PEX6 (42931608 - 42946981 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PEX6: --
Human Gene Mutation Database (HGMD): PEX6
Locus Specific Mutation Databases (LSDB): PEX6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PEX6 |
|
Disorders
/ Diseases
for PEX6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PEX6 for disorders About GeneDecksing
OMIM gene information: 601498
OMIM disorders: --
UniProtKB/Swiss-Prot: PEX6_HUMAN, Q13608
Defects in PEX6 are the cause of peroxisome biogenesis disorder complementation group 4 (PBD-CG4)[MIM:614862]; also known as PBD-CGC. PBD refers to a group of peroxisomal disorders arising from a failure of proteinimport into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome(ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasiapunctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlappingphenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 14 distinctgenetic groups as concluded from complementation studies Defects in PEX6 are the cause of peroxisome biogenesis disorder 4A (PBD4A) [MIM:614862]. A fatal peroxisomebiogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologicdysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities,liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular andskeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals withthe classic form of the disease (classic Zellweger syndrome) die within the first year of life Defects in PEX6 are the cause of peroxisome biogenesis disorder 4B (PBD4B) [MIM:614863]. A peroxisomebiogenesis disorder that includes neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD), two mildermanifestations of the Zellweger disease spectrum. The clinical course of patients with the NALD and IRD presentationis variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinaldystrophy and vision impairment. Children with the NALD presentation may reach their teens, while patients with theIRD presentation may reach adulthood. The clinical conditions are often slowly progressive in particular with respectto loss of hearing and vision. The biochemical abnormalities include accumulation of phytanic acid, very long chainfatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid
20/28  diseases for PEX6 (see all 28): About MalaCardsperoxisomal biogenesis disorder, complementation group 4 peroxisomal biogenesis disorder peroxisome biogenesis disorders peroxisome biogenesis factor
peroxisomal biogenesis disorder, complementation group 6 peroxisome biogenesis disorders, zellweger syndrome spectrum maternally inherited leigh syndrome beta-ketothiolase deficiency
rhizomelic chondrodysplasia punctata open-angle glaucoma chondrodysplasia punctata zellweger syndrome spectrum
ketothiolase deficiency zellweger syndrome refsum disease infantile refsum disease
neonatal adrenoleukodystrophy hypertrophic cardiomyopathy familial hypertrophic cardiomyopathy adrenoleukodystrophy
3 diseases from the University of Copenhagen DISEASES database for PEX6:Zellweger syndrome Infantile refsum disease Adrenoleukodystrophy 4 Novoseek disease relationships for PEX6 gene About this table
GeneTests: PEX6
Zellweger Syndrome Spectrum
Export disorders for PEX6 gene to outside databases
|
Publications
for PEX6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PEX6 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with PEX6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor. (PubMed id 8670792)1, 2, 3, 9 Yahraus T.... Gould S.J. (1996)
- Genomic structure and identification of 11 novel mutations of the PEX6 'peroxisome assembly factor-2' gene in patients with peroxisome biogenesis disorders. (PubMed id 10408779)1, 2, 9 Zhang Z.... Kondo N. (1999)
- Human peroxisome assembly factor-2 (PAF-2): a gene responsible for group C peroxisome biogenesis disorder in humans. (PubMed id 8940266)1, 2, 9 Fukuda S.... Kondo N. (1996)
- The peroxin Pex6p gene is impaired in peroxisomal biogenesis disorders of complementation group 6. (PubMed id 11355018)1, 2, 9 Matsumoto N.... Fujiki Y. (2001)
- Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. (PubMed id 19105186)1, 2, 9 Yik W.Y....Hacia J.G. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. (PubMed id 12717447)1, 2 Matsumoto N.... Fujiki Y. (2003)
- Spectrum of PEX6 mutations in Zellweger syndrome spec trum patients. (PubMed id 19877282)1, 9 Ebberink M.S....Waterham H.R. (2010)
- Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease. (PubMed id 9671729)1, 9 Geisbrecht B.V....Gould S.J. (1998)
- Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p. (PubMed id 16854980)1, 9 Tamura S....Fujiki Y. (2006)
|
External Searches for PEX6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PEX6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PEX6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PEX6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PEX6 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PEX6 | | dbPEX, PEX Gene Database | http://www.dbpex.org/home.php?select_db=PEX6 |
|
| | |
About This Section
| Patent Information for PEX6 gene:
Search GeneIP for patents involving PEX6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PEX6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PEX6 | | OriGene shRNA RFP for PEX6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEX6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEX6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PEX6 | | OriGene 3'-UTR Clone for PEX6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEX6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEX6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PEX6 | | OriGene Custom Protein Services for PEX6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PEX6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PEX6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEX6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEX6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEX6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEX6 |
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| | | | Search Tocris compounds for PEX6 |
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 | | | PEX6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEX6 |
|  |  |  | | | | ThermoFisher Antibodies for PEX6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEX6 |
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