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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PAPOLG Gene

protein-coding   GIFtS: 53
GCID: GC02P060983

poly(A) polymerase gamma

 Explore 1 disease affiliated with
PAPOLG via our new
 Human Malady Compendium 
Biological research products
for PAPOLG
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Poly(A) Polymerase Gamma1 2     Neo-PAP3
Neo-Poly(A) Polymerase2 3     Nuclear Poly(A) Polymerase Gamma2
Polynucleotide Adenylyltransferase Gamma2 3     SRP RNA 3' Adenylating Enzyme/Pap22
PAP-Gamma1     Neo-PAP3
SRP RNA 3'-Adenylating Enzyme2 3     PAP23
EC 2.7.7.193 8     PAPG3
FLJ129721     

External Ids:    HGNC: 149821   Entrez Gene: 648952   Ensembl: ENSG000001154217   UniProtKB: Q9BWT33   

Export aliases for PAPOLG gene to outside databases

Previous GC identifers: GC02P061111 GC02P060941 GC02P060957 GC02P060895 GC02P060836 GC02P060725


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PAPOLG:
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3'
end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at
the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is
exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity
factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene,
which is located on chromosome 14. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
Function: Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small
RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA

Gene Wiki entry for PAPOLG


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PAPOLG gene promoter:
         E2F-4   E2F-5   E2F-1   E2F   E2F-2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPAPOLG promoter sequence
   Search SABiosciences Chromatin IP Primers for PAPOLG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PAPOLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

PAPOLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAPOLG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P060983:  view genomic region     (about GC identifiers)

Start:
60,983,365 bp from pter      End:
61,029,221 bp from pter
Size:
45,857 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3 (See protein sequence)
Recommended Name: Poly(A) polymerase gamma  
Size: 736 amino acids; 82803 Da
Cofactor: Binds 2 magnesium ions. Also active with manganese (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=BAB14604.1; Type=Erroneous initiation;
Secondary accessions: B2RBH4 Q969N1 Q9H8L2 Q9HAD0

Explore the universe of human proteins at neXtProt for PAPOLG: NX_Q9BWT3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BWT3

  • 4/10 DME Specific Peptides for PAPOLG (Q9BWT3) (see all 10)
     WAMLVAR  CQLYPNA  KFFLVFS  SESKNLP 

    PAPOLG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_075045.2  
    ENSEMBL proteins: 
     ENSP00000238714   ENSP00000405599   ENSP00000414070   ENSP00000405570  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--


    PAPOLG for ontologies           About GeneDecksing



    PAPOLG Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PAPOLG for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR007012 PolA_pol_cen_dom
     IPR002934 Nucleotidyltransferase
     IPR007010 PolA_pol_RNA-bd_dom
     IPR014492 PolyA_polymerase
     IPR011068 NuclTrfase_I_C

    Graphical View of Domain Structure for InterPro Entry Q9BWT3

    ProtoNet protein and cluster: Q9BWT3

    2 Blocks protein families:
    IPB002934 DNA polymerase
    IPB007012 Poly(A) polymerase


    UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
    Similarity: Belongs to the poly(A) polymerase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
    Function: Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small
    RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA
    Catalytic activity: ATP + RNA(n) = diphosphate + RNA(n+1)

    Enzyme Number (IUBMB): EC 2.7.7.191 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAPOLG
    8/151 QIAGEN miScript miRNA Assays for microRNAs that regulate PAPOLG (see all 151):
    hsa-miR-411* hsa-miR-579 hsa-miR-3653 hsa-miR-200b hsa-miR-3612 hsa-miR-30b* hsa-miR-455-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPAPOLG 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPOLG

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004652polynucleotide adenylyltransferase activity IBA--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--


    PAPOLG for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PAPOLG:
     Increased homologous recombina 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA surveillance pathway
    mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for PAPOLG):
        mRNA surveillance pathway


    PAPOLG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PAPOLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for PAPOLG (Q9BWT33 ENSP000002387144) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
    NFYAP235113, ENSP000003457024I2D: score=1 STRING: ENSP00000345702
    PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
    CPSF3ENSP000002381124STRING: ENSP00000238112
    CPSF2ENSP000002988754STRING: ENSP00000298875
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006378mRNA polyadenylation IBA--
    GO:0006397mRNA processing ----
    GO:0043631RNA polyadenylation ----


    PAPOLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PAPOLG

    3 HMDB Compounds for PAPOLG    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about PAPOLG / PAPOG 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PAPOLG gene: 
    NM_022894.3  

    Unigene Cluster for PAPOLG:

    Poly(A) polymerase gamma
    Hs.387471  [show with all ESTs]
    Unigene Representative Sequence: NM_022894
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238714 ENST00000496283 ENST00000414060 ENST00000453839 ENST00000483370
    ENST00000412217(uc002sai.3 uc002saj.3 uc002sak.3 uc010fch.3)
    ENST00000470208

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PAPOLG
    8/151 QIAGEN miScript miRNA Assays for microRNAs that regulate PAPOLG (see all 151):
    hsa-miR-411* hsa-miR-579 hsa-miR-3653 hsa-miR-200b hsa-miR-3612 hsa-miR-30b* hsa-miR-455-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPAPOLG 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PAPOLG (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PAPOLG
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PAPOLG (NM_022894)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PAPOLG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PAPOLG

    Additional cDNA sequence: 

    AB209304.1 AF075029.1 AF312211.1 AJ308101.1 AK021867.1 AK023034.1 AK023544.1 AK024249.1 
    AK314663.1 AY029162.1 BC016738.1 BC028593.2 BC068493.1 BC110906.1 BC111701.1 BC113747.1 
    BX647824.1 

    9 DOTS entries:

    DT.440367  DT.108261  DT.97764195  DT.92426087  DT.91977037  DT.40120101  DT.100751014  DT.95369399 
    DT.95151734 

    24/80 AceView cDNA sequences (see all 80):

    AL708655 AI926507 AU119633 AF312211 BU674687 AK023034 AI872488 BQ229755 
    NM_022894 BX279843 AK024249 CF541139 AJ308101 BM692821 BM671387 BG498675 
    AI279419 AK023544 AI694611 AA461432 AI480041 AW515951 AW504644 AI690023 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PAPOLG (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
    SP1:                                                                                                                    -                                   -   
    SP2:                                                                                                                                                            
    SP3:              -     -                                                                                                                                       
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19 ^ 20a · 20b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PAPOLG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PAPOLG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PAPOLG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PAPOLG

    SOURCE GeneReport for Unigene cluster: Hs.387471

    UniProtKB/Swiss-Prot: PAPOG_HUMAN, Q9BWT3
    Tissue specificity: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors

        SABiosciences Custom PCR Arrays for PAPOLG
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PAPOLG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PAPOLG gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008571961 poly(A) polymerase gamma-like 73.86(n)
    73.91(a)
      100857196  XM_003640881.1  XP_003640929.1 
    lizard
    (Anolis carolinensis)
    Reptilia PAPOLG6
    --
    64(a)
    1 ↔ 1
    1(259426924-259455630)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420228072   -- 78.79(n)    142022807 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637622 hypothetical protein MGC63762 76.21(n)   393593  BC056818.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hrg1 , 3 mRNA polyadenylation polynucleotide
    adenylyltransferase3
    hiiragi1
    55(a)3
    53.77(n)1
    55.37(a)1
      56E33
    496361  NM_166372.11  NP_725919.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T15H9.63 poly(A) polymerase 45(a)
    (best of 2)
      II(9607641-9609305)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAPS11 poly(A) polymerase 1 48.97(n)
    41.42(a)
      838378  NM_101661.4  NP_173240.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g03196001 hypothetical protein 53.19(n)
    47.23(a)
      4340886  NM_001064042.2  NP_001057507.2 


    ENSEMBL Gene Tree for PAPOLG (if available)
    TreeFam Gene Tree for PAPOLG (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PAPOLG gene
    PAPOLB2  PAPOLA2  
    3 SIMAP similar genes for PAPOLG using alignment to 8 protein entries:     PAPOG_HUMAN (see all proteins):
    PAPOLB    PAPOLA    TPAP

    PAPOLG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/775 NCBI SNPs in PAPOLG are shown (see all 775    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830316601,2
    --60981641(+) CTTGGC/TTGGGT 1 -- us2k10--------
    rs1876564291,2
    --60981652(+) GTGGTA/GGCTCA 1 -- us2k10--------
    rs778279161,2
    C,--60981696(+) TGGGCA/GGATTA 1 -- us2k10--------
    rs621493751,2
    C,F,--60981709(+) TGATGT/ACAGGA 1 -- us2k15Minor allele frequency- A:0.23NA WA EA 362
    rs67611321,2
    C,--60981888(+) AACCTC/TTGCCT 1 -- us2k13Minor allele frequency- T:0.24NA WA 240
    rs76089651,2
    C,F,A,--60981897(+) CTCTCG/AGGTTC 1 -- us2k19Minor allele frequency- A:0.26NA WA CSA EA 369
    rs751695891,2
    C--60981971(-) ATACAA/GAAAAC 1 -- us2k13Minor allele frequency- G:0.17NA 6
    rs753212221,2
    C--60981984(+) TTAGTA/TGAGAC 1 -- us2k13Minor allele frequency- T:0.00NA 6
    rs772231431,2
    F--60982021(+) GCCTCG/AAACTC 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs65458311,2
    C,F,H,--60982103(+) GCCACG/ATCAGG 1 -- us2k1 tfbs327Minor allele frequency- A:0.44NS EA NA WA CSA 2769

    HapMap Linkage Disequilibrium report for PAPOLG (60983365 - 61029221 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PAPOLG
         3 CNVs: 2386 3361 8373

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PAPOLG for disorders           About GeneDecksing

    1 disease for PAPOLG:    About MalaCards
    malaria


    Export disorders for PAPOLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PAPOLG gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with PAPOLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. (PubMed id 11463842)1, 2 Topalian S.L....Manley J.L. (2001)
    4. Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. (PubMed id 11287430)1, 2 Perumal K.... Reddy R. (2001)
    5. A novel nuclear human poly(A) polymerase (PAP), PAP gamma. (PubMed id 11431479)1, 9 Kyriakopoulou C.B....Virtanen A. (2001)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. A single mutation in human mitochondrial DNA polymera se Pol gammaA affects both polymerization and proofreading activities of only t he holoenzyme. (PubMed id 20513922)1 Lee Y.S....Yin Y.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64895 HGNC: 14982 AceView: PAPOLG Ensembl:ENSG00000115421 euGenes: HUgn64895
    ECgene: PAPOLG Kegg: 64895 H-InvDB: PAPOLG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PAPOLG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PAPOLG gene:
    Search GeneIP for patents involving PAPOLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in PAPOLG promoter
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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