OLFM2 Gene
protein-coding GIFtS : 54
GCID: GC19 M009964
olfactomedin 2
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Aliasesfor OLFM2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Olfactomedin 2 1 2 Neuronal Olfactomedin Related ER Localized Protein 22 NOE21 2 3 Noelin 22 OlfC1 2 Noelin-21 NOELIN22 Olfactomedin-23 NOELIN2_V12 Olfactomedin-23
Export aliases for OLFM2 gene to outside databases Previous GC identifers: GC19M010085 GC19M010187 GC19M009809 GC19M009825 GC19M009545
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Summariesfor OLFM2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for OLFM2
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Genomic Viewsfor OLFM2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011295.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OLFM2 gene promoter: Max Bach1 ER-alpha USF1 USF-1 Bach2 USF2 USF-1:USF-2 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for OLFM2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFM2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2 OLFM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M009964: view genomic region
(about GC identifiers )
Start:
9,964,394 bp from pter
End:
10,047,228 bp from pter
Size:
82,835 bases
Orientation:
minus strand
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Proteinsfor OLFM2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NOE2_HUMAN, O95897 (See
protein sequence )Recommended Name: Noelin-2 precursor Size : 454 amino acids; 51386 Da
Subunit : Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-formingGluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity)
Subcellular location : Secreted (Probable). Cell junction, synapse (By similarity)
Secondary accessions : Q6IMJ3 Q96FC2Explore the universe of human proteins at neXtProt for OLFM2: NX_O95897 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O95897 OLFM2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_477512.1 ENSEMBL proteins: ENSP00000264833 ENSP00000464877 ENSP00000466018 ENSP00000465809 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
OLFM2 for ontologies About GeneDecksing OLFM2 Antibody Products: Assay Products for OLFM2:
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Protein
Domains / Familiesfor OLFM2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
OLFM2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O95897 ProtoNet protein and cluster: O95897
1 Blocks protein family : IPB003112 Olfactomedin-like UniProtKB/Swiss-Prot: NOE2_HUMAN, O95897 Similarity : Contains 1 olfactomedin-like domain
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Functionfor OLFM2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OLFM2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OLFM2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OLFM2 (NM_058164 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OLFM2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OLFM2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM2
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Pathways & Interactionsfor OLFM2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OLFM2 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5/15 Interacting proteins for OLFM2 (O95897 2 , 3 ENSP00000264833 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 15 )About this table
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Drugs & Compoundsfor OLFM2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for OLFM2 Search CenterWatch for drugs/clinical trials and news about OLFM2 / NOE2
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Transcriptsfor OLFM2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OLFM2 gene: NM_058164.2 Unigene Cluster for OLFM2:
Olfactomedin 2 Hs.169743 [show with all ESTs ] Unigene Representative Sequence: BM920627 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000264833 (uc002mmp.3 ) ENST00000590841 ENST00000592448 ENST00000593091 ENST00000590410 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OLFM2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OLFM2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OLFM2 (NM_058164 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OLFM2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OLFM2
Additional cDNA sequence: AF131839.1 BC011361.1
4 DOTS entries : DT.437658 DT.95071875
DT.91707321 DT.100837294 24/114 AceView cDNA sequences (see all 114 ):
CR597123 AI902497 CR592581 BM554133 CR592038 C00947 CR594920 T04866 CR598222 R40423 BM479224 AW962045 AW273242 CR604836 AI834308 CR612883 CR606369 BM690143 BI917371 BQ428091 BI914004 BI834112 BF341903 CA425768 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for OLFM2 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c SP1 :     -         -           SP2 :             -           SP3 :           -   -           SP4 :     -                  
ECgene alternative splicing isoforms for OLFM2
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Expression for OLFM2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OLFM2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GATCTGTTTC
About this image OLFM2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See OLFM2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OLFM2 SOURCE GeneReport for Unigene cluster: Hs.169743 SABiosciences Custom PCR Arrays for OLFM2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OLFM2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat OLFM2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OLFM2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OLFM2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM2
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Orthologsfor OLFM2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for OLFM2 gene from 5/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for OLFM2 (if available)TreeFam Gene Tree for OLFM2 (if available)
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Paralogsfor OLFM2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for OLFM2 gene GLDN 2 OLFM3 2 OLFML2B 2 MYOC 2 OLFML3 2 OLFML2A 2 OLFM1 2 OLFML1 2 OLFM4 2 9 SIMAP similar genes for OLFM2 using alignment to 5 protein entries: NOE2_HUMAN (see all proteins ):OLFM1 OLFM3 OLFML2B FLJ00237 OLFML2A MYOC LPHN3 LPHN2 LPHN1
OLFM2 for paralogs About GeneDecksing
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Genomic Variantsfor OLFM2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for OLFM2 (9964394 - 10047228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for OLFM2 1 CNV : 5084 Human Gene Mutation Database (HGMD) : OLFM2 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OLFM2
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Disorders
/ Diseasesfor OLFM2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
OLFM2 for disorders About GeneDecksing 3 diseases for OLFM2 : About MalaCards open-angle glaucoma neuronitis glaucoma 1 disease from the University of Copenhagen DISEASES database for OLFM2 :Glaucoma Human Genome Epidemiology (HuGE) Navigator: OLFM2 (1 document)Export disorders for OLFM2 gene to outside databases
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Publicationsfor OLFM2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OLFM2 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with OLFM2) Utopia : connect your pdf to the dynamic world of online information
Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PubMed id 15123989) 1 , 2 , 9 Mukhopadhyay A.... Ray K. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 1 , 2 Grimwood J.... Lucas S.M. (2004) SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. (PubMed id 17122126) 1 , 9 Funayama T....Shimada N. (2006) Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462) 1 Elks C.E....Murray A. (2010) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PubMed id 12766061) 1 Tomarev S.I....Malyukova I. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for OLFM2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OLFM2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OLFM2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing OLFM2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for OLFM2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for OLFM2 gene: Search GeneIP for patents involving OLFM2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OLFM2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for OLFM2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for OLFM2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OLFM2 OriGene Protein Over-expression Lysate for OLFM2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OLFM2 OriGene 3'-UTR Clone for OLFM2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OLFM2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OLFM2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OLFM2 OriGene Custom Protein Services for OLFM2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OLFM2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OLFM2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFM2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat OLFM2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OLFM2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OLFM2
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OLFM2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFM2
ThermoFisher Antibodies for OLFM2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OLFM2
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Aliases for OLFM2
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Disorders / Diseases for OLFM2
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Drugs / Compounds for OLFM2
Expression for OLFM2
Function for OLFM2
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Pathways / Interactions for OLFM2
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Transcripts for OLFM2
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