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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OGFR Gene

protein-coding   GIFtS: 52
GCID: GC20P061436

opioid growth factor receptor
 Explore 14 diseases affiliated with
OGFR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OGFR    

Aliases
for OGFR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Opioid Growth Factor Receptor1 2
Protein 7-602 3
Zeta-Type Opioid Receptor2 3
7-601
7-60 Protein2
OGFr3

External Ids:    HGNC: 157681   Entrez Gene: 110542   Ensembl: ENSG000000604917   OMIM: 6064595   UniProtKB: Q9NZT23   

Export aliases for OGFR gene to outside databases

Previous GC identifers: GC20P061313 GC20P062115 GC20P062162 GC20P060906 GC20P058154


Summaries
for OGFR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OGFR:
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as (Met(5))-enkephalin. OGF
is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound
receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the
nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units.
Several transcripts containing between zero and eight repeat units have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth
regulation

Gene Wiki entry for OGFR (OGFr)


Genomic Views
for OGFR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011333.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OGFR gene promoter:
         Brachyury   HNF-4alpha2   Ik-3   HNF-4alpha1   PPAR-gamma1   POU2F1   CP2   POU2F1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OGFR promoter sequence
   Search SABiosciences Chromatin IP Primers for OGFR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OGFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

OGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OGFR gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061436:  view genomic region     (about GC identifiers)

Start:
 61,436,177 bp from pter      End:
 61,445,352 bp from pter
Size:
 9,176 bases      Orientation:
 plus strand

Proteins
for OGFR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2 (See protein sequence)
Recommended Name: Opioid growth factor receptor  
Size: 677 amino acids; 73325 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=The OGF/OGFR complex is probably
translocated to the nucleus
Sequence caution: Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Sequence=AAD03745.1; Type=Frameshift;
Positions=1, 181; Sequence=CAC28882.1; Type=Erroneous gene model prediction;
Secondary accessions: O96029 Q4VXW5 Q96CM2 Q9BQW1 Q9H4H0 Q9H7J5 Q9NZT3 Q9NZT4
Alternative splicing: 2 isoforms:  Q9NZT2-1   Q9NZT2-2   

Explore the universe of human proteins at neXtProt for OGFR: NX_Q9NZT2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZT2

    • OGFR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031372.2  
    ENSEMBL proteins: 
     ENSP00000290291   ENSP00000359499   ENSP00000359491   ENSP00000395168  

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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OGFR

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--


    OGFR for ontologies           About GeneDecksing



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    Uscn Antibodies for OGFR
    Search ThermoFisher Antibodies for OGFR

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    Uscn ELISAs and CLIAs for OGFR

    Protein Domains /
    Families
    for OGFR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OGFR for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006757 OGF_rcpt
     IPR006770 OGF_rcpt_rpt

    Graphical View of Domain Structure for InterPro Entry Q9NZT2

    ProtoNet protein and cluster: Q9NZT2

    1 Blocks protein family: IPB006757 Opioid growth factor receptor (OGFr) conserved region

    UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
    Similarity: Belongs to the opioid growth factor receptor family


    Function
    for OGFR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
    Function: Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth
    regulation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OGFR
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OGFR:
    hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-670 hsa-miR-125b hsa-miR-524-5p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: OGFR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OGFR (see all 7)
    OriGene shRNA RFP: OGFR
    OriGene siRNA: OGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OGFR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OGFR

    Clone
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    GenScript: all cDNA clones in your preferred vector: OGFR (NM_007346)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGFR 

    Cell Line
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    Search LifeMap BioReagents cell lines for OGFR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGFR

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0004985opioid receptor activity NAS10677613


    OGFR for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for OGFR:
     Cell division defect  Increased S DNA content  Increased number of mitotic ce 


    Pathways & Interactions
    for OGFR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/12 pathways (see all 12)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		Cellular Apoptosis Pathway0.65
    		p53 Mediated Apoptosis0.84
    		ERK5 Signaling0.61
    		Mitochondrial Apoptosis0.73
    		eIF2 Pathway0.60
    		Telomerase Components in Cell Signaling0.72
    		Rac1 Pathway0.58
    2CREB Pathway
    		CREB Pathway1.00
    		Activation of PKC through GPCR0.63
    		IP3 Pathway0.68
    3TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		MAPK Family Pathway0.60
    4PTEN Pathway
    		PTEN Pathway1.00
    		Phospholipase-C Pathway0.56
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for OGFR (see all 29)
        MAPK Signaling
    Nuclear Receptor Activation by Vitamin-A
    DHA Signaling
    Actin-Based Motility by Rho Family GTPases
    Telomerase Components in Cell Signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OGFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for OGFR (Q9NZT23 ENSP000002902914) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    ATG10Q9H0Y03I2D: score=1 
    GSTK1Q9Y2Q33I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS10677613
    GO:0038003opioid receptor signaling pathway NAS10677613


    OGFR for ontologies           About GeneDecksing



    Drugs & Compounds
    for OGFR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OGFR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OGFR
    1 Novoseek chemical compound relationship for OGFR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naltrexone 80 7 19683562 (1), 17332915 (1), 19605761 (1), 17974995 (1)

    Search CenterWatch for drugs/clinical trials and news about OGFR 

    Transcripts
    for OGFR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OGFR gene: 
    NM_007346.2  

    Unigene Cluster for OGFR:

    Opioid growth factor receptor
    Hs.67896  [show with all ESTs]
    Unigene Representative Sequence: AF172453
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290291(uc002ydj.3 uc002ydk.3) ENST00000370468 ENST00000370461(uc002ydl.3)
    ENST00000450048

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OGFR
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OGFR:
    hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-670 hsa-miR-125b hsa-miR-524-5p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: OGFR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OGFR (see all 7)
    OriGene shRNA RFP: OGFR
    OriGene siRNA: OGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OGFR
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OGFR (NM_007346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OGFR 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OGFR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OGFR

    Additional cDNA sequence: 

    AF109134.1 AF172449.1 AF172450.1 AF172451.1 AF172452.1 AF172453.1 AK022234.1 AK314696.1 
    BC008768.2 BC014137.2 BC032666.1 

    17 DOTS entries:

    DT.100774374  DT.75153574  DT.100774376  DT.100774380  DT.100774373  DT.100680511  DT.100774382  DT.100774377 
    DT.120821617  DT.421390  DT.102830219  DT.120821608  DT.120821623  DT.120821639  DT.91727063  DT.95198481 
    DT.95198510 

    24/201 AceView cDNA sequences (see all 201):

    BU181115 BU623154 BM562128 CN482202 BG121198 AU121661 CD673049 BM551600 
    BM126905 BM914572 CB216777 CA433738 BM755951 BM470017 CK906337 BM723315 
    AW118282 CD672065 CA454373 BM552204 CA390011 AI468339 BG251627 BM555341 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OGFR (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:        -     -           -                 -                                       
    SP2:        -     -           -                 -                                       
    SP3:                                            -                                       
    SP4:                                                                                    
    SP5:        -     -                                                                     


    ECgene alternative splicing isoforms for OGFR

    Expression
    for OGFR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OGFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCACAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OGFR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OGFR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OGFR

    SOURCE GeneReport for Unigene cluster: Hs.67896

    UniProtKB/Swiss-Prot: OGFR_HUMAN, Q9NZT2
    Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser
    extent in brain and pancreas. Expressed in fetal tissues including liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including OGFR: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OGFR

    Orthologs
    for OGFR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for OGFR gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ogfr1 , 5 opioid growth factor receptor1, 5 67.36(n)1
    59.49(a)1    		   2 (103.13 cM)5
    720751  NM_031373.31  NP_113550.31 
     1805892455 
    chicken
    (Gallus gallus)    		 Aves OGFR1 opioid growth factor receptor 54.24(n)
    47.63(a)    		   428150  XM_425708.3  XP_425708.2 
    lizard
    (Anolis carolinensis)    		 Reptilia OGFR6
    		 --
    		 61(a)
    		 1 ↔ 1
    		 4(152419751-152428190)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC054206.12   -- 72.31(n)    BC054206.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CK018359.12   -- 79.45(n)    CK018359.1 


    ENSEMBL Gene Tree for OGFR (if available)
    TreeFam Gene Tree for OGFR (if available) 

    Paralogs
    for OGFR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OGFR gene
    OGFRL12  
    1 SIMAP similar gene for OGFR using alignment to 4 protein entries:     OGFR_HUMAN (see all proteins):
    OGFRL1

    OGFR for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OGFR
    PGOHUM00000244582 PGOHUM00000246597


    Genomic Variants
    for OGFR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/296 NCBI SNPs in OGFR are shown (see all 296)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1443912501,2
    		C,--61434291(+) CTCTG-/CACACAC 1 -- us2k10--------
    rs1850998251,2
    		--61434334(+) AGAAGA/CAATTT 1 -- us2k10--------
    rs1878566741,2
    		--61434376(+) GCAATA/GTCTCT 1 -- us2k10--------
    rs1159396221,2
    		--61434450(+) TCCCCG/ATAGAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1384674701,2
    		--61434594(+) CCCCCA/GACTCC 1 -- us2k10--------
    rs1143202711,2
    		--61434699(+) GCCCTG/TGCCAC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1923583631,2
    		--61434710(+) TGCACC/TAAGTT 1 -- us2k10--------
    rs1430356071,2
    		--61434875(+) GGTCCC/TTAACC 1 -- us2k10--------
    rs1846216721,2
    		--61435027(+) CTCCAC/TCTTTC 1 -- us2k10--------
    rs117001921,2
    		C,F,H,--61435047(+) CATTAC/TAGGGA 1 -- us2k118Minor allele frequency- T:0.04NS EA NA WA 2340

    HapMap Linkage Disequilibrium report for OGFR (61436177 - 61445352 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OGFR
         1 CNV: 31044

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    Disorders / Diseases
    for OGFR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OGFR for disorders           About GeneDecksing

    OMIM gene information: 606459    OMIM disorders: --

    14 diseases for OGFR:    About MalaCards
    squamous cell carcinoma of the head and neck    squamous cell carcinoma    keratopathy    colon cancer
    pancreatic cancer    pancreatitis    thyroid cancer    hepatocellular cancer
    ovarian cancer    thyroiditis    adenocarcinoma    carcinoma
    leukemia    breast cancer

    6 Novoseek disease relationships for OGFR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 57.7 18 9121309 (2), 12655527 (2), 16685459 (2), 18813788 (2) (see all 10)
    pancreatic cancer 44 10 17332915 (3), 18636152 (3), 10601579 (1)
    tumors 35.6 64 12655527 (6), 16685459 (5), 18813788 (3), 12747745 (3) (see all 16)
    cancer 29.3 7 19675283 (3), 19835629 (1), 12747745 (1), 10569617 (1)
    colon cancer 22.3 6 16820893 (2), 8760211 (2)
    adenocarcinoma 0 1 10601579 (1)


    Export disorders for OGFR gene to outside databases

    Publications
    for OGFR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OGFR gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with OGFR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PubMed id 10677613)1, 2, 3, 9 Zagon I.S.... McLaughlin P.J. (2000)
    2. The biology of the opioid growth factor receptor (OGFr). (PubMed id 11890982)1, 2, 9 Zagon I.S.... McLaughlin P.J. (2002)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    7. Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. (PubMed id 16685459)1, 9 McLaughlin P.J. and Zagon I.S. (2006)
    8. Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation. (PubMed id 19244545)1, 9 Cheng F....Zagon I.S. (2009)
    9. Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck. (PubMed id 17273790)1, 9 McLaughlin P.J....Zagon I.S. (2007)
    10. Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. (PubMed id 18636152)1, 9 Zagon I.S....McLaughlin P.J. (2008)

    External Searches for OGFR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OGFR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11054 HGNC: 15768 AceView: OGFR Ensembl:ENSG00000060491 euGenes: HUgn11054
    ECgene: OGFR H-InvDB: OGFR

    Other Databases showing OGFR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OGFR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OGFR Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/OGFr

    Intellectual Property
    for OGFR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OGFR gene:
    Search GeneIP for patents involving OGFR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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