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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKIRAS1 Gene

protein-coding   GIFtS: 50
GCID: GC03M023933

NFKB inhibitor interacting Ras-like 1

(Previous name: NFKB inhibitor interacting Ras-like protein 1 )
 Explore 4 diseases affiliated with
NKIRAS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKIRAS1    

Aliases
for NKIRAS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NFKB Inhibitor Interacting Ras-Like 11 2     I-Kappa-B-Interacting Ras-Like Protein 12 3
KBRAS11 2 3     Kappa B-Ras 12
KappaB-Ras13     NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 12
NFKB Inhibitor Interacting Ras-Like Protein 11 2     KappaB-Ras13
Kappa B-Ras Protein 12 3     

External Ids:    HGNC: 178991   Entrez Gene: 285122   Ensembl: ENSG000001978857   OMIM: 6044965   UniProtKB: Q9NYS03   

Export aliases for NKIRAS1 gene to outside databases

Previous GC identifers: GC03M023908 GC03M023879


Summaries
for NKIRAS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B
subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB




Genomic Views
for NKIRAS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKIRAS1 gene promoter:
         AML1a   NRSF form 1   NRSF form 2   NF-kappaB   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   Msx-1   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKIRAS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKIRAS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKIRAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.1

NKIRAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M023933:  view genomic region     (about GC identifiers)

Start:
 23,933,151 bp from pter      End:
 23,988,082 bp from pter
Size:
 54,932 bases      Orientation:
 minus strand

Proteins
for NKIRAS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 1  
Size: 192 amino acids; 21643 Da
Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only
interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also
interacts with c-Rel (REL)
Subcellular location: Cytoplasm
Secondary accessions: Q96K18

Explore the universe of human proteins at neXtProt for NKIRAS1: NX_Q9NYS0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYS0

    • NKIRAS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065078.1  
    ENSEMBL proteins: 
     ENSP00000373411   ENSP00000393785   ENSP00000392307   ENSP00000400385   ENSP00000406543  
     ENSP00000396063   ENSP00000415225   ENSP00000394214  

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    Novus Biologicals NKIRAS1 Proteins
    Novus Biologicals NKIRAS1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NKIRAS1
    Uscn Proteins for NKIRAS1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--


    NKIRAS1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NKIRAS1

    Protein Domains /
    Families
    for NKIRAS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKIRAS1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9NYS0

    ProtoNet protein and cluster: Q9NYS0

    UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the
    conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar
    to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly
    different from other small GTPases proteins
    Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


    Function
    for NKIRAS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
    degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
    degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B
    subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKIRAS1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NKIRAS1 (see all 14):
    hsa-miR-607 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-4272 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKIRAS1 (see all 7)
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKIRAS1

    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10657303
    GO:0005525GTP binding IEA--


    NKIRAS1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nkiras1tm1Brs for NKIRAS1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nkiras1):
     no phenotypic analysis 

    NKIRAS1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NKIRAS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway1.00


    1 BioSystems Pathway for NKIRAS1 
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKIRAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/17 Interacting proteins for NKIRAS1 (Q9NYS03 ENSP000003734114) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    NFKBIBQ156533, ENSP000003129884I2D: score=3 STRING: ENSP00000312988
    NFKBIAP259633, ENSP000002167974I2D: score=2 STRING: ENSP00000216797
    BMPR1BO002383, ENSP000002645684I2D: score=3 STRING: ENSP00000264568
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007249I-kappaB kinase/NF-kappaB cascade NAS10657303
    GO:0007264small GTPase mediated signal transduction IEA--


    NKIRAS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKIRAS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKIRAS1

    1 HMDB Compound for NKIRAS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about NKIRAS1 / KBRS1 

    Transcripts
    for NKIRAS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKIRAS1 gene: 
    NM_020345.3  

    Unigene Cluster for NKIRAS1:

    NFKB inhibitor interacting Ras-like 1
    Hs.173202  [show with all ESTs]
    Unigene Representative Sequence: NM_020345
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388759 ENST00000443659 ENST00000421515(uc003cck.3) ENST00000425478(uc003ccj.3)
    ENST00000437230 ENST00000412028 ENST00000415901 ENST00000416026

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NKIRAS1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKIRAS1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NKIRAS1 (see all 14):
    hsa-miR-607 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-4272 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKIRAS1 (see all 7)
    OriGene shRNA RFP: NKIRAS1
    OriGene siRNA: NKIRAS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKIRAS1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKIRAS1

    Additional cDNA sequence: 

    AF229839.1 AK027749.1 BC012145.1 BC066940.1 BC150589.1 

    7 DOTS entries:

    DT.100811879  DT.100811882  DT.120901956  DT.97822718  DT.100811880  DT.102839491  DT.120902089 

    24/93 AceView cDNA sequences (see all 93):

    CR600782 AA010714 BE504686 CA426818 CR606911 CA429686 CR602142 AA010575 
    AA370473 AW002634 AF229839 NM_020345 AI470823 BC012145 N79148 AA458628 
    AA551591 AI302092 BM696013 AI187968 AL533534 BE936194 W47636 AI796219 

    GeneLoc Exon Structure


    Expression
    for NKIRAS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKIRAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTGAGGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NKIRAS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKIRAS1

    SOURCE GeneReport for Unigene cluster: Hs.173202

    UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:     
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    Orthologs
    for NKIRAS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NKIRAS1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nkiras11 , 5 NFKB inhibitor interacting Ras-like protein 11, 5 86.81(n)1
    95.31(a)1    		   14 (7.08 cM)5
    697211  NM_023526.31  NP_076015.21 
     182711365 
    chicken
    (Gallus gallus)    		 Aves NKIRAS11 NFKB inhibitor interacting Ras-like 1 76.01(n)
    78.34(a)    		   420654  XM_418753.3  XP_418753.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NKIRAS16
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343357.1(669754-682964)
    zebrafish
    (Danio rerio)    		 Actinopterygii nkiras11 NFKB inhibitor interacting Ras-like 1 68.24(n)
    73.3(a)    		   100002175  NM_001100076.1  NP_001093546.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG305031 CG30503 51.31(n)
    43.82(a)    		   246656  NM_001144141.2  NP_001137613.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F52A8.61 Protein F52A8.6 49.73(n)
    43.85(a)    		   172487  NM_059675.5  NP_492076.1 


    ENSEMBL Gene Tree for NKIRAS1 (if available)
    TreeFam Gene Tree for NKIRAS1 (if available) 

    Paralogs
    for NKIRAS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKIRAS1 gene
    NKIRAS22  
    14 SIMAP similar genes for NKIRAS1 using alignment to 2 protein entries:     KBRS1_HUMAN (see all proteins):
    NKIRAS2    RAB7B    RHEBL1    DKFZp547A0616    RAP1B    KRAS
    RAP2A    RAP2B    NRAS    RALB    RAP2C    c-bas/has
    RRAS2    HRAS

    NKIRAS1 for paralogs           About GeneDecksing



    Genomic Variants
    for NKIRAS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/438 NCBI SNPs in NKIRAS1 are shown (see all 438)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs14691,2
    		C,H,--23933804(+) TATGAC/ATAGTT 1 -- ut315Minor allele frequency- A:0.00MN NS EA 604
    rs1429561111,2
    		--23933835(+) AGATAC/GAGTCT 1 -- ut310--------
    rs89331,2
    		C,F,A,H,--23933969(-) ATCACG/TCTCTA 1 -- ut3129Minor allele frequency- T:0.16MN NA NS EA WA CSA 3180
    rs67899831,2
    		C,F,A,H,--23934115(+) TGTTTT/GGGGTC 1 -- ut3122Minor allele frequency- G:0.13NA NS EA WA 2470
    rs1507040231,2
    		--23934122(+) GGTCCA/TATTTA 1 -- ut310--------
    rs1925319711,2
    		--23934132(+) AGACAC/TAAAAA 1 -- ut310--------
    rs799687701,2
    		--23934225(+) ACACAG/TAATGA 1 -- ut310--------
    rs348690951,2
    		C,F,--23934277(-) CACCTA/GTGTGT 1 -- ut313Minor allele frequency- G:0.03NS WA 206
    rs1494651241,2
    		--23934322(+) TCACAA/CGTACA 1 -- ut310--------
    rs1843868711,2
    		--23934392(+) TATTAA/TTTCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NKIRAS1 (23933151 - 23988082 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKIRAS1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKIRAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKIRAS1

    Disorders / Diseases
    for NKIRAS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKIRAS1 for disorders           About GeneDecksing

    OMIM gene information: 604496    OMIM disorders: --

    4 diseases for NKIRAS1:    About MalaCards
    renal cell carcinoma    rheumatoid arthritis    arthritis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: NKIRAS1 (2 documents)

    Export disorders for NKIRAS1 gene to outside databases

    Publications
    for NKIRAS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKIRAS1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NKIRAS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 3, 9 Fenwick C....Ghosh S. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)1, 2 Chen Y.... Ghosh G. (2004)
    5. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PubMed id 12672800)1, 2 Chen Y.... Ghosh G. (2003)
    6. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 9 Dieguez-Gonzalez R....Gonzalez A. (2008)
    7. Prognostic significance of kappaB-Ras1 expression in g liomas. (PubMed id 21302000)1 Lin H....Cheng J. (2012)
    8. [Methylation of some miRNA genes is involved in the re gulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]. (PubMed id 23156677)1 Khodyrev D.S....Braga E.A. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    External Searches for NKIRAS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NKIRAS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28512 HGNC: 17899 AceView: NKIRAS1 Ensembl:ENSG00000197885 euGenes: HUgn28512
    ECgene: NKIRAS1 H-InvDB: NKIRAS1

    Other Databases showing NKIRAS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKIRAS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKIRAS1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKIRAS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKIRAS1 gene:
    Search GeneIP for patents involving NKIRAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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