NEIL1 Gene
protein-coding GIFtS: 55
GCID: GC15P075639
|
|
nei endonuclease VIII-like 1 (E. coli)
| |
Aliases
for NEIL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nei Endonuclease VIII-Like 1 (E. Coli)1 2 | | DNA Glycosylase/AP Lyase Neil12 3 | | FPG11 2 3 | | DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil12 3 | | NEI11 2 | | FLJ224021 | | HFPG11 | | Endonuclease 8-Like 12 | | Endonuclease VIII-Like 12 3 | | Endonuclease VIII2 | | Nei Homolog 12 3 | | EC 3.2.2.-3 | | Nei-Like Protein 12 3 | | EC 4.2.99.183 | | NEH12 3 | | |
Export aliases for NEIL1 gene to outside databasesPrevious GC identifers: GC15P071517 GC15P068730 GC15P073215 GC15P073355 GC15P073426 GC15P052397 |
Summaries
for NEIL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NEIL1:
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzymeparticipates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarilyoxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Feb 2012)
UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylasethat recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol,formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-deltaelimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNAglycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches
Gene Wiki entry for NEIL1
|
Genomic Views
for NEIL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEIL1 gene promoter:
c-Fos USF1 AP-1 NRSF form 1 NRSF form 2 YY1 FOXO4 USF-1 HSF1short c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEIL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEIL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q33.33NEIL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P075639: view genomic region
(about GC identifiers)
Start:
|
75,639,296 bp from pter |
End:
|
75,647,592 bp from pter |
Size:
|
8,297 bases |
Orientation:
|
plus strand |
|
Proteins
for NEIL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4 (See
protein sequence)Recommended Name: Endonuclease 8-like 1 Size: 390 amino acids; 43684 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Nucleus. Chromosome. Note=During mitosis, associates withcentrosomes and condensed chromatin
Rna editing: Modified_positions=242; Note=The edited form removes thymine glycol from duplex DNA 30 times more slowlythan the form encoded in the genome, whereas editing enhances repair of the guanidinohydantoin lesion by NEIL1. Therecoding site is a preferred editing site for the RNA editing adenosine deaminase ADAR1
Sequence caution: Sequence=AK128372; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction;
1 PDB 3D structure from  and Proteopedia  for NEIL1:1TDH (3D)
Secondary accessions: D3DW75 Q6ZRA7 Q86XW7 Q9H6C3Explore the universe of human proteins at neXtProt for NEIL1: NX_Q96FI4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96FI4
NEIL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243481.1 NP_078884.2
ENSEMBL proteins: ENSP00000456466 ENSP00000347170 ENSP00000457541 ENSP00000457081 ENSP00000455745 ENSP00000454729 ENSP00000456945 ENSP00000455949 ENSP00000457352 ENSP00000455730 ENSP00000457056 ENSP00000456852 ENSP00000454292 ENSP00000457371
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NEIL1 for ontologies About GeneDecksing
NEIL1 Antibody Products:
Assay Products for NEIL1: |
Protein
Domains /
Families
for NEIL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEIL1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96FI4ProtoNet protein and cluster: Q96FI4 UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4Similarity: Belongs to the FPG family |
Function
for NEIL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylasethat recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol,formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-deltaelimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNAglycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatchesCatalytic activity: Removes damaged bases from DNA, leaving an abasic siteCatalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-eliminationreaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphateInduction: Up-regulated during S-phaseEnzyme Numbers (IUBMB): EC 4.2.99.181 EC 3.2.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NEIL1 (NM_024608) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEIL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
NEIL1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NEIL1:
Animal Models:
Mouse knock-outs for NEIL1: Neil1tm1Rsld Neil1tm1Bjor
12 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Neil1):
NEIL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NEIL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Resolution of Abasic Sites (AP sites) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for NEIL1):
NEIL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEIL1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for NEIL1 (Q96FI43 ENSP000003471704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
NEIL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEIL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NEIL1 for compounds About GeneDecksing
 Browse Tocris compounds for NEIL1
1 DrugBank Compound for NEIL1 About this table
10/12 Novoseek chemical compound relationships for NEIL1 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 2,6-diamino-4-hydroxy-5-formamidopyrimidine |
90.5 |
1 |
15595846 (1) |
| fapy |
90.1 |
3 |
8734295 (1), 15595846 (1), 19496823 (1) |
| 5-hydroxyuracil |
89.9 |
3 |
18662981 (1), 18032376 (1), 14522990 (1) |
| dihydrouracil |
88.5 |
8 |
15907775 (4) |
| thymine glycol |
88.4 |
1 |
15319300 (1) |
| 8-oxoguanine |
83.4 |
2 |
15350146 (1), 14522990 (1) |
| polynucleotide |
60 |
1 |
16982218 (1) |
| phosphonate |
56.7 |
3 |
16982218 (1), 15260972 (1), 17715144 (1) |
| cytosine |
53.4 |
1 |
14522990 (1) |
| oxygen |
26.1 |
5 |
16118226 (2), 17611195 (1), 17389588 (1) |
Search CenterWatch for drugs/clinical trials and news about NEIL1
|
Transcripts
for NEIL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NEIL1 gene (2 alternative transcripts): NM_001256552.1 NM_024608.3 Unigene Cluster for NEIL1: Nei endonuclease VIII-like 1 (E. coli) Hs.512732 [show with all ESTs]Unigene Representative Sequence: AK09700818/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24): ENST00000564500 ENST00000355059(uc002bad.3) ENST00000566752 ENST00000566313
ENST00000568059 ENST00000568881 ENST00000561643 ENST00000567959 ENST00000564951
ENST00000568519 ENST00000569390 ENST00000567657 ENST00000564784 ENST00000569035(uc002bae.3)
ENST00000567681 ENST00000565051 ENST00000564257 ENST00000567005
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NEIL1 (NM_024608) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEIL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL1 |
Additional cDNA sequence: AB079068.1 AK026055.1 AK026216.1 AK097008.1 BC010876.1 NR_046311.1 20 DOTS entries: DT.214283 DT.75186708 DT.101984918 DT.100780758 DT.97858864 DT.87017892 DT.95310279 DT.100780754 DT.121052741 DT.40222964 DT.121052678 DT.100834116 DT.121052819 DT.121052950 DT.91758166 DT.95169184 DT.100670599 DT.100682869 DT.40195464 DT.91818435 24/122 AceView cDNA sequences (see all 122): AI913135 AA370630 AK097008 AI393566 AW575225 AI865117 BF058910 AI290102 BI908874 CA944521 AI638424 AW444910 CA442550 W80730 BQ028756 AI816136 BM678088 CD722353 AA830735 BQ028738 AW439765 AI925612 BI916872 AI816095
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NEIL1 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | - | | - | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | - | | - | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NEIL1
|
Expression
for NEIL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NEIL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAAATGC
About this image
See NEIL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEIL1
SOURCE GeneReport for Unigene cluster: Hs.512732
UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including NEIL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEIL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEIL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEIL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEIL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL1 |
Orthologs
for NEIL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NEIL1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Neil11 , 5 |
nei endonuclease VIII-like 1 (E. coli)1, 5 |
81.49(n)1
79.69(a)1 |
|
9 (30.89 cM)5
727741 NM_028347.21 NP_082623.11
571432565 |
chicken
(Gallus gallus) |
Aves |
NEIL11 |
nei endonuclease VIII-like 1 (E. coli) |
64.53(n)
58.72(a) |
|
770068 NM_001080876.1 NP_001074345.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ054799.12 |
-- |
71.8(n) |
|
BJ054799.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc563612 |
similar to nei endonuclease VIII-like 1 (E. coli) |
73.38(n) |
|
393253 AY398387.1 |
ENSEMBL Gene Tree for NEIL1 (if available)
TreeFam Gene Tree for NEIL1 (if available) |
Paralogs
for NEIL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NEIL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NEIL1 (75639296 - 75647592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NEIL1: --
Human Gene Mutation Database (HGMD): NEIL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEIL1 |
|
Disorders
/ Diseases
for NEIL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEIL1 for disorders About GeneDecksing
OMIM gene information: 608844
OMIM disorders: --
20/21  diseases for NEIL1 (see all 21): About MalaCardssteroid-resistant nephrotic syndrome sclerosing cholangitis primary sclerosing cholangitis cholangitis
nephrotic syndrome cockayne syndrome werner syndrome familial colorectal cancer
renal cell carcinoma squamous cell carcinoma gigantism multiple sclerosis
colorectal cancer gastric cancer lung cancer breast cancer
adenoma carcinoma hypoxia tuberculosis
1 Novoseek disease relationship for NEIL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
3 |
19443904 (2), 18594018 (1) |
Human Genome Epidemiology (HuGE) Navigator: NEIL1 (9 documents)
Export disorders for NEIL1 gene to outside databases
|
Publications
for NEIL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NEIL1 gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with NEIL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. (PubMed id 11904416)1, 2, 3, 9 Hazra T.K.... Mitra S. (2002)
- The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. (PubMed id 15232006)1, 2, 9 Doublie S.... Wallace S.S. (2004)
- Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PubMed id 14522990)1, 2, 9 Dou H.... Hazra T.K. (2003)
- A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. (PubMed id 12509226)1, 2, 9 Bandaru V.... Bond J.P. (2002)
- Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. (PubMed id 21697813)1, 2 Sanna-Cherchi S.... Gharavi A.G. (2011)
- RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. (PubMed id 21068368)1, 2 Yeo J.... Beal P.A. (2010)
- Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis. (PubMed id 17556049)1, 2 Hildrestrand G.A....Luna L. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. (PubMed id 12200441)1, 2 Takao M.... Yasui A. (2002)
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External Searches for NEIL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NEIL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NEIL1 gene
(According to HUGE)
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Specialized Databases showing NEIL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for NEIL1 gene:
Search GeneIP for patents involving NEIL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NEIL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for NEIL1 | | OriGene shRNA RFP for NEIL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEIL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEIL1 | | | OriGene Protein Over-expression Lysate for NEIL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NEIL1 | | OriGene 3'-UTR Clone for NEIL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NEIL1 | | OriGene Custom Protein Services for NEIL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEIL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEIL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEIL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEIL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEIL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEIL1 |
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| | | | Search Tocris compounds for NEIL1 |
| |  |  |  |  | | | | | | Recombinant Protein for NEIL1 |
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 | | | NEIL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL1 |
|  |  |  | | | | ThermoFisher Antibodies for NEIL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL1 |
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