MT4 Gene
protein-coding GIFtS: 43
GCID: GC16P056598
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metallothionein 4(Previous name: metallothionein IV )
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Aliases
for MT4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Metallothionein 41 2 | | MT-IV2 3 | | MTIV1 2 5 | | Metallothionein-41 | | Metallothionein IV1 2 | | Metallothionein-IV3 | | MT-42 3 | | Metallothionein-IV3 |
Export aliases for MT4 gene to outside databasesPrevious GC identifers: GC16P046982 GC16P056650 GC16P056333 GC16P056374 GC16P055156 GC16P042469 |
Summaries
for MT4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MT4_HUMAN, P47944Function: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during thedifferentiation of stratified epithelia
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Genomic Views
for MT4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MT4 gene promoter:
TBP SRY IRF-2 NF-1 AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13MT4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P056598: view genomic region
(about GC identifiers)
Start:
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56,598,961 bp from pter |
End:
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56,602,869 bp from pter |
Size:
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3,909 bases |
Orientation:
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plus strand |
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Proteins
for MT4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MT4_HUMAN, P47944 (See
protein sequence)Recommended Name: Metallothionein-4 Size: 62 amino acids; 6509 Da
Secondary accessions: Q14DA1Explore the universe of human proteins at neXtProt for MT4: NX_P47944
MT4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116324.1
ENSEMBL proteins: ENSP00000219162
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
NAS | -- |
MT4 for ontologies About GeneDecksing
MT4 Antibody Products:
Assay Products for MT4: |
Protein
Domains /
Families
for MT4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MT4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47944ProtoNet protein and cluster: P47944 UniProtKB/Swiss-Prot: MT4_HUMAN, P47944Similarity: Belongs to the metallothionein superfamily. Type 1 family |
Function
for MT4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MT4_HUMAN, P47944Function: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during thedifferentiation of stratified epithelia
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MT4 (NM_032935) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MT4 for ontologies About GeneDecksing
|
Pathways & Interactions
for MT4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT4
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006875 | cellular metal ion homeostasis |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
MT4 for ontologies About GeneDecksing
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Drugs & Compounds
for MT4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MT4 for compounds About GeneDecksing
 Browse Tocris compounds for MT4
1 HMDB Compound for MT4 About this table
2 Novoseek chemical compound relationships for MT4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
49 |
3 |
16556599 (2), 8003488 (1) |
| copper |
26.6 |
1 |
16556599 (1) |
Search CenterWatch for drugs/clinical trials and news about MT4
|
Transcripts
for MT4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MT4 gene: NM_032935.2 Unigene Cluster for MT4: Metallothionein 4 Hs.567624 Unigene Representative Sequence: BC1134421 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000219162(uc002eje.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MT4 (NM_032935) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT4 |
Additional cDNA sequence: BC113442.1 BC113444.1 1 DOTS entry: DT.99949145 1 AceView cDNA sequence: NM_032935
GeneLoc Exon Structure
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Expression
for MT4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCCATCC
About this image
See MT4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT4
SOURCE GeneReport for Unigene cluster: Hs.567624
SABiosciences Custom PCR Arrays for MT4
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT4 |
Orthologs
for MT4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for MT4 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1C5U7_CHICK6 |
Metallothionein |
54(a) |
1 ↔ 1 |
11(2100507-2103780) |
lizard
(Anolis carolinensis) |
Reptilia |
MT46 |
-- |
62(a) |
1 ↔ 1 |
GL343675.1(166582-172851) |
zebrafish
(Danio rerio) |
Actinopterygii |
mt26 |
metallothionein 2 |
62(a) |
1 → many |
18(17193795-17195147) |
ENSEMBL Gene Tree for MT4 (if available)
TreeFam Gene Tree for MT4 (if available) |
Paralogs
for MT4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MT4 gene
- MT1G2 MT1E2 MT1X2 MT1F2 MT1B2 MT2A2 MT1M2 MT1A2
- MT32 MT1H2
12 SIMAP similar genes for MT4 using alignment to 1 protein entry: MT4_HUMAN:MT1G MT1E MT1L MT1H MT1F MT1A
MT2A MT1B MTP MT1X MTE MT3
MT4 for paralogs About GeneDecksing
|
Genomic Variants
for MT4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT4 |
|
Disorders
/ Diseases
for MT4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MT4 for disorders About GeneDecksing
OMIM gene information: 606206
OMIM disorders: --
4  diseases for MT4: About MalaCardswernicke-korsakoff syndrome squamous cell carcinoma hepatocellular carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for MT4:Wernicke-Korsakoff syndrome Human Genome Epidemiology (HuGE) Navigator: MT4 (3 documents)
Export disorders for MT4 gene to outside databases
|
Publications
for MT4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MT4 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with MT4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. (PubMed id 8003488)1, 2, 3, 9 Quaife C.J.... Palmiter R.D. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
- Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PubMed id 19515364)1 Gundacker C....Gencik M. (2009)
- The Association of Metallothionein-4 Gene Polymorphis m and Renal Function in Long-Term Lead-Exposed Workers. (PubMed id 19921116)1 Chen H.I....Chuang H.Y. (2009)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)1 Izmailova E....Aldovini A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. (PubMed id 16556599)9 Meloni G....Vasak M. (2006)
- Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. (PubMed id 11246971)9 Sogawa C.A....Ogawa N. (2001)
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External Searches for MT4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MT4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MT4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MT4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MT4 gene:
Search GeneIP for patents involving MT4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MT4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MT4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT4 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for MT4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MT4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MT4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MT4 | | OriGene Custom Protein Services for MT4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT4 |
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| | | | Search Tocris compounds for MT4 |
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 | | | MT4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MT4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT4 |
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