MPND Gene
protein-coding GIFtS: 44
GCID: GC19P004343
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MPN domain containing
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Aliases
for MPND gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MPN Domain Containing1 2 | | FLJ149811 | | MPN Domain-Containing Protein2 | | EC 3.4.-.-3 |
Export aliases for MPND gene to outside databasesPrevious GC identifers: GC19P004295 GC19P004105 |
Summaries
for MPND gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594Function: Probable protease (By similarity)
|
Genomic Views
for MPND gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MPND gene promoter:
SREBP-1a SREBP-1c STAT3 STAT5A NF-kappaB NF-kappaB1 SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPND
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPND |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3MPND Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P004343: view genomic region
(about GC identifiers)
Start:
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4,343,524 bp from pter |
End:
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4,360,083 bp from pter |
Size:
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16,560 bases |
Orientation:
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plus strand |
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Proteins
for MPND gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594 (See
protein sequence)Recommended Name: MPN domain-containing protein Size: 471 amino acids; 50662 Da
Secondary accessions: Q96SJ0 Q9Y2P1 Q9Y2P2Alternative splicing: 2 isoforms: Q8N594-1 Q8N594-2 Explore the universe of human proteins at neXtProt for MPND: NX_Q8N594
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N594
MPND Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001153318.1 NP_116257.2
ENSEMBL proteins: ENSP00000262966 ENSP00000353015
Human Recombinant Protein Products:
MPND Antibody Products:
Assay Products for MPND: |
Protein
Domains /
Families
for MPND gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPND for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N594ProtoNet protein and cluster: Q8N594 1 Blocks protein family: IPB000555 Mov34 family
UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594Domain: The JAMM motif may mediate the protease activity (By similarity)Similarity: Belongs to the peptidase M67 familySimilarity: Contains 1 MPN (JAB/Mov34) domain |
Function
for MPND gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MPND_HUMAN, Q8N594Function: Probable protease (By similarity)Enzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPND (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPND (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MPND (NM_032868) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPND | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPND |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPND |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008233 | peptidase activity |
IEA | -- |
MPND for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MPND:
|
Pathways & Interactions
for MPND gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPND
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for MPND (Q8N5943 ENSP000002629664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
MPND for ontologies About GeneDecksing
|
Drugs & Compounds
for MPND gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MPND
Search CenterWatch for drugs/clinical trials and news about MPND
|
Transcripts
for MPND gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MPND gene (2 alternative transcripts): NM_001159846.1 NM_032868.4 Unigene Cluster for MPND: MPN domain containing Hs.321689 [show with all ESTs]Unigene Representative Sequence: NM_0328682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262966(uc010dtx.2 uc002mae.3) ENST00000359935(uc002mag.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPND (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPND (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MPND (NM_032868) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MPND | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPND |
Additional cDNA sequence: AK027887.1 AK308468.1 BC032652.1 10 DOTS entries: DT.75125944 DT.75102001 DT.100760163 DT.100777587 DT.100760119 DT.100777592 DT.100777588 DT.100777589 DT.92449455 DT.40272258 24/98 AceView cDNA sequences (see all 98): BE048147 BE463545 CR613172 CR610197 CR605933 BE466766 CR600604 BU150675 CR618730 F27272 AA402556 AI337143 AA228985 BU732307 AW249465 BM903875 BX414299 AK024930 BX094516 BC032652 BG696748 AI222357 AA422148 NM_032868
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MPND About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MPND
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Expression
for MPND gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MPND expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGTGGAGA
About this image
See MPND Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MPND
SOURCE GeneReport for Unigene cluster: Hs.321689
SABiosciences Custom PCR Arrays for MPND
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPND
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MPND | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPND | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPND | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPND |
Orthologs
for MPND gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MPND gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for MPND (if available)
TreeFam Gene Tree for MPND (if available) |
Paralogs
for MPND gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MPND gene
- MYSM12
MPND for paralogs About GeneDecksing
|
Genomic Variants
for MPND gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MPND (4343524 - 4360083 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MPND
1 CNV: 5075 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPND |
|
Disorders
/ Diseases
for MPND gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MPND gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MPND gene integrated from 9 sources:
(articles sorted by number of sources associating them with MPND) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MPND gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MPND gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPND gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPND gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MPND | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MPND gene:
Search GeneIP for patents involving MPND
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPND gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MPND | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MPND | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MPND | | | OriGene Protein Over-expression Lysate for MPND | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MPND | | OriGene 3'-UTR Clone for MPND | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MPND | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MPND | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MPND | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MPND | | OriGene Custom Protein Services for MPND | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MPND | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MPND | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MPND | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MPND | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MPND | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MPND |
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 |  |  |  | |
| | | | Search Tocris compounds for MPND |
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 | | | MPND Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MPND |
|  |  |  | | | | Search ThermoFisher Antibodies for MPND |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MPND |
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