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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORN4 Gene

protein-coding   GIFtS: 41
GCID: GC10M099365

MORN repeat containing 4

(Previous name: chromosome 10 open reading frame 83 )
(Previous symbol: C10orf83)
 Explore 2 diseases affiliated with
MORN4 via our new
 Human Malady Compendium 
Biological research products
for MORN4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
MORN Repeat Containing 41 2     Chromosome 10 Open Reading Frame 831
C10orf831 2 3     44050 Protein2
BA548K23.41     MORN Repeat-Containing Protein 42
Protein 440502 3     Retinophilin1
FLJ259251     

External Ids:    HGNC: 240011   Entrez Gene: 1188122   Ensembl: ENSG000001711607   UniProtKB: Q8NDC43   

Export aliases for MORN4 gene to outside databases

Previous GC identifer: GC10M093000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORN4 gene promoter:
         RORalpha1   FOXO1a   Sox9   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MORN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.2

MORN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M099365:  view genomic region     (about GC identifiers)

Start:
99,374,310 bp from pter      End:
99,393,913 bp from pter
Size:
19,604 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MORN4_HUMAN, Q8NDC4 (See protein sequence)
Recommended Name: MORN repeat-containing protein 4  
Size: 146 amino acids; 16236 Da
Secondary accessions: Q86Y54
Alternative splicing: 2 isoforms:  Q8NDC4-1   Q8NDC4-2   

Explore the universe of human proteins at neXtProt for MORN4: NX_Q8NDC4

MORN4 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_001092301.1  NP_849154.1  

ENSEMBL proteins: 
 ENSP00000307636   ENSP00000441070   ENSP00000423222   ENSP00000359669   ENSP00000335498  

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Uscn Proteins for MORN4


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Uscn ELISAs and CLIAs for MORN4


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MORN4 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR003409 MORN

Graphical View of Domain Structure for InterPro Entry Q8NDC4

ProtoNet protein and cluster: Q8NDC4

UniProtKB/Swiss-Prot: MORN4_HUMAN, Q8NDC4
Similarity: Contains 4 MORN repeats


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MORN4
8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate MORN4 (see all 17):
hsa-miR-579 hsa-miR-148b* hsa-miR-34b* hsa-miR-4254 hsa-miR-139-5p hsa-miR-4299 hsa-miR-766 hsa-miR-515-5p
SwitchGear 3'UTR luciferase reporter plasmidMORN4 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORN4

2 Interacting proteins for MORN4 (Q8NDC43) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PPP1R8Q129723I2D: score=4 
CDC37Q165433I2D: score=2 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MORN4
Search CenterWatch for drugs/clinical trials and news about MORN4 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MORN4 gene (2 alternative transcripts): 
NM_001098831.1  NM_178832.3  

Unigene Cluster for MORN4:

MORN repeat containing 4
Hs.217409  [show with all ESTs]
Unigene Representative Sequence: NM_178832
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000307450 ENST00000478953(uc001kod.4) ENST00000515674(uc001koe.3)
ENST00000370635(uc009xvv.1) ENST00000335628(uc001kob.4 uc001koc.4)


miRNA
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hsa-miR-579 hsa-miR-148b* hsa-miR-34b* hsa-miR-4254 hsa-miR-139-5p hsa-miR-4299 hsa-miR-766 hsa-miR-515-5p
SwitchGear 3'UTR luciferase reporter plasmidMORN4 3' UTR sequence
Inhib. RNA
Products:
     
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORN4
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN4 
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORN4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN4

Additional cDNA sequence: 

AJ312050.1 AJ431726.1 AK098791.1 AK289406.1 AL834132.1 BC010230.2 BC022054.1 BC040015.1 
BC093023.1 DQ338435.1 DQ338436.1 

5 DOTS entries:

DT.91721938  DT.442751  DT.306535  DT.306536  DT.100740351 

24/88 AceView cDNA sequences (see all 88):

BM126422 BU931819 AA885574 AJ431726 BU197109 BE551005 BM453881 NM_178832 
AK098791 BX107861 CK819016 CB990425 AL834132 AA908763 CB961583 BC040015 
AI300363 CF994060 AA340109 N59201 BX371969 AI291631 W56517 BE618478 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MORN4    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:        -     -           -                                 
SP2:                          -                                 
SP3:                    -     -           -                     
SP4:                                                            


ECgene alternative splicing isoforms for MORN4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MORN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCAGGCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

MORN4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
3 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
Gut TubeMidgutMidgut Endoderm CellsEndoderm
EyeRetinaEye
Gut TubeMidgutGut Tube
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See MORN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MORN4

SOURCE GeneReport for Unigene cluster: Hs.217409
    SABiosciences Custom PCR Arrays for MORN4
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MORN4
Browse OriGene validated miRNA SYBR primer pairs
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORN4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MORN4 gene from 6/24 species (see all 24)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Morn41 , 5 MORN repeat containing 41, 5 91.78(n)1
97.95(a)1
  19 (35.72 cM)5
2261231  NM_198108.21  NP_932776.11 
 420749395 
chicken
(Gallus gallus)
Aves MORN41 MORN repeat containing 4 78.54(n)
85.62(a)
  425290  NM_001031335.1  NP_001026506.1 
lizard
(Anolis carolinensis)
Reptilia MORN46
--
87(a)
1 ↔ 1
3(39221251-39223387)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.139682 Transcribed sequence with weak similarity to protein refNP_079124.1 (H.sapiens) hypothetical protein FLJ13941 [Homo sapiens] less 76.49(n)    BX740266.1 
zebrafish
(Danio rerio)
Actinopterygii morn41 MORN repeat containing 4 69.66(n)
76.55(a)
  550131  NM_001017559.1  NP_001017559.1 
fruit fly
(Drosophila melanogaster)
Insecta rtp1 retinophilin 53.14(n)
50.72(a)
  40627  NM_141263.3  NP_649520.1 


ENSEMBL Gene Tree for MORN4 (if available)
TreeFam Gene Tree for MORN4 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MORN4 gene
JPH22  RSPH10B2  JPH42  JPH12  ALS2CL2  JPH32  RSPH10B22  MORN12  
RSPH12  ALS22  MORN32  
14 SIMAP similar genes for MORN4 using alignment to 3 protein entries:     MORN4_HUMAN (see all proteins):
LOC118812    SETD7    ANKMY1    ALS2CL    ALS2    MORN1
MORN3    RSPH10B    RSPH1    RSPH10B2    DKFZp779I2251    JPH1
JPH2    JPH3

MORN4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/394 NCBI SNPs in MORN4 are shown (see all 394    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs782410521,2
--93021126(+) CATCAG/TTGGAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
rs1136711741,2
--93021254(+) CAGCTG/AAATGA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1917733671,2
--99373811(+) GACCTC/TGGAGA 2 -- ds50010--------
rs1381540961,2
--99373886(+) AGGACA/GTGCAT 2 -- ds50010--------
rs1489342351,2
C,--99373998(+) GGCCA-/TAAC  
        
TAACT
2 -- ds50010--------
rs760139911,2
C,--99374047(+) GAGGTC/ACAGTA 2 -- ds50012Minor allele frequency- A:0.10WA 120
rs800075651,2
C,--99374060(+) GGGAGC/TTGGAA 2 -- ds50012Minor allele frequency- T:0.15WA 120
rs1495507561,2
--99374111(+) CTACTA/GGTTGG 2 -- ds50010--------
rs1433011091,2
--99374162(+) TCATAC/TGTCCT 2 -- ds50010--------
rs1820542321,2
--99374192(+) AATTAG/TATGAC 2 -- ds50010--------

HapMap Linkage Disequilibrium report for MORN4 (99374310 - 99393913 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MORN4: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MORN4
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MORN4 for disorders           About GeneDecksing

2 diseases for MORN4:    About MalaCards
pneumonia    malaria

1 disease from the University of Copenhagen DISEASES database for MORN4:
Learning disability

Export disorders for MORN4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MORN4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MORN4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  2. Drosophila retinophilin contains MORN repeats and is conserved in humans. (PubMed id 17285308)1 Mecklenburg K.L. (2007)
  3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  4. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
  7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
  8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
  9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  10. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 118812 HGNC: 24001 AceView: C10orf83 Ensembl:ENSG00000171160 euGenes: HUgn118812
ECgene: MORN4 H-InvDB: MORN4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MORN4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MORN4 gene:
Search GeneIP for patents involving MORN4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MORN4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MORN4  
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MORN4
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MORN4
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORN4
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORN4
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN4
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 GenScript Custom Purified and Recombinant Proteins Services for MORN4 GenScript cDNA clones with any tag delivered in your preferred vector for MORN4
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 GenScript Custom overexpressing Cell Line Services for MORN4 CloneReady with Over 120,000 Genes
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 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
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 Regulatory tfbs in MORN4 promoter
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN4
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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