MARK3 Gene
protein-coding GIFtS: 61
GCID: GC14P103851
|
|
MAP/microtubule affinity-regulating kinase 3
| |
Aliases
for MARK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAP/Microtubule Affinity-Regulating Kinase 31 2 | | EMK-22 3 | | CTAK11 2 3 | | Par-1a2 3 | | KP781 2 | | ELKL Motif Kinase 22 3 | | Cdc25C-Associated Protein Kinase 12 3 | | EC 2.7.11.13 8 | | Protein Kinase STK102 3 | | PAR1A2 | | Ser/Thr Protein Kinase PAR-12 3 | | EMK23 | | Serine/Threonine-Protein Kinase P782 3 | | CTAK11 2 3 | | C-TAK12 3 | | EC 2.7.118 |
Export aliases for MARK3 gene to outside databasesPrevious GC identifers: GC14P101243 GC14P097667 GC14P101841 GC14P102921 GC14P084029 |
Summaries
for MARK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MARK3:
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tauproteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediatingphosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus
Gene Wiki entry for MARK3
|
Genomic Views
for MARK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MARK3 gene promoter:
NF-YB CBF-B CBF-A NF-YA NF-YC CP1C CP1A NF-Y CBF-C CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MARK3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARK3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32.3MARK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P103851: view genomic region
(about GC identifiers)
Start:
|
103,851,701 bp from pter |
End:
|
103,970,168 bp from pter |
Size:
|
118,468 bases |
Orientation:
|
plus strand |
|
Proteins
for MARK3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448 (See
protein sequence)Recommended Name: MAP/microtubule affinity-regulating kinase 3 Size: 753 amino acids; 84489 Da
Subcellular location: Cell membrane; Peripheral membrane protein
2 PDB 3D structures from  and Proteopedia  for MARK3:2QNJ (3D)
3FE3 (3D)
Secondary accessions: O60219 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34Alternative splicing: 7 isoforms: P27448-5 P27448-2 P27448-3 P27448-4 P27448-6 P27448-7 P27448-8 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MARK3: NX_P27448
Post-translational modifications:
Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P27448
4/27 DME Specific Peptides for MARK3 (P27448) (see all 27)
MARK3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001122390.1 NP_001122391.1 NP_001122392.1 NP_001122393.1 NP_002367.4
ENSEMBL proteins: ENSP00000402104 ENSP00000408092 ENSP00000411397 ENSP00000303698 ENSP00000216288 ENSP00000450772 ENSP00000454169 ENSP00000335347 ENSP00000452829 ENSP00000450460 ENSP00000452893 ENSP00000451623
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IDA | -- |
MARK3 for ontologies About GeneDecksing
MARK3 Antibody Products:
Assay Products for MARK3: |
Protein
Domains /
Families
for MARK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MARK3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P27448ProtoNet protein and cluster: P27448 2 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB001772 Kinase-associated
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamilySimilarity: Contains 1 KA1 (kinase-associated) domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 UBA domain |
Function
for MARK3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediatingphosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleusCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564 Genatlas biochemistry entry for MARK3:MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARK3 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARK3 (see all 8)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): MARK3 (NM_001128918) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARK3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MARK3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MARK3:
Animal Models:
Mouse knock-out Mark3tm1Hpw for MARK3
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mark3):
MARK3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MARK3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | Wnt / Hedgehog / Notch | | | 3 | Cytoskeleton remodeling Neurofilaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MARK3
2 
Cell Signaling Technology (CST) Pathways for MARK3
MARK3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARK3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for MARK3 (P274481, 2, 3 ENSP000004113974) via UniProtKB, MINT, STRING, and/or I2D (see all 46)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SFN | P319472, 3, ENSP000003409894 | MINT-66900 MINT-3975719 I2D:
score=5 STRING: ENSP00000340989 | | PKP2 | Q999592, 3, ENSP000000708464 | MINT-16617 MINT-16618 I2D:
score=2 STRING: ENSP00000070846 | | PNPLA2 | Q96AD52, 3, ENSP000003377014 | MINT-63622 I2D:
score=5 STRING: ENSP00000337701 | | PRKCQ | Q047592, 3, ENSP000002631254 | MINT-4787821 I2D:
score=3 STRING: ENSP00000263125 | | PPM1B | O756882, 3, ENSP000002824124 | MINT-8247539 I2D:
score=1 STRING: ENSP00000282412 |
About this table
|
Drugs & Compounds
for MARK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MARK3
2 HMDB Compounds for MARK3 About this table
Search CenterWatch for drugs/clinical trials and news about MARK3
|
Transcripts
for MARK3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MARK3 gene (5 alternative transcripts): NM_001128918.1 NM_001128919.1 NM_001128920.1 NM_001128921.1 NM_002376.5 Unigene Cluster for MARK3: MAP/microtubule affinity-regulating kinase 3 Hs.35828 [show with all ESTs]Unigene Representative Sequence: NM_00112891818/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26): ENST00000440884 ENST00000559328 ENST00000560603 ENST00000416682 ENST00000429436(uc001ymz.4 uc001ymx.4 uc001ymw.4 uc001yna.4 uc001ymy.4 uc010awp.3 uc010tyb.2 uc010awq.3)
ENST00000303622 ENST00000216288 ENST00000553942(uc021sef.1) ENST00000560417
ENST00000558223 ENST00000335102 ENST00000561225 ENST00000561071 ENST00000558698
ENST00000560731 ENST00000559268 ENST00000561164 ENST00000554627
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARK3 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARK3 (see all 8)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): MARK3 (NM_001128918) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MARK3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3 |
Additional cDNA sequence: AF170723.1 AF387637.1 AF465413.1 AK023963.1 AK055814.1 AK056714.1 AK124459.1 AK124796.1 AK296643.1 AK307448.1 BC024773.1 BX161395.1 BX248250.1 DQ368336.1 M80359.1 M83780.1 U64205.1 24/37 DOTS entries (see all 37): DT.86855293 DT.95264963 DT.100714279 DT.100698434 DT.100844722 DT.100844716 DT.100844721 DT.317922 DT.100673793 DT.120767212 DT.100029578 DT.100844711 DT.120767219 DT.120767148 DT.120767164 DT.95124116 DT.95264961 DT.97785685 DT.100844733 DT.100844732 DT.449218 DT.95264965 DT.100844734 DT.101979967 24/430 AceView cDNA sequences (see all 430): BM702885 BQ018304 BM988013 BQ054388 BX357829 BQ955135 BF056508 AU124963 BG741259 AI332609 CA397900 CB529992 BX484862 AA642662 CB528929 BU634468 BI850828 F02748 CF552147 AA737060 AU132239 BE208064 BM699216 BX119061
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 (see all 14) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | |
| ExUns: | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | · | 20d | · | 20e | · | 20f | · | 20g |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MARK3
|
Expression
for MARK3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MARK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGTGGTTT
About this image
See MARK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MARK3
SOURCE GeneReport for Unigene cluster: Hs.35828
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for MARK3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARK3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MARK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARK3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK3 |
Orthologs
for MARK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MARK3 gene from 7/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MARK31 |
MAP/microtubule affinity-regulating kinase 3 |
84.37(n)
96.28(a) |
|
423480 XM_421385.3 XP_421385.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MARK36 |
-- |
88(a) |
1 ↔ 1 |
GL343232.1(163823-226907) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.19672 |
Xenopus laevis Ser/Thr protein kinase PAR-1A mRNA, more |
79.58(n) |
|
AF509737.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC047179.12 |
-- |
73.64(n) |
|
334300 BC047179.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
KP78a3
par-11 |
protein amino acid phosphorylation protein
kinase3
C-TAK1-like1 |
56(a)
(best of 4)3
55.76(n)1
59.07(a)1 |
|
86E43
27688521 NM_206178.21 NP_995900.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
kin-293
par-11 |
serine/threonine-protein kinase3
Protein PAR-11 |
39(a)
(best of 2)3
51.5(n)1
53.83(a)1 |
|
X(2880113-2887689)3
1799121 NM_001129495.11 NP_001122967.11 |
rice
(Oryza sativa) |
Liliopsida |
-- |
CAMK_KIN1/SNF1/Nim1_like_AMPKh.1 - CAMK includes c... |
23(a) |
possible ortholog |
7(5101510-5106299) |
ENSEMBL Gene Tree for MARK3 (if available)
TreeFam Gene Tree for MARK3 (if available) |
Paralogs
for MARK3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MARK3 gene
- BRSK12 NUAK12 MARK12 BRSK22 SIK32 SNRK2 SIK22 NUAK22
- MARK22 NIM12 SIK12 MARK42
18/90 SIMAP similar genes for MARK3 using alignment to 7 protein entries: MARK3_HUMAN (see all proteins)
(see all similar genes):DKFZp547M202 MARK4 BRSK2 MARK2 KIAA0999 MARK1
HUNK SIK3 NUAK2 PHKG2 Par1b CDK3
PDPK1 STK32A Nbla00650 CDKL1 NUAK1 PASK
MARK3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for MARK3
PGOHUM00000239434 PGOHUM00000237761 PGOHUM00000261899
|
Genomic Variants
for MARK3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MARK3 (103851701 - 103970168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MARK3
2 CNVs: 5768 5769 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARK3 |
|
Disorders
/ Diseases
for MARK3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MARK3 for disorders About GeneDecksing
OMIM gene information: 602678
OMIM disorders: --
9  diseases for MARK3: About MalaCardspeutz-jeghers syndrome cerebral palsy microphthalmia osteoporosis
cerebritis obesity arthritis malaria
carcinoma
Human Genome Epidemiology (HuGE) Navigator: MARK3 (4 documents)
Export disorders for MARK3 gene to outside databases
|
Publications
for MARK3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MARK3 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with MARK3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 2, 9 Dequiedt F....Kettmann R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. (PubMed id 11433294)1, 2 Sun T.-Q....Williams L.T. (2001)
- C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. (PubMed id 9543386)1, 2 Peng C.Y.... Piwnica-Worms H. (1998)
- Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. (PubMed id 9533022)1, 3 Ono T....Okamoto T. (1997)
- Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)1, 9 Muller J....Morrison D.K. (2003)
- C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 9 Muller J....Morrison D.K. (2001)
- Systematic survey of deubiquitinase localization ident ifies USP21 as a regulator of centrosome- and microtubule-associated functions. (PubMed id 22298430)1 Urbe S....Clague M.J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for MARK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MARK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MARK3 gene
(According to HUGE)
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Specialized Databases showing MARK3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MARK3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MARK3 gene:
Search GeneIP for patents involving MARK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MARK3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for MARK3 | | OriGene shRNA RFP for MARK3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MARK3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MARK3 | | | OriGene Protein Over-expression Lysate for MARK3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MARK3 | | OriGene 3'-UTR Clone for MARK3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MARK3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MARK3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MARK3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MARK3 | | OriGene Custom Protein Services for MARK3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MARK3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MARK3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MARK3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MARK3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MARK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MARK3 |
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| | Antibodies & Assays for MARK3 |
| | | | Search Tocris compounds for MARK3 |
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 | | | MARK3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MARK3 |
|  |  |  | | | | ThermoFisher Antibodies for MARK3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MARK3 |
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