MAGED1 Gene
protein-coding GIFtS: 65
GCID: GC0XP051562
|
|
melanoma antigen family D, 1
| |
Aliases
for MAGED1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family D, 11 2 | | MAGE Tumor Antigen CCF2 3 | | NRAGE1 2 3 | | MAGE-D1 Antigen2 3 | | DLXIN-11 2 | | Melanoma-Associated Antigen D12 | | Neurotrophin Receptor-Interacting MAGE Homolog2 3 | | |
Export aliases for MAGED1 gene to outside databasesPrevious GC identifers: GC0XU990274 GC0XP049684 GC0XP050230 GC0XP050553 GC0XP051469 GC0XP048983 |
Summaries
for MAGED1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGED1:
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumorspecific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by thisgene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. Thisgene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway.Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: MAGD1_HUMAN, Q9Y5V3Function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. BindsNGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitatesNGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act throughrecruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex
Gene Wiki entry for MAGED1
|
Genomic Views
for MAGED1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011638.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGED1 gene promoter:
AhR RP58 AML1a Roaz MZF-1 POU2F1 POU2F1a Zic1 Pax-4a LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGED1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGED1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.23MAGED1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP051562: view genomic region
(about GC identifiers)
Start:
|
51,546,103 bp from pter |
End:
|
51,645,453 bp from pter |
Size:
|
99,351 bases |
Orientation:
|
plus strand |
|
Proteins
for MAGED1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGD1_HUMAN, Q9Y5V3 (See
protein sequence)Recommended Name: Melanoma-associated antigen D1 Size: 778 amino acids; 86161 Da
Subunit: Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interactswith the p75 neurotrophin receptor. Interacts with TRIM28 and PJA1
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF (By similarity)
Sequence caution: Sequence=AAD31421.1; Type=Erroneous initiation; Sequence=AAG35551.1; Type=Erroneous initiation;
Secondary accessions: Q5VSH6 Q8IZ84 Q8WY92 Q9H352 Q9HBT4 Q9UF36Alternative splicing: 2 isoforms: Q9Y5V3-1 Q9Y5V3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAGED1: NX_Q9Y5V3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5V3
MAGED1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001005332.1 NP_001005333.1 NP_008917.3
ENSEMBL proteins: ENSP00000364927 ENSP00000364874 ENSP00000325333 ENSP00000364847 Reactome Protein details: Q9Y5V3
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MAGED1 for ontologies About GeneDecksing
MAGED1 Antibody Products:
Assay Products for MAGED1: |
Protein
Domains /
Families
for MAGED1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGED1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y5V3ProtoNet protein and cluster: Q9Y5V3 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGD1_HUMAN, Q9Y5V3Similarity: Contains 1 MAGE domain |
Function
for MAGED1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGD1_HUMAN, Q9Y5V3Function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. BindsNGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitatesNGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act throughrecruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex Genatlas biochemistry entry for MAGED1:putative melanoma antigen,family D,member 1,expressed in breast,colon,brain,fetal tissue,tumoral cell(breast,lung,prostate,Wilms),not recognized by T cells but expressed only in tumor and germ-line cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MAGED1 (NM_001005333) | |  | Sino Biological Human cDNA Clone for MAGED1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGED1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGED1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003713 | transcription coactivator activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
MAGED1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MAGED1:
Animal Models:
Mouse knock-outs for MAGED1: Maged1tm1.1Urfm Maged1tm1Tnab
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Maged1):
MAGED1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAGED1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Development HGF signaling pathway | | | 3 | Ubiquitinated Orc1 is degraded by the proteasome | | | 4 | Role of DCC in regulating apoptosis | | | 5 | p75(NTR)-mediated signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MAGED1
1  GeneGo (Thomson Reuters) Pathway for MAGED1
2  BioSystems Pathways for MAGED1
5/8 
Reactome Pathways for MAGED1 (see all 8)
1 
Kegg Pathway (Kegg details for MAGED1):
MAGED1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGED1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/83 Interacting proteins for MAGED1 (Q9Y5V31, 2, 3 ENSP000003648474) via UniProtKB, MINT, STRING, and/or I2D (see all 83)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PJA1 | Q8NG271, 3, ENSP000003550144 | EBI-716006,EBI-714606 I2D:
score=4 STRING: ENSP00000355014 | | RBFOX1 | Q9NWB12, 3, ENSP000003091174 | MINT-2866864 I2D:
score=3 STRING: ENSP00000309117 | | CD2BP2 | O954002, 3, ENSP000003049034 | MINT-62646 MINT-62645 MINT-62657 I2D:
score=1 STRING: ENSP00000304903 | | XIAP | P981702, 3, ENSP000003478584 | MINT-14016 MINT-14015 I2D:
score=3 STRING: ENSP00000347858 | | DLX5 | P561783, ENSP000002225984 | I2D:
score=3 STRING: ENSP00000222598 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
TAS | 15930293 | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006915 | apoptotic process |
TAS | -- | | GO:0042981 | regulation of apoptotic process |
TAS | -- | | GO:0043065 | positive regulation of apoptotic process |
IEA | -- |
MAGED1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGED1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGED1
Search CenterWatch for drugs/clinical trials and news about MAGED1 / MAGD1
|
Transcripts
for MAGED1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGED1 gene (3 alternative transcripts): NM_001005332.1 NM_001005333.1 NM_006986.3 Unigene Cluster for MAGED1: Melanoma antigen family D, 1 Hs.5258 [show with all ESTs]Unigene Representative Sequence: NM_00100533311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375772(uc004dpm.3) ENST00000375722 ENST00000326587(uc011mnx.1 uc004dpo.3)
ENST00000375695(uc004dpn.3) ENST00000486579 ENST00000470461 ENST00000494718
ENST00000485420 ENST00000482188 ENST00000482599 ENST00000473931
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MAGED1 (NM_001005333) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGED1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGED1 |
Additional cDNA sequence: AF124440.1 AF132205.1 AF217963.1 AF258554.1 AF300328.1 AK298574.1 AK308706.1 AK314053.1 AL133628.1 BC014070.2 BC032473.2 21 DOTS entries: DT.101963599 DT.95206453 DT.100059993 DT.219594 DT.91860774 DT.100880296 DT.100051130 DT.100841503 DT.100880302 DT.100880308 DT.95228626 DT.100880309 DT.92463530 DT.95228623 DT.100880299 DT.121317465 DT.92463513 DT.92463514 DT.95228627 DT.100059994 DT.91962654 24/1072 AceView cDNA sequences (see all 1072): CA431011 T81022 BU527549 BX399799 BE728596 BQ688333 BU844601 AF124440 AI074540 AW732486 T06682 BU856154 BU527145 BX395528 T31438 BU168807 BU190480 BU161316 BU189265 BF525584 AI916903 BM694422 BQ898148 BQ880716
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAGED1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAGED1
|
Expression
for MAGED1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGED1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGATAAAT
About this image
See MAGED1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGED1
SOURCE GeneReport for Unigene cluster: Hs.5258
UniProtKB/Swiss-Prot: MAGD1_HUMAN, Q9Y5V3Tissue specificity: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors.Seems to be ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including MAGED1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGED1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAGED1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGED1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGED1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED1 |
Orthologs
for MAGED1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGED1 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
38(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
34(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
22(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGED1 (if available)
TreeFam Gene Tree for MAGED1 (if available) |
Paralogs
for MAGED1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGED1 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/26 SIMAP similar genes for MAGED1 using alignment to 1 protein entry: MAGD1_HUMAN(see all similar genes):FLJ00163 MAGED2 MAGEH1 NDNL2 TRO MAGEA4
MAGEA12 MAGEC4 MAGEF1 MAGE-B1 MAGEB1 MAGEB2
MAGEB3 MAGEA2B MAGEA2 MAGEA9 MAGEA9B NDN
MAGED1 for paralogs About GeneDecksing
|
Genomic Variants
for MAGED1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGED1 (51546103 - 51645453 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAGED1: --
Locus Specific Mutation Databases (LSDB): MAGED1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGED1 |
|
Disorders
/ Diseases
for MAGED1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGED1 for disorders About GeneDecksing
OMIM gene information: 300224
OMIM disorders: --
17  diseases for MAGED1: About MalaCardsmelanoma prader-willi syndrome seborrheic keratosis keratosis
multiple myeloma hepatitis b myeloma esophageal carcinoma
esophagitis pancreatic cancer breast cancer pancreatitis
ataxia hepatitis prostatitis carcinoma
neuronitis
2 diseases from the University of Copenhagen DISEASES database for MAGED1:Prader-Willi syndrome Seborrheic keratosis 2 Novoseek disease relationships for MAGED1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
32.8 |
4 |
8935336 (1), 9673893 (1) |
| tumors |
0 |
2 |
17453828 (2) |
Human Genome Epidemiology (HuGE) Navigator: MAGED1 (2 documents)
Export disorders for MAGED1 gene to outside databases
|
Publications
for MAGED1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGED1 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with MAGED1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a new, unorthodox member of the MAGE gene family. (PubMed id 10409427)1, 2, 3 Pold M.... Berenson J.R. (1999)
- NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis. (PubMed id 10985348)1, 2, 9 Salehi A.H.... Barker P.A. (2000)
- hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. (PubMed id 15094062)1, 2, 9 Wen C.-J.... Li C.-J. (2004)
- A new melanoma antigen-encoding gene subfamily in human chromosome X. (PubMed id 11280991)1, 2, 9 Zhang C.G.... He F.C. (2001)
- MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of the translational initiation codon in human MAGED1. (PubMed id 11087672)1, 2 Kubu C.J.... Verdi J.M. (2000)
- MAGE-D1 inhibits proliferation, migration and invasio n of human breast cancer cells. (PubMed id 19639218)1, 9 Du Q....Fang W.G. (2009)
- Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion. (PubMed id 16125672)1, 9 Xue B....Li C. (2005)
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External Searches for MAGED1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MAGED1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MAGED1 gene
(According to HUGE)
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Specialized Databases showing MAGED1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for MAGED1 gene:
Search GeneIP for patents involving MAGED1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MAGED1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAGED1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGED1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGED1 | | | OriGene Protein Over-expression Lysate for MAGED1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAGED1 | | OriGene 3'-UTR Clone for MAGED1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAGED1 | | OriGene Custom Protein Services for MAGED1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGED1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGED1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGED1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGED1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGED1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGED1 |
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| | | | Search Tocris compounds for MAGED1 |
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 | | | MAGED1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED1 |
|  |  |  | | | | ThermoFisher Antibodies for MAGED1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGED1 |
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