KRT72 Gene
protein-coding GIFtS: 46
GCID: GC12M052979
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|
keratin 72
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Aliases
for KRT72 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 721 2 | | Cytokeratin-723 | | K6IRS21 2 3 5 | | Keratin 6, Inner Root Sheath, 22 | | KRT6IRS21 2 3 5 | | Keratin Protein K6irs2 | | KRT61 2 3 | | Keratin, Type II Cytoskeletal 722 | | K6irs1 2 | | Keratin-723 | | Type II Inner Root Sheath-Specific Keratin-K6irs22 3 | | Cytokeratin-723 | | Type-II Keratin Kb352 3 | | KB353 | | CK-722 3 | | Keratin-723 | | K722 3 | | |
Export aliases for KRT72 gene to outside databasesPrevious GC identifers: GC12M051266 GC12M050023 |
Summaries
for KRT72 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT72:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type IIkeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressedduring differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that isspecifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region ofchromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.(providedby RefSeq, Jun 2009)
UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath(IRS) of the hair follicle (Probable)
|
Genomic Views
for KRT72 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT72 gene promoter:
Oct-B1 NF-1 AML1a Nkx2-5 C/EBPalpha GATA-1 PPAR-alpha CHOP-10 HSF2 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT72
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT72 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13KRT72 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M052979: view genomic region
(about GC identifiers)
Start:
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52,979,373 bp from pter |
End:
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52,995,322 bp from pter |
Size:
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15,950 bases |
Orientation:
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minus strand |
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Proteins
for KRT72 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4 (See
protein sequence)Recommended Name: Keratin, type II cytoskeletal 72 Size: 511 amino acids; 55877 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)(40-55 and 56-70 kDa, respectively)
Caution: Was initially thought to be the ortholog of mouse KRT71 (PubMed:11703281)
Sequence caution: Sequence=BAC04039.1; Type=Erroneous initiation;
Secondary accessions: B4DEI8 H9KV51 Q8NA87 Q8WWY9 Q8WWZ0Alternative splicing: 3 isoforms: Q14CN4-1 Q14CN4-2 Q14CN4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KRT72: NX_Q14CN4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14CN4
KRT72 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001139697.1 NP_001139698.1 NP_542785.1
ENSEMBL proteins: ENSP00000441160 ENSP00000346269 ENSP00000446881 ENSP00000449324 ENSP00000293745 ENSP00000446151
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045095 | keratin filament |
IEA | -- |
KRT72 for ontologies About GeneDecksing
KRT72 Antibody Products:
Assay Products for KRT72: |
Protein
Domains /
Families
for KRT72 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT72 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14CN4ProtoNet protein and cluster: Q14CN4 2 Blocks protein families: IPB001664 Intermediate filament protein IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4Similarity: Belongs to the intermediate filament family |
Function
for KRT72 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath(IRS) of the hair follicle (Probable)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT72 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT72 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT72 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT72 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT72 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT72 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT72:
|
Pathways & Interactions
for KRT72 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT72
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for KRT72 (Q14CN43 ENSP000002937454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRT72 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT72
Search CenterWatch for drugs/clinical trials and news about KRT72 / K2C72
|
Transcripts
for KRT72 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT72 gene (3 alternative transcripts): NM_001146225.1 NM_001146226.1 NM_080747.2 Unigene Cluster for KRT72: Keratin 72 Hs.662013 [show with all ESTs]Unigene Representative Sequence: NM_0807476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537672 ENST00000354310 ENST00000550829 ENST00000549979 ENST00000293745(uc001sar.2 uc001saq.2 uc010sns.1)
ENST00000398066(uc010snt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT72 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT72 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): KRT72 (NM_080747) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT72 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT72 |
Additional cDNA sequence: AK093060.1 AK293645.1 AK302016.1 AY033495.1 BC113686.1 3 DOTS entries: DT.75142748 DT.100010973 DT.121117938 4 AceView cDNA sequences: NM_080747 AY033495 AX747893 AK093060
GeneLoc Exon Structure
|
Expression
for KRT72 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT72 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTCTTGG
About this image
See KRT72 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT72
SOURCE GeneReport for Unigene cluster: Hs.662013
UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4Tissue specificity: Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantarepidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specificallypresent in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxleylayers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (atprotein level)
SABiosciences Custom PCR Arrays for KRT72
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT72
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT72 |
Orthologs
for KRT72 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT72 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for KRT72 (if available)
TreeFam Gene Tree for KRT72 (if available) |
Paralogs
for KRT72 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT72 gene
- KRT742 KRT772 KRT6B2 KRT832 KRT762 KRT862 KRT32 KRT842
- KRT82 KRT812 KRT712 KRT8P112 KRT782 KRT72 ENSG000001704422 KRT792
- KRT732 KRT52 KRT6C2 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/41 SIMAP similar genes for KRT72 using alignment to 4 protein entries: K2C72_HUMAN (see all proteins)
(see all similar genes):KRT7 KRT71 KRTHB6 KRT79 KRT5 KRT121P
KRT3 KRT6A KRT6B KRT6C KRT4 KRT74
KRT75 KRT8 KRT76 KRT78 KRT1 KRT1B
KRT72 for paralogs About GeneDecksing
|
Genomic Variants
for KRT72 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT72 (52979373 - 52995322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT72: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT72 |
|
Disorders
/ Diseases
for KRT72 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT72 for disorders About GeneDecksing
OMIM gene information: 608246
OMIM disorders: --
4  diseases for KRT72: About MalaCardspachyonychia congenita pharyngitis breast cancer neuronitis
1 disease from the University of Copenhagen DISEASES database for KRT72:Pachyonychia congenita Export disorders for KRT72 gene to outside databases
|
Publications
for KRT72 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT72 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KRT72) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans. (PubMed id 11703281)1, 2, 3, 9 Porter R.M....McLean W.H. (2001)
- K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. (PubMed id 12648212)1, 2, 3 Langbein L....Schweizer J. (2003)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Comparison of immunohistochemical staining in breast p apillary neoplasms of cytokeratin 5/6 and p63 in core needle biopsies and surgic al excisions. (PubMed id 22553810)1 Koo J.S....Park B.W. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Reliability of the 34bE12, keratin 5/6, p63, bcl-2, an d AMACR in the diagnosis of prostate carcinoma. (PubMed id 20189848)1 Boran C....Akyol M. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. (PubMed id 17388661)1 Bertheau P....de The H. (2007)
- K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)2 Langbein L.... Schweizer J. (2006)
|
External Searches for KRT72 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT72 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT72 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT72 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT72 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT72 gene:
Search GeneIP for patents involving KRT72
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT72 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for KRT72 | | OriGene Custom Protein Services for KRT72 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT72 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT72 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT72 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT72 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT72 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT72 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT72 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT72 |
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