KLK1 Gene

Aliases
for KLK1 gene

Previous GC identifers: GC19M051951 GC19M051683 GC19M055998 GC19M056014 GC19M047656

Summaries
for KLK1 gene

Genomic Views
for KLK1 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLK1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLK1

KLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051322:  view genomic region     (about GC identifiers)

Proteins
for KLK1 gene

1 PDB 3D structure from and Proteopedia for KLK1:

1SPJ (3D)    

Explore the universe of human proteins at neXtProt for KLK1: NX_P06870

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for KLK1 (Kallikrein 1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KLK1 OriGene Custom Protein Services for KLK1
	GenScript Purified and Recombinant Proteins for KLK1
	Novus Biologicals KLK1 Proteins Novus Biologicals KLK1 Lysates
	Sino Biological Recombinant Protein for KLK1
	ProSpec Recombinant Protein for KLK1
	Uscn Proteins for KLK1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KLK1 (Kallikrein 1)
	OriGene Antibodies: KLK1 OriGene Custom Antibody Services for KLK1
	GenScript Custom Superior Antibodies Services for KLK1
	Novus Biologicals KLK1 Antibodies
	Search for Antibodies for KLK1 at Abcam
	Uscn Antibodies for KLK1
	ThermoFisher Antibodies for KLK1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript KLK1-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK1

Protein Domains /
Families
for KLK1 gene

ProtoNet protein and cluster: P06870

Function
for KLK1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLK1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KLK1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLK1 OriGene shRNA RFP: KLK1 OriGene siRNA: KLK1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLK1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KLK1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLK1 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLK1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KLK1 (NM_002257)
		Sino Biological Human cDNA Clone for KLK1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLK1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLK1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLK1
		Search LifeMap BioReagents cell lines for KLK1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for KLK1 gene

	Super-pathway	contained gene-specific pathways
1	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96
2	Cell adhesion_ECM remodeling	Cell adhesion_ECM remodeling 1.00 Cell adhesion ECM remodeling 1.00
3	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 1.00
4	MSP-RON Signaling	MSP-RON Signaling 1.00
5	Endocrine and other factor-regulated calcium reabsorption	Endocrine and other factor-regulated calcium reabsorption 1.00

1 EMD Millipore Pathway for KLK1

Cell adhesion ECM remodeling

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KLK1

	MSP-RON Signaling
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

1 GeneGo (Thomson Reuters) Pathway for KLK1

Cell adhesion ECM remodeling

1 BioSystems Pathway for KLK1

Blood Clotting Cascade

2        Reactome Pathways for KLK1

	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Metabolism of proteins

1         Kegg Pathway  (Kegg details for KLK1)

Endocrine and other factor-regulated calcium reabsorption

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for KLK1 gene

Transcripts
for KLK1 gene

Expression
for KLK1 gene

KLK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTACGTC

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	GABA neuron-like cells (Generation of motor ...)			Brain
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLK1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KLK1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLK1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLK1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLK1

Orthologs
for KLK1 gene

Paralogs
for KLK1 gene

Paralogs for KLK1 gene

KLK10²  KLK4²  PRSS37²  KLK11²  KLK7²  KLK14²  KLK9²  KLK13²  

KLK6²  KLK12²  KLK2²  KLK15²  KLK5²  PRSS1²  PRSS58²  PRSS3²  

KLK3²  KLK8²  

18/76 SIMAP similar genes for KLK1 using alignment to 4 protein entries:     KLK1_HUMAN (see all proteins) (see all similar genes):

KLK2    APS    KLK3    KLK8    KLK7    KLK11

KLK13    TRY8    TRY6    PRSS3    KLK6    PRSS2

DKFZp586F0824    KLK5    KLK12    KLK15    PRSS1    KLK4

KLK1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for KLK1
PGOHUM00000259349

Genomic Variants
for KLK1 gene

10/186 NCBI SNPs in KLK1 are shown (see all 186)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs55151,2	C,F,H,	pathogenic	51323676(-)	GGGTCG/ACCACA	2	/H /R	mis1 ese3		29		MN NS EA NA CSA WA EU	8504
rs360627301,2	C,F	--	47663096(+)	TCAGAG/ATTCCA	3	--	ds5001		3		NA	6
rs24722591,2	H	--	47663283(+)	gcctcC/Ataagt	3	--	ds5001		4		NS EA	418
rs362176231,2	C,	--	47663294(+)	TCAAGC/TGATCC	3	--	ds5001		3		NA WA	122
rs32128141,2	C,F,	--	47663336(-)	CACACG/AACTGT	3	--	ds5001		6		NS NA MN WA	344
rs32128131,2	C,F,	--	47663423(-)	AGGTCA/TGGAGT	3	--	ds5001 tfbs3		2		NS	92
rs32128121,2	C,F,H,	--	47663528(-)	ATTACC/GAAGAA	3	--	ds5001		10		NS EA NA WA	770
rs32128541,2	H,	--	47663651(-)	acttcA/Caaggg	3	--	ut31 tfbs3		6		NS EA	444
rs32128111,2	C,F,	--	47663697(-)	TTCGCC/TTTGGT	3	--	ut31		8		NS NA WA	356
rs32128531,2	C,F,H,	--	47663834(-)	ACCCCG/AAGACA	3	--	ut31 tfbs3		11		NS NA MN	1000

HapMap Linkage Disequilibrium report for KLK1 (51322404 - 51327043 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KLK1: --
Human Gene Mutation Database (HGMD): KLK1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLK1

DNA2.0 Custom Variant and Variant Library Synthesis for KLK1

Disorders / Diseases
for KLK1 gene

20/37 diseases for KLK1

4 Novoseek disease relationships for KLK1 gene    About this table

Publications
for KLK1 gene

PubMed articles for KLK1 gene, integrated from 9 sources (see all 136): (articles sorted by number of sources associating them with KLK1)

Utopia: connect your pdf to the dynamic world of online information

1. Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux. (PubMed id 15086490)^{1, 4, 9} Lee-Chen G.J....Lin C.Y. (2004)
2. Association of the tissue kallikrein gene promoter with ESRD and hypertension. (PubMed id 11849458)^{1, 4, 9} Yu H....Bowden D.W. (2002)
3. Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker. (PubMed id 1684954)^{1, 3, 9} Richards R.I....Shaw D. (1991)
4. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)^{1, 4, 9} Iwai N....Shioji K. (2004)
5. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)^{1, 3} (2006)
6. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)^{1, 3} Lundwall A....Yousef G.M. (2006)
7. 1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding. (PubMed id 15651049)^{1, 2} Laxmikanthan G.... Blaber M. (2005)
8. Relationship between the regulatory region polymorphism of human tissue kallikrein gene and essential hypertension. (PubMed id 15905889)^{1, 4} Hua H....Chao J. (2005)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
10. Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity. (PubMed id 11912256)^{1, 4} Slim R....Alhenc-Gelas F. (2002)

External Searches for KLK1 gene

Genome Databases showing KLK1 gene

Other Databases showing KLK1 gene

Specialized Databases showing KLK1 gene

Products
for KLK1 gene