KLHL36 Gene
protein-coding GIFtS: 41
GCID: GC16P084682
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kelch-like family member 36(Previous names: chromosome 16 open reading frame 44, kelch-like 36 (Drosophila)...)
(Previous symbol: C16orf44)
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Aliases
for KLHL36 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 361 2 | | Kelch-Like 36 (Drosophila)1 | | C16orf441 2 3 | | Kelch-Like 362 | | FLJ125431 | | Kelch-Like Protein 362 | | Chromosome 16 Open Reading Frame 441 | | |
Export aliases for KLHL36 gene to outside databasesPrevious GC identifers: GC16P083240 GC16P070437 |
Summaries
for KLHL36 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates theubiquitination and subsequent proteasomal degradation of target proteins
|
Genomic Views
for KLHL36 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL36 gene promoter:
AhR Elk-1 Pax-5 Nkx2-2 Arnt CREB deltaCREB c-Myc ATF En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL36
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL36 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1KLHL36 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P084682: view genomic region
(about GC identifiers)
Start:
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84,682,131 bp from pter |
End:
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84,701,292 bp from pter |
Size:
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19,162 bases |
Orientation:
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plus strand |
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Proteins
for KLHL36 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3 (See
protein sequence)Recommended Name: Kelch-like protein 36 Size: 616 amino acids; 69896 Da
Subunit: Interacts with CUL3
Secondary accessions: Q8N5G6 Q9H9U6Alternative splicing: 2 isoforms: Q8N4N3-1 Q8N4N3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KLHL36: NX_Q8N4N3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4N3
KLHL36 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079007.2
ENSEMBL proteins: ENSP00000456743 ENSP00000258157 ENSP00000455244 ENSP00000455746 ENSP00000455966
Human Recombinant Protein Products:
KLHL36 Antibody Products:
Assay Products for KLHL36: |
Protein
Domains /
Families
for KLHL36 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL36 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8N4N3ProtoNet protein and cluster: Q8N4N3 3 Blocks protein families: IPB000210 BTB/POZ domain IPB011498 Kelch IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL36 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates theubiquitination and subsequent proteasomal degradation of target proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL36 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHL36 (NM_024731) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL36 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL36 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL36 |
3 GenomeRNAi human phenotypes for KLHL36:
|
Pathways & Interactions
for KLHL36 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: KLH36_HUMAN, Q8N4N3Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL36
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
KLHL36 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLHL36 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL36
Search CenterWatch for drugs/clinical trials and news about KLHL36 / KLH36
|
Transcripts
for KLHL36 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL36 gene: NM_024731.2 Unigene Cluster for KLHL36: Kelch-like 36 (Drosophila) Hs.578546 [show with all ESTs]Unigene Representative Sequence: AK0740567 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000564996(uc002fig.3 uc010chl.3) ENST00000258157 ENST00000567410
ENST00000569472 ENST00000565743 ENST00000564159 ENST00000325279
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL36 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL36 (NM_024731) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL36 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL36 |
Additional cDNA sequence: AK022605.1 AK074056.1 AK122745.1 BC032400.1 BC033821.1 4 DOTS entries: DT.99995869 DT.40273441 DT.95122048 DT.91869005 24/144 AceView cDNA sequences (see all 144): AI754075 AA810619 AA974595 BC008051 BM542313 AW672960 AI829973 NM_024731 BC032400 BE646123 BU176780 AI871638 AI335839 AA780393 AI242357 AU124814 BF982609 BC033821 BQ427706 H95653 BQ223128 BF508299 AK074056 AI078749
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL36 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
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| SP1: | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLHL36
|
Expression
for KLHL36 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCGCTTCG
About this image
See KLHL36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL36
SOURCE GeneReport for Unigene cluster: Hs.578546
SABiosciences Custom PCR Arrays for KLHL36
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL36
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL36 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL36 |
Orthologs
for KLHL36 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHL36 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for KLHL36 (if available)
TreeFam Gene Tree for KLHL36 (if available) |
Paralogs
for KLHL36 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL36 gene
- KLHL422 KLHL132 KLHL222 KLHL262 KLHL342 KBTBD132 KBTBD112 KLHL312
- KLHL92 KLHL322 KLHL142 KLHDC7B2 KLHL152 KLHL332 KLHDC7A2
18/33 SIMAP similar genes for KLHL36 using alignment to 4 protein entries: KLH36_HUMAN (see all proteins)
(see all similar genes):FLJ00127 ZBTB4 ZBTB38 ZNF295 ZBTB7C BACH2
ZBTB21 HIC1 ZBTB14 KLHL2 ZNF131 NACC1
BTBD9 DKFZp686L0695 KLHL13 KLHL9 ZBTB20 KLHL18
KLHL36 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL36 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL36 (84682131 - 84701292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL36: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL36 |
|
Disorders
/ Diseases
for KLHL36 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KLHL36 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL36 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL36) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. (PubMed id 14528312)2 Furukawa M.... Xiong Y. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KLHL36 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHL36 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL36 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL36 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL36 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHL36 gene:
Search GeneIP for patents involving KLHL36
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL36 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHL36 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL36 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL36 | | | OriGene Protein Over-expression Lysate for KLHL36 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHL36 | | OriGene 3'-UTR Clone for KLHL36 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL36 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL36 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KLHL36 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL36 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL36 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL36 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL36 |
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 |  |  |  | |
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 | | | KLHL36 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL36 |
|  |  |  | | | | Search ThermoFisher Antibodies for KLHL36 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL36 |
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