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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF2A Gene

protein-coding   GIFtS: 60
GCID: GC05P061601

kinesin heavy chain member 2A

(Previous name: kinesin heavy chain member 2 )
(Previous symbol: KIF2)
 Explore 6 diseases affiliated with
KIF2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIF2A    

Aliases
for KIF2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kinesin Heavy Chain Member 2A1 2     Kinesin-23
KIF21 2 3 5     Kinesin-Like Protein KIF2A2
HK21 2     KNS23
Kinesin Heavy Chain Member 21     Kinesin-23
Kinesin, Heavy Chain, 22     HK21 2

External Ids:    HGNC: 63181   Entrez Gene: 37962   Ensembl: ENSG000000687967   OMIM: 6025915   UniProtKB: O001393   

Export aliases for KIF2A gene to outside databases

Previous GC identifers: GC05P061638 GC05P058558


Summaries
for KIF2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KIF2A:
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded
protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139
Function: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule
dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of
chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover.
Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity

summary for KIF2A:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for KIF2A


Genomic Views
for KIF2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF2A gene promoter:
         ISGF-3   AP-2alpha isoform 3   CUTL1   AP-2alpha isoform 2   Cdc5   FOXJ2 (long isoform)   FOXJ2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF2A promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12-q13   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12-q13

KIF2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF2A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P061601:  view genomic region     (about GC identifiers)

Start:
 61,601,989 bp from pter      End:
 61,833,076 bp from pter
Size:
 231,088 bases      Orientation:
 plus strand

Proteins
for KIF2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139 (See protein sequence)
Recommended Name: Kinesin-like protein KIF2A  
Size: 706 amino acids; 79955 Da
Subunit: Interacts with AURKA, PSRC1 and PLK1
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle
pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to
metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1.
Recruited to mitotic spindles by interaction with PSRC1
Miscellaneous: HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS)
lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles
Sequence caution: Sequence=AAP84320.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIF2A:
2GRY (3D)    
Secondary accessions: A5YM42 A5YM54 B4DY54 D3DW97 Q7Z5I3 Q8N5Q7
Alternative splicing: 4 isoforms:  O00139-3   O00139-1   O00139-2   O00139-4   (Contains a phosphoserine at position 579 (By similarity). No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF2A: NX_O00139

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00139

    • KIF2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001091981.1  NP_001230881.1  NP_001230882.1  NP_004511.2  

    ENSEMBL proteins: 
     ENSP00000385622   ENSP00000370493   ENSP00000423542   ENSP00000385000   ENSP00000425411  
     ENSP00000423772   ENSP00000421041  
    Reactome Protein details: O00139
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIF2A

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922colocalizes with spindle pole IDA18411309
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule ----
    GO:0005875microtubule associated complex IEA--


    KIF2A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KIF2A

    Protein Domains /
    Families
    for KIF2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KIF2A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry O00139

    ProtoNet protein and cluster: O00139

    1 Blocks protein family: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139
    Similarity: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily
    Similarity: Contains 1 kinesin-motor domain


    Function
    for KIF2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139
    Function: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule
    dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of
    chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover.
    Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity

    miRNA
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    hsa-mir-1 (MIRT003853), hsa-mir-183 (MIRT004016)

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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF2A (see all 23):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-3614-3p hsa-miR-202 hsa-miR-15a hsa-miR-218 hsa-miR-3692 hsa-miR-124
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS9177777
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI18411309
    GO:0005524ATP binding IEA--


    KIF2A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KIF2A:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Kif2atm1Noh for KIF2A
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kif2a):
     behavior/neurological  cellular  mortality/aging  nervous system  no phenotypic analysis 

    KIF2A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KIF2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4Kinesins
    		Kinesins1.00
    		Kinesins move along microtubules consuming ATP0.95
    5Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for KIF2A 
        PLK1 signaling events

    5/18        Reactome Pathways for KIF2A (see all 18)
        Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Cell Cycle
    M Phase
    Transport of antigen loaded MHC II molecules to surface



    KIF2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for KIF2A (O001393 ENSP000003850004) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLC2Q9H0B63, ENSP000003148374I2D: score=1 STRING: ENSP00000314837
    TSNAXQ995983, ENSP000003555994I2D: score=1 STRING: ENSP00000355599
    KLC1Q078663, ENSP000004149824I2D: score=1 STRING: ENSP00000414982
    CLSTN1O949853, ENSP000003665134I2D: score=1 STRING: ENSP00000366513
    PSMB3P497203I2D: score=5 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007018microtubule-based movement TAS--
    GO:0007052mitotic spindle organization IDA18411309


    KIF2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for KIF2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KIF2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]
    Search CenterWatch for drugs/clinical trials and news about KIF2A 

    Transcripts
    for KIF2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIF2A gene (4 alternative transcripts): 
    NM_001098511.2  NM_001243952.1  NM_001243953.1  NM_004520.4  

    Unigene Cluster for KIF2A:

    Kinesin heavy chain member 2A
    Hs.558351  [show with all ESTs]
    Unigene Representative Sequence: NM_001243952
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401507 ENST00000509663 ENST00000381103(uc003jsz.4 uc003jsx.4 uc010iwp.3 uc003jsy.4 uc010iwq.3)
    ENST00000514082 ENST00000407818 ENST00000504883 ENST00000512541 ENST00000506857
    ENST00000512006 ENST00000509624

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF2A
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF2A (see all 23):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-3614-3p hsa-miR-202 hsa-miR-15a hsa-miR-218 hsa-miR-3692 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: KIF2A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF119867.2 AK057153.1 AK297347.1 AK302270.1 AK307880.1 AK315866.1 AY317140.1 AY429552.1 
    BC031828.2 BC047544.1 EF560716.1 EF560728.1 Y08319.1 

    13 DOTS entries:

    DT.454311  DT.100862004  DT.95119316  DT.101986330  DT.92005971  DT.120847501  DT.95276142  DT.97837631 
    DT.100681062  DT.92446375  DT.95355297  DT.100645026  DT.75172654 

    24/361 AceView cDNA sequences (see all 361):

    AA527276 BM662068 AA031268 BM802813 BQ772907 AW512269 BQ695086 AI240360 
    CB242998 AY280614 BU753140 BC031828 N77163 BQ945774 BE302377 BX952712 
    AA866142 F05365 BM703979 AW955281 BU631283 BE018816 AI417513 F09084 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIF2A (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                            -                                                     -                                                         
    SP2:                                                                                                  -                                                         
    SP3:                                            -                                                                                                               
    SP4:                                      -     -                                                                                                               
    SP5:        -     -     -     -     -     -     -     -     -                                         -                                                         

    ExUns: 20a · 20b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KIF2A

    Expression
    for KIF2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATTATAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KIF2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF2A

    SOURCE GeneReport for Unigene cluster: Hs.558351
        SABiosciences Custom PCR Arrays for KIF2A
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    In Situ
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    Orthologs
    for KIF2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF2A gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kif2a1 , 5 kinesin family member 2A1, 5 92.06(n)1
    98.16(a)1    		   13 (58.06 cM)5
    165631  NM_001145779.11  NP_001139251.11 
     1069589965 
    chicken
    (Gallus gallus)    		 Aves KIF2A1 kinesin heavy chain member 2A 87.58(n)
    95.33(a)    		   427156  NM_001039312.2  NP_001034401.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KIF2A6
    		 --
    		 95(a)
    		 1 ↔ 1
    		 2(8244907-8298509)
    African clawed frog
    (Xenopus laevis)    		 Amphibia kif2-A-prov2 kinesin-related protein XKIF2 80.47(n)    U36486.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1036701 zgc:103670 73.48(n)
    85.29(a)    		   447926  NM_001004664.2  NP_001004664.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Klp10A1 CG1453-PA 52.19(n)
    54.7(a)    		   32049  NM_167270.1  NP_727494.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea klp-71 Protein KLP-7 52.04(n)
    52.81(a)    		   176511  NM_001027506.1  NP_001022677.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.163032 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.95(n)    NM_192882.1 


    ENSEMBL Gene Tree for KIF2A (if available)
    TreeFam Gene Tree for KIF2A (if available) 

    Paralogs
    for KIF2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF2A gene
    KIF2B2  KIF242  KIF2C2  
    8 SIMAP similar genes for KIF2A using alignment to 5 protein entries:     KIF2A_HUMAN (see all proteins):
    KIF2B    KIF2C    KIF5C    KIF27    KIF5B    KIF3A
    KIF6    KIF5A

    KIF2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF2A
    PGOHUM00000250058


    Genomic Variants
    for KIF2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1306 NCBI SNPs in KIF2A are shown (see all 1306)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs358080561,2
    		C,F,--61600006(+) TACAAA/C/G/T 
                AAATT     		4 -- us2k13NA 124
    rs1882497681,2
    		--61600072(+) GAGAAA/TAACTT 4 -- us2k10--------
    rs1458113351,2
    		--61600118(+) CATGCC/TACTGC 4 -- us2k10--------
    rs1115474421,2
    		C,--61600160(+) GTCTCTAA/-TAATA 4 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs131597501,2
    		C,A,--61600316(+) GAGCTC/TGAAGA 4 -- us2k16Minor allele frequency- T:0.43NA WA CSA EA 363
    rs133611431,2
    		C,F,H,--61600367(+) TAAACC/GCTGAT 4 -- us2k111Minor allele frequency- G:0.42NS EA NA WA CSA 778
    rs126969881,2
    		C,F,--61600395(+) GAAACA/CGGGGT 4 -- us2k112Minor allele frequency- C:0.13NA WA CSA EA 375
    rs1119562981,2
    		C,--61600644(+) ATAAGC/TATTGA 4 -- us2k12Minor allele frequency- T:0.18CSA WA 120
    rs133612191,2
    		C,F,--61600714(+) AGGGAG/CATTAT 4 -- us2k17Minor allele frequency- C:0.32NA WA EA 366
    rs131787291,2
    		C,--61600845(+) accccG/Atctct 4 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for KIF2A (61601989 - 61833076 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for KIF2A
         3 CNVs: 2580 3555 8485

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    Disorders / Diseases
    for KIF2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KIF2A for disorders           About GeneDecksing

    OMIM gene information: 602591    OMIM disorders: --

    6 diseases for KIF2A:    About MalaCards
    tongue cancer    vaccinia    osteosarcoma    breast cancer
    schizophrenia    malaria

    1 disease from the University of Copenhagen DISEASES database for KIF2A:
    Tongue cancer
    Human Genome Epidemiology (HuGE) Navigator: KIF2A (1 document)

    Export disorders for KIF2A gene to outside databases

    Publications
    for KIF2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF2A gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with KIF2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. (PubMed id 9177777)1, 2, 3, 9 Debernardi S.... Delia D. (1997)
    2. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. (PubMed id 19351716)1, 2 Jang C.Y.... Fang G. (2009)
    3. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. (PubMed id 18411309)1, 2 Jang C.Y....Fang G. (2008)
    4. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PubMed id 17538014)1, 2 Manning A.L....Compton D.A. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia. (PubMed id 16959419)1, 9 Li C....He L. (2006)
    7. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    8. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)

    External Searches for KIF2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
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    Genome Databases showing KIF2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3796 HGNC: 6318 AceView: KIF2 Ensembl:ENSG00000068796 euGenes: HUgn3796
    ECgene: KIF2A H-InvDB: KIF2A

    Other Databases showing KIF2A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KIF2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF2A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KIF2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KIF2A gene:
    Search GeneIP for patents involving KIF2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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