JTB Gene
protein-coding GIFtS: 51
GCID: GC01M153946
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|
jumping translocation breakpoint
| |
Aliases
for JTB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Jumping Translocation Breakpoint1 2 | | HJTB2 | | HJT1 | | HSPC2222 | | Jumping Translocation Breakpoint Protein2 3 | | Protein JTB2 | | Prostate Androgen-Regulated Protein2 3 | | PAR Protein3 | | PAR2 5 | | |
Export aliases for JTB gene to outside databasesPrevious GC identifers: GC01M151763 GC01M149677 GC01M150722 GC01M151163 GC01M150759 GC01M152213 GC01M125309 |
Summaries
for JTB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: JTB_HUMAN, O76095Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May bea component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPCcomplex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and isrequired for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibitsapoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrialmembrane potential (By similarity)
Gene Wiki entry for JTB
|
Genomic Views
for JTB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JTB gene promoter:
AP-2gamma C/EBPalpha PPAR-gamma1 POU2F1 POU2F1a AP-2beta ZIC2/Zic2 PPAR-gamma2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for JTB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JTB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21JTB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153946: view genomic region
(about GC identifiers)
Start:
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153,946,745 bp from pter |
End:
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153,950,451 bp from pter |
Size:
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3,707 bases |
Orientation:
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minus strand |
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Proteins
for JTB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 (See
protein sequence)Recommended Name: Protein JTB precursor Size: 146 amino acids; 16358 Da
Subunit: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed ofBIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Mitochondrion (By similarity).Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome andalong spindle fibers during prophase and metaphase. Detected at the midbody during telophase
1 PDB 3D structure from  and Proteopedia  for JTB:2KJX (3D)
Secondary accessions: O95442 Q6IB19 Q9P0Q4Alternative splicing: 2 isoforms: O76095-1 O76095-2 Explore the universe of human proteins at neXtProt for JTB: NX_O76095
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O76095
JTB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006685.1
ENSEMBL proteins: ENSP00000271843 ENSP00000349069 ENSP00000357578 ENSP00000395250
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
JTB for ontologies About GeneDecksing
JTB Antibody Products:
Assay Products for JTB: |
Protein
Domains /
Families
for JTB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JTB for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O76095ProtoNet protein and cluster: O76095 1 Blocks protein family: IPB008657 Jumping translocation breakpoint
UniProtKB/Swiss-Prot: JTB_HUMAN, O76095Similarity: Belongs to the JTB family |
Function
for JTB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: JTB_HUMAN, O76095Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May bea component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPCcomplex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and isrequired for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibitsapoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrialmembrane potential (By similarity)Induction: Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, anddecrease to low levels at G1. Levels are lowest at the transition from G1 to S phase Genatlas biochemistry entry for JTB:jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JTB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JTB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for JTB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JTB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JTB |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019901 | protein kinase binding |
IDA | -- |
JTB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for JTB:
|
Pathways & Interactions
for JTB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JTB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for JTB (O760952, 3 ENSP000002718434) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
JTB for ontologies About GeneDecksing
|
Drugs & Compounds
for JTB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JTB
Search CenterWatch for drugs/clinical trials and news about JTB
|
Transcripts
for JTB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JTB gene: NM_006694.3 Unigene Cluster for JTB: Jumping translocation breakpoint Hs.6396 [show with all ESTs]Unigene Representative Sequence: BQ0625936 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000271843(uc001fds.3) ENST00000356648 ENST00000368589 ENST00000428469
ENST00000461365 ENST00000471173
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JTB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JTB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: JTB (NM_006694) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JTB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JTB |
Additional cDNA sequence: AB016488.1 AF115850.2 AF131797.1 AF151056.1 AK312106.1 BC000499.1 BC000996.2 BC001363.1 BC001667.1 BC004239.1 BC019277.1 BT007285.1 CR456985.1 24/26 DOTS entries (see all 26): DT.421099 DT.75130019 DT.75133749 DT.100817416 DT.100817421 DT.97844584 DT.95277027 DT.92453787 DT.95277035 DT.121436598 DT.121436576 DT.121436568 DT.100039009 DT.95277024 DT.100817411 DT.100817420 DT.95155142 DT.92453774 DT.121436377 DT.97844583 DT.92453775 DT.95104852 DT.95277026 DT.100817403 24/930 AceView cDNA sequences (see all 930): CA777260 BQ053240 BM312894 BG169213 BU617222 AI581804 BQ066456 BC001667 BE744397 BM696188 AA630680 BU631724 BG676049 AI521993 AI149434 BI116017 AI032032 AI431853 BE790802 BE880512 CF126823 BQ652220 AI024017 AI860163
GeneLoc Exon Structure
|
Expression
for JTB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JTB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTCATCT
About this image
See JTB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JTB
SOURCE GeneReport for Unigene cluster: Hs.6396
UniProtKB/Swiss-Prot: JTB_HUMAN, O76095Tissue specificity: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed inmany of their malignant counterparts
SABiosciences Custom PCR Arrays for JTB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JTB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JTB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JTB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JTB |
Orthologs
for JTB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for JTB gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for JTB (if available)
TreeFam Gene Tree for JTB (if available) |
Paralogs
for JTB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JTB gene
JTB for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for JTB
PGOHUM00000246593
|
Genomic Variants
for JTB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JTB (153946745 - 153950451 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for JTB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JTB |
|
Disorders
/ Diseases
for JTB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JTB for disorders About GeneDecksing
OMIM gene information: 604671
OMIM disorders: --
8  diseases for JTB: About MalaCardslymph node tuberculosis tuberculous meningitis prostatitis abdominal tuberculosis
meningitis tuberculosis hepatocellular carcinoma carcinoma
2 diseases from the University of Copenhagen DISEASES database for JTB:Lymph node tuberculosis Abdominal tuberculosis Export disorders for JTB gene to outside databases
|
Publications
for JTB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JTB gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with JTB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PubMed id 10321732)1, 2, 3 Hatakeyama S.... Ishikawa F. (1999)
- The structure of the extracellular domain of the jumpi ng translocation breakpoint protein reveals a variation of the midkine fold. (PubMed id 22079049)1, 2 Rousseau F....Lingel A. (2012)
- PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PubMed id 21225229)1, 2 Platica M.... Platica O. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PubMed id 10762645)1, 2 Platica O.... Platica M. (2000)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- HBsAg inhibits the translocation of JTB into mitochond ria in HepG2 cells and potentially plays a role in HCC progression. (PubMed id 22615844)1 Liu Y.P....Ren J.L. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Interacting with HBsAg compromises resistance of jump ing translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells. (PubMed id 19487072)1 Pan J.S....Ren J.L. (2009)
|
External Searches for JTB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing JTB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JTB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JTB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for JTB gene:
Search GeneIP for patents involving JTB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JTB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JTB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JTB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JTB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JTB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JTB |
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 | | | JTB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JTB |
|  |  |  | | | | Search ThermoFisher Antibodies for JTB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JTB |
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