JMJD6 Gene
protein-coding GIFtS: 54
GCID: GC17M074708
|
|
jumonji domain containing 6(Previous name: phosphatidylserine receptor )
(Previous symbol: PTDSR)
| |
Aliases
for JMJD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Jumonji Domain Containing 61 2 | | Lysyl-Hydroxylase JMJD62 3 | | Phosphatidylserine Receptor1 2 3 | | Peptide-Lysine 5-Dioxygenase JMJD62 3 | | PTDSR1 2 3 | | PSR2 5 | | PTDSR11 2 | | Bifunctional Arginine Demethylase And Lysyl-Hydroxylase JMJD62 | | KIAA05851 3 | | EC 1.14.11.-3 | | Histone Arginine Demethylase JMJD62 3 | | Protein PTDSR3 | | JmjC Domain-Containing Protein 62 3 | | EC 1.14.118 | | Jumonji Domain-Containing Protein 62 3 | | |
Export aliases for JMJD6 gene to outside databasesPrevious GC identifers: GC17M072221 GC17M070137 |
Summaries
for JMJD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for JMJD6:
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function asprotein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserinereceptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does notdirectly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserinereceptor. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1Function: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as alysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNAsplicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNAhydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase whichdemethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histonecode. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysinedemethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator ofhematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity ofU2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses
Gene Wiki entry for JMJD6
|
Genomic Views
for JMJD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JMJD6 gene promoter:
Max1 Max AML1a MyoD c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for JMJD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25JMJD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M074708: view genomic region
(about GC identifiers)
Start:
|
74,708,914 bp from pter |
End:
|
74,722,881 bp from pter |
Size:
|
13,968 bases |
Orientation:
|
minus strand |
|
Proteins
for JMJD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1 (See
protein sequence)Recommended Name: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 Size: 403 amino acids; 46462 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65
Subcellular location: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside ofregions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleusand reappears in the telophase of the cell cycle
Caution: Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition ofphosphatidylserine, a specific marker only present at the surface of apoptotic cells. Phosphatidylserine receptorprobably participates in apoptotic cell phagocytosis. This protein was identified using phage display expressing mAb217, an antibody that specifically recognizes phosphatidylserine receptor. However, its nuclear localization and thefact that mAb 217 antibody still recognizes the phosphatidylserine receptor in mice lacking JMJD6, strongly suggestthat it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal
Sequence caution: Sequence=AAH47003.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAA25511.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from  and Proteopedia  for JMJD6:3K2O (3D)
3LD8 (3D)
3LDB (3D)
Secondary accessions: B3KMN8 B4DGX1 Q86VY0 Q8IUM5 Q9Y4E2Alternative splicing: 3 isoforms: Q6NYC1-1 Q6NYC1-2 Q6NYC1-3 Explore the universe of human proteins at neXtProt for JMJD6: NX_Q6NYC1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NYC1
4/20 DME Specific Peptides for JMJD6 (Q6NYC1) (see all 20)
JMJD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001074930.1 NP_055982.2
ENSEMBL proteins: ENSP00000394085 ENSP00000442362 ENSP00000302916 ENSP00000380750 ENSP00000465330
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
JMJD6 for ontologies About GeneDecksing
JMJD6 Antibody Products:
Assay Products for JMJD6: |
Protein
Domains /
Families
for JMJD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JMJD6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NYC1ProtoNet protein and cluster: Q6NYC1 UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1Domain: The nuclear localization signal motifs are necessary and sufficient to target it into the nucleusSimilarity: Belongs to the JMJD6 familySimilarity: Contains 1 JmjC domain |
Function
for JMJD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1Function: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as alysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNAsplicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNAhydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase whichdemethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histonecode. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysinedemethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator ofhematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity ofU2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responsesBiophysicochemical properties: Kinetic parameters: KM=39 uM for 2-oxoglutarate;Induction: Up-regulated upon cytokine treatment, but not upon TNF treatmentEnzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): JMJD6 (NM_015167) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JMJD6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD6 |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
JMJD6 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for JMJD6:
Animal Models:
Mouse knock-outs for JMJD6: Jmjd6tm1Ysfk Jmjd6tm1Flv Jmjd6tm1Gbf Jmjd6tm1.1Gbf
15/17 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Jmjd6) (see all 17):
JMJD6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for JMJD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JMJD6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for JMJD6 (Q6NYC13 ENSP000003940854) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001568 | blood vessel development |
-- | -- | | GO:0001822 | kidney development |
IEA | -- | | GO:0002040 | sprouting angiogenesis |
ISS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
JMJD6 for ontologies About GeneDecksing
|
Drugs & Compounds
for JMJD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
JMJD6 for compounds About GeneDecksing
 Browse Tocris compounds for JMJD6
10/124 HMDB Compounds for JMJD6 (see all 124) About this table
4 Novoseek chemical compound relationships for JMJD6 gene About this table
Search CenterWatch for drugs/clinical trials and news about JMJD6
|
Transcripts
for JMJD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JMJD6 gene (2 alternative transcripts): NM_001081461.1 NM_015167.2 Unigene Cluster for JMJD6: Jumonji domain containing 6 Hs.514505 [show with all ESTs]Unigene Representative Sequence: NM_0010814617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445478(uc002jsn.1) ENST00000542934 ENST00000303996(uc002jso.3)
ENST00000591460 ENST00000397625 ENST00000585429 ENST00000589982
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): JMJD6 (NM_015167) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JMJD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD6 |
Additional cDNA sequence: AB011157.1 AB073711.1 AK021780.1 AK294816.1 AK314541.1 BC016837.1 BC047003.1 BC066654.1 15 DOTS entries: DT.100701748 DT.95298523 DT.100812905 DT.316217 DT.100812903 DT.120924927 DT.91824600 DT.203158 DT.95298519 DT.100812912 DT.100812901 DT.100812900 DT.100812909 DT.120925009 DT.95298521 24/263 AceView cDNA sequences (see all 263): BQ669508 BX090664 CD365078 BU727487 AI918265 BC016837 BQ716899 BU732500 CR602714 BM709041 AA262232 CD673337 CA420455 AI926454 AI565339 BI910055 BF940715 BQ669329 BX345922 AI827036 BQ668503 BC047003 AK021780 BU070317
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD6 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for JMJD6
|
Expression
for JMJD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JMJD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGAAACG
About this image
See JMJD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JMJD6
SOURCE GeneReport for Unigene cluster: Hs.514505
UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1Tissue specificity: Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level inbrain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients withchronic pancreatitis. Expressed in nursing thymic epithelial cells
SABiosciences Expression via Pathway-Focused PCR Arrays including JMJD6: | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Hypoxia Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD6 |
Orthologs
for JMJD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for JMJD6 gene from 8/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
JMJD61 |
jumonji domain containing 6 |
82.69(n)
94.2(a) |
|
417355 NM_001030703.1 NP_001025874.1 |
lizard
(Anolis carolinensis) |
Reptilia |
JMJD66 |
-- |
91(a) |
1 ↔ 1 |
2(111674370-111693335) |
African clawed frog
(Xenopus laevis) |
Amphibia |
cg5383-prov2 |
phosphatidylserine receptor |
78.97(n) |
|
BC045252.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC2669622 |
phosphatidylserine receptor |
73.22(n) |
|
266962 AF401484.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
PSR1 |
phosphatidylserine receptor |
64.46(n)
70.63(a) |
|
42616 NM_142769.3 NP_651026.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
psr-11 |
Protein PSR-1 |
56.13(n)
55.04(a) |
|
177229 NM_001047475.2 NP_001040940.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G782806 |
transferase |
11(a) |
1 ↔ 1 |
1(29452555-29457373) |
rice
(Oryza sativa) |
Liliopsida |
-- |
OsFBO14 - F-box and other domain containing protei... |
11(a) |
1 ↔ 1 |
3(15612874-15620237) |
ENSEMBL Gene Tree for JMJD6 (if available)
TreeFam Gene Tree for JMJD6 (if available) |
Paralogs
for JMJD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JMJD6 gene
- JMJD42
JMJD6 for paralogs About GeneDecksing
|
Genomic Variants
for JMJD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JMJD6 (74708914 - 74722881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for JMJD6
1 CNV: 73037 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JMJD6 |
|
Disorders
/ Diseases
for JMJD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JMJD6 for disorders About GeneDecksing
OMIM gene information: 604914
OMIM disorders: --
19  diseases for JMJD6: About MalaCardstrigeminal neuralgia wiskott-aldrich syndrome chorioretinal scar heart block
congenital heart block retinal perforation retinal detachment chorioretinitis
bronchiectasis cystic fibrosis periodontal disease retinitis
fibrosis periodontitis cholesterol pancreatitis
prostatitis neuronitis sepsis
4 diseases from the University of Copenhagen DISEASES database for JMJD6:Trigeminal neuralgia Periodontal disease Intramuscular hemangioma Chorioretinal scar 1 Novoseek disease relationship for JMJD6 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
37 |
2 |
11877474 (2) |
Export disorders for JMJD6 gene to outside databases
|
Publications
for JMJD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JMJD6 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with JMJD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. (PubMed id 15622002)1, 2, 9 Koeninger J.... Friess H. (2005)
- Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. (PubMed id 15072554)1, 2, 9 Cao W.M.... Ishida T. (2004)
- Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. (PubMed id 11877474)1, 3, 9 Vandivier R.W....Henson P.M. (2002)
- Crystal structure of the 2-oxoglutarate- and Fe(II)-d ependent lysyl hydroxylase JMJD6. (PubMed id 20684070)1, 2 Mantri M....Schofield C.J. (2010)
- Interaction of JMJD6 with single-stranded RNA. (PubMed id 20679243)1, 2 Hong X....Zhang G. (2010)
- Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PubMed id 19574390)1, 2 Webby C.J....Boettger A. (2009)
- JMJD6 is a histone arginine demethylase. (PubMed id 17947579)1, 2 Chang B.... Bruick R.K. (2007)
- Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. (PubMed id 14729065)1, 2 Cui P.... Pei D. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for JMJD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing JMJD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing JMJD6 gene
(According to HUGE)
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Specialized Databases showing JMJD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for JMJD6 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for JMJD6 gene:
Search GeneIP for patents involving JMJD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for JMJD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for JMJD6 | | OriGene shRNA RFP for JMJD6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JMJD6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD6 | | | OriGene Protein Over-expression Lysate for JMJD6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for JMJD6 | | OriGene 3'-UTR Clone for JMJD6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for JMJD6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for JMJD6 | | OriGene Custom Protein Services for JMJD6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JMJD6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JMJD6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JMJD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD6 |
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| | | | Search Tocris compounds for JMJD6 |
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 | | | JMJD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD6 |
|  |  |  | | | | ThermoFisher Antibody for JMJD6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD6 |
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