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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGA8 Gene

protein-coding GIFtS: 60
GCID: GC10M015599

integrin, alpha 8

Explore 14 diseases affiliated with
ITGA8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha 8¹ ²
Integrin Alpha-8²

External Ids:	HGNC: 6144¹	Entrez Gene: 8516²	Ensembl: ENSG00000077943⁷	OMIM: 604063⁵	UniProtKB: P53708³

Export aliases for ITGA8 gene to outside databases

Previous GC identifers: GC10M015541 GC10M015709 GC10M015563

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708

Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the

recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of

ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis.

Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor

neurons

Gene Wiki entry for ITGA8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGA8 gene promoter:
GR RP58 ATF-2 FOXD1 CRE-BP1 MEF-2A AREB6 c-Myb GR-alpha aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGA8 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGA8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13

ITGA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA8 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M015599: view genomic region (about GC identifiers)

Start:	15,555,948 bp from pter	End:	15,762,124 bp from pter
Size:	206,177 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708 (See protein sequence)

Recommended Name: Integrin alpha-8 precursor

Size: 1063 amino acids; 117474 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked

by a disulfide bond. Alpha-8 associates with beta-1

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: B0YJ31 Q5VX94

Explore the universe of human proteins at neXtProt for ITGA8: NX_P53708

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53708

ITGA8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003629.1

ENSEMBL proteins:

ENSP00000367316

Reactome Protein details: P53708
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	TAS	7768999
GO:0034678	alpha8-beta1 integrin complex	TAS	--
GO:0045177	apical part of cell	IEA	--

ITGA8 for ontologies About GeneDecksing

ITGA8 Antibody Products:

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	Novus Biologicals ITGA8 Antibodies
	Search for Antibodies for ITGA8 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for ITGA8

Assay Products for ITGA8:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ITGA8
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGA8 for domains About GeneDecksing

5 InterPro domains/families:

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P53708

ProtoNet protein and cluster: P53708

3 Blocks protein families:

IPB000413 Integrins alpha chain

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708

Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the

recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of

ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis.

Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor

neurons

miRNA Products:		OriGene 3'-UTR Clone: ITGA8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA8
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGA8
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA8 (see all 4) OriGene shRNA RFP: ITGA8 OriGene siRNA: ITGA8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA8

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGA8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: ITGA8 (NM_003638)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGA8
		Search LifeMap BioReagents cell lines for ITGA8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA8

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0046872	metal ion binding	IEA	--

ITGA8 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ITGA8:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Itga8^tm1Lfr for ITGA8
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Itga8):

behavior/neurological	cellular	hearing/vestibular/ear	mortality/aging	nervous system
renal/urinary system	respiratory system

ITGA8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66			HGF Pathway	0.24

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ITGA8

	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion PLAU signaling

5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA8 (see all 33)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

2 GeneGo (Thomson Reuters) Pathways for ITGA8

	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion PLAU signaling

3 BioSystems Pathways for ITGA8

	Integrin-mediated cell adhesion
	Focal Adhesion
	Arrhythmogenic right ventricular cardiomyopathy

5 Reactome Pathways for ITGA8

	Molecules associated with elastic fibres
	Extracellular matrix organization
	Integrin cell surface interactions
	Elastic fibre formation
	Signal Transduction

5/7 Kegg Pathways (Kegg details for ITGA8) (see all 7):

	Focal adhesion
	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Regulation of actin cytoskeleton
	Hypertrophic cardiomyopathy (HCM)

ITGA8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGA8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/106 Interacting proteins for ITGA8 (P53708³ ENSP00000367316⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 106)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FN1	P02751³, ENSP00000346839⁴	I2D: score=1 STRING: ENSP00000346839
ITGB1	P05556³, ENSP00000364094⁴	I2D: score=4 STRING: ENSP00000364094
ITGA3	P26006³, ENSP00000007722⁴	I2D: score=1 STRING: ENSP00000007722
NPNT	Q6UXI9³, ENSP00000369323⁴	I2D: score=2 STRING: ENSP00000369323
VTN	P04004³, ENSP00000226218⁴	I2D: score=1 STRING: ENSP00000226218

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001656	metanephros development	IEA	--
GO:0007155	cell adhesion	--	--
GO:0007160	cell-matrix adhesion	NAS	7768999
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007399	nervous system development	IEA	--

ITGA8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGA8
Search CenterWatch for drugs/clinical trials and news about ITGA8 / ITA8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGA8 gene:

NM_003638.1

Unigene Cluster for ITGA8:

Integrin, alpha 8

Hs.171311 [show with all ESTs]

Unigene Representative Sequence: NM_003638

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378076(uc001ioc.1 uc010qcb.1) ENST00000477064 ENST00000468882

miRNA Products:		OriGene 3'-UTR Clone: ITGA8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA8
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGA8
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA8 (see all 4) OriGene shRNA RFP: ITGA8 OriGene siRNA: ITGA8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA8 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA8 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGA8 (NM_003638)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGA8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGA8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA8

Additional cDNA sequence:

AK297740.1 AK308240.1 L36531.1

4 DOTS entries:

DT.312805 DT.312806 DT.91671353 DT.95091367

24/40 AceView cDNA sequences (see all 40):

AI658695 BX106890 AI521164 AA131272 NM_003638 BF437627 BF446919 F01262

BX092288 AA779994 AA297173 AL697739 BF437411 CA388792 CB963509 AI023787

AA131323 AI685895 BF939224 AA630195 L36531 CD357514 AI193623 CA395504

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAGAAAAA

About this image

ITGA8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Mesoderm-like cells (Derivation of cardio...)

Beating cell clusters (Spontaneous differen...)

See ITGA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGA8

SOURCE GeneReport for Unigene cluster: Hs.171311

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708

Tissue specificity: Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and

hepatic stellar cells and vascular and visceral smooth muscle (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA8:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Focal Adhesions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGA8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGA8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGA8 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITGA8¹	integrin, alpha 8	76.03(n) 77.33(a)		396225 NM_205288.1 NP_990619.1
lizard (Anolis carolinensis)	Reptilia	-- ITGA8⁶	--	73(a) 67(a)	1 ↔ many 1 ↔ many	6(18899064-18926935) 6(18941396-18994045)
zebrafish (Danio rerio)	Actinopterygii	itga8⁶	integrin, alpha 8	62(a)	1 ↔ 1	16(30612031-30742249)
fruit fly (Drosophila melanogaster)	Insecta	scb³	calcium-dependent cell-matrix adhesion cell adhesion more	27(a) (best of 3)		--
worm (Caenorhabditis elegans)	Secernentea	pat-2¹	Protein PAT-2	45.88(n) 34.15(a)		176240 NM_066547.2 NP_498948.1

ENSEMBL Gene Tree for ITGA8 (if available)
TreeFam Gene Tree for ITGA8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGA8 gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGAM² ITGA11² ITGA2² ITGA5²

ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGAL² ITGA9² ITGA4²

ITGA10²

3 SIMAP similar genes for ITGA8 using alignment to 1 protein entry: ITA8_HUMAN:

ITGAV ITGA5 ITGA2B

ITGA8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs67683436^1,2	C	--	15591201(+)	`TTCTG-/TTTTTTT TTTTTTTTTTTTTT`	1	--	int¹		0	--	--	--	--
rs78824027^1,2	C	--	15591216(+)	`TTTTTG/TTTTTT`	1	--	int¹		1		NA	2
rs199857532^1,2		--	15603213(+)	`CTATA-/TATATATATA TATATATATATGTATAT`	1	--	int¹		0	--	--	--	--
rs200898205^1,2		--	15603215(+)	`ATATA-/TATATATAT ATATATATATGTATAT`	1	--	int¹		0	--	--	--	--
rs139910952^1,2		--	15608834(+)	`AGGCCA/GGGTGC`	1	--	int¹		0	--	--	--	--
rs149726951^1,2		--	15608867(+)	`AGCACC/TCTGGG`	1	--	int¹		0	--	--	--	--
rs111491564^1,2	C,F,	--	15609020(+)	`GGTGTG/TGTGGC`	1	--	int¹		3		WA CSA	122
rs35286236^1,2	C	--	15622126(+)	`AAAAA-/AGAGAA`	1	--	int¹		1		NA	2
rs10715351^1,2	C,	--	15641722(+)	`TGAGA-/GCAGTC`	1	--	int¹		2		NA CSA	4
rs77441927^1,2	C	--	15652509(+)	`AAAAAA/CCCCAT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ITGA8 (15555948 - 15762124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for ITGA8
13 CNVs: 85123 75125 100876 75129 75126 75124 75127 85120 4667 85121 48488 75128 85122
2 Indels: 48489 11032

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGA8

DNA2.0 Custom Variant and Variant Library Synthesis for ITGA8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGA8 for disorders           About GeneDecksing

OMIM gene information: 604063    OMIM disorders: --

14 diseases for ITGA8:    About MalaCards

bullous keratopathy laryngeal squamous cell carcinoma keratopathy squamous cell carcinoma

polycystic kidney disease kidney disease laryngitis parkinson's disease

glomerulonephritis alzheimer's disease carcinoma melanoma

hepatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: ITGA8 (3 documents)

Export disorders for ITGA8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGA8 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with ITGA8)

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Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. (PubMed id 7768999)^{1, 2, 3, 9} Schnapp L.M.... Pytela R. (1995)
Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). (PubMed id 15579315)^{1, 2, 9} Ekwa-Ekoka C.... Schnapp L.M. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. (PubMed id 12415008)^{1, 2} Lu M.... Schnapp L.M. (2002)
Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. (PubMed id 10504498)^{1, 2} Hartner A.... Sterzel R.B. (1999)
A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. (PubMed id 18277079)^{1, 9} Zeltner R....Hartner A. (2008)
Expression and promoter analysis of a highly restricte d integrin alpha gene in vascular smooth muscle. (PubMed id 23142384)¹ Kitchen C.M....Miano J.M. (2013)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Integrin alpha8beta1 confers anoikis susceptibility t o human intestinal epithelial crypt cells. (PubMed id 20678483)¹ Benoit Y.D....Beaulieu J.F. (2010)
[Expression and significance of integrins subunits in laryngeal squamous cell carcinoma]. (PubMed id 20942236)¹ Ni R....Gao X. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8516	HGNC: 6144	AceView: ITGA8	Ensembl:ENSG00000077943	euGenes: HUgn8516
ECgene: ITGA8	Kegg: 8516	H-InvDB: ITGA8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ITGA8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGA8	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/itga8/

Intellectual Property for ITGA8 gene
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Patent Information for ITGA8 gene:
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integrin, alpha 8

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