INSL4 Gene
protein-coding GIFtS : 47
GCID: GC09 P005231
insulin-like 4 (placenta)
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Aliasesfor INSL4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Insulin-Like 4 (Placenta) 1 2 Early Placenta Insulin-Like Peptide2 EPIL1 2 3 Early Placenta Insulin-Like Peptide (EPIL)2 Insulin-Like Peptide 42 3 Placentin3 PLACENTIN2
Export aliases for INSL4 gene to outside databases Previous GC identifers: GC09P005385 GC09P005212 GC09P005221 GC09P005266
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Summariesfor INSL4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for INSL4 : INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641 Function : May play an important role in trophoblast development and in the regulation of bone formationGene Wiki entry for INSL4
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Genomic Viewsfor INSL4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008413.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the INSL4 gene promoter: LHX3b/Lhx3b LHX3a/Lhx3a Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for INSL4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9p24 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24 INSL4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P005231: view genomic region
(about GC identifiers )
Start:
5,231,419 bp from pter
End:
5,235,304 bp from pter
Size:
3,886 bases
Orientation:
plus strand
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Proteinsfor INSL4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641 (See
protein sequence )Recommended Name: Early placenta insulin-like peptide precursor Size : 139 amino acids; 15445 Da
Subcellular location : Secreted (By similarity)
Developmental stage : Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblastis different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments
Secondary accessions : A8K678 Q5W127Explore the universe of human proteins at neXtProt for INSL4: NX_Q14641 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q14641 INSL4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_002186.1 ENSEMBL proteins: ENSP00000239316 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
INSL4 for ontologies About GeneDecksing INSL4 Antibody Products: Assay Products for INSL4:
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Protein
Domains / Familiesfor INSL4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
INSL4 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q14641 ProtoNet protein and cluster: Q14641
1 Blocks protein family : IPB004825 Insulin/IGF/relaxin UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641 Similarity : Belongs to the insulin family
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Functionfor INSL4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641 Function : May play an important role in trophoblast development and in the regulation of bone formation
Genatlas biochemistry entry for INSL4 : insulin-like 4,growth factor expressed in placenta and uterus Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for INSL4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for INSL4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: INSL4 (NM_002195 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INSL4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat INSL4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL4
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
INSL4 for ontologies About GeneDecksing
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Pathways & Interactionsfor INSL4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSL4 Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
INSL4 for ontologies About GeneDecksing
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Drugs & Compoundsfor INSL4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
INSL4 for compounds About GeneDecksing Browse Tocris compounds for INSL4 1 Novoseek chemical compound relationship for INSL4 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine
0
1
8702754 (1)
Search CenterWatch for drugs/clinical trials and news about INSL4
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Transcriptsfor INSL4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for INSL4 gene: NM_002195.1 Unigene Cluster for INSL4:
Insulin-like 4 (placenta) Hs.418506 [show with all ESTs ] Unigene Representative Sequence: AL574010 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000239316 (uc003ziy.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for INSL4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for INSL4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: INSL4 (NM_002195 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INSL4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat INSL4
Additional cDNA sequence: AK291543.1 BC026254.1 L34838.1
2 DOTS entries : DT.100747192 DT.314754
24/47 AceView cDNA sequences (see all 47 ):
CR601901 AU136752 BQ007399 CF527906 BX102762 N69496 AI088100 CF528405 L34838 BV167944 AI128289 NM_002195 CF528060 AI784163 BV178729 BC026254 BX371720 AL574010 AI148843 BQ004108 R75761 AL550042 AA777897 BQ011259 GeneLoc Exon Structure
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Expression for INSL4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section INSL4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACAAAAAAAA
About this image INSL4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Syncytiotrophoblast-like cells (Generation of syncyt... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See INSL4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for INSL4 SOURCE GeneReport for Unigene cluster: Hs.418506 UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641 Tissue specificity : Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in bothearly placentas and molar pregnancies and were reduced in choriocarcinoma cells SABiosciences Custom PCR Arrays for INSL4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for INSL4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat INSL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat INSL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat INSL4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL4
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Orthologsfor INSL4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for INSL4 (if available)TreeFam Gene Tree for INSL4 (if available)
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Paralogsfor INSL4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for INSL4 gene
INSL4 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for INSL4 PGOHUM00000235954
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Genomic Variantsfor INSL4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for INSL4 (5231419 - 5235304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for INSL4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing INSL4
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Disorders
/ Diseasesfor INSL4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
INSL4 for disorders About GeneDecksing
OMIM gene information: 600910
OMIM disorders : --3 diseases for INSL4 : About MalaCards ulcerative colitis breast cancer choriocarcinoma 4 Novoseek disease relationships for INSL4 gene About this table
Export disorders for INSL4 gene to outside databases
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Publicationsfor INSL4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for INSL4 gene, integrated from 9 sources (see all 29 ): (articles sorted by number of sources associating them with INSL4) Utopia : connect your pdf to the dynamic world of online information
Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. (PubMed id 8666396) 1 , 2 , 3, 9 Chassin D.... Bellet D. (1995) Identification of pro-EPIL and EPIL peptides translated from insulin- like 4 (INSL4) mRNA in human placenta. (PubMed id 9284764) 1 , 2 , 9 Bellet D.... Bidart J.-M. (1997) Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues. (PubMed id 9740319) 1 , 2 , 9 Laurent A.... Vidaud M. (1998) The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome. (PubMed id 9730618) 1 , 3, 9 Veitia R....McElreavey K. (1998) Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PubMed id 12414911) 1 , 2 , 9 Janneau J.-L.... Bellet D. (2002) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth. (PubMed id 15958731) 1 , 9 Millar L....Bryant-Greenwood G. (2005) Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. (PubMed id 12606452) 1 , 9 Bieche I....Vidaud M. (2003)
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External Searches for INSL4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing INSL4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing INSL4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing INSL4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for INSL4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for INSL4 gene: Search GeneIP for patents involving INSL4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor INSL4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for INSL4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for INSL4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for INSL4 OriGene Protein Over-expression Lysate for INSL4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for INSL4 OriGene 3'-UTR Clone for INSL4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for INSL4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for INSL4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for INSL4 OriGene Custom Protein Services for INSL4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INSL4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing INSL4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat INSL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat INSL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat INSL4
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INSL4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL4
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat INSL4
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