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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSL4 Gene

protein-coding   GIFtS: 47
GCID: GC09P005231

insulin-like 4 (placenta)

 Explore 3 diseases affiliated with
INSL4 via our new
 Human Malady Compendium 
Biological research products
for INSL4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Insulin-Like 4 (Placenta)1 2     Early Placenta Insulin-Like Peptide2
EPIL1 2 3     Early Placenta Insulin-Like Peptide (EPIL)2
Insulin-Like Peptide 42 3     Placentin3
PLACENTIN2     

External Ids:    HGNC: 60871   Entrez Gene: 36412   Ensembl: ENSG000001202117   OMIM: 6009105   UniProtKB: Q146413   

Export aliases for INSL4 gene to outside databases

Previous GC identifers: GC09P005385 GC09P005212 GC09P005221 GC09P005266


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSL4:
INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes
post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all
three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental
cytotrophoblast and syncytiotrophoblast. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641
Function: May play an important role in trophoblast development and in the regulation of bone formation

Gene Wiki entry for INSL4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSL4 gene promoter:
         LHX3b/Lhx3b   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24

INSL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSL4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005231:  view genomic region     (about GC identifiers)

Start:
5,231,419 bp from pter      End:
5,235,304 bp from pter
Size:
3,886 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641 (See protein sequence)
Recommended Name: Early placenta insulin-like peptide precursor  
Size: 139 amino acids; 15445 Da
Subcellular location: Secreted (By similarity)
Developmental stage: Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast
is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium
of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments
Secondary accessions: A8K678 Q5W127

Explore the universe of human proteins at neXtProt for INSL4: NX_Q14641

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14641

  • INSL4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002186.1  
    ENSEMBL proteins: 
     ENSP00000239316  

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    Uscn Proteins for INSL4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8702754
    GO:0005625soluble fraction ----


    INSL4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    INSL4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023258 Placentin
     IPR022421 Relaxin

    Graphical View of Domain Structure for InterPro Entry Q14641

    ProtoNet protein and cluster: Q14641

    1 Blocks protein family: IPB004825 Insulin/IGF/relaxin

    UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641
    Similarity: Belongs to the insulin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641
    Function: May play an important role in trophoblast development and in the regulation of bone formation

         Genatlas biochemistry entry for INSL4:
    insulin-like 4,growth factor expressed in placenta and uterus

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8702754
    GO:0005159insulin-like growth factor receptor binding TAS8666396
    GO:0005179hormone activity IEA--


    INSL4 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSL4

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8702754
    GO:0007267cell-cell signaling TAS8702754
    GO:0007275multicellular organismal development TAS8702754
    GO:0007565female pregnancy TAS8702754
    GO:0008283cell proliferation TAS8702754


    INSL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INSL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSL4
    1 Novoseek chemical compound relationship for INSL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 8702754 (1)

    Search CenterWatch for drugs/clinical trials and news about INSL4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section

    REFSEQ mRNAs for INSL4 gene: 
    NM_002195.1  

    Unigene Cluster for INSL4:

    Insulin-like 4 (placenta)
    Hs.418506  [show with all ESTs]
    Unigene Representative Sequence: AL574010
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239316(uc003ziy.3)

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    Additional cDNA sequence: 

    AK291543.1 BC026254.1 L34838.1 

    2 DOTS entries:

    DT.100747192  DT.314754 

    24/47 AceView cDNA sequences (see all 47):

    CR601901 AU136752 BQ007399 CF527906 BX102762 N69496 AI088100 CF528405 
    L34838 BV167944 AI128289 NM_002195 CF528060 AI784163 BV178729 BC026254 
    BX371720 AL574010 AI148843 BQ004108 R75761 AL550042 AA777897 BQ011259 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    INSL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INSL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSL4

    SOURCE GeneReport for Unigene cluster: Hs.418506

    UniProtKB/Swiss-Prot: INSL4_HUMAN, Q14641
    Tissue specificity: Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both
    early placentas and molar pregnancies and were reduced in choriocarcinoma cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for INSL4 (if available)
    TreeFam Gene Tree for INSL4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INSL4 gene

    INSL4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for INSL4
    PGOHUM00000235954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/152 NCBI SNPs in INSL4 are shown (see all 152    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727016911,2
    C,--5229419(+) CCCATT/ACCCTT 1 -- us2k12Minor allele frequency- A:0.13NA 122
    rs121152491,2
    C,F,H,--5229426(+) CCTTAT/CGATTT 1 -- us2k15Minor allele frequency- C:0.10NS EA WA 538
    rs780537601,2
    C--5229440(+) CCGATA/GGGAGG 1 -- us2k10--------
    rs783566991,2
    F,--5229457(+) TATCCC/TAGACC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1144328811,2
    --5229523(+) ACCTCC/TCTTGA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1120431171,2
    --5229556(+) AATTAC/TAGTAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs592242111,2
    C,--5229637(+) TCCTTA/GTGGGA 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1446250031,2
    --5229791(+) ATTCCA/TACCCG 1 -- us2k10--------
    rs1511418251,2
    --5229796(+) TACCCA/GTCAAT 1 -- us2k10--------
    rs580347041,2
    C,--5229798(+) CCCGTC/TAATTT 1 -- us2k12Minor allele frequency- T:0.08WA 120

    HapMap Linkage Disequilibrium report for INSL4 (5231419 - 5235304 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INSL4: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INSL4 for disorders           About GeneDecksing

    OMIM gene information: 600910    OMIM disorders: --

    3 diseases for INSL4:    About MalaCards
    ulcerative colitis    breast cancer    choriocarcinoma

    4 Novoseek disease relationships for INSL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 5.13 7 18035692 (5), 11861376 (1), 16322324 (1)
    metastasis 0.842 2 18035692 (1), 12414911 (1)
    tumors 0 3 16322324 (2), 12414911 (1)
    cancer 0 3 16322324 (2), 18035692 (1)


    Export disorders for INSL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSL4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with INSL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. (PubMed id 8666396)1, 2, 3, 9 Chassin D.... Bellet D. (1995)
    2. Identification of pro-EPIL and EPIL peptides translated from insulin- like 4 (INSL4) mRNA in human placenta. (PubMed id 9284764)1, 2, 9 Bellet D.... Bidart J.-M. (1997)
    3. Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues. (PubMed id 9740319)1, 2, 9 Laurent A.... Vidaud M. (1998)
    4. The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome. (PubMed id 9730618)1, 3, 9 Veitia R....McElreavey K. (1998)
    5. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PubMed id 12414911)1, 2, 9 Janneau J.-L.... Bellet D. (2002)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    9. Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth. (PubMed id 15958731)1, 9 Millar L....Bryant-Greenwood G. (2005)
    10. Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. (PubMed id 12606452)1, 9 Bieche I....Vidaud M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3641 HGNC: 6087 AceView: INSL4 Ensembl:ENSG00000120211 euGenes: HUgn3641
    ECgene: INSL4 H-InvDB: INSL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSL4 gene:
    Search GeneIP for patents involving INSL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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