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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IFNA1 Gene

protein-coding GIFtS: 60
GCID: GC09P021430

interferon, alpha 1

Explore 321 diseases affiliated with
IFNA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon, Alpha 1¹ ²		Interferon Alpha-D² ³
IFNA@¹ ² ⁵		LeIF D² ³
IFL¹ ²		IFN-Alpha-1/13¹
IFN¹ ²		IFN-Alpha 1b²
IFN-ALPHA¹ ²		Interferon Alpha 1b²
IFN-AlphaD¹		Interferon Alpha-1/13²
IFNA13¹ ²		Interferon-Alpha1¹

External Ids:	HGNC: 5417¹	Entrez Gene: 3439²	Ensembl: ENSG00000197919⁷	OMIM: 147660⁵	UniProtKB: P01562³

Export aliases for IFNA1 gene to outside databases

Previous GC identifers: GC09P021768 GC09P021641

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IFNA1:

The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the

encoded protein is secreted. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two

enzymes: a protein kinase and an oligoadenylate synthetase

Gene Wiki entry for IFNA1 (Interferon, alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IFNA1 gene promoter:
c-Fos STAT1 Sp1 AP-1 STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IFNA1 promoter sequence

Search SABiosciences Chromatin IP Primers for IFNA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IFNA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p22

IFNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IFNA1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P021430: view genomic region (about GC identifiers)

Start:	21,440,440 bp from pter	End:	21,441,315 bp from pter
Size:	876 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562 (See protein sequence)

Recommended Name: Interferon alpha-1/13 precursor

Size: 189 amino acids; 21725 Da

Subcellular location: Secreted

Miscellaneous: Interferons alpha-1 and alpha-13 have identical protein sequences

1 PDB 3D structure from and Proteopedia for IFNA1:

3UX9 (3D)

Secondary accessions: D4Q9M8 Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3

Explore the universe of human proteins at neXtProt for IFNA1: NX_P01562

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01562

IFNA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_076918.1

ENSEMBL proteins:

ENSP00000276927

Reactome Protein details: P01562
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IFNA1 (IFN-alpha D, IFN-alpha 1, IFN)
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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IFNA1
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	--	--

IFNA1 for ontologies About GeneDecksing

IFNA1 Antibody Products:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IFNA1 for domains About GeneDecksing

4 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR015589 Interferon_alpha

IPR000471 Interferon_alpha/beta/delta

IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P01562

ProtoNet protein and cluster: P01562

1 Blocks protein family: IPB000471 Interferon alpha

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562

Similarity: Belongs to the alpha/beta interferon family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two

enzymes: a protein kinase and an oligoadenylate synthetase

Genatlas biochemistry entry for IFNA1:

interferon type I,alpha 1,leukocyte

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNA1:
		hsa-miR-577 hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IFNA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IFNA1 OriGene shRNA RFP: IFNA1 OriGene siRNA: IFNA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IFNA1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IFNA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: IFNA1 (NM_024013)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IFNA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IFNA1
		Search LifeMap BioReagents cell lines for IFNA1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFNA1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	--	--
GO:0005132	interferon-alpha/beta receptor binding	--	--

IFNA1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of IFNA signaling

Regulation of IFNA signaling	1.00	TRAF6 mediated IRF7 activation	0.33
Immune response_IFN alpha/beta signaling pathway	0.71	Cytokine Network	0.28
Immune response IFN alpha/beta signaling pathway	0.71	Regulation of autophagy	0.26
Expression of Interferon-alpha and beta	0.52

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	1.00			Toll-Like receptor Signaling Pathways	0.51
	Toll-like receptor signaling pathway	0.97

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

1.00

Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways

0.91

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Innate Immune System

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IFNA1

	Immune response IFN alpha/beta signaling pathway
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

1 R&D Systems Pathway for IFNA1

Toll-Like receptor Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IFNA1

	Cytokine Network
	Interferon Pathway
	JAK-STAT Pathway
	all-trans-Retinoic Acid Mediated Apoptosis

2 GeneGo (Thomson Reuters) Pathways for IFNA1

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response IFN alpha/beta signaling pathway

2 BioSystems Pathways for IFNA1

	Toll-like receptor signaling pathway
	IL-2 Signaling Pathway

5/11 Reactome Pathways for IFNA1 (see all 11)

	Hemostasis
	Regulation of IFNA signaling
	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

5/12 Kegg Pathways (Kegg details for IFNA1) (see all 12):

	Cytokine-cytokine receptor interaction
	Regulation of autophagy
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Cytosolic DNA-sensing pathway

IFNA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IFNA1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IFNA1 (P01562³ ENSP00000276927⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL2	P60568³, ENSP00000226730⁴	I2D: score=1 STRING: ENSP00000226730
IRF9	Q00978³, ENSP00000380073⁴	I2D: score=1 STRING: ENSP00000380073
CR2	P20023³, ENSP00000356024⁴	I2D: score=3 STRING: ENSP00000356024
IFNAR1	P17181³, ENSP00000270139⁴	I2D: score=1 STRING: ENSP00000270139

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007596	blood coagulation	--	--
GO:0009615	response to virus	--	--
GO:0019221	cytokine-mediated signaling pathway	--	--
GO:0045087	innate immune response	--	--
GO:0060337	type I interferon-mediated signaling pathway	--	--

IFNA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IFNA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IFNA1
10/128 Novoseek chemical compound relationships for IFNA1 gene (see all 128) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ifn-alpha	95	2125	16142050 (22), 15389589 (13), 15581417 (12), 11505050 (12) (see all 99)
ribavirin	92.7	1832	9862245 (8), 11233844 (7), 14586901 (6), 10438811 (6) (see all 99)
2',5'-oligoadenylate	88.7	197	7648430 (5), 1723088 (4), 9260891 (3), 1379287 (3) (see all 99)
polyinosinic-polycytidylic acid	77.1	57	11786977 (7), 2153928 (3), 2177082 (3), 9920723 (3) (see all 33)
poly(i-c)	73	57	1330423 (2), 8444700 (2), 12519390 (2), 17108037 (2) (see all 40)
hydroxyurea	72.5	306	7994025 (6), 11798827 (5), 8652857 (4), 14635203 (4) (see all 99)
alanine	72.2	151	1279945 (2), 8228388 (1), 8790560 (1), 8816142 (1) (see all 99)
lamivudine	70.6	368	16904047 (7), 10861649 (6), 11526544 (5), 18307594 (5) (see all 99)
5fluorouracil	67	945	17699726 (8), 9463483 (8), 17275163 (8), 7646900 (7) (see all 99)
dacarbazine	66.4	66	10359134 (3), 9586887 (2), 17600290 (2), 7992096 (1) (see all 41)

Search CenterWatch for drugs/clinical trials and news about IFNA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IFNA1 gene:

NM_024013.2

Unigene Cluster for IFNA1:

Interferon, alpha 1

Hs.37026

Unigene Representative Sequence: AB578885

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000276927(uc003zpd.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IFNA1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate IFNA1:
		hsa-miR-577 hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IFNA1 3' UTR sequence

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IFNA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA1

Additional cDNA sequence:

AB578885.1 AB578886.1 BC074928.2 BC074929.2 BC112002.1 BC112300.1 BC112302.1 JN848523.1

V00537.1 V00538.1

2 DOTS entries:

DT.209454 DT.121155340

5 AceView cDNA sequences:

BC074929 NM_024013 BC074928 V00537 V00538

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IFNA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See IFNA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IFNA1

SOURCE GeneReport for Unigene cluster: Hs.37026

SABiosciences Expression via Pathway-Focused PCR Arrays including IFNA1 (see all 16):

HIV Host Response in human mouse rat

Antiviral Response in human mouse rat

Interferons & Receptors in human mouse rat

NFKB Signaling Pathway in human mouse rat

Common Cytokines in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IFNA1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IFNA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IFNA1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	--	32(a)	1 → many	Un(24396419-24396970)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 6)	--	28(a) 27(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2(61647787-61648344) 2(61644933-61645472)
zebrafish (Danio rerio)	Actinopterygii	ifnphi3⁶ ifnphi2⁶	interferon phi 2	28(a) 24(a)	many ↔ many many ↔ many	3(22558521-22560658) 3(22565711-22572180)

ENSEMBL Gene Tree for IFNA1 (if available)
TreeFam Gene Tree for IFNA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IFNA1 gene

IFNA13¹ ² IFNA7² IFNA2² IFNE² IFNA4² IFNA14² IFNA5² IFNK²

IFNA21² IFNA17² IFNA6² IFNB1² IFNW1² IFNA16² IFNA10² IFNA8²

18 SIMAP similar genes for IFNA1 using alignment to 2 protein entries: IFNA1_HUMAN (see all proteins):

IFNA13 IFNA5 IFNA10 IFNA14 IFNA17 IFNA21

IFNA4 IFNA6 IFNA7 IFN-2 IFNA IFNA2

IFNA2B IFNA16 IFNA8 IFNW1 IFNE IFNB1

IFNA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IFNA1_HUMAN, P01562

Polymorphism: Two forms exist; alpha-1a (shown here) and alpha-1b

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148494751^1,2		--	21438555(+)	`ATGGAA/GCACTT`	1	--	us2k¹		0	--	--	--	--
rs115842484^1,2		--	21438581(+)	`CCTGTC/GAGGTT`	1	--	us2k¹		1		WA	118
rs1332190^1,2	C,F,O,A,H,	--	21438684(-)	`TCCATC/TGTCTA`	1	--	us2k¹		35		NS EA NA WA CSA	3169
rs187684226^1,2		--	21438709(+)	`TTTCTA/GCTTTC`	1	--	us2k¹		0	--	--	--	--
rs10964994^1,2	C,F,H,,	--	21438720(+)	`ATGTAG/ACCTCT`	1	--	us2k¹ tfbs³		3		NS NA	174
rs201148017^1,2		--	21438880(+)	`GCCCC-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs1831583^1,2	C,F,	--	21439076(+)	`TTTATA/CTACCT`	1	--	us2k¹		8		NA NS EA	314
rs192556492^1,2		--	21439160(+)	`TATGAC/TTTTTA`	1	--	us2k¹		0	--	--	--	--
rs201693512^1,2		--	21439171(+)	`ATCTT-/TTATTGTG`	1	--	us2k¹		0	--	--	--	--
rs184074174^1,2		--	21439249(+)	`TCAAGC/TTTGAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IFNA1 (21440440 - 21441315 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFNA1
1 CNV: 8623

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IFNA1

DNA2.0 Custom Variant and Variant Library Synthesis for IFNA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IFNA1 for disorders           About GeneDecksing

OMIM gene information: 147660    OMIM disorders: --

20/321 diseases for IFNA1 (see all 321):    About MalaCards

htlv-1 associated myelopathy pure red-cell aplasia subacute sclerosing panencephalitis tick-borne encephalitis

eastern equine encephalitis porphyria cutanea tarda relapsing-remitting multiple sclerosis churg-strauss syndrome

venezuelan equine encephalitis diffuse large b-cell lymphoma langerhans-cell histiocytosis disseminated intravascular coagulation

human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease parainfluenza virus type 3 focal segmental glomerulosclerosis

chronic inflammatory demyelinating polyneuropathy polyarteritis nodosa inclusion body myositis human immunodeficiency virus infectious disease

20/22 diseases from the University of Copenhagen DISEASES database for IFNA1 (see all 22):

Hepatitis C Hepatitis Hepatitis B Renal cell carcinoma

Leukemia Melanoma Liver cirrhosis Leukopenia

Systemic lupus erythematosus Myeloma Hepatocellular carcinoma Influenza

Cryoglobulinemia Lymphoma Human immunodeficiency virus infectious disease Thrombocytopenia

Colorectal cancer Carcinoma Kaposi's sarcoma Multiple sclerosis

10/96 Novoseek disease relationships for IFNA1 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c chronic	95.1	1710	10846411 (5), 9751011 (4), 15313671 (4), 12639294 (4) (see all 99)
hepatitis c	90.5	867	9136611 (5), 9348307 (4), 9363321 (4), 11068424 (4) (see all 99)
hepatitis b chronic	85.1	414	11983129 (5), 16171525 (4), 16118673 (4), 10462338 (4) (see all 99)
myeloid leukemia chronic	85	293	8249110 (2), 9362160 (2), 11236254 (2), 11865642 (2) (see all 99)
metastatic renal cell carcinoma	83.6	124	15852669 (2), 8647158 (2), 12778059 (2), 19047813 (2) (see all 99)
virus infection	83.1	475	11983129 (5), 8895920 (4), 17516539 (4), 9269299 (3) (see all 99)
hepatitis chronic	82.2	163	12768394 (3), 9731580 (3), 1688684 (2), 7521417 (2) (see all 99)
hepatitis chronic active	78.6	109	9136611 (4), 8021761 (3), 16394599 (2), 7564784 (2) (see all 82)
cml chronic phase	77.5	35	11042556 (2), 12973833 (2), 12620292 (1), 11369652 (1) (see all 30)
leukemia hairy cell	77.2	58	9830322 (3), 9001417 (3), 1851909 (2), 1697012 (1) (see all 53)

Genetic Association Database (GAD): IFNA1
Human Genome Epidemiology (HuGE) Navigator: IFNA1 (23 documents)

Export disorders for IFNA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IFNA1 gene, integrated from 9 sources (see all 5271):
(articles sorted by number of sources associating them with IFNA1)

Utopia: connect your pdf to the dynamic
world of online information

Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. (PubMed id 11315919)^{1, 4, 9} Donn R.P....Thomson W. (2001)
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PubMed id 1385305)^{1, 3, 9} Olopade O.I....Diaz M.O. (1992)
Novel cis-active structures in the coding region medi ate CRM1-dependent nuclear export of IFN-I+ 1 mRNA. (PubMed id 20857263)^{1, 2} Kimura T....Yamada H. (2010)
Association between IFNA genotype and the risk of systemic lupus erythematosus. (PubMed id 15674657)^{1, 4} Nakashima H....Harada M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. (PubMed id 12761564)^{1, 4} Aucan C....Hill A.V. (2003)
IFN-alpha-1a gene is the major variant in the North American population. (PubMed id 11032395)^{1, 2} Hussain M.... Liao M.-J. (2000)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PubMed id 9425112)^{1, 2} Nyman T.A.... Kalkkinen N. (1998)
Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. (PubMed id 2985969)^{1, 2} Capon D.J.... Goeddel D.V. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3439	HGNC: 5417	AceView: IFNA1	Ensembl:ENSG00000197919	euGenes: HUgn3439
ECgene: IFNA1	Kegg: 3439	H-InvDB: IFNA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IFNA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IFNA1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ifna1/

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interferon, alpha 1

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