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hydatidiform mole associated and imprinted (non-protein...
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Aliases
for HYMAI gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): non-coding RNA
Quality score for this RNA gene is 2
| Aliases |
|---|
| Hydatidiform Mole Associated And Imprinted (Non-Protein Coding)1 2 | | NCRNA000201 2 |
Export aliases for HYMAI gene to outside databasesPrevious GC identifers: GC06U990239 GC06M141887 |
Summaries
for HYMAI gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HYMAI:
This gene, which encodes a non-protein coding transcript, exhibits differential DNA methylation between the twoparental alleles at an adjacent CpG island, and is expressed only from the paternal allele. It is believed to be oneof the causative genes for transient neonatal diabetes mellitus (TNDM), which is a rare disease characterized byintrauterine growth retardation, dehydration, and failure to thrive due to a lack of normal insulin secretion.(provided by RefSeq, Oct 2010)
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Genomic Views
for HYMAI gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HYMAI gene promoter:
AP-1 ATF-2 Pax-2 Pax-2a c-Jun ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for HYMAI
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYMAI |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24.2 HGNC cytogenetic band: 6q24.2HYMAI Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M144365: view genomic region
(about GC identifiers)
Start:
|
144,324,023 bp from pter |
End:
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144,329,867 bp from pter |
Size:
|
5,845 bases |
Orientation:
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minus strand |
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Proteins
for HYMAI gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
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Protein
Domains /
Families
for HYMAI gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for HYMAI gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYMAI |
|
Pathways & Interactions
for HYMAI gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HYMAI
|
Drugs & Compounds
for HYMAI gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HYMAI
Search CenterWatch for drugs/clinical trials and news about HYMAI 
|
Transcripts
for HYMAI gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Clusters for HYMAI: Hydatidiform mole associated and imprinted (non-protein coding) Hs.657760 [show with all ESTs], Hs.743783 Unigene Representative Sequences: BC059359, AF241534
Additional cDNA sequence: AF241534.1 NR_002768.1 1 DOTS entry: DT.70105190
GeneLoc Exon Structure
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Expression
for HYMAI gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for HYMAI:none
HYMAI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATATTGA
About this image
Genevestigator expression for HYMAI
SOURCE GeneReport for Unigene clusters: Hs.657760 Hs.743783
SABiosciences Custom PCR Arrays for HYMAI
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HYMAI | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYMAI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYMAI | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYMAI |
Orthologs
for HYMAI gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for HYMAI gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HYMAI gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HYMAI gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HYMAI for disorders About GeneDecksing
OMIM gene information: 606546
OMIM disorders: --
3  diseases for HYMAI: About MalaCardstransient neonatal diabetes mellitus neonatal diabetes mellitus diabetes mellitus
GeneTests: HYMAI
Diabetes Mellitus, 6q24-Related Transient Neonatal
Human Genome Epidemiology (HuGE) Navigator: HYMAI (1 document)
Export disorders for HYMAI gene to outside databases
|
Publications
for HYMAI gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HYMAI gene integrated from 9 sources:
(articles sorted by number of sources associating them with HYMAI) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. (PubMed id 10936046)1, 3 Arima T....Surani M.A. (2000)
- Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. (PubMed id 16873690)1 Gloyn A.L....Frayling T.M. (2006)
- The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. (PubMed id 16928428)1 Arima T....Kono T. (2006)
- Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. (PubMed id 15286800)1 Ma D....Kelsey G. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. (PubMed id 11935319)1 Mackay D.J....Robinson D.O. (2002)
- Diabetes Mellitus, 6q24-Related T ransient Neonatal (PubMed id 20301706)1 Temple I.K. and Mackay D.J.G. (1993)
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External Searches for HYMAI gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HYMAI gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HYMAI gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HYMAI gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HYMAI | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HYMAI gene:
Search GeneIP for patents involving HYMAI
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HYMAI gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HYMAI | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYMAI | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYMAI | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYMAI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYMAI | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYMAI |
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| | | | Search Tocris compounds for HYMAI |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYMAI |
|  |  |  | | | | Search ThermoFisher Antibodies for HYMAI |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HYMAI |
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