HTR3E Gene
protein-coding GIFtS: 52
GCID: GC03P183814
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5-hydroxytryptamine (serotonin) receptor 3E, ionotropic(Previous names: 5-hydroxytryptamine (serotonin) receptor 3, family member...)
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Aliases for HTR3E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic1 2 | | 5-HT3c12 | | 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member E1 2 | | 5-Hydroxytryptamine Receptor 3 Subunit E2 | | 5-HT3-E2 3 | | 5-Hydroxytryptamine Receptor 3E2 | | 5-HT3E2 3 | | Serotonin Receptor 3E3 |
Export aliases for HTR3E gene to outside databasesPrevious GC identifers: GC03P185217 GC03P185139 GC03P185136 GC03P185300 GC03P181225 |
Summaries for HTR3E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for HTR3E: This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a rolein neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3.Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Feb2012) UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ionchannel
summary
for HTR3E: Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression. Gene Wiki entry for HTR3E
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Genomic Views for HTR3E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HTR3E gene promoter: Sp1 RREB-1 CUTL1 LCR-F1 MEF-2A CP2 FOXO4 FOXO1a aMEF-2 FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR3E
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR3E |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27HTR3E Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P183814: view genomic region
(about GC identifiers)
Start:
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183,814,852 bp from pter |
End:
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183,824,783 bp from pter |
Size:
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9,932 bases |
Orientation:
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plus strand |
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Proteins for HTR3E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 3E precursor Size: 456 amino acids; 51438 Da
Subunit: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmicreticulum unless complexed with HTR3A
Secondary accessions: A8IKD7 E9PGF1 Q495G1 Q495G3 Q6V706 Q6V707 Q7Z6B2Alternative splicing: 5 isoforms: A5X5Y0-1 A5X5Y0-2 A5X5Y0-3 A5X5Y0-4 A5X5Y0-6 Explore the universe of human proteins at neXtProt for HTR3E: NX_A5X5Y0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A5X5Y0 HTR3E Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (5 alternative transcripts):
NP_001243542.1 NP_001243543.1 NP_872395.2 NP_938055.1 NP_938056.1 ENSEMBL proteins: ENSP00000401444 ENSP00000401900 ENSP00000335511 ENSP00000391254 ENSP00000395833 ENSP00000406050 Reactome Protein details: A5X5Y0 Human Recombinant Protein Products for HTR3E:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HTR3E for ontologies About GeneDecksing
HTR3E Antibody Products: Assay Products for HTR3E: |
Protein
Domains / Families for HTR3E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR3E for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A5X5Y0ProtoNet protein and cluster: A5X5Y0 UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)subfamily. HTR3E sub-subfamily |
Function for HTR3E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: 5HT3E_HUMAN, A5X5Y0Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ionchannel Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004872 | receptor activity |
-- | -- | | GO:0005230 | extracellular ligand-gated ion channel activity |
IEA | -- |
HTR3E for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3E OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3E OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3E |
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Pathways & Interactions for HTR3E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | CREB Pathway | | | 3 | SLC-mediated transmembrane transport | | | 4 | GABA A receptor activation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR3E 3
Reactome Pathways for HTR3E
HTR3E for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HTR3E
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 4 Interacting proteins for HTR3E (ENSP000003355114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0034220 | ion transmembrane transport |
TAS | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
HTR3E for ontologies About GeneDecksing
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Drugs & Compounds for HTR3E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for HTR3E available from Tocris Bioscience About this table Search CenterWatch for drugs/clinical trials and news about HTR3E / 5HT3E 
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Transcripts for HTR3E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HTR3E gene (5 alternative transcripts): NM_001256613.1 NM_001256614.1 NM_182589.2 NM_198313.2 NM_198314.2 Unigene Cluster for HTR3E: 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic Hs.449179 Unigene Representative Sequence: DQ6440226 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000415389(uc010hxq.3 uc003fml.4) ENST00000425359 ENST00000335304(uc003fmm.3 uc003fmn.3 uc010hxr.3) ENST00000431041 ENST00000436361 ENST00000440596
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3E OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3E OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HTR3E (NM_182589) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR3E | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR3E  |
Additional cDNA sequence: AY159813.2 AY349352.1 AY349353.1 BC101182.1 BC101183.2 BC101184.2 BC101185.2 DQ644022.1 EU165354.1 1 DOTS entry: DT.101978509 4 AceView cDNA sequences: AY349353 AY349352 NM_182589 AY159813 GeneLoc Exon Structure
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Expression for HTR3E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR3E expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TATCCCAATC
 About this image See HTR3E Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.449179
UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0Tissue specificity: Expressed in adult colon and intestine SABiosciences Custom PCR Arrays for HTR3E
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR3E Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HTR3E | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR3E | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR3E | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3E |
Orthologs for HTR3E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR3E gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for HTR3E (if available) TreeFam Gene Tree for HTR3E (if available)  |
Paralogs for HTR3E gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for HTR3E gene
- HTR3A2 HTR3C2 HTR3D2 HTR3B2 ZACN2
9 SIMAP similar genes for HTR3E using alignment to 2 protein entries: 5HT3E_HUMAN (see all proteins):HTR3C HTR3D HTR3A HTR3B CHRNA7-2 CHRNB1 CHRNA2 CHRNA5 CHRNA6
HTR3E for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HTR3E PGOHUM00000238286
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Genomic Variants for HTR3E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for HTR3E (183814852 - 183824783 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HTR3E: -- Human Gene Mutation Database (HGMD): HTR3E
Locus Specific Mutation Databases (LSDB): HTR3E
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR3E |
|
Disorders
/ Diseases for HTR3E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR3E for disorders About GeneDecksing
OMIM gene information: 610123
OMIM disorders: --
6 diseases for HTR3E: About MalaCardsirritable bowel syndrome sleep apnea apnea neuronitis diarrhea schizophrenia 1 disease from the University of Copenhagen DISEASES database for HTR3E:Irritable bowel syndrome Human Genome Epidemiology (HuGE) Navigator: HTR3E (6 documents) Export disorders for HTR3E gene to outside databases
|
Publications for HTR3E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HTR3E gene, integrated from 9 sources (see all 18): (articles sorted by number of sources associating them with HTR3E) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PubMed id 12801637)1, 2, 3 Niesler B.... Rappold G.A. (2003)
- The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PubMed id 15157181)1, 3 Peters J.A....Lambert J.J. (2004)
- A cluster of novel serotonin receptor 3-like genes on human chromosome 3. (PubMed id 14597179)1, 2 Karnovsky A.M.... Roberds S.L. (2003)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. (PubMed id 21192076)1 Kapeller J....Niesler B. (2011)
- Two naturally occurring variants of the serotonin rec eptor gene HTR3C are associated with nausea in pregnancy. (PubMed id 20021265)1 Goecke T.W....Fasching P.A. (2010)
- A coding variant of the novel serotonin receptor subu nit 5-HT3E influences sustained attention in schizophrenia patients. (PubMed id 20356718)1 Lennertz L....MAPssner R. (2010)
- RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct i nteractions with 5-HT3A, -C, -D, and -E subunits. (PubMed id 20522555)1 Walstab J....Niesler B. (2010)
- Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PubMed id 20602613)1 Hammer C....Niesler B. (2010)
- A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1 Larkin E.K....Redline S. (2010)
|
External Searches for HTR3E gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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|
Genome Databases showing HTR3E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HTR3E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR3E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HTR3E | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HTR3E gene: Search GeneIP for patents involving HTR3E
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HTR3E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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 | | HTR3E Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3E |
|  |  |  |  | | | ThermoFisher Antibodies for HTR3E |
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