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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPA2 Gene

protein-coding GIFtS: 65
GCID: GC14P065002

heat shock 70kDa protein 2

(Previous name: heat shock 70kD protein 2 )

Explore 27 diseases affiliated with
HSPA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 2¹ ²
Heat Shock 70kD Protein 2¹ ²
HSP70-2²
HSP70-3²
Heat Shock-Related 70 KDa Protein 2²
Heat Shock 70 KDa Protein 2³

External Ids:	HGNC: 5235¹	Entrez Gene: 3306²	Ensembl: ENSG00000126803⁷	OMIM: 140560⁵	UniProtKB: P54652³

Export aliases for HSPA2 gene to outside databases

Previous GC identifers: GC14P062330 GC14P058796 GC14P062992 GC14P064072 GC14P045179

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652

Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate

the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate

in all these processes through their ability to recognize nonnative conformations of other proteins. They bind

extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane

translocation, or following stress-induced damage

Gene Wiki entry for HSPA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPA2 gene promoter:
p53 HTF Pax-2 Pax-2a Tal-1beta CP2 Ik-2 POU2F1 POU2F1a ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPA2 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23

HSPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P065002: view genomic region (about GC identifiers)

Start:	65,002,623 bp from pter	End:	65,009,955 bp from pter
Size:	7,333 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652 (See protein sequence)

Recommended Name: Heat shock-related 70 kDa protein 2

Size: 639 amino acids; 70021 Da

Subunit: Interacts with ZNF541. Component of the CatSper complex (By similarity)

2 PDB 3D structures from and Proteopedia for HSPA2:

3I33 (3D)

4FSV (3D)

Secondary accessions: Q15508 Q53XM3 Q9UE78

Explore the universe of human proteins at neXtProt for HSPA2: NX_P54652

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P54652

HSPA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_068814.2

ENSEMBL proteins:

ENSP00000378199 ENSP00000247207

Reactome Protein details: P54652
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals HSPA2 Protein Novus Biologicals HSPA2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HSPA2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000795	synaptonemal complex	IEA	--
GO:0001673	male germ cell nucleus	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0009986	cell surface	IDA	12493773
GO:0036128	CatSper complex	ISS	--

HSPA2 for ontologies About GeneDecksing

HSPA2 Antibody Products:

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	Novus Biologicals HSPA2 Antibodies
	Abcam antibodies for HSPA2
	Uscn Antibodies for HSPA2
	ThermoFisher Antibodies for HSPA2

Assay Products for HSPA2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for HSPA2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HSPA2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPA2 for domains About GeneDecksing

2 InterPro domains/families:

IPR018181 Heat_shock_70_CS

IPR013126 Hsp_70_fam

Graphical View of Domain Structure for InterPro Entry P54652

ProtoNet protein and cluster: P54652

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652

Similarity: Belongs to the heat shock protein 70 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652

Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate

the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate

in all these processes through their ability to recognize nonnative conformations of other proteins. They bind

extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane

translocation, or following stress-induced damage

Genatlas biochemistry entry for HSPA2:

heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohn's disease

miRNA Products:		OriGene 3'-UTR Clone: HSPA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA2:
		hsa-miR-4311 hsa-miR-1271 hsa-miR-371-5p hsa-miR-382 hsa-miR-19b hsa-miR-3143 hsa-miR-96 hsa-miR-19a

		SwitchGear 3'UTR luciferase reporter plasmid: HSPA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA2 (see all 7) OriGene shRNA RFP: HSPA2 OriGene siRNA: HSPA2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HSPA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: HSPA2 (NM_021979)
		Sino Biological Human cDNA Clone for HSPA2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSPA2
		Search LifeMap BioReagents cell lines for HSPA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16713569
GO:0005524	ATP binding	IEA	--
GO:0051082	unfolded protein binding	TAS	3037489
GO:0051861	glycolipid binding	IEA	--

HSPA2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Hspa2^tm1Dix for HSPA2
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hspa2):

endocrine/exocrine gland

reproductive system

HSPA2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	1.00			Development_Glucocorticoid receptor signaling	0.27
	CFTR folding and maturation (norm and CF)	0.37			Development Glucocorticoid receptor signaling	0.27

Meiotic Synapsis

	Meiotic Synapsis	1.00			Chromosome Maintenance	0.56
	Meiosis	0.70

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Measles

Measles

1.00

Influenza A

0.35

Proteolysis Putative ubiquitin pathway

Proteolysis Putative ubiquitin pathway

1.00

Proteolysis_Putative ubiquitin pathway

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HSPA2

	Development Glucocorticoid receptor signaling
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

5/6 GeneGo (Thomson Reuters) Pathways for HSPA2 (see all 6)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Regulation of degradation of deltaF508 CFTR in CF
	CFTR folding and maturation (norm and CF)
	Proteolysis Putative ubiquitin pathway

1 BioSystems Pathway for HSPA2

Parkin-Ubiquitin Proteasomal System pathway

5 Reactome Pathways for HSPA2

	Synapsis
	Meiotic Synapsis
	Cell Cycle
	Meiosis
	Chromosome Maintenance

5/8 Kegg Pathways (Kegg details for HSPA2) (see all 8):

	Spliceosome
	MAPK signaling pathway
	Protein processing in endoplasmic reticulum
	Endocytosis
	Antigen processing and presentation

HSPA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/163 Interacting proteins for HSPA2 (P54652^{1, 2, 3} ENSP00000247207⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 163)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPBP1	Q9NZL4¹^,²^,³, ENSP00000255631⁴	EBI-356991,EBI-356763 MINT-2871513 MINT-66487 I2D: score=5 STRING: ENSP00000255631
MAP3K3	Q99759²^,³, ENSP00000354927⁴	MINT-48390 I2D: score=3 STRING: ENSP00000354927
MEOX2	P50222²^,³, ENSP00000262041⁴	MINT-2860884 I2D: score=3 STRING: ENSP00000262041
RIPK2	O43353²^,³	MINT-49058 I2D: score=2
TAB2	Q9NYJ8²^,³	MINT-49186 I2D: score=2

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006986	response to unfolded protein	TAS	7829106
GO:0007140	male meiosis	TAS	8622925
GO:0007141	male meiosis I	IEA	--
GO:0007286	spermatid development	IEA	--
GO:0031662	positive regulation of cyclin-dependent protein kinase activity involved in G2/M	IEA	--

HSPA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPA2
Search CenterWatch for drugs/clinical trials and news about HSPA2 / HSP72

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPA2 gene:

NM_021979.3

Unigene Cluster for HSPA2:

Heat shock 70kDa protein 2

Hs.432648 [show with all ESTs]

Unigene Representative Sequence: NM_021979

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394709(uc001xhj.3) ENST00000554883 ENST00000247207(uc001xhk.4)

miRNA Products:		OriGene 3'-UTR Clone: HSPA2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA2:
		hsa-miR-4311 hsa-miR-1271 hsa-miR-371-5p hsa-miR-382 hsa-miR-19b hsa-miR-3143 hsa-miR-96 hsa-miR-19a

		SwitchGear 3'UTR luciferase reporter plasmid: HSPA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA2 (see all 7) OriGene shRNA RFP: HSPA2 OriGene siRNA: HSPA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPA2 (NM_021979)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSPA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA2

Additional cDNA sequence:

AK097824.1 BC001752.1 BC034365.1 BC036107.1 BT009815.1

12 DOTS entries:

DT.100026736 DT.91785830 DT.101983142 DT.120759401 DT.100689865 DT.100878670 DT.95365758 DT.100675724

DT.100878669 DT.120759371 DT.120759393 DT.92334502

24/243 AceView cDNA sequences (see all 243):

AU279621 NM_021979 AL040891 BQ440635 AI580818 BP373997 CR601304 BP349131

CD514561 BQ670728 CD653825 BP341969 AL046354 CN482552 F03817 CR596961

BP373114 BP375233 BP372586 AL040890 CB155424 CA389240 CR592476 BQ422962

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 (see all 6) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b
SP1:			-		-
SP2:					-
SP3:									-		-		-
SP4:											-		-		-
SP5:

ECgene alternative splicing isoforms for HSPA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATTTGTT

About this image

HSPA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPA2

SOURCE GeneReport for Unigene cluster: Hs.432648

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA2:

Cellular Stress Responses in human mouse rat

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

Cardiotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSPA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA2 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HSPA2¹	heat shock 70kDa protein 2	80.7(n) 92.11(a)		423504 NM_001006685.1 NP_001006686.1
lizard (Anolis carolinensis)	Reptilia	HSPA2⁶	--	92(a)	1 ↔ 1	1(1380946-1382853)
fruit fly (Drosophila melanogaster)	Insecta	Hsc70-4³	neurotransmitter secretion chaperone	83(a) (best of 11)		88E4 --
worm (Caenorhabditis elegans)	Secernentea	hsp-1³	HSP-1 heat shock 70kd protein A	83(a) (best of 7)		IV(17279119-17281340) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ERD2¹	heat shock protein-70 cognate protein	65.68(n) 74.59(a)		842094 NM_104519.1 NP_176036.1
wheat (Triticum aestivum)	Liliopsida	Ta.24515²	Triticum aestivum 70 kDa heat shock protein (TaHSP7 more	82.78(n)		AF005993.1

ENSEMBL Gene Tree for HSPA2 (if available)
TreeFam Gene Tree for HSPA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4313734^1,2	C,F,A,H,	--	65005228(+)	`CACAAT/CCTATG`	1	--	us2k¹		25		NS EA NA WA	2526
rs147398993^1,2		--	65005233(+)	`CCTATA/GTAAAG`	1	--	us2k¹		0	--	--	--	--
rs139698044^1,2		--	65005244(+)	`AATGGC/TTTTCC`	1	--	us2k¹		0	--	--	--	--
rs45564031^1,2	C,F,	--	65005317(+)	`AGCAAC/TGCACT`	1	--	us2k¹		6		NS NA	186
rs45511097^1,2	C,F,	--	65005318(+)	`GCAACG/ACACTT`	1	--	us2k¹		7		NS NA	306
rs184634122^1,2		--	65005466(+)	`TAGTAA/GGTACC`	1	--	us2k¹		0	--	--	--	--
rs147158418^1,2		--	65005551(+)	`TCCTGA/GAGACC`	1	--	us2k¹		0	--	--	--	--
rs140403801^1,2		--	65005558(+)	`GACCAC/TTTATT`	1	--	us2k¹		0	--	--	--	--
rs188671856^1,2		--	65005561(+)	`CATTTA/GTTTTA`	1	--	us2k¹		0	--	--	--	--
rs45458795^1,2	C,F,	--	65005590(+)	`TCGTTC/GTGTCG`	1	--	us2k¹		5		NS	184

HapMap Linkage Disequilibrium report for HSPA2 (65002623 - 65009955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPA2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPA2

DNA2.0 Custom Variant and Variant Library Synthesis for HSPA2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPA2 for disorders           About GeneDecksing

OMIM gene information: 140560    OMIM disorders: --

20/27 diseases for HSPA2 (see all 27):    About MalaCards

visceral leishmaniasis ankylosing spondylitis systemic lupus erythematosus lupus erythematosus

male infertility inflammatory bowel disease hearing loss ulcerative colitis

spondylitis leishmaniasis varicocele infertility

toxoplasmosis crohn's disease measles alzheimer's disease

influenza breast cancer myeloma ataxia

Genetic Association Database (GAD): HSPA2
Human Genome Epidemiology (HuGE) Navigator: HSPA2 (16 documents)

Export disorders for HSPA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HSPA2 gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with HSPA2)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism. (PubMed id 12730033)^{1, 4} Debler J....Gross M. (2003)
Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. (PubMed id 12771604)^{1, 4} Waterer G.W....Wunderink R.G. (2003)
Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population. (PubMed id 12782964)^{1, 4} Clarimon J....Comas D. (2003)
Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis. (PubMed id 11334675)^{1, 4} Meddeb-Garnaoui A....Dellagi K. (2001)
Genetic factors determine extent of bone loss in inflammatory bowel disease. (PubMed id 11040178)^{1, 4} Schulte C.M....Schulte K.M. (2000)
Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican mestizo population. (PubMed id 11196683)^{1, 4} Vargas-Alarcon G....Arnaiz-Villena A. (2000)
A heat shock gene at 14q22: mapping and expression. (PubMed id 7849706)^{1, 2} Roux A.-F.... Cox D.W. (1994)
Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). (PubMed id 7829106)^{1, 2} Bonnycastle L.L.C.... Schellenberg G.D. (1994)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3306	HGNC: 5235	AceView: HSPA2	Ensembl:ENSG00000126803	euGenes: HUgn3306
ECgene: HSPA2	Kegg: 3306	H-InvDB: HSPA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HSPA2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSPA2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hspa2/

Intellectual Property for HSPA2 gene
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Patent Information for HSPA2 gene:
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GeneCards and IP:
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heat shock 70kDa protein 2

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heat shock 70kDa protein 2

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