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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HRH1 Gene

protein-coding GIFtS: 64
GCID: GC03P011113

histamine receptor H1

Explore 52 diseases affiliated with
HRH1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histamine Receptor H1¹ ²		HisH1¹
H1R² ³		Histamine H(1) Receptor²
HH1R² ³		Histamine H1 Receptor²
H1-R²		Histamine Receptor, Subclass H1²

External Ids:	HGNC: 5182¹	Entrez Gene: 3269²	Ensembl: ENSG00000196639⁷	OMIM: 600167⁵	UniProtKB: P35367³

Export aliases for HRH1 gene to outside databases

Previous GC identifers: GC03P011223 GC03P011270 GC03P011271 GC03P011272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HRH1:

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its

various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until

recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled

receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to

contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the

central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367

Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles,

increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal

medulla, as well as mediating neurotransmission in the central nervous system

summary for HRH1:

Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These

receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous

system, airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils,

dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems. H1

receptor activation induces a wide range of biological responses due to their widespread distribution. In

smooth muscle, H1 activation increases tension and the contractile response, and in vascular endothelial

cells receptor activation increases cell permeability. In the adrenal medulla, histamine acting at H1

receptors stimulates both adrenalin and noradrenalin release. Furthermore, H1 activation induces

prostacyclin and platelet-activating factor synthesis, promotes von Willebrand factor and nitric oxide

release, liberates arachidonic acid from phospholipids, and causes vasodilation of capillaries and

arterioles. At a physiological level, H1 receptors are involved in a wide array of processes including

thermal regulation, memory and learning, and control of the sleep-wake cycle, food intake, and emotional and

aggressive behaviors. Histamine acting through the H1 receptor has proinflammatory effects, and is involved

in the development of various aspects of the antigen-specific immune response. Activation of these receptors

triggers maturation of dendritic cells and modulates the balance of Th1 and Th2 cells. H1 receptors are

involved in the pathological process of allergy, including allergic rhinits, atopic dermatitis, anaphylaxis

and asthma, and also have a role in autoimmune diseases and malignancy.

Gene Wiki entry for HRH1 (Histamine H1 receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HRH1 gene promoter:
GR GCNF STAT5A MIF-1 S8 HSF2 GCNF-1 c-Myb GR-alpha GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HRH1 promoter sequence

Search SABiosciences Chromatin IP Primers for HRH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRH1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25

HRH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P011113: view genomic region (about GC identifiers)

Start:	11,178,779 bp from pter	End:	11,305,243 bp from pter
Size:	126,465 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367 (See protein sequence)

Recommended Name: Histamine H1 receptor

Size: 487 amino acids; 55784 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for HRH1:

3RZE (3D)

Secondary accessions: A8K047 Q6P9E5

Explore the universe of human proteins at neXtProt for HRH1: NX_P35367

Post-translational modifications:

Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal

transduction through the receptor molecule¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35367

HRH1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000852.1 NP_001091681.1 NP_001091682.1 NP_001091683.1

ENSEMBL proteins:

ENSP00000406705 ENSP00000397028 ENSP00000392383 ENSP00000380247

Reactome Protein details: P35367
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant HRH1 Protein
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	Novus Biologicals HRH1 Proteins Novus Biologicals HRH1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HRH1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	TAS	--

HRH1 for ontologies About GeneDecksing

HRH1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HRH1
	R&D Systems Antibodies for HRH1 (Histamine H1 R)
	OriGene Antibodies: HRH1 OriGene Custom Antibody Services for HRH1
	GenScript Custom Superior Antibodies Services for HRH1
	Novus Biologicals HRH1 Antibodies
	Search for Antibodies for HRH1 at Abcam
	Uscn Antibodies for HRH1
	ThermoFisher Antibodies for HRH1

Assay Products for HRH1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript HRH1-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HRH1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HRH1 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

IPR000921 Histamine_H1_rcpt

Graphical View of Domain Structure for InterPro Entry P35367

ProtoNet protein and cluster: P35367

1 Blocks protein family: IPB000921 Histamine H1 receptor signature

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367

Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles,

increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal

medulla, as well as mediating neurotransmission in the central nervous system

Genatlas biochemistry entry for HRH1:

histamine H1 receptor,ubiquitous,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating

contraction on smooth muscle in the gut and bronchs and decreasing blood pressure

miRNA Products:		miRTarBase miRNAs that target HRH1: hsa-mir-192 (MIRT004851)

		OriGene 3'-UTR Clone (see all 4): HRH1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HRH1
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate HRH1 (see all 31):
		hsa-miR-2052 hsa-miR-3910 hsa-miR-3128 hsa-miR-875-3p hsa-miR-631 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-578

		SwitchGear 3'UTR luciferase reporter plasmid: HRH1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRH1 (see all 7) OriGene shRNA RFP: HRH1 OriGene siRNA: HRH1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRH1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HRH1

Clone Products:		EMD Millipore Clones for the Expression of HRH1
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): HRH1 (NM_001098212)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH1

Cell Line Products:		GenScript HRH1-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for HRH1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	TAS	7925364
GO:0004969	histamine receptor activity	ISS	--
GO:0051381	histamine binding	--	--

HRH1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Hrh1^tm1Wtn for HRH1
     8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hrh1):

adipose tissue	behavior/neurological	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system

HRH1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Development_Ligand-independent activation of ESR1 and ESR2

Development_Ligand-independent activation of ESR1 and ESR2

1.00

Development Ligand-independent activation of ESR1 and ESR2

0.97

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Transcription CREB pathway

Transcription CREB pathway

1.00

Transcription_CREB pathway

0.93

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for HRH1

	Transcription CREB pathway
	Development Ligand-independent activation of ESR1 and ESR2

2 GeneGo (Thomson Reuters) Pathways for HRH1

	Development Ligand-independent activation of ESR1 and ESR2
	Transcription CREB pathway

2 BioSystems Pathways for HRH1

	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/9 Reactome Pathways for HRH1 (see all 9)

	GPCR downstream signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)

2 Kegg Pathways (Kegg details for HRH1):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction

HRH1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HRH1

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	10818238
GO:0007186	G-protein coupled receptor signaling pathway	TAS	7925364
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	TAS	8280179
GO:0007268	synaptic transmission	--	--
GO:0009629	response to gravity	--	--

HRH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HRH1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HRH1 available from Tocris Bioscience About this table

Compound	Action	CAS #
HTMT dimaleate	H1 / H2 agonist	[195867-54-0]
Olopatadine hydrochloride	H1 antagonist; ocular antiallergic agent	[140462-76-6]
Loratidine	Peripheral H1 antagonist; antiallergic agent	[79794-75-5]
Fexofenadine hydrochloride	H1 receptor antagonist; non-sedating antiallergic agent	[153439-40-8]
2-Pyridylethylamine dihydrochloride	H1 receptor agonist	[3343-39-3]

10/11 HMDB Compounds for HRH1 (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
Brompheniramine	Antihistamine compound (see all 18)	86-22-6	--
Cetirizine	Benaday (see all 9)	83881-51-0	--
Chlorpheniramine	Chlor-trimeton (see all 8)	113-92-8	--
Diphenhydramine	Alledryl (see all 14)	147-24-0	--
Doxylamine	Alsadorm (see all 8)	562-10-7	--
Fexofenadine	Allegra (see all 6)	83799-24-0	--
Histamine	1H-Imidazole-4-ethanamine (see all 27)	51-45-6	--
Loratadine	Alavert (see all 20)	79794-75-5	--
Olanzapine	Lanzac (see all 5)	132539-06-1	--
Quetiapine	Quetiapine fumarate (see all 2)	111974-69-7	--

10/77 DrugBank Compounds for HRH1 (see all 77) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Clemastine	Clemastina [INN-Spanish] (see all 3)	15686-51-8	target	antagonist	1678430 8930778 2890562 6387510 6701456 11752352 4074605 6449094 7513381 1266718
Doxepin	Doxepin Hcl (see all 5)	1668-19-5	target	antagonist	2141000 7238574 15255990 7855217 19179941 15286093 11752352 6086881 17685877 3011460
Fexofenadine	Carboxyterfenadine (see all 6)	83799-24-0	target	antagonist	12712828 9506246 19545214 15286093 11752352 10597865 18336052 10864400 18797058 15352500
Loratadine	Loratadina [Spanish] (see all 2)	79794-75-5	target	antagonist	1977506 1303773 7581058 11752352 10597865 1303772 15942272 11291777 8174605 9444440
Triprolidine	--	486-12-4	target	antagonist	2568212 10493107 8907591 11752352 2866055 7853212 7214150 3011460 7913608 10582735
Olopatadine	--	113806-05-6	target	antagonist	15646365 12046981 20482305 8951675 11752352 20406593 15942272 11496828 20402382
Astemizole	--	68844-77-9	target	antagonist	6204835 6146346 2892659 11752352 3147222 10597865 8001268 10597866
Desloratadine	Descarboethoxyloratadine (see all 3)	100643-71-8	target	antagonist	7581058 15564772 12642846 11752352 18336052 17902729 18797058 8174605
Pheniramine	Feniramina [inn-spanish] (see all 5)	86-21-5	target	antagonist	2567596 20027159 7714410 14506317 11752352 17016423 8835636 11526976
Azelastine	Azelastina [INN-Spanish] (see all 3)	58581-89-8	target	antagonist	9585822 10478514 19209282 11752352 2540229 17723160 8829888

10/121 Novoseek chemical compound relationships for HRH1 gene (see all 121) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
histamine	92.7	363	1972050 (5), 8088416 (4), 11603849 (4), 8198587 (3) (see all 99)
mepyramine	91.8	39	7853212 (3), 8114011 (1), 8806799 (1), 7693285 (1) (see all 35)
ebastine	91.7	19	8808167 (2), 9196279 (2), 8828024 (1), 11419742 (1) (see all 14)
terfenadine	89.1	32	1972050 (4), 1976343 (2), 9196279 (2), 8886862 (1) (see all 25)
mizolastine	88.2	6	10209699 (2), 16402861 (1), 11510627 (1), 11683039 (1) (see all 5)
chlorpheniramine	87.9	17	12950664 (1), 7541689 (1), 7853212 (1), 7648771 (1) (see all 15)
triprolidine	87.5	4	7853212 (1), 16569656 (1), 7913608 (1), 7650688 (1)
anti-histamine	86.6	18	8750798 (2), 7625332 (1), 8564232 (1), 17558437 (1) (see all 13)
cetirizine	86.4	16	7510611 (2), 8886862 (1), 10876807 (1), 1676245 (1) (see all 15)
epinastine	86.2	14	8750798 (2), 10807498 (2), 18396776 (1), 7650688 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about HRH1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HRH1 gene (4 alternative transcripts):

NM_000861.3 NM_001098211.1 NM_001098212.1 NM_001098213.1

Unigene Cluster for HRH1:

Histamine receptor H1

Hs.1570 [show with all ESTs]

Unigene Representative Sequence: NM_001098213

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000438284 ENST00000431010(uc010hdr.3 uc010hds.3 uc010hdt.3)

ENST00000413416 ENST00000397056(uc003bwb.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): HRH1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HRH1
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate HRH1 (see all 31):
		hsa-miR-2052 hsa-miR-3910 hsa-miR-3128 hsa-miR-875-3p hsa-miR-631 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-578

		SwitchGear 3'UTR luciferase reporter plasmid: HRH1 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRH1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): HRH1 (NM_001098212)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH1

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HRH1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRH1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRH1

Additional cDNA sequence:

AF026261.1 AK289412.1 AK292157.1 AK312879.1 AY136743.1 BC060802.1 D28481.1 Z34897.1

5 DOTS entries:

DT.108434 DT.120856026 DT.120856016 DT.405455 DT.75141601

24/51 AceView cDNA sequences (see all 51):

BU187066 BQ019585 AI203543 AA373094 AA582697 Z34897 BX436453 BQ017843

D28481 AY136743 BF513144 BQ014690 AW452821 AF026261 AI122972 BI333356

CB114530 AI954670 AI565677 AA613545 BU170773 AW003867 CD519236 AI742102

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HRH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTGTCAAA

About this image

HRH1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HRH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRH1

SOURCE GeneReport for Unigene cluster: Hs.1570

SABiosciences Expression via Pathway-Focused PCR Arrays including HRH1:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Obesity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HRH1 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100858928¹	histamine H1 receptor-like	59.18(n) 60.41(a)		100858928 XM_003641988.1 XP_003642036.1
lizard (Anolis carolinensis)	Reptilia	HRH1⁶	--	47(a)	1 ↔ 1	2(157913858-157915342)
zebrafish (Danio rerio)	Actinopterygii	hrh1¹	histamine receptor H1	62.11(n) 62(a)		735302 NM_001042731.1 NP_001036196.1

ENSEMBL Gene Tree for HRH1 (if available)
TreeFam Gene Tree for HRH1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HRH1 gene

HRH4² CHRM5² CHRM1² CHRM2² HRH3² CHRM4² CHRM3²

3 SIMAP similar genes for HRH1 using alignment to 2 protein entries: HRH1_HUMAN (see all proteins):

CHRM2 CHRM4 CHRM3

HRH1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60728932^1,2	C,	--	11176812(+)	`TGGTGG/TCTTAG`	1	--	us2k¹		2		WA	120
rs147796928^1,2		--	11176863(+)	`AAGAAC/TCTGGG`	1	--	us2k¹		0	--	--	--	--
rs6778270^1,2	C,F,A,H,	--	11176867(+)	`ACCTGA/GGAACA`	1	--	us2k¹		27		NS EA NA WA	2970
rs146675065^1,2		--	11177002(+)	`TTTTGA/TTTTGT`	1	--	us2k¹		0	--	--	--	--
rs58618653^1,2	C,	--	11177040(+)	`ATAGAG/ATTTCG`	1	--	us2k¹		6		WA CSA NA EA	364
rs114659279^1,2	F,	--	11177045(+)	`GTTTCG/ACTCTT`	1	--	us2k¹		2		WA NA	238
rs148351063^1,2		--	11177077(+)	`TGGTGC/TGATCT`	1	--	us2k¹		0	--	--	--	--
rs188045715^1,2		--	11177091(+)	`CTCACC/TGCAGC`	1	--	us2k¹		0	--	--	--	--
rs57925479^1,2	C,	--	11177095(+)	`CCGCAG/ACCTCC`	1	--	us2k¹		5		WA CSA NA EA	362
rs193248061^1,2		--	11177100(+)	`GCCTCC/TGCCTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HRH1 (11178779 - 11305243 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HRH1
2 Indels: 98232 46271

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HRH1 for disorders           About GeneDecksing

OMIM gene information: 600167    OMIM disorders: --

20/52 diseases for HRH1 (see all 52):    About MalaCards

atopic dermatitis dermatitis asthma cholinergic urticaria

arthus reaction rhinitis allergic rhinitis urticaria

food allergy otitis media chronic rhinitis interstitial nephritis

angioedema conjunctivitis anorexia nervosa allergic conjunctivitis

inflammatory bowel disease synovial sarcoma bronchial asthma acute lymphoblastic leukemia

5 diseases from the University of Copenhagen DISEASES database for HRH1:

Allergic rhinitis Urticaria Asthma Hypersensitivity reaction type I disease

Conjunctivitis

10/46 Novoseek disease relationships for HRH1 gene (see all 46) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
allergic rhinitis	75.6	13	9664202 (1), 18498711 (1), 19558341 (1), 8732234 (1) (see all 13)
urticaria chronic	75.2	2	8828024 (1), 1685361 (1)
rhinitis allergic perennial	70.6	2	8828024 (1), 12269652 (1)
conjunctivitis allergic	69	4	12431041 (1), 19558341 (1), 17075271 (1)
chronic rhinitis	67.1	1	10879992 (1)
rhinitis allergic seasonal	65.2	3	15160440 (1), 16882083 (1), 9585822 (1)
prurigo	64.6	1	19558341 (1)
urticaria	56.8	6	17902729 (1), 20128233 (1), 14727529 (1), 2083605 (1) (see all 6)
rhinitis	56.2	2	9923056 (1), 1972050 (1)
asthma	51.5	9	1976343 (1), 11243501 (1), 15661077 (1), 16484687 (1) (see all 9)

Genetic Association Database (GAD): HRH1
Human Genome Epidemiology (HuGE) Navigator: HRH1 (14 documents)

Export disorders for HRH1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HRH1 gene, integrated from 9 sources (see all 632):
(articles sorted by number of sources associating them with HRH1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of the human histamine H1 receptor gene. (PubMed id 8003029)^{1, 2, 3} Fukui K.... Ito S. (1994)
Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. (PubMed id 8280179)^{1, 2, 9} de Backer M.D.... Luyten W.H.M.L. (1993)
Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. (PubMed id 7925364)^{1, 2, 9} Moguilevsky N.... Bollen A. (1994)
Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PubMed id 15953854)^{1, 4, 9} Choi J.H....Park H.S. (2005)
Structure of the human histamine H1 receptor complex with doxepin. (PubMed id 21697825)^{1, 2} Shimamura T....Iwata S. (2011)
Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response. (PubMed id 12429384)^{1, 4} Mancama D....Kerwin R. (2002)
Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment. (PubMed id 12218662)^{1, 4} Hong C.J....Tsai S.J. (2002)
Histamine H1 receptor induces cytosolic calcium incre ase and aquaporin translocation in human salivary gland cells. (PubMed id 19443731)^{1, 9} Kim J.H....Park K. (2009)
Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy. (PubMed id 11603849)^{1, 9} Brew O.B. and Sullivan M.H. (2001)
Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor. (PubMed id 17547532)^{1, 9} Pochampally R.R....Prockop D.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3269	HGNC: 5182	AceView: HRH1	Ensembl:ENSG00000196639	euGenes: HUgn3269
ECgene: HRH1	Kegg: 3269	H-InvDB: HRH1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HRH1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HRH1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HRH1 gene:
Search GeneIP for patents involving HRH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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histamine receptor H1

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