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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HCN2 Gene

protein-coding   GIFtS: 65
GCID: GC19P000589

hyperpolarization activated cyclic nucleotide-gated potassium...


(Previous symbol: BCNG2)
 Explore 11 diseases affiliated with
HCN2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HCN2    

Aliases
for HCN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 21 2     Brain Cyclic Nucleotide-Gated Channel 22 3
BCNG21 2 3 5     Brain Cyclic Nucleotide Gated Channel 22
BCNG-21 2 3     Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 22
HAC-11 2     

External Ids:    HGNC: 48461   Entrez Gene: 6102   Ensembl: ENSG000000998227   OMIM: 6027815   UniProtKB: Q9UL513   

Export aliases for HCN2 gene to outside databases

Previous GC identifers: GC19P000641 GC19P000529 GC19P000540 GC19P000359


Summaries
for HCN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HCN2:
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic
activity in both heart and brain.(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: HCN2_HUMAN, Q9UL51
Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.
Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the
distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions
and pH; acidic pH shifts the activation to more negative voltages (By similarity)

Gene Wiki entry for HCN2


Genomic Views
for HCN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HCN2 gene promoter:
         AP-1   NRSF form 1   AP-2alpha isoform 2   AP-2alpha   NRSF form 2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HCN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HCN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

HCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HCN2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000589:  view genomic region     (about GC identifiers)

Start:
 589,893 bp from pter      End:
 617,159 bp from pter
Size:
 27,267 bases      Orientation:
 plus strand

Proteins
for HCN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HCN2_HUMAN, Q9UL51 (See protein sequence)
Recommended Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2  
Size: 889 amino acids; 96950 Da
Subunit: The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.
Heteromultimer with HCN1. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2 (By
similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Inhibited by extracellular cesium ions
1 PDB 3D structure from and Proteopedia for HCN2:
3U10 (3D)    
Secondary accessions: O60742 O60743 O75267 Q9UBS2

Explore the universe of human proteins at neXtProt for HCN2: NX_Q9UL51

Post-translational modifications:

  • Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the
    • stimulatory effect of cGMP on gating (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL51

    • HCN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001185.3  
    ENSEMBL proteins: 
     ENSP00000251287  
    Reactome Protein details: Q9UL51
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HCN2
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    Novus Biologicals HCN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HCN2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS9630217
    GO:0030424axon ----
    GO:0043025neuronal cell body ----


    HCN2 for ontologies           About GeneDecksing



    HCN2 Antibody Products: 
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    Uscn Antibodies for HCN2
    ThermoFisher Antibodies for HCN2

    Assay Products for HCN2: 
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    Uscn ELISAs and CLIAs for HCN2

    Protein Domains /
    Families
    for HCN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HCN2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR003938 K_chnl_volt-dep_EAG/ELK/ERG

    Graphical View of Domain Structure for InterPro Entry Q9UL51

    ProtoNet protein and cluster: Q9UL51

    2 Blocks protein families:
    IPB000595 Cyclic nucleotide-binding domain
    IPB013621 Ion transport N-terminal


    UniProtKB/Swiss-Prot: HCN2_HUMAN, Q9UL51
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel HCN family
    Similarity: Contains 1 cyclic nucleotide-binding domain


    Function
    for HCN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HCN2_HUMAN, Q9UL51
    Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.
    Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the
    distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions
    and pH; acidic pH shifts the activation to more negative voltages (By similarity)

         Genatlas biochemistry entry for HCN2:
    hyperpolarization-activated and cyclic nucleotide gated potassium channel 2,expressed in brain and heart (conduction
    tissues and contractile myocytes),pace-maker channel of the heart

    miRNA
    Products:            		miRTarBase miRNAs that target HCN2:
    hsa-mir-133a (MIRT001204), hsa-mir-1 (MIRT001205)

    OriGene 3'-UTR Clone: HCN2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HCN2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate HCN2 (see all 18):
    hsa-miR-137 hsa-miR-181c hsa-miR-25 hsa-miR-654-5p hsa-miR-4325 hsa-miR-92b hsa-miR-181b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmid: HCN2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HCN2 (see all 7)
    OriGene shRNA RFP: HCN2
    OriGene siRNA: HCN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HCN2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HCN2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HCN2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HCN2
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    GenScript: all cDNA clones in your preferred vector: HCN2 (NM_001194)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HCN2 

    Cell Line
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    Search LifeMap BioReagents cell lines for HCN2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCN2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005249voltage-gated potassium channel activity IEA--
    GO:0005261cation channel activity TAS10228147
    GO:0005272sodium channel activity IEA--
    GO:0005515protein binding ----
    GO:0030552cAMP binding IEA--


    HCN2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HCN2:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for HCN2: Hcn2tm1.2Lex Hcn2tm1Lex Hcn2tm1Ldw
         8 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Hcn2):
     behavior/neurological  cardiovascular system  growth/size  hearing/vestibular/ear  integument 
     mortality/aging  nervous system  reproductive system 

    HCN2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HCN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    2HCN channels
    		HCN channels1.00
    3Antiarrhythmic Pathway, Pharmacodynamics
    		Antiarrhythmic Pathway, Pharmacodynamics1.00
    4Potassium transporters: inward current
    		Potassium transporters: inward current1.00
    5Sodium channels and transporters: inward current
    		Sodium channels and transporters: inward current1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HCN2
        Potassium transporters- inward current
    Sodium channels and transporters- inward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HCN2
        Sperm Motility

    3        Reactome Pathways for HCN2
        Potassium Channels
    HCN channels
    Neuronal System

    1 PharmGKB Pathway for HCN2
        Antiarrhythmic Pathway, Pharmacodynamics


    HCN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HCN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for HCN2 (Q9UL513 ENSP000002512874) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCN1O607413, ENSP000003073424I2D: score=3 STRING: ENSP00000307342
    HCN4Q9Y3Q43, ENSP000002619174I2D: score=2 STRING: ENSP00000261917
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport TAS10228147
    GO:0006936muscle contraction TAS10228147
    GO:0007267cell-cell signaling TAS9630217
    GO:0007268synaptic transmission TAS--
    GO:0007420brain development ----


    HCN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HCN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HCN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HCN2

    3 HMDB Compounds for HCN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    SodiumSodium (see all 2)7440-23-5--

    2 DrugBank Compounds for HCN2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4target--17139284 17016423 10592235
    Cyclic Guanosine Monophosphate-- 7665-99-8target--17139284 17016423 10592235

    2 Novoseek chemical compound relationships for HCN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 33.9 2 15961404 (1), 16368742 (1)
    cysteine 9.79 1 16446506 (1)

    Search CenterWatch for drugs/clinical trials and news about HCN2 

    Transcripts
    for HCN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HCN2 gene: 
    NM_001194.3  

    Unigene Cluster for HCN2:

    Hyperpolarization activated cyclic nucleotide-gated potassium channel 2
    Hs.124161  [show with all ESTs]
    Unigene Representative Sequence: AJ012582
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000251287(uc002lpe.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HCN2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate HCN2 (see all 18):
    hsa-miR-137 hsa-miR-181c hsa-miR-25 hsa-miR-654-5p hsa-miR-4325 hsa-miR-92b hsa-miR-181b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmid: HCN2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HCN2 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF064877.1 AF065164.2 AJ012582.1 BC039619.1 DQ854815.1 

    1 DOTS entry:

    DT.205481 

    24/38 AceView cDNA sequences (see all 38):

    BI490383 BF057277 BI490063 AF064851 CK902965 BI756607 CA488767 BF510959 
    NM_001194 AI422949 AJ012582 CB054838 BV205340 AI809833 AW073171 CA488537 
    BV205342 BE546989 AF065164 BC039619 BM929321 AW452312 BI752028 AF064877 

    GeneLoc Exon Structure


    Expression
    for HCN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HCN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCATTGCGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HCN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HCN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HCN2

    SOURCE GeneReport for Unigene cluster: Hs.124161

    UniProtKB/Swiss-Prot: HCN2_HUMAN, Q9UL51
    Tissue specificity: Highly expressed throughout the brain. Detected at low levels in heart

        SABiosciences Expression via Pathway-Focused PCR Array including HCN2: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HCN2

    Orthologs
    for HCN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HCN2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7703841 potassium/sodium hyperpolarization-activated cyclic more 80.16(n)
    83.19(a)    		   770384  XM_003642867.1  XP_003642915.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HCN26
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL344297.1(1163-15536)
    zebrafish
    (Danio rerio)    		 Actinopterygii hcn21 hyperpolarization activated cyclic nucleotide-gated more 70.01(n)
    77.23(a)    		   557285  XM_680322.4  XP_685414.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ih3 intracellular cyclic nucleotide activated
    cation more    		 53(a)     --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPIK6
    CNGC3.C6
    (see all 29)    		 cyclic nucleotide gated channel
    (see all 29)    		 9(a)
    14(a)
    (see all 29)    		 possible ortholog
    possible ortholog
    (see all 29)    		 2(10894486-10898642)
    2(19058130-19061436)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 28)    		 potassium channel KAT1, putative, expressed
    (see all 28)    		 20(a)
    19(a)
    (see all 28)    		 possible ortholog
    possible ortholog
    (see all 28)    		 6(19563212-19568252)
    1(31760179-31762843)


    ENSEMBL Gene Tree for HCN2 (if available)
    TreeFam Gene Tree for HCN2 (if available) 

    Paralogs
    for HCN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HCN2 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  KCNH42  CNGA22  CNGA12  
    HCN12  KCNH72  KCNH22  CNGB12  CNGA42  CNGA32  CNGB32  KCNH12  
    KCNH82  
    3 SIMAP similar genes for HCN2 using alignment to 1 protein entry:     HCN2_HUMAN:
    HCN3    HCN1    HCN4

    HCN2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HCN2
    PGOHUM00000246721 PGOHUM00000247045


    Genomic Variants
    for HCN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/844 NCBI SNPs in HCN2 are shown (see all 844)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1813205461,2
    		--587908(+) AGCCGA/GGCGTG 1 -- us2k10--------
    rs1839925051,2
    		--587911(+) CGAGCA/GTGGTG 1 -- us2k10--------
    rs357751771,2
    		--587919(-) GCGCCC/TGCCAC 1 -- us2k10--------
    rs341446391,2
    		--587923(-) ACAGGA/CGCCTG 1 -- us2k10--------
    rs1886719191,2
    		--587924(+) AGGCGC/TCTGTA 1 -- us2k10--------
    rs110851291,2
    		C,A,H,--587964(+) agaatC/Tgctta 1 -- us2k10--------
    rs75077201,2
    		C,A,H,--587977(+) CCCGGG/TAGTCG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs118828701,2
    		C,H,--588053(+) aactcA/Taaaat 1 -- us2k1 tfbs34Minor allele frequency- T:0.09NA WA 242
    rs72513011,2
    		C,--588196(+) CAGAGA/CCGTCG 1 -- us2k12Minor allele frequency- C:0.33CSA 3
    rs1479615391,2
    		--588225(+) ACCCC-/GGAGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HCN2 (589893 - 617159 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for HCN2
         6 CNVs: 73266 30052 30050 43526 30051 30053
    Human Gene Mutation Database (HGMD): HCN2

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    Disorders / Diseases
    for HCN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HCN2 for disorders           About GeneDecksing

    OMIM gene information: 602781    OMIM disorders: --

    11 diseases for HCN2:    About MalaCards
    idiopathic generalized epilepsy    generalized epilepsy    status epilepticus    febrile convulsions
    febrile seizures    convulsions    thyrotoxicosis    seizures
    aldosteronism    thyroiditis    neuronitis

    1 Novoseek disease relationship for HCN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy 24.8 5 20437590 (2)

    Genetic Association Database (GAD): HCN2
    Human Genome Epidemiology (HuGE) Navigator: HCN2 (6 documents)

    Export disorders for HCN2 gene to outside databases

    Publications
    for HCN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HCN2 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with HCN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a gene encoding a hyperpolarization-activated 'pacemaker' channel of brain. (PubMed id 9630217)1, 2, 3 Santoro B.... Tibbs G.R. (1998)
    2. Two pacemaker channels from human heart with profoundly different activation kinetics. (PubMed id 10228147)1, 2, 9 Ludwig A.... Biel M. (1999)
    3. [Association between familial febrile convulsions and HCN2 gene] (PubMed id 15932727)1, 4 Ma Y.N....Qi Y. (2005)
    4. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (2005)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. The human gene coding for HCN2, a pacemaker channel of the heart. (PubMed id 10524219)1, 2 Vaccari T....DiFrancesco D. (1999)
    7. Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. (PubMed id 9405696)1, 3 Santoro B....Kandel E.R. (1997)
    8. Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. (PubMed id 17931874)1, 9 Tang B....Escayg A. (2008)
    9. Augmented currents of an HCN2 variant in patients wit h febrile seizure syndromes. (PubMed id 20437590)1, 9 Dibbens L.M....Petrou S. (2010)
    10. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. (PubMed id 16777944)1, 9 Elinder F....Larsson H.P. (2006)

    External Searches for HCN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HCN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 610 HGNC: 4846 AceView: HCN2 Ensembl:ENSG00000099822 euGenes: HUgn610
    ECgene: HCN2 H-InvDB: HCN2

    Other Databases showing HCN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HCN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HCN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HCN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HCN2 gene:
    Search GeneIP for patents involving HCN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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