GPR62 Gene
protein-coding GIFtS: 43
GCID: GC03P051964
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G protein-coupled receptor 62
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Aliases
for GPR62 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 621 2 | | GPCR82 | | G-Protein Coupled Receptor GPCR82 3 | | KPG_0052 | | G-Protein Coupled Receptor KPG_0052 3 | | Probable G-Protein Coupled Receptor 622 | | HGPCR81 | | |
Export aliases for GPR62 gene to outside databasesPrevious GC identifers: GC03P051082 GC03P051243 GC03P051845 GC03P051948 |
Summaries
for GPR62 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7Function: Orphan receptor
Gene Wiki entry for GPR62
|
Genomic Views
for GPR62 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR62 gene promoter:
PPAR-alpha GR Max1 HOXA3 NRSF form 1 Lmo2 GR-alpha NRSF form 2 C/EBPalpha GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR62
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR62 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.1GPR62 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P051964: view genomic region
(about GC identifiers)
Start:
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51,989,330 bp from pter |
End:
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51,991,520 bp from pter |
Size:
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2,191 bases |
Orientation:
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plus strand |
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Proteins
for GPR62 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 62 Size: 368 amino acids; 37614 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: F1DAM4 Q5KU27Explore the universe of human proteins at neXtProt for GPR62: NX_Q9BZJ7
GPR62 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543141.3
ENSEMBL proteins: ENSP00000319250
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
GPR62 for ontologies About GeneDecksing
GPR62 Antibody Products:
Assay Products for GPR62: |
Protein
Domains /
Families
for GPR62 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR62 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BZJ7ProtoNet protein and cluster: Q9BZJ7 UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for GPR62 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7Function: Orphan receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR62 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR62 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GPR62 (NM_080865) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR62 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR62 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR62 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
GPR62 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPR62:
|
Pathways & Interactions
for GPR62 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GPCRs, Other | |
1  BioSystems Pathway for GPR62
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR62
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
GPR62 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR62 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR62
Search CenterWatch for drugs/clinical trials and news about GPR62
|
Transcripts
for GPR62 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR62 gene: NM_080865.3 Unigene Cluster for GPR62: G protein-coupled receptor 62 Hs.232213 [show with all ESTs]Unigene Representative Sequence: NM_0808651 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000322241(uc003dca.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR62 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR62 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR62 (NM_080865) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR62 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR62 |
Additional cDNA sequence: AB032600.1 BC026357.1 HQ709188.1 3 DOTS entries: DT.75155412 DT.40129726 DT.95350995 10 AceView cDNA sequences: NM_080865 BI550945 AI951672 BF940605 BI820558 AI083852 BC026357 AI991916 AI678943 BG700144
GeneLoc Exon Structure
|
Expression
for GPR62 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR62 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAGGGGC
About this image
See GPR62 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR62
SOURCE GeneReport for Unigene cluster: Hs.232213
UniProtKB/Swiss-Prot: GPR62_HUMAN, Q9BZJ7Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus andhippocampus
SABiosciences Expression via Pathway-Focused PCR Array including GPR62: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR62
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GPR62 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR62 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR62 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR62 |
Orthologs
for GPR62 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for GPR62 (if available)
TreeFam Gene Tree for GPR62 (if available) |
Paralogs
for GPR62 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR62 gene
- GPR1012 GPR1612 GPR612
GPR62 for paralogs About GeneDecksing
|
Genomic Variants
for GPR62 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR62 (51989330 - 51991520 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPR62: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR62 |
|
Disorders
/ Diseases
for GPR62 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 GPR62 for disorders About MalaCards
GPR62 for disorders About GeneDecksing
OMIM gene information: 606917
OMIM disorders: --
Export disorders for GPR62 gene to outside databases
|
Publications
for GPR62 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR62 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GPR62) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of four novel human G protein-coupled receptors expressed in the brain. (PubMed id 11165367)1, 2, 3 Lee D.K.... O'Dowd B.F. (2001)
- Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GPR62 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR62 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR62 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR62 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR62 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for GPR62 gene:
Search GeneIP for patents involving GPR62
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR62 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for GPR62 | | OriGene shRNA RFP for GPR62 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR62 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR62 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR62 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR62 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR62 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GPR62 | | OriGene Custom Protein Services for GPR62 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR62 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR62 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR62 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR62 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR62 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR62 |
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 |  |  |  | |
| | | | Search Tocris compounds for GPR62 |
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 | | | GPR62 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR62 |
|  |  |  | | | | ThermoFisher Antibodies for GPR62 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR62 |
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