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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GHRHR Gene

protein-coding   GIFtS: 60
GCID: GC07P030978

growth hormone releasing hormone receptor

 Explore 40 diseases affiliated with
GHRHR via our new
 Human Malady Compendium 
Biological research products
for GHRHR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Growth Hormone Releasing Hormone Receptor1 2     GHRFR2 5
GRFR2 3     IGHD1B2 5
GHRH Receptor2 3     Growth Hormone-Releasing Hormone Receptor2
GRF Receptor2 3     Growth Hormone-Releasing Factor Receptor3

External Ids:    HGNC: 42661   Entrez Gene: 26922   Ensembl: ENSG000001061287   OMIM: 1391915   UniProtKB: Q026433   

Export aliases for GHRHR gene to outside databases

Previous GC identifers: GC07P030646 GC07P030745 GC07P030776 GC07P030970 GC07P030885


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GHRHR:
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to
synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone
deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. (provided by RefSeq,
Jun 2010)

UniProtKB/Swiss-Prot: GHRHR_HUMAN, Q02643
Function: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth,
growth hormone gene transcription and growth hormone secretion

Gene Wiki entry for GHRHR (Growth-hormone-releasing hormone receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GHRHR gene promoter:
         ER-alpha   STAT5B   STAT1   STAT1beta   AP-4   Gfi-1   STAT1alpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGHRHR promoter sequence
   Search SABiosciences Chromatin IP Primers for GHRHR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GHRHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14

GHRHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GHRHR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P030978:  view genomic region     (about GC identifiers)

Start:
30,978,284 bp from pter      End:
31,032,869 bp from pter
Size:
54,586 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 31,053,140-31,068,651     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GHRHR_HUMAN, Q02643 (See protein sequence)
Recommended Name: Growth hormone-releasing hormone receptor precursor  
Size: 423 amino acids; 47402 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for GHRHR:
2XDG (3D)    
Secondary accessions: Q99863

Explore the universe of human proteins at neXtProt for GHRHR: NX_Q02643

GHRHR Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_000814.2  
ENSEMBL proteins: 
 ENSP00000320180   ENSP00000387113   ENSP00000379529   ENSP00000386919   ENSP00000386602  
 ENSP00000338184  
Reactome Protein details: Q02643
Human Recombinant Protein Products: 
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Novus Biologicals GHRHR Lysate
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Uscn Proteins for GHRHR

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005624membrane fraction ----
GO:0005637nuclear inner membrane IDA10461027
GO:0005640nuclear outer membrane IDA10461027
GO:0005737cytoplasm IDA10461027
GO:0005886plasma membrane TAS--


GHRHR for ontologies           About GeneDecksing



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ThermoFisher Antibody for GHRHR

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Uscn ELISAs and CLIAs for GHRHR


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GHRHR for domains           About GeneDecksing

5 InterPro domains/families:
 IPR001879 GPCR_2_extracellular_dom
 IPR000832 GPCR_2_secretin-like
 IPR003288 GPCR_2_GHRH_rcpt
 IPR017983 GPCR_2_secretin-like_CS
 IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry Q02643

ProtoNet protein and cluster: Q02643

2 Blocks protein families:
IPB000832 G-protein coupled receptors family 2 (secretin-like)
IPB003288 Growth hormone-releasing hormone receptor signature


UniProtKB/Swiss-Prot: GHRHR_HUMAN, Q02643
Similarity: Belongs to the G-protein coupled receptor 2 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: GHRHR_HUMAN, Q02643
Function: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth,
growth hormone gene transcription and growth hormone secretion

     Genatlas biochemistry entry for GHRHR:
growth hormone releasing hormone receptor,G protein coupled receptor superfamily

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Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRHR

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IC1333056
GO:0005515protein binding IPI7680413
GO:0016520growth hormone-releasing hormone receptor activity IMP7680413
GO:0017046peptide hormone binding IPI7680413
GO:0019838growth factor binding IPI7680413


GHRHR for ontologies           About GeneDecksing


Animal Models:
     10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ghrhr):
 adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
 integument  limbs/digits/tail  nervous system  reproductive system  skeleton 

GHRHR for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
2G beta:gamma signalling through PLC beta
Glucagon-type ligand receptors0.52
G alpha (s) signalling events0.14
Class B/2 (Secretin family receptors)0.20
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.75
Neuroactive ligand-receptor interaction0.38
4GPCRs, Class B Secretin-like
GPCRs, Class B Secretin-like1.00
5GPCRs, Other
GPCRs, Other1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GHRHR
    GHRH Signaling

2 BioSystems Pathways for GHRHR 
    GPCRs, Class B Secretin-like
GPCRs, Other

5/7        Reactome Pathways for GHRHR (see all 7)
    GPCR downstream signaling
Glucagon-type ligand receptors
Signal Transduction
Signaling by GPCR
GPCR ligand binding


1         Kegg Pathway  (Kegg details for GHRHR):
    Neuroactive ligand-receptor interaction


GHRHR for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GHRHR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/66 Interacting proteins for GHRHR (Q026433 ENSP000003201804) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
InteractantInteraction Details
GeneCardExternal ID(s)
GHRHP012863, ENSP000002375274I2D: score=1 STRING: ENSP00000237527
GHRLQ9UBU33, ENSP000003350744I2D: score=1 STRING: ENSP00000335074
MLNRO431933, ENSP000002187214I2D: score=1 STRING: ENSP00000218721
ADCY2ENSP000003429524STRING: ENSP00000342952
ADCY8ENSP000002863554STRING: ENSP00000286355
About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction ----
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA1333056
GO:0007190activation of adenylate cyclase activity IEA--


GHRHR for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GHRHR for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GHRHR

1 DrugBank Compound for GHRHR    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Sermorelin-- 86168-78-7targetagonist14499707 11752352

10/16 Novoseek chemical compound relationships for GHRHR gene (see all 16)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ghrp 73.8 1 11081183 (1)
hexarelin 50.4 1 10084578 (1)
adenylate 48 5 9605937 (1), 11165046 (1), 16553291 (1)
ribonucleic acid 33.5 4 7559877 (2), 19029774 (1)
forskolin 29.8 1 9482665 (1)
cyclic amp 16.7 1 11380500 (1)
glucose 4.61 1 18413425 (1)
lysine 0 1 11875102 (1)
calcium 0 2 9798733 (1), 15728367 (1)
silver 0 1 8660323 (1)

Search CenterWatch for drugs/clinical trials and news about GHRHR 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GHRHR gene (2 alternative transcripts): 
NM_000823.3  NM_001009824.1  

Unigene Clusters for GHRHR:

Growth hormone releasing hormone receptor
Hs.767  [show with all ESTs], Hs.733003
Unigene Representative Sequences: AF282259, S79912
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000466427 ENST00000326139(uc003tbx.3) ENST00000409904(uc003tby.3)
ENST00000396227 ENST00000409233 ENST00000409316(uc003tbz.3) ENST00000489974
ENST00000461424 ENST00000461390 ENST00000463164 ENST00000473133 ENST00000337750


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SwitchGear 3'UTR luciferase reporter plasmidGHRHR 3' UTR sequence
Inhib. RNA
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GHRHR
Clone
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GenScript: all cDNA clones in your preferred vector: GHRHR (NM_000823)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GHRHR 
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Additional cDNA sequence: S79912.1 

4 DOTS entries:

DT.408967  DT.95266259  DT.454889  DT.95266258 

15 AceView cDNA sequences:

AF282262 AF282259 AF282260 AY557192 L09237 AF282261 L01406 CD107584 
BV183588 AB058895 S79912 BV196206 NM_000823 T29545 AV750179 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GHRHR (see all 7)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:                    -           -                 -                                                                     
SP2:                                -                 -     -                                                               
SP3:                                -                 -                                                                     
SP4:                                                                                      -     -     -                     
SP5:                                -                 -     -                                                               


ECgene alternative splicing isoforms for GHRHR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GHRHR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCTGAGCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See GHRHR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GHRHR

SOURCE GeneReport for Unigene clusters: Hs.767 Hs.733003

UniProtKB/Swiss-Prot: GHRHR_HUMAN, Q02643
Tissue specificity: Pituitary gland

    SABiosciences Expression via Pathway-Focused PCR Array including GHRHR: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GHRHR

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GHRHR gene from 4/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves GHRHR1 growth hormone releasing hormone receptor 62.94(n)
62.29(a)
  420385  NM_001037834.2  NP_001032923.1 
lizard
(Anolis carolinensis)
Reptilia GHRHR6
--
51(a)
1 ↔ 1
6(1945618-1962094)
zebrafish
(Danio rerio)
Actinopterygii ghrhrl1 growth hormone releasing hormone receptor, like 60.96(n)
57.37(a)
  793334  NM_001082482.1  NP_001075951.1 
honey bee
(Apis mellifera)
Insecta --
--
(see all 4)
--
3(a)
24(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
Group9.2(517685-519657)
Group9.2(531165-533904)


ENSEMBL Gene Tree for GHRHR (if available)
TreeFam Gene Tree for GHRHR (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GHRHR gene
GLP1R2  GCGR2  CALCR2  CRHR22  PTH1R2  VIPR12  CRHR12  PTH2R2  
CALCRL2  ADCYAP1R12  SCTR2  GLP2R2  VIPR22  GIPR2  
15 SIMAP similar genes for GHRHR using alignment to 6 protein entries:     GHRHR_HUMAN (see all proteins):
GHRHRpsv    PTHR2    GLP2R    SCTR    VIPR1    VIPR2
GCGR    ADCYAP1R1    GIPR    PTH1R    CRHR1    PTH2R
GLP1R    CRHR2    CALCR

GHRHR for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/404 NCBI SNPs in GHRHR are shown (see all 404    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49884961,2
C,F,H,non-pathogenic31058191(+) GCCCTG/ACGACC 2 /T /A mis1 ese327Minor allele frequency- A:0.14NA EU CSAM EA NS WA 6167
rs49884981,2
C,F,H,non-pathogenic31059081(+) GCTGAG/TGAGGT 2 E D mis1 ese331Minor allele frequency- T:0.08NS EA NA EU CSAM WA 9268
rs49884991,2
C,non-pathogenic31059097(+) TCTTCT/GGGCAT 1 -- int110Minor allele frequency- G:0.04NA EU CSAM EA NS WA 1227
rs7403361,2
C,F,H,non-pathogenic31061182(+) TTCCAC/TAGCGA 2 H syn1 ese328Minor allele frequency- T:0.06NA EA NS EU CSAM MN WA 8523
rs1219181181,2
C,pathogenic31060303(+) AGCCCA/TCTTCG 2 H L mis10--------
rs1927147771,2
--31001697(+) GAATCC/TTGAGT 1 -- us2k10--------
rs1841362371,2
--31001708(+) GTATAC/TAGAAT 1 -- us2k10--------
rs20755851,2
C,F,H,--31001860(+) TCCTGT/CGCATT 1 -- us2k129Minor allele frequency- C:0.33NS EA NA EU CSAM WA 3331
rs1878212891,2
--31001868(+) ATTGTA/GGATGC 1 -- us2k10--------
rs1926998421,2
--31001896(+) CTCTAC/TTCATT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for GHRHR (30978284 - 31032869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for GHRHR: --
Human Gene Mutation Database (HGMD): GHRHR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GHRHR for disorders           About GeneDecksing

OMIM gene information: 139191   
OMIM disorders: 612781  
UniProtKB/Swiss-Prot: GHRHR_HUMAN, Q02643
  • Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known
  • as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients
    have low but detectable levels of GH

    20/40 diseases for GHRHR (see all 40):    About MalaCards
    growth hormone deficiency    isolated growth hormone deficiency    short stature    dwarfism
    growth hormone secreting pituitary adenoma    multiple endocrine neoplasia    islet cell tumor    pancreatic islet cell tumors
    non-hodgkin lymphoma    pituitary adenoma    pituitary hypoplasia    somatotrophinoma
    prolactinoma    hodgkin's lymphoma    pituitary tumor    acromegaly
    epithelial ovarian cancer    hypopituitarism    adenoma    hypothyroidism

    1 disease from the University of Copenhagen DISEASES database for GHRHR:
    Pituitary hypoplasia

    10/22 Novoseek disease relationships for GHRHR gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    growth hormone deficiency 80.7 19 16355809 (1), 19209235 (1), 10822217 (1), 12414875 (1) (see all 10)
    dwarfism 73.1 18 10549302 (2), 10084571 (2), 19733620 (1), 11145605 (1) (see all 10)
    short stature 64.3 2 9238854 (1), 9814493 (1)
    pituitary tumors 61.4 8 11502843 (4), 10999842 (1), 9176381 (1), 12429040 (1)
    pituitary adenoma 60.1 25 19029774 (4), 7559877 (3), 10359139 (2), 9667225 (2) (see all 8)
    growth failure 53.3 1 8528260 (1)
    acromegaly 51.8 8 11158006 (3), 9024267 (1), 11453963 (1), 11165046 (1)
    hypoplasia 51.3 10 10782778 (2), 8875435 (2), 15049962 (1), 11036940 (1)
    prolactinoma 43.1 5 10359139 (4), 12165656 (1)
    somatic mutations 41.3 1 8396832 (1)

    Genatlas disease: GHRHR
    dwarfism with growth hormone deficiency

    Genetic Association Database (GAD): GHRHR
    Human Genome Epidemiology (HuGE) Navigator: GHRHR (25 documents)

    Export disorders for GHRHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GHRHR gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with GHRHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. (PubMed id 7680413)1, 2, 3, 9 Gaylinn B.D....Thorner M.O. (1993)
    2. A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency. (PubMed id 12534354)1, 2, 9 Carakushansky M.... Salvatori R. (2003)
    3. Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB. (PubMed id 11232012)1, 2, 9 Salvatori R....Levine M.A. (2001)
    4. Familial dwarfism due to a novel mutation of the growth hormone- releasing hormone receptor gene. (PubMed id 10084571)1, 2, 9 Salvatori R.... Levine M.A. (1999)
    5. Pituitary growth hormone and growth hormone-releasing hormone receptor genes and associations with mammographic measures and serum growth hormone. (PubMed id 16284391)1, 4, 9 Mulhall C....Boyd N.F. (2005)
    6. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4, 9 Canzian F....Kaaks R. (2005)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. (PubMed id 1333056)1, 2 Mayo K.E. (1992)
    9. Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers. (PubMed id 15944917)1, 9 Gallego R....Morel G. (2005)
    10. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. (PubMed id 7559877)1, 9 Hashimoto K.... Kishimoto T. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2692 HGNC: 4266 AceView: GHRHR Ensembl:ENSG00000106128 euGenes: HUgn2692
    ECgene: GHRHR Kegg: 2692 H-InvDB: GHRHR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GHRHR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GHRHR gene:
    Search GeneIP for patents involving GHRHR

    GeneCards and IP:
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